Anthony D Maher

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi Statistical total correlation spectroscopy scaling for enhancement of metabolic information recovery in biological NMR spectra
    Anthony D Maher
    Neuroscience Research Australia, Barker Street, Randwick 2031, Australia
    Anal Chem 84:1083-91. 2012
  2. doi ¹H NMR-based metabonomics for investigating diabetes
    Anthony D Maher
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington SW72AZ, UK
    Future Med Chem 1:737-47. 2009
  3. doi Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    Anal Chem 80:7354-62. 2008
  4. doi Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington, SW7 2AZ, United Kingdom
    Anal Chem 81:288-95. 2009
  5. doi Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma
    Anthony D Maher
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, London, UK
    Clin Chem 54:2063-6. 2008
  6. pmc Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations
    Caroline D Rae
    Neuroscience Research Australia, and Brain Sciences UNSW, Randwick, NSW, Australia
    J Neurochem 129:304-14. 2014
  7. pmc Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation
    Leon M Smith
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Anal Chem 81:4847-56. 2009
  8. doi Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification
    Judith M Fonville
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Anal Chem 82:1811-21. 2010
  9. doi Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery
    Caroline J Sands
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom
    Anal Chem 81:6458-66. 2009
  10. ncbi Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples
    Leon M Smith
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Anal Chem 79:5682-9. 2007

Collaborators

Detail Information

Publications14

  1. doi Statistical total correlation spectroscopy scaling for enhancement of metabolic information recovery in biological NMR spectra
    Anthony D Maher
    Neuroscience Research Australia, Barker Street, Randwick 2031, Australia
    Anal Chem 84:1083-91. 2012
    ..This approach is generally appropriate for many types of NMR-based complex mixture analyses and hence for wider applications in bioanalytical science...
  2. doi ¹H NMR-based metabonomics for investigating diabetes
    Anthony D Maher
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington SW72AZ, UK
    Future Med Chem 1:737-47. 2009
    ..Continuing technological improvements will expand our knowledge of the causes and progression of this disease, and enhance treatment options for individuals...
  3. doi Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    Anal Chem 80:7354-62. 2008
    ....
  4. doi Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington, SW7 2AZ, United Kingdom
    Anal Chem 81:288-95. 2009
    ..The novel approach adopted here has the potential to capture dynamic information in any complex mixture of reacting chemicals including other biofluids or cell extracts...
  5. doi Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma
    Anthony D Maher
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, London, UK
    Clin Chem 54:2063-6. 2008
    ..Although studies have revealed decreased sperm motility, the quantitative biochemical changes that underlie the infertility mechanism remain poorly understood...
  6. pmc Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations
    Caroline D Rae
    Neuroscience Research Australia, and Brain Sciences UNSW, Randwick, NSW, Australia
    J Neurochem 129:304-14. 2014
    ..1 mM] has significant effects on brain metabolism. Higher ethanol [1.0-60 mM] likely decreases metabolism through action at α4β3δ-containing GABA(A) receptors. ..
  7. pmc Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation
    Leon M Smith
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Anal Chem 81:4847-56. 2009
    ....
  8. doi Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification
    Judith M Fonville
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Anal Chem 82:1811-21. 2010
    ....
  9. doi Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery
    Caroline J Sands
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom
    Anal Chem 81:6458-66. 2009
    ..Additionally, this tool could prove useful for applications outside of metabolic analysis, for example, in process chemistry for following chemical reactions and equilibria and detecting impurities...
  10. ncbi Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples
    Leon M Smith
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Anal Chem 79:5682-9. 2007
    ..Both methods either alone or in combination have the potential for general applications to any complex mixture analysis where the sample contains compounds with a range of diffusion coefficients...
  11. doi 1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies
    Derek J Crockford
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Sir Alexander Fleming Building, Imperial College London, UK
    Anal Chem 80:6835-44. 2008
    ..This approach is of great potential value in the description of population xenometabolomes and in population pharmacology studies, and indeed for drug metabolism studies in general...
  12. ncbi Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    Anal Chem 79:5204-11. 2007
    ....
  13. doi γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB
    Fatima A Nasrallah
    Neuroscience Research Australia, Randwick, NSW, Australia
    J Neurochem 115:58-67. 2010
    ..These results offer an explanation for the steep dose-response curve of GHB seen in vivo, and suggest potential target receptors for further investigation...
  14. doi Statistical integration of 1H NMR and MRS data from different biofluids and tissues enhances recovery of biological information from individuals with HIV-1 infection
    Anthony D Maher
    Neuroscience Research Australia, Barker St, Randwick 2031, Australia
    J Proteome Res 10:1737-45. 2011
    ..The results underscore the utility of tools such as SHY and OPLS for coanalysis of high dimensional data sets to recover biological information unobtainable when such data are analyzed in isolation...