Daqing Ma

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia
    Yi Shu
    Division of Surgery, Department of Surgery, Imperial College London, London, United Kingdom
    Anesthesiology 113:360-8. 2010
  2. doi request reprint Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain
    Yi Shu
    Anesthetics, Pain Medicine and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Neurobiol Dis 45:743-50. 2012
  3. pmc Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice
    Marcela P Vizcaychipi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 6:e26394. 2011
  4. pmc Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia
    Ting Yang
    Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 7:e37020. 2012
  5. pmc Xenon treatment protects against cold ischemia associated delayed graft function and prolongs graft survival in rats
    H Zhao
    Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Am J Transplant 13:2006-18. 2013
  6. pmc Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury
    Hailin Zhao
    Anaesthetics, Pain Medicine, and Intensive Care, Dept of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Am J Physiol Renal Physiol 306:F801-11. 2014
  7. doi request reprint Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats
    Hailin Zhao
    1Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    FASEB J 27:4076-88. 2013
  8. doi request reprint A novel strategy for preserving renal grafts in an ex vivo setting: potential for enhancing the marginal donor pool
    Hailin Zhao
    1D M, Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    FASEB J 27:4822-33. 2013
  9. pmc Intraocular pressure vs intracranial pressure in disease conditions: a prospective cohort study (Beijing iCOP study)
    Zhen Li
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    BMC Neurol 12:66. 2012
  10. pmc Sedation improves early outcome in severely septic Sprague Dawley rats
    Hong Qiao
    Department of Anesthesiology, First Hospital, Peking University, NO, 8 Xishiku St, Beijing 100034, PR China
    Crit Care 13:R136. 2009

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia
    Yi Shu
    Division of Surgery, Department of Surgery, Imperial College London, London, United Kingdom
    Anesthesiology 113:360-8. 2010
    ..Preconditioning (pretreatment) can reduce tissue injury caused by a severe insult; the authors investigated whether pretreatment strategies can protect the developing brain from anesthetic-induced neurotoxicity...
  2. doi request reprint Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain
    Yi Shu
    Anesthetics, Pain Medicine and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Neurobiol Dis 45:743-50. 2012
    ..Nociceptive stimulation and prolonged anesthesia produced significantly more apoptosis than prolonged anesthesia alone when administered to neonates during the synaptogenic period...
  3. pmc Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice
    Marcela P Vizcaychipi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 6:e26394. 2011
    ..028). Our data indicated that surgery and/or Isoflurane induced memory deficit was attenuated by xenon pretreatment. This was associated with a reduction in the plasma level of IL-1β and an upregulation of Hsp72 in the hippocampus...
  4. pmc Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia
    Ting Yang
    Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 7:e37020. 2012
    ..These data suggest that anesthetic agents with neuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the future...
  5. pmc Xenon treatment protects against cold ischemia associated delayed graft function and prolongs graft survival in rats
    H Zhao
    Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Am J Transplant 13:2006-18. 2013
    ..Our data suggest that xenon treatment attenuates DGF and enhances graft survival. This approach could be translated into clinical practice leading to a considerable improvement in long-term graft survival. ..
  6. pmc Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury
    Hailin Zhao
    Anaesthetics, Pain Medicine, and Intensive Care, Dept of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Am J Physiol Renal Physiol 306:F801-11. 2014
    ..Given the pivotal role of TLR-4 in ischemia-reperfusion injury and associated delayed graft function and allograft rejection, inhibition of TLR-4 using pharmacological agents could be beneficial for long-term graft survival. ..
  7. doi request reprint Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats
    Hailin Zhao
    1Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    FASEB J 27:4076-88. 2013
    ..Furthermore, xenon works additively with cyclosporin A to preserve post-transplant renal function...
  8. doi request reprint A novel strategy for preserving renal grafts in an ex vivo setting: potential for enhancing the marginal donor pool
    Hailin Zhao
    1D M, Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    FASEB J 27:4822-33. 2013
    ..The current study has significant clinical implications, in which the use of Xe ex vivo could enhance the marginal donor pool of renal grafts by preventing graft loss due to ischemia...
  9. pmc Intraocular pressure vs intracranial pressure in disease conditions: a prospective cohort study (Beijing iCOP study)
    Zhen Li
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    BMC Neurol 12:66. 2012
    ..The aim of the current study was to further clarify the potential correlation between ICP and IOP...
  10. pmc Sedation improves early outcome in severely septic Sprague Dawley rats
    Hong Qiao
    Department of Anesthesiology, First Hospital, Peking University, NO, 8 Xishiku St, Beijing 100034, PR China
    Crit Care 13:R136. 2009
    ..We sought to compare the effects of dexmedetomidine and midazolam, at equi-sedative doses, on inflammation and apoptosis in an animal model of severe sepsis...
