Research Topics
Genomes and Genes | Pradeep K LutherSummaryAffiliation: Imperial College Country: UK Publications
|
Detail Information
Publications
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact musclePradeep K Luther
Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
Proc Natl Acad Sci U S A 108:11423-8. 2011..This binding implies a physical mechanism for communicating the relative sliding between thick and thin filaments that does not involve myosin and which could modulate the contractile process...
Cryoelectron microscopy of refrozen cryosectionsPradeep K Luther
Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
J Struct Biol 142:233-40. 2003..We conclude that this approach has considerable potential for obtaining intermediate- and high-resolution structural detail from bulk tissue...- Heterogeneity of Z-band structure within a single muscle sarcomere: implications for sarcomere assemblyPradeep K Luther
Biological Structure and Function Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
J Mol Biol 332:161-9. 2003..These multiple Z-band structures suggest that different isoforms of nebulin and titin with a variable number of Z-repeats could be present within a single sarcomere... - The vertebrate muscle Z-disc: sarcomere anchor for structure and signallingPradeep K Luther
Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK
J Muscle Res Cell Motil 30:171-85. 2009..Comprehensive reviews on the roles of the numerous proteins located at the Z-disc in signalling and disease have been published; the aim here is different, namely to review the advances in structural aspects of the Z-disc... - Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac musclePradeep K Luther
Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW72AZ, UK
J Mol Biol 384:60-72. 2008..However, in the MyBP-C-deficient hearts these extra meridional reflections are weak or absent, suggesting that they are due to MyBP-C itself or to MyBP-C in combination with a head perturbation brought about by the presence of MyBP-C... - Muscle Z-band ultrastructure: titin Z-repeats and Z-band periodicities do not matchPradeep K Luther
Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
J Mol Biol 319:1157-64. 2002..Hence, the 39 nm periodicity is an important conserved feature of Z-bands and either cannot be explained by titin Z-repeats as previously suggested or may correlate with two Z-repeats... - Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domainJohn M Squire
Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, Fleming Building, London SW7 2AZ, UK
J Mol Biol 331:713-24. 2003..Further analysis of the MyBP-C sequence identifies a possible actin-binding domain in the Pro-Ala-rich sequence found at the N terminus of skeletal MyBP-C and between domains C0 and C1 in the cardiac sequence... - Molecular architecture in muscle contractile assembliesJohn M Squire
Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, London SW7 2AZ, United Kindom
Adv Protein Chem 71:17-87. 2005 - Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscleAnupama Vydyanath
Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
J Muscle Res Cell Motil 33:61-74. 2012.... 
Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomographyThomas Burgoyne
Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
Cardiovasc Res 77:707-12. 2008..For comparison, we also measure the thin filament lengths in skeletal muscle (frog sartorius)...- Titin organisation and the 3D architecture of the vertebrate-striated muscle I-bandCarlo Knupp
Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, UK
J Mol Biol 322:731-9. 2002..We show that there are good structural and mechanical reasons why titin might be organised as Liversage et al., suggested and we discuss the possible relationships between A-band arrangements in successive sarcomeres along a myofibril... - Zebrafish--topical, transparent, and tractable for ultrastructural studiesJohn M Squire
Muscle Contraction Group, Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK
J Gen Physiol 131:439-43. 2008 - The three-dimensional structure of a vertebrate wide (slow muscle) Z-band: lessons on Z-band assemblyPradeep K Luther
Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London, SW7 2AZ, UK
J Mol Biol 315:9-20. 2002..We discuss this in the context of our results and present a systematic classification of Z-band types according to the numbers of Z-links and titin Z-repeats... - Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1Pankaj K Bhavsar
Heart Science Centre, National Heart and Lung Institute, Imperial College, Harefield, Middlesex, London, UK
J Cardiovasc Transl Res 3:688-95. 2010..Together these data show that clenbuterol acts to induce mild cardiac hypertrophy in cardiac myocytes via paracrine signalling involving fibroblast-derived IGF-1...