Steve Marston

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?
    Steven B Marston
    Cardiovascular Science, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    J Mol Cell Cardiol 45:603-7. 2008
  2. doi request reprint How do MYBPC3 mutations cause hypertrophic cardiomyopathy?
    Steven Marston
    NHLI, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:75-80. 2012
  3. pmc The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy
    Adam M Jacques
    Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Dovehouse Street, London, UK
    Cardiovasc Res 79:481-91. 2008
  4. doi request reprint Tropomyosin isoform expression and phosphorylation in the human heart in health and disease
    Steven B Marston
    Myocardial Function, NHLI, Imperial College London, London, W12 0NN, UK
    J Muscle Res Cell Motil 34:189-97. 2013
  5. ncbi request reprint Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications
    Steven B Marston
    Imperial College London, National Heart and Lung Institute, Dovehouse St, London SW3 6LY, UK
    Circ Res 93:1170-8. 2003
  6. pmc How does genotype define phenotype? Microphysiology of a tropomyosin mutation in situ shows the limitations of reductionism
    Steven Marston
    Imperial College London, NHLI, London SW3 6LY, UK
    J Physiol 586:2821. 2008
  7. ncbi request reprint Role of tropomyosin in the regulation of contraction in smooth muscle
    Steve Marston
    National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, UK
    Adv Exp Med Biol 644:110-23. 2008
  8. doi request reprint How do mutations in contractile proteins cause the primary familial cardiomyopathies?
    Steven B Marston
    NHLI, Imperial College London, UK
    J Cardiovasc Transl Res 4:245-55. 2011
  9. ncbi request reprint Functional characterisation of a mutant actin (Met132Val) from a patient with nemaline myopathy
    Steven Marston
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Neuromuscul Disord 14:167-74. 2004
  10. pmc Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle
    Anupama Vydyanath
    Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:61-74. 2012

