Pradeep K Luther

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 108:11423-8. 2011
  2. pmc The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 30:171-85. 2009
  3. ncbi request reprint Cryoelectron microscopy of refrozen cryosections
    Pradeep K Luther
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
    J Struct Biol 142:233-40. 2003
  4. ncbi request reprint Heterogeneity of Z-band structure within a single muscle sarcomere: implications for sarcomere assembly
    Pradeep K Luther
    Biological Structure and Function Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 332:161-9. 2003
  5. pmc Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW72AZ, UK
    J Mol Biol 384:60-72. 2008
  6. ncbi request reprint Muscle Z-band ultrastructure: titin Z-repeats and Z-band periodicities do not match
    Pradeep K Luther
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 319:1157-64. 2002
  7. ncbi request reprint Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domain
    John M Squire
    Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, Fleming Building, London SW7 2AZ, UK
    J Mol Biol 331:713-24. 2003
  8. ncbi request reprint Molecular architecture in muscle contractile assemblies
    John M Squire
    Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, London SW7 2AZ, United Kindom
    Adv Protein Chem 71:17-87. 2005
  9. pmc Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle
    Anupama Vydyanath
    Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:61-74. 2012
  10. ncbi request reprint Titin organisation and the 3D architecture of the vertebrate-striated muscle I-band
    Carlo Knupp
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, UK
    J Mol Biol 322:731-9. 2002

Detail Information

Publications15

  1. pmc Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 108:11423-8. 2011
    ..This binding implies a physical mechanism for communicating the relative sliding between thick and thin filaments that does not involve myosin and which could modulate the contractile process...
  2. pmc The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 30:171-85. 2009
    ..Comprehensive reviews on the roles of the numerous proteins located at the Z-disc in signalling and disease have been published; the aim here is different, namely to review the advances in structural aspects of the Z-disc...
  3. ncbi request reprint Cryoelectron microscopy of refrozen cryosections
    Pradeep K Luther
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
    J Struct Biol 142:233-40. 2003
    ..We conclude that this approach has considerable potential for obtaining intermediate- and high-resolution structural detail from bulk tissue...
  4. ncbi request reprint Heterogeneity of Z-band structure within a single muscle sarcomere: implications for sarcomere assembly
    Pradeep K Luther
    Biological Structure and Function Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 332:161-9. 2003
    ..These multiple Z-band structures suggest that different isoforms of nebulin and titin with a variable number of Z-repeats could be present within a single sarcomere...
  5. pmc Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle
    Pradeep K Luther
    Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW72AZ, UK
    J Mol Biol 384:60-72. 2008
    ..However, in the MyBP-C-deficient hearts these extra meridional reflections are weak or absent, suggesting that they are due to MyBP-C itself or to MyBP-C in combination with a head perturbation brought about by the presence of MyBP-C...
  6. ncbi request reprint Muscle Z-band ultrastructure: titin Z-repeats and Z-band periodicities do not match
    Pradeep K Luther
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 319:1157-64. 2002
    ..Hence, the 39 nm periodicity is an important conserved feature of Z-bands and either cannot be explained by titin Z-repeats as previously suggested or may correlate with two Z-repeats...
  7. ncbi request reprint Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domain
    John M Squire
    Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, Fleming Building, London SW7 2AZ, UK
    J Mol Biol 331:713-24. 2003
    ..Further analysis of the MyBP-C sequence identifies a possible actin-binding domain in the Pro-Ala-rich sequence found at the N terminus of skeletal MyBP-C and between domains C0 and C1 in the cardiac sequence...
  8. ncbi request reprint Molecular architecture in muscle contractile assemblies
    John M Squire
    Biological Structure and Function Section, Biomedical Sciences Division, Imperial College London, London SW7 2AZ, United Kindom
    Adv Protein Chem 71:17-87. 2005
  9. pmc Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle
    Anupama Vydyanath
    Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    J Muscle Res Cell Motil 33:61-74. 2012
    ....
  10. ncbi request reprint Titin organisation and the 3D architecture of the vertebrate-striated muscle I-band
    Carlo Knupp
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, UK
    J Mol Biol 322:731-9. 2002
    ..We show that there are good structural and mechanical reasons why titin might be organised as Liversage et al., suggested and we discuss the possible relationships between A-band arrangements in successive sarcomeres along a myofibril...
  11. doi request reprint Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography
    Thomas Burgoyne
    Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Cardiovasc Res 77:707-12. 2008
    ..For comparison, we also measure the thin filament lengths in skeletal muscle (frog sartorius)...
  12. pmc Zebrafish--topical, transparent, and tractable for ultrastructural studies
    John M Squire
    Muscle Contraction Group, Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK
    J Gen Physiol 131:439-43. 2008
  13. ncbi request reprint The three-dimensional structure of a vertebrate wide (slow muscle) Z-band: lessons on Z-band assembly
    Pradeep K Luther
    Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Exhibition Road, London, SW7 2AZ, UK
    J Mol Biol 315:9-20. 2002
    ..We discuss this in the context of our results and present a systematic classification of Z-band types according to the numbers of Z-links and titin Z-repeats...
  14. doi request reprint Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method
    John M Squire
    Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London WC1H 9JB, UK
    Anal Biochem 439:204-11. 2013
    ....
  15. doi request reprint Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1
    Pankaj K Bhavsar
    Heart Science Centre, National Heart and Lung Institute, Imperial College, Harefield, Middlesex, London, UK
    J Cardiovasc Transl Res 3:688-95. 2010
    ..Together these data show that clenbuterol acts to induce mild cardiac hypertrophy in cardiac myocytes via paracrine signalling involving fibroblast-derived IGF-1...