R J Lucas

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamster
    R J Lucas
    Department of Biology, Imperial College of Science Technology and Medicine, London, UK
    Neurosci Lett 249:147-50. 1998
  2. ncbi request reprint Neither functional rod photoreceptors nor rod or cone outer segments are required for the photic inhibition of pineal melatonin
    R J Lucas
    Department of Biology, Imperial College of Science Technology and Medicine, London, United Kingdom
    Endocrinology 140:1520-4. 1999
  3. ncbi request reprint Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors
    R J Lucas
    Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK
    Science 284:505-7. 1999
  4. ncbi request reprint Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
    Science 299:245-7. 2003
  5. ncbi request reprint Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience, Faculty of Medicine, Imperial College, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
    Behav Brain Res 125:97-102. 2001
  6. ncbi request reprint Characterization of an ocular photopigment capable of driving pupillary constriction in mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK
    Nat Neurosci 4:621-6. 2001
  7. ncbi request reprint Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina
    S Sekaran
    Department of Visual Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, W6 8RF, United Kingdom
    Curr Biol 15:1099-107. 2005
  8. ncbi request reprint Circadian clocks: A cry in the dark?
    R J Lucas
    Department of Biology, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Curr Biol 9:R825-8. 1999
  9. ncbi request reprint Circadian rhythms: Something to cry about?
    R J Lucas
    Department of Biology, Sir Alexander Fleming Building, Imperial College, Imperial College Road, London SW7 2AZ, UK
    Curr Biol 9:R214-7. 1999
  10. ncbi request reprint Addition of human melanopsin renders mammalian cells photoresponsive
    Z Melyan
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Nature 433:741-5. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamster
    R J Lucas
    Department of Biology, Imperial College of Science Technology and Medicine, London, UK
    Neurosci Lett 249:147-50. 1998
    ..This phenotypic effect within the SCN raises the possibility that some of the circadian consequences of the tau mutation are associated with an increased expression of the VIP gene...
  2. ncbi request reprint Neither functional rod photoreceptors nor rod or cone outer segments are required for the photic inhibition of pineal melatonin
    R J Lucas
    Department of Biology, Imperial College of Science Technology and Medicine, London, United Kingdom
    Endocrinology 140:1520-4. 1999
    ....
  3. ncbi request reprint Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors
    R J Lucas
    Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK
    Science 284:505-7. 1999
    ..These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology...
  4. ncbi request reprint Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
    Science 299:245-7. 2003
    ....
  5. ncbi request reprint Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience, Faculty of Medicine, Imperial College, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
    Behav Brain Res 125:97-102. 2001
    ..There is some indirect evidence in favour of this hypothesis. A definitive resolution of this issue is likely to employ comparisons of circadian action spectra in wild type and retinally degenerate mice...
  6. ncbi request reprint Characterization of an ocular photopigment capable of driving pupillary constriction in mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK
    Nat Neurosci 4:621-6. 2001
    ..These data represent the first functional characterization of a non-rod, non-cone photoreceptive system in the mammalian CNS...
  7. ncbi request reprint Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina
    S Sekaran
    Department of Visual Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, W6 8RF, United Kingdom
    Curr Biol 15:1099-107. 2005
    ..In the mouse retina, the rod and cone photoreceptors become light responsive from postnatal day 10 (P10); however, the development of photosensitivity of the ipRGCs remains largely unexplored...
  8. ncbi request reprint Circadian clocks: A cry in the dark?
    R J Lucas
    Department of Biology, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Curr Biol 9:R825-8. 1999
    ..In Drosophila, they appear to be responsible for the entrainment of the circadian clock by the light-dark cycle, while in mammals they perform an important role in rhythm generation itself...
  9. ncbi request reprint Circadian rhythms: Something to cry about?
    R J Lucas
    Department of Biology, Sir Alexander Fleming Building, Imperial College, Imperial College Road, London SW7 2AZ, UK
    Curr Biol 9:R214-7. 1999
    ..While the evidence reported is intriguing, the notion that cryptochromes have the same role in all species requires further investigation...
  10. ncbi request reprint Addition of human melanopsin renders mammalian cells photoresponsive
    Z Melyan
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Nature 433:741-5. 2005
    ..We also present evidence to show that melanopsin functions as a bistable pigment in this system, having an intrinsic photoisomerase regeneration function that is chromatically shifted to longer wavelengths...
  11. ncbi request reprint Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development
    L C Bibb
    Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Hum Mol Genet 10:1571-9. 2001
    ..These data support concerns about the extent to which we can extrapolate from rodent models regarding embryonic development and disease pathophysiology...
  12. ncbi request reprint The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigment
    M W Hankins
    Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imerial College, London W6 8RF, United Kingdom
    Curr Biol 12:191-8. 2002
    ..However, previous work has demonstrated that the mammalian eye contains non-rod, non-cone photoreceptors. This study aimed to determine whether such photoreceptors contribute to retinal adaptation...
  13. pmc Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 424:76-81. 2003
    ..Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions...