Research Topics
| A L MaliziaSummaryAffiliation: Imperial College School of Medicine Country: UK Publications
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Detail Information
Publications
The frontal lobes and neurosurgery for psychiatric disordersA L Malizia
Psychopharmacology Unit, University of Bristol BS8 1TD and MRC Cyclotron Unit, Hammersmith Hospital, London, UK
J Psychopharmacol 11:179-87. 1997..Current advances in clinical neuroscience methods should be used in patients with these lesions to elucidate the neural substrate of post-operative changes and optimize clinical practice...
Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivoA L Malizia
Cyclotron Unit, MRC CRC, Hammersmith Hospital, London, UK
J Psychopharmacol 11:279-81. 1997..The MOCC is likely to be useful to determine sequential indices of relative serotonin reuptake blockade in patients on treatment...
Desipramine binding to noradrenaline reuptake sites in cardiac sympathetic neurons in man in vivoA L Malizia
Psychopharmacology Unit, University of Bristol, Bristol, UK
Eur J Pharmacol 391:263-7. 2000..In conclusion, [11C]meta-hydroxyephedrine in the multiple organs' coincidences counter gives a valid, low radiation method to assess noradrenergic reuptake blockade in the clinic...
Analysis of dynamic radioligand displacement or "activation" studiesK J Friston
Wellcome Department of Cognitive Neurology, National Hospital, London, UK
J Cereb Blood Flow Metab 17:80-93. 1997..We were able to demonstrate, and make statistical inferences about, regional increases in k2 (or decreases in the volume of distribution) in prefrontal and other cortical areas...
Venlafaxine occupation at the noradrenaline reuptake site: in-vivo determination in healthy volunteersJ K Melichar
Psychopharmacology Unit, University of Bristol, UK
J Psychopharmacol 15:9-12. 2001..o. thus showing that noradrenaline reuptake blockade is observable at this dose. This effect is predominantly seen in volunteers who received > 1 mg/kg venlafaxine...
What do brain imaging studies tell us about anxiety disorders?A L Malizia
Psychopharmacology Unit, University of Bristol, UK
J Psychopharmacol 13:372-8. 1999..Most studies of binding at the benzodiazepine-GABA(A) receptor are not interpretable because of substantial methodological problems, however, regional and/or global reductions are the most consistent finding in panic disorder...
New insights into the role of the GABA(A)-benzodiazepine receptor in psychiatric disorderD J Nutt
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
Br J Psychiatry 179:390-6. 2001..In the 40 years since the first benzodiazepine was brought into clinical use there has been a substantial growth in understanding the molecular basis of action of these drugs and the role of their receptors in disease states...
Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjectsM R Daglish
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
Am J Psychiatry 158:1680-6. 2001..CONCLUSIONS: The patterns of cerebral activation reflect the different brain regions mediating the salience of opiate-related stimuli and the subjective experience of craving for opiates...