Collaborators

Detail Information

Publications27

  1. pmc Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?
    Steven B Marston
    Cardiovascular Science, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    J Mol Cell Cardiol 45:603-7. 2008
    ..In contrast, some animal models used to study the mechanisms of heart failure give the opposite result-high levels of troponin I phosphorylation and low Ca2+-sensitivity. Which is right?..
  2. doi request reprint How do MYBPC3 mutations cause hypertrophic cardiomyopathy?
    Steven Marston
    NHLI, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:75-80. 2012
    ..In this review we investigate the mechanism for MyBP-C haploinsufficiency and consider how this haploinsufficiency could cause hypertrophic cardiomyopathy...
  3. pmc The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy
    Adam M Jacques
    Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Dovehouse Street, London, UK
    Cardiovasc Res 79:481-91. 2008
    ....
  4. doi request reprint Tropomyosin isoform expression and phosphorylation in the human heart in health and disease
    Steven B Marston
    Myocardial Function, NHLI, Imperial College London, London, W12 0NN, UK
    J Muscle Res Cell Motil 34:189-97. 2013
    ..Neither the isoform distribution nor the level of phosphorylation changed significantly in the pathological heart muscle samples...
  5. ncbi request reprint Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications
    Steven B Marston
    Imperial College London, National Heart and Lung Institute, Dovehouse St, London SW3 6LY, UK
    Circ Res 93:1170-8. 2003
    ....
  6. pmc How does genotype define phenotype? Microphysiology of a tropomyosin mutation in situ shows the limitations of reductionism
    Steven Marston
    Imperial College London, NHLI, London SW3 6LY, UK
    J Physiol 586:2821. 2008
  7. ncbi request reprint Role of tropomyosin in the regulation of contraction in smooth muscle
    Steve Marston
    National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, UK
    Adv Exp Med Biol 644:110-23. 2008
    ..Caldesmon and calmodulin control the tropomyosin-mediated transition between on and offactivity states...
  8. doi request reprint How do mutations in contractile proteins cause the primary familial cardiomyopathies?
    Steven B Marston
    NHLI, Imperial College London, UK
    J Cardiovasc Transl Res 4:245-55. 2011
    ..A plausible link between uncoupling and DCM has been proposed via blunting of the response to α-adrenergic stimulation...
  9. ncbi request reprint Functional characterisation of a mutant actin (Met132Val) from a patient with nemaline myopathy
    Steven Marston
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Neuromuscul Disord 14:167-74. 2004
    ..We conclude that the mutant mRNA and protein is expressed and that the mutation reduces polymerisability and alters thin filament function...
  10. pmc Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle
    Anupama Vydyanath
    Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:61-74. 2012
    ....
  11. ncbi request reprint Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
    Andrew E Messer
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    J Mol Cell Cardiol 42:247-59. 2007
    ..35-0.75). We suggest that changes in troponin function can account for the contractile abnormality in failing heart muscle and that the functional changes in troponin are due to reduced phosphorylation of troponin I at the PKA sites...
  12. doi request reprint The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle
    Andrew E Messer
    National Heart and Lung Institute, Imperial College London, London, UK
    Proteomics Clin Appl 3:1371-82. 2009
    ....
  13. ncbi request reprint On mechanosensation, acto/myosin interaction, and hypertrophy
    Ralph Knoll
    Heart Science Section, National Heart and Lung Institute, Imperial College, London W12 0NN, UK
    Trends Cardiovasc Med 22:17-22. 2012
    ..In this article, we introduce contractility per se as an important mechanosensory mechanism, and we differentiate extracellular from intracellular mechanosensory effects...
  14. ncbi request reprint Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: evidence for a cooperative switching mechanism
    Saira Ansari
    Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Biol Chem 283:47-56. 2008
    ..The results are used to discuss both caldesmon inhibition and Ca(2+)-calmodulin-caldesmon activation of actin-tropomyosin...
  15. doi request reprint Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts
    O Neal Copeland
    NHLI, Cardiovascular Science, Imperial College London, London, UK
    J Muscle Res Cell Motil 31:207-14. 2010
    ..We also found elevated skeletal muscle alpha-actin (60 +/- 7%) in a mouse model of dilated cardiomyopathy...
  16. ncbi request reprint Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle
    Adam M Jacques
    Cardiovascular Science, NHLI, Imperial College London, London, United Kingdom
    J Mol Cell Cardiol 45:209-16. 2008
    ..0+/-0.3 mol Pi/mol in myectomy samples. We conclude that MyBP-C is a highly phosphorylated protein in vivo and that diminished MyBP-C phosphorylation is a feature of both end-stage heart failure and hypertrophic cardiomyopathy...
  17. ncbi request reprint The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase
    Mustapha Alahyan
    Myocardial Systems Biology Group, National Heart and Lung Institute, Imperial College, London SW3 6LY
    J Biol Chem 281:19433-48. 2006
    ..This inhibition is sufficient to account for the inhibition of the steady state actomyosin ATPase by caldesmon and tropomyosin...
  18. doi request reprint Direct visualisation and kinetic analysis of normal and nemaline myopathy actin polymerisation using total internal reflection microscopy
    Juan Juan Feng
    NHLI, Cardiovascular Science and Molecular Medicine, Imperial College London, London, UK
    J Muscle Res Cell Motil 30:85-92. 2009
    ..This technique was used to study polymerisation of a mutant actin (D286G) from a transgenic mouse model. D286G actin elongated at a 40% lower rate than non-transgenic actin...
  19. ncbi request reprint Fatal hypertrophic cardiomyopathy and nemaline myopathy associated with ACTA1 K336E mutation
    Adele d'Amico
    Unit of Molecular Medicine and Pathology, Dept of Laboratory Medicine, Bambino Gesu Children s Research Hospital, Rome, Italy
    Neuromuscul Disord 16:548-52. 2006
    ..This is the first report on a hypertrophic cardiomyopathy associated with nemaline myopathy and an ACTA1 mutation...
  20. ncbi request reprint Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma
    Ivan S Chernik
    Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119992, Russia
    Mol Cell Biochem 295:9-17. 2007
    ....
  21. ncbi request reprint Calcium, contractions, and tropomyosin Focus on "divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins"
    Steven B Marston
    Physiol Genomics 9:57-8. 2002
  22. ncbi request reprint Interaction of the small heat shock protein with molecular mass 25 kDa (hsp25) with actin
    Olesya O Panasenko
    Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russia
    Eur J Biochem 270:892-901. 2003
    ..HSP25 predominantly acts as a chaperone and preferentially interacts with thermally unfolded actin, preventing the formation of insoluble aggregates...
  23. ncbi request reprint Small heat shock protein with apparent molecular mass 20 kDa (Hsp20, HspB6) is not a genuine actin-binding protein
    Olesya V Bukach
    Department of Biochemistry, School of Biology, Moscow State University, 119992 Moscow, Russia
    J Muscle Res Cell Motil 26:175-81. 2005
    ..Since Hsp20 is not a genuine actin-binding protein, the earlier described correlation between Hsp20 phosphorylation and smooth muscle relaxation cannot be explained by direct interaction of Hsp20 with actin...
  24. ncbi request reprint pH-induced changes of the structure of small heat shock proteins with molecular mass 24/27kDa (HspB1)
    Ivan S Chernik
    Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russia
    Biochem Biophys Res Commun 324:1199-203. 2004
    ..It is concluded that small changes of pH strongly affect the quaternary structure of small heat shock proteins and by this means can influence their functioning in the cell...
  25. ncbi request reprint Some properties of human small heat shock protein Hsp22 (H11 or HspB8)
    Maria V Kim
    Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russia
    Biochem Biophys Res Commun 315:796-801. 2004
    ....
  26. ncbi request reprint Phosphorylation of the minimal inhibitory region at the C-terminus of caldesmon alters its structural and actin binding properties
    Valerie B Patchell
    School of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1596:121-30. 2002
    ..The data are discussed in the context of the inhibitory association of the C-terminal domain of caldesmon with F-actin...