  11. ncbi request reprint Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 106:746-53. 2007
    ..Therefore, the current study sought to investigate xenon's putative protective properties against anesthetic-induced neuronal apoptosis...
  12. ncbi request reprint alpha2-Adrenoceptor agonists: shedding light on neuroprotection?
    Daqing Ma
    Department of Anaesthetics, Imperial College London, Chelsea and Westminster Campus, London SW10 9NH, UK
    Br Med Bull 71:77-92. 2004
    ..The remarkable safety profile of alpha(2)-adrenoceptor agonists and their high potency of neuroprotection should prompt clinical trials to evaluate their neuroprotective efficacy in humans...
  13. pmc Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Road, London SW10 9NH, United Kingdom
    J Am Soc Nephrol 20:713-20. 2009
    ..If these data are confirmed in the clinical setting, then preconditioning with xenon may be beneficial before procedures that temporarily interrupt renal perfusion...
  14. ncbi request reprint Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
    Ann Neurol 58:182-93. 2005
    ..If applied to humans, these data suggest that low (subanesthetic) concentrations of xenon in combination with mild hypothermia may provide a safe and effective therapy for perinatal asphyxia...
  15. ncbi request reprint Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models
    Nishanthan Rajakumaraswamy
    Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 409:128-33. 2006
    ..The long-term neurological function data corroborated these morphological data. Our study demonstrates that the combination of xenon and Dex offers neuroprotection additively in vitro and synergistically in vivo...
  16. ncbi request reprint Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
    Maleeha Rizvi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK
    Exp Biol Med (Maywood) 235:886-91. 2010
    ..These results suggest that unlike other noble gases, preconditioning with the anesthetic noble gas xenon may have a role in protection against renal ischemic injury...
  17. doi request reprint Role of interleukin-1beta in postoperative cognitive dysfunction
    Mario Cibelli
    Department of Anesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Ann Neurol 68:360-8. 2010
    ..We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery...
  18. ncbi request reprint Xenon preconditioning reduces brain damage from neonatal asphyxia in rats
    Daqing Ma
    Department of Anaesthetics, Intensive Care and Pain Medicine, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    J Cereb Blood Flow Metab 26:199-208. 2006
    ..These studies provide evidence for xenon's preconditioning effect, which might be caused by a pCREB-regulated synthesis of proteins that promote survival against neuronal injury...
  19. doi request reprint Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
    Anesthesiology 110:1077-85. 2009
    ....
  20. doi request reprint Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model
    Yan Luo
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Anesthesiology 109:782-9. 2008
    ..Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury...
  21. ncbi request reprint The therapeutic potential of atorvastatin in a mouse model of postoperative cognitive decline
    Marcela P Vizcaychipi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom Department of Pain Management, Gongli Hospital, Pudong, China Department of Anaesthetics, Wycombe Hospital, Buckinghamshire Hospitals NHS Trust, High Wycombe, Buckinghamshire, United Kingdom Department of Anesthesiology, Hubei University of Medicine, Hubei, China
    Ann Surg 259:1235-44. 2014
    ..We hypothesized that atorvastatin, shown to exert neuroprotective potential in central nervous system (CNS) disorders, would attenuate neuroinflammation and improve cognitive function in mice after surgery and anesthesia...
  22. doi request reprint Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term
    Robert D Sanders
    Departments of Anaesthetics, Medical Research Council Clinical Sciences Centre, Queen Charlotte s and Chelsea Hospital, Imperial College London, London, United Kingdom
    Anesthesiology 113:233-49. 2010
    ..Although most of these neuroprotective strategies have not yet entered clinical practice, there is a significant hope that further developments will enhance hypothermic neuroprotection...
  23. doi request reprint General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westerminster Hospital, London, UK
    Anesth Analg 106:1708-11. 2008
    ..Exposure to anesthetics triggers apoptotic neurodegeneration in the neonatal rat brain; whether neuronal apoptosis also occurs in the spinal cord, a crucial target for analgesic and anesthetic drugs, is unknown...
  24. doi request reprint Systemic inflammation enhances surgery-induced cognitive dysfunction in mice
    Antonio Rei Fidalgo
    Anaesthesia, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Chelsea and Westminster Hospital, Imperial College School of Medicine, 369 Fulham Road, SW10 9NH London, United Kingdom
    Neurosci Lett 498:63-6. 2011
    ..Our data suggest that sub-clinical infection may sensitise the immune system augmenting the severity of post-operative cognitive dysfunction...
