Research Topics
Genomes and Genes | R J LucasSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamsterR J Lucas
Department of Biology, Imperial College of Science Technology and Medicine, London, UK
Neurosci Lett 249:147-50. 1998..This phenotypic effect within the SCN raises the possibility that some of the circadian consequences of the tau mutation are associated with an increased expression of the VIP gene...- Neither functional rod photoreceptors nor rod or cone outer segments are required for the photic inhibition of pineal melatoninR J Lucas
Department of Biology, Imperial College of Science Technology and Medicine, London, United Kingdom
Endocrinology 140:1520-4. 1999.... - Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptorsR J Lucas
Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK
Science 284:505-7. 1999..These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology... - Diminished pupillary light reflex at high irradiances in melanopsin-knockout miceR J Lucas
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
Science 299:245-7. 2003.... - Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate miceR J Lucas
Department of Integrative and Molecular Neuroscience, Division of Neuroscience, Faculty of Medicine, Imperial College, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
Behav Brain Res 125:97-102. 2001..There is some indirect evidence in favour of this hypothesis. A definitive resolution of this issue is likely to employ comparisons of circadian action spectra in wild type and retinally degenerate mice... - Characterization of an ocular photopigment capable of driving pupillary constriction in miceR J Lucas
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK
Nat Neurosci 4:621-6. 2001..These data represent the first functional characterization of a non-rod, non-cone photoreceptive system in the mammalian CNS... - Melanopsin-dependent photoreception provides earliest light detection in the mammalian retinaS Sekaran
Department of Visual Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, W6 8RF, United Kingdom
Curr Biol 15:1099-107. 2005..In the mouse retina, the rod and cone photoreceptors become light responsive from postnatal day 10 (P10); however, the development of photosensitivity of the ipRGCs remains largely unexplored... - Circadian clocks: A cry in the dark?R J Lucas
Department of Biology, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
Curr Biol 9:R825-8. 1999..In Drosophila, they appear to be responsible for the entrainment of the circadian clock by the light-dark cycle, while in mammals they perform an important role in rhythm generation itself... - Circadian rhythms: Something to cry about?R J Lucas
Department of Biology, Sir Alexander Fleming Building, Imperial College, Imperial College Road, London SW7 2AZ, UK
Curr Biol 9:R214-7. 1999..While the evidence reported is intriguing, the notion that cryptochromes have the same role in all species requires further investigation... - Addition of human melanopsin renders mammalian cells photoresponsiveZ Melyan
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
Nature 433:741-5. 2005..We also present evidence to show that melanopsin functions as a bistable pigment in this system, having an intrinsic photoisomerase regeneration function that is chromatically shifted to longer wavelengths... - Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye developmentL C Bibb
Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
Hum Mol Genet 10:1571-9. 2001..These data support concerns about the extent to which we can extrapolate from rodent models regarding embryonic development and disease pathophysiology... - The primary visual pathway in humans is regulated according to long-term light exposure through the action of a nonclassical photopigmentM W Hankins
Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imerial College, London W6 8RF, United Kingdom
Curr Biol 12:191-8. 2002..However, previous work has demonstrated that the mammalian eye contains non-rod, non-cone photoreceptors. This study aimed to determine whether such photoreceptors contribute to retinal adaptation... 
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in miceS Hattar
Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 424:76-81. 2003..Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions...