Cristina Lo Celso

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow
    Cristina Lo Celso
    Center for Regenerative Medicine, Boston, Massachusetts, USA
    Nat Protoc 6:1-14. 2011
  2. pmc Dormancy in the stem cell niche
    Roberta Sottocornola
    Department of Life Sciences, Division of Cell and Molecular Biology, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ, UK
    Stem Cell Res Ther 3:10. 2012
  3. pmc Differential niche and Wnt requirements during acute myeloid leukemia progression
    Steven W Lane
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 118:2849-56. 2011
  4. doi request reprint In vivo imaging of hematopoietic stem cells and their microenvironment
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Biophotonics 2:619-31. 2009
  5. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
  6. doi request reprint In vivo imaging of hematopoietic stem cells in the bone marrow niche
    Oliver Barrett
    Division of Cell and Molecular Biology, Imperial College, London, UK
    Methods Mol Biol 916:231-42. 2012
  7. pmc Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells
    Abel Sanchez-Aguilera
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9607-12. 2011
  8. pmc Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3
    Viktor Janzen
    Center for Regenerative Medicine, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Stem Cell 2:584-94. 2008
  9. pmc Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 118:1264-73. 2011
  10. pmc Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled
    Adam L Maclean
    Theoretical Systems Biology, Division of Molecular Biosciences, Imperial College London, Sir Ernst Chain Building, London SW7 2AZ, UK
    J R Soc Interface 10:20120968. 2013

Collaborators

Detail Information

Publications17

  1. pmc In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow
    Cristina Lo Celso
    Center for Regenerative Medicine, Boston, Massachusetts, USA
    Nat Protoc 6:1-14. 2011
    ..In this paper, we describe how to isolate, label and inject HSPCs, as well as how to perform calvarium intravital microscopy and analyze the resulting images. A typical experiment can be performed and analyzed in ∼1 week...
  2. pmc Dormancy in the stem cell niche
    Roberta Sottocornola
    Department of Life Sciences, Division of Cell and Molecular Biology, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ, UK
    Stem Cell Res Ther 3:10. 2012
    ..to multiple regenerating tissues or specific to the hematopoietic system? If cancer is maintained by a few cancer stem cells, do they also contain a subpopulation of dormant cells, and could this be exploited for therapeutic purposes?..
  3. pmc Differential niche and Wnt requirements during acute myeloid leukemia progression
    Steven W Lane
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 118:2849-56. 2011
    ..These data identify differential engagement of HM associated with leukemic progression and identify an LSC niche that is physically distinct and independent of the constraints of Wnt signaling that apply to normal HSCs...
  4. doi request reprint In vivo imaging of hematopoietic stem cells and their microenvironment
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Biophotonics 2:619-31. 2009
    ..We outline the current technical challenges that remain to be overcome before stem cells and their niche can be more fully characterized using the live imaging technology...
  5. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
    ..Our analysis permits observing in real time, at a single cell level, processes that previously have been studied only by their long-term outcome at the organismal level...
  6. doi request reprint In vivo imaging of hematopoietic stem cells in the bone marrow niche
    Oliver Barrett
    Division of Cell and Molecular Biology, Imperial College, London, UK
    Methods Mol Biol 916:231-42. 2012
    ....
  7. pmc Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells
    Abel Sanchez-Aguilera
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9607-12. 2011
    ..These data suggest that Vav1 activity is required specifically for SDF1α-dependent perivascular homing of HSPC and suggest a critical role for this localization in retention and subsequent engraftment...
  8. pmc Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3
    Viktor Janzen
    Center for Regenerative Medicine, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Stem Cell 2:584-94. 2008
    ..Caspase-3 contributes to stem cell quiescence, dampening specific signaling events and thereby cell responsiveness to microenvironmental stimuli...
  9. pmc Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 118:1264-73. 2011
    ....
  10. pmc Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled
    Adam L Maclean
    Theoretical Systems Biology, Division of Molecular Biosciences, Imperial College London, Sir Ernst Chain Building, London SW7 2AZ, UK
    J R Soc Interface 10:20120968. 2013
    ..Our results suggest that maintaining a viable population of HSCs and their progenies in the niche may often already be nearly sufficient to eradicate LSCs from the system...
  11. pmc The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
    Steven W Lane
    Department of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 115:3489-97. 2010
    ....
  12. doi request reprint Analysis of the hematopoietic stem cell niche
    Cristina Lo Celso
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2007
    ..In this unit we describe a collection of protocols spanning a wide range of techniques that can help every researcher tackling questions regarding the nature of the HSC niche...
  13. pmc Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Heather E Fleming
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 2:274-83. 2008
    ..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
  14. pmc Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:103-7. 2009
    ..Galpha(s) governs specific aspects of HSPC localization under physiological conditions in vivo and may be pharmacologically targeted to improve transplantation efficiency...
  15. pmc In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
    Joji Fujisaki
    Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 474:216-9. 2011
    ..In addition to processes supporting stem-cell function, the niche will provide a relative sanctuary from immune attack...
  16. pmc Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics
    Paul P Szotek
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:12469-73. 2008
    ..Together, these characteristics identify the label-retaining cell population as a candidate for the putative somatic stem/progenitor cells of the coelomic epithelium of the mouse ovary...
  17. ncbi request reprint Stem cells remember their grade
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute, Boston, MA 02114, USA
    Cell Stem Cell 1:132-4. 2007
    ..In this issue of Cell Stem Cell, Dykstra et al. (2007) reveal stem cell gradation and the extent to which that gradation is retained in stem cell daughters of hematopoietic stem cells...