  25. ncbi request reprint Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Imperial College, London, UK
    Anesthesiology 99:748-51. 2003
  26. ncbi request reprint Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype
    Daqing Ma
    Department of Anaesthetics, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Eur J Pharmacol 502:87-97. 2004
    ..Our data suggest that the neuroprotective effect of dexmedetomidine is mediated by activation of the alpha2A adrenergic receptor subtype...
  27. pmc Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
    Jianteng Gu
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Rd, London SW10 9NH, UK
    Crit Care 15:R153. 2011
    ..We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischemia-reperfusion induced kidney injury in vitro and in vivo...
  28. doi request reprint The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats
    Lei Zhuang
    Department of Anesthesiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Crit Care Med 40:1724-30. 2012
    ..Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats...
  29. ncbi request reprint Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus
    Yanjie Wan
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London
    Anesthesiology 106:436-43. 2007
    ..The authors investigated the role of cytokine-mediated inflammation within the central nervous system in the development of cognitive dysfunction in a rat model...
  30. doi request reprint The role of HMGB1 in inflammation-mediated organ injury
    Paladd Asavarut
    Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Acta Anaesthesiol Taiwan 51:28-33. 2013
    ..Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury...
  31. pmc The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
    Niccolò Terrando
    Department of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Crit Care 14:R88. 2010
    ..Disabling the interleukin (IL)-1 signaling pathway is sufficient to reduce inflammation and ameliorate the disability...
  32. ncbi request reprint Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury
    Noorulhuda Jawad
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 460:232-6. 2009
    ..84+/-0.09 (p<0.01), but argon showed an improvement in reducing ability to 1.15+/-0.11 (p<0.05). Our data suggest that the cheap and widely available noble gas argon may have potential as a neuroprotectant for the future...
  33. doi request reprint A clinically relevant model of perinatal global ischemic brain damage in rats
    Ting Yang
    Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
    Brain Res 1383:317-23. 2011
    ..This model mimics hypoxic ischemic encephalopathy in humans and may be appropriate for investigating therapeutic interventions...
  34. ncbi request reprint Xenon exerts age-independent antinociception in Fischer rats
    Daqing Ma
    Department of Anesthetics and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 100:1313-8. 2004
  35. ncbi request reprint Anaesthesia induced neuroprotection
    Robert D Sanders
    Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    Best Pract Res Clin Anaesthesiol 19:461-74. 2005
    ..In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed...
  36. ncbi request reprint Xenon: elemental anaesthesia in clinical practice
    Robert D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Br Med Bull 71:115-35. 2004
    ..Furthermore, we highlight specific areas where xenon demonstrates advantages over other anaesthetics, including safety, beneficial pharmacokinetics, cardiovascular stability, analgesia and neuroprotection...
  37. doi request reprint Statins: the role in the treatment and prevention of Alzheimer's neurodegeneration
    Chen Pac-Soo
    Anaesthetics, Pain Medicine and Intensive Care, Division of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK
    J Alzheimers Dis 27:1-10. 2011
    ..This review will discuss evidence for the role of statins in the treatment and prevention of AD neurodegeneration...
  38. doi request reprint Do inhalational anesthetics cause cognitive dysfunction?
    Rele Ologunde
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Acta Anaesthesiol Taiwan 49:149-53. 2011
    ..Other factors such as neuroinflammation and pro-inflammatory cytokines may also play a role. This paper reviews the role of inhalational anesthetics in the etiology and underlying mechanisms that result in POCD...
  39. doi request reprint Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma
    Jiaolin Ning
    1Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China 2Department of Nephrology, People s Liberation Army Chengdu Military Area Command General Hospital, Chengdu, Sichuan, China 3Department of Hepatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China 4State Key Laboratory of Trauma and Burns, Surgery Research Institute, Department of Traumatic Surgery, Daping Hospital, Third Military Medical University, Chongqing, China 5Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom 6Surgical Outcomes Research Centre, University College London Hospital and Wellcome Department of Imaging Neuroscience, University College London, London, United Kingdom
    Crit Care Med 42:e68-78. 2014
    ..Furthermore, the optimal duration of regional traumatic limb hypothermic treatment was also evaluated...
  40. ncbi request reprint Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro
    Laura L Benzonana
    Section of Anesthetics, Pain Medicine, and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    Anesthesiology 119:593-605. 2013
    ..HIFs are also heavily implicated in tumorigenesis and high levels correlate with poor prognosis...
  41. ncbi request reprint Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats
    Robert D Sanders
    Sir Ivan Magill Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Anesth Analg 100:1295-302, table of contents. 2005
    ..05), whereas Dex 10 microg/kg had little effect. Neonatal rats showed the greatest hypnotic sensitivity to Dex (P < 0.05)...
  42. ncbi request reprint Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat
    Daqing Ma
    Department of Anesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:690-8. 2003
    ....
  43. doi request reprint Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats
    Hailin Zhao
    Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Kidney Int 85:112-23. 2014
    ..Thus, xenon treatment promoted recovery from ischemia-reperfusion injury and reduced susceptibility to the subsequent development of CAN in allografts. ..
  44. ncbi request reprint Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice
    Robert D Sanders
    Department of Leukocyte Biology, Imperial College London, London, UK Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK Wellcome Department of Imaging Neuroscience, University College, London, UK
    Influenza Other Respir Viruses 7:895-9. 2013
    ..Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal. ..
  45. doi request reprint Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
    Loukia Katsouri
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neurobiol Aging 34:1105-15. 2013
    ..These findings suggest that chronic treatment with prazosin leads to an anti-inflammatory response with potential beneficial effects on cognitive performance...
  46. doi request reprint Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice
    Robert D Sanders
    Department of Leukocyte Biology, Imperial College, London, UK
    Crit Care Med 41:1627-36. 2013
    ..Herein we sought to elucidate the impact and mechanism of benzodiazepine-induced susceptibility to infection at anxiolytic doses in mice...
  47. ncbi request reprint Effects of xenon on in vitro and in vivo models of neuronal injury
    Stefan Wilhelm
    Chelsea and Westminster Hospital, London, United Kingdom
    Anesthesiology 96:1485-91. 2002
    ..Because of the pivotal role that NMDA receptors play in neuronal injury, the authors investigated the efficacy of xenon as a neuroprotectant in both in vitro and in vivo paradigms...
  48. pmc Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice
    Marcela P Vizcaychipi
    Department of Surgery and Cancer, Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, United Kingdom
    Anesthesiology 114:891-900. 2011
    ..Heat shock protein 72 (Hsp72) confers neuroprotection against acute neurologic injury. We hypothesized that overexpression of Hsp72 would prevent the development of postoperative memory loss...
  49. doi request reprint Hypothermia and xenon: novel noble guardians in hypoxic-ischemic encephalopathy?
    N Lobo
    Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    J Neurosci Res 91:473-8. 2013
    ..With promising results being reported, it is, perhaps, only a matter of time before xenon and hypothermia become established as a standard care for neonates with HIE...
  50. doi request reprint Central nervous system inflammation in disease related conditions: mechanistic prospects
    Anthony Fung
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Brain Res 1446:144-55. 2012
    ..This uncertainty has led to an increasing body of work exploring the processes involved in both the passage of inflammation into, and the effect of cytokines on, the CNS...
  51. doi request reprint Cancer recurrence after surgery: direct and indirect effects of anesthetic agents
    Aniket N Tavare
    Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 130:1237-50. 2012
    ....
  52. ncbi request reprint Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action
    Cecilia Dawson
    Department of Anaesthetics and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 100:894-904. 2004
    ..Because of these differences, the authors explored whether the two analgesics in combination would provide satisfactory analgesia...
  53. doi request reprint Neuroinflammation: the role and consequences
    Monty Lyman
    Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Neurosci Res 79:1-12. 2014
    ..The wide scope and numerous complexities of neuroinflammation suggest that combinations of different preventative and therapeutic approaches may be efficacious. ..
  54. doi request reprint Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells
    John P M White
    Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369, Fulham Road, London, SW10 9NH, United Kingdom
    Life Sci 88:141-9. 2011
    ....
  55. ncbi request reprint The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice
    H Mayumi Homi
    Department of Anesthesiology Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Anesthesiology 99:876-81. 2003
    ..However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cerebral artery occlusion...
  56. ncbi request reprint The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer's disease development: biomarkers and preventive strategies
    Ayush K Kapila
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    J Alzheimers Dis 41:1-13. 2014
    ....
  57. doi request reprint Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Ann Surg 255:901-7. 2012
    ....
  58. ncbi request reprint Xenon and the inflammatory response to cardiopulmonary bypass in the rat
    Jeffrey A Clark
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:488-93. 2005
    ..The purpose of this study was to investigate the effect of xenon on the inflammatory response to cardiopulmonary bypass...
  59. doi request reprint Xenon induces transcription of ADNP in neonatal rat brain
    Davide Cattano
    Department of Surgery, Division of Anesthesiology and Intensive Care, University of Pisa School of Medicine, Pisa, Italy
    Neurosci Lett 440:217-21. 2008
    ..The differential expression of ADNP in the rat neonatal brain may account for the preconditioning and neuroprotective effects exerted by gas xenon...