C M Lloyd

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
  2. pmc IL-25 drives remodelling in allergic airways disease induced by house dust mite
    Lisa G Gregory
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK
    Thorax 68:82-90. 2013
  3. pmc Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression
    John D Campbell
    MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, London SW7 2 AZ, UK
    J Exp Med 206:1535-47. 2009
  4. pmc Lung macrophages contribute to house dust mite driven airway remodeling via HIF-1α
    Adam J Byrne
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 8:e69246. 2013
  5. ncbi request reprint T cells in asthma: influences of genetics, environment, and T-cell plasticity
    Clare M Lloyd
    National Heart and Lung Institute, Sir Alexander Fleming Building, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 131:1267-74; quiz 1275. 2013
  6. pmc Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF)
    Sophie Pegorier
    Leukocyte Biology Section, Faculty of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:85. 2010
  7. pmc IL-33 family members and asthma - bridging innate and adaptive immune responses
    Clare M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Faculty of Medicine, Imperial College, South Kensington, London SW7 2AZ, UK
    Curr Opin Immunol 22:800-6. 2010
  8. pmc Chronic inflammation and asthma
    Jenna R Murdoch
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Mutat Res 690:24-39. 2010
  9. pmc Tolerizing allergic responses in the lung
    C M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Mucosal Immunol 3:334-44. 2010
  10. pmc Functions of T cells in asthma: more than just T(H)2 cells
    Clare M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Nat Rev Immunol 10:838-48. 2010

Collaborators

Detail Information

Publications48

  1. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
    ..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations...
  2. pmc IL-25 drives remodelling in allergic airways disease induced by house dust mite
    Lisa G Gregory
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK
    Thorax 68:82-90. 2013
    ..Overexpression of the transforming growth factor β family signalling molecule smad2 in the airway epithelium provokes enhanced allergen-induced airway remodelling in mice, concomitant with elevated levels of interleukin (IL)-25...
  3. pmc Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression
    John D Campbell
    MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, London SW7 2 AZ, UK
    J Exp Med 206:1535-47. 2009
    ..Our results provide, for the first time, in vivo evidence of linked epitope suppression and IL-10 induction in both human allergic disease and a mouse model designed to closely mimic peptide therapy in humans...
  4. pmc Lung macrophages contribute to house dust mite driven airway remodeling via HIF-1α
    Adam J Byrne
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 8:e69246. 2013
    ..These findings indicate that strategies to reduce activation of macrophage derived HIF-1α may be used as a target to improve asthma pathology...
  5. ncbi request reprint T cells in asthma: influences of genetics, environment, and T-cell plasticity
    Clare M Lloyd
    National Heart and Lung Institute, Sir Alexander Fleming Building, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 131:1267-74; quiz 1275. 2013
    ..Indeed, an important concept that needs to be addressed, both in animal models and clinically, is that of T-cell plasticity and how lymphocytic responses are determined by environmental influences...
  6. pmc Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF)
    Sophie Pegorier
    Leukocyte Biology Section, Faculty of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:85. 2010
    ..However, the role of BMPs in lung remodelling remains unclear. BMPs may regulate tissue remodelling in asthma by controlling TGF-beta-induced profibrotic functions in lung fibroblasts...
  7. pmc IL-33 family members and asthma - bridging innate and adaptive immune responses
    Clare M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Faculty of Medicine, Imperial College, South Kensington, London SW7 2AZ, UK
    Curr Opin Immunol 22:800-6. 2010
    ..However, the induction of IL-33 expression by environmental or endogenous triggers now suggests a wider role for the pathway during infection, inflammation and tissue damage...
  8. pmc Chronic inflammation and asthma
    Jenna R Murdoch
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Mutat Res 690:24-39. 2010
    ..In this review, the key cellular and molecular mediators relating to chronic allergic airway disease are discussed, as well as emerging players in the regulation of chronic allergic inflammation...
  9. pmc Tolerizing allergic responses in the lung
    C M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Mucosal Immunol 3:334-44. 2010
    ..Further understanding of the mechanisms used by the pulmonary immune system to maintain tolerance might result in exploitation of novel avenues for therapy to treat the growing number of chronic asthmatic patients...
  10. pmc Functions of T cells in asthma: more than just T(H)2 cells
    Clare M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Nat Rev Immunol 10:838-48. 2010
    ..Here, we discuss the roles of different T cell subsets in the allergic lung, consider how each subset can contribute to the development of allergic pathology and evaluate how we might manipulate these cells for new asthma therapies...
  11. pmc Building better mouse models of asthma
    Clare M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, England
    Curr Allergy Asthma Rep 7:231-6. 2007
    ..This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling...
  12. pmc Allergen-induced airway remodelling
    C M Lloyd
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Eur Respir J 29:1020-32. 2007
    ..In this review the key questions relating allergen exposure to development of remodelling are discussed, as well as the steps that are being undertaken to investigate them...
  13. pmc Chemokines in allergic airway disease
    Clare M Lloyd
    Leukocyte Biology, Biomedical Sciences Division, Faculty of Medicine, South Kensington Campus, Imperial College, London SW7 2AZ, UK
    Curr Opin Pharmacol 3:443-8. 2003
    ..However, recent advances have been made regarding the therapeutic potential of blocking the chemokine receptors CCR3, CCR4 and CCR8 in allergic airway disease...
  14. pmc Regulatory T cells in asthma
    Clare M Lloyd
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI, Imperial College, London SW7 2AZ, UK
    Immunity 31:438-49. 2009
    ..Ultimately, the ability to enhance regulatory function in affected individuals may represent an effective treatment for asthma...
  15. ncbi request reprint Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling
    S J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine Imperial College, London SW7 2AZ, UK
    Clin Exp Allergy 35:388-96. 2005
    ..Airway inflammation and remodelling are important pathophysiologic features of chronic asthma. Although current steroid use demonstrates anti-inflammatory activity, there are limited effects on the structural changes in the lung tissue...
  16. pmc Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization
    S Tourdot
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK
    Clin Exp Allergy 38:1016-24. 2008
    ..However, most of these studies focused on acute inflammation and little is known of its long-term consequences on remodelling of the airway tissue...
  17. pmc Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response
    J N Francis
    Section of Allergy and Clinical Immunology, Imperial College London, London, UK
    Clin Exp Immunol 152:440-7. 2008
    ..05). Thus, CCR6 may be important in the regulation of T cell recruitment to tissue and up-regulation of CCL20 expression may contribute to the recruitment and/or retention of effector T cells in allergic asthma...
  18. ncbi request reprint Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
    J Zhao
    Department of Asthma Allergy and Respiratory Science, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
    Mucosal Immunol 6:335-46. 2013
    ..Targeting the Th17/Treg axis might therefore be therapeutic in neutrophilic and glucocorticoid-refractory asthma...
  19. pmc CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 122:617-24.e6. 2008
    ..We have previously demonstrated that prophylactic administration of CD4(+)CD25(+) regulatory T cells suppresses the development of acute allergen-induced airway inflammation in vivo...
  20. pmc Inhaled house dust mite induces pulmonary T helper 2 cytokine production
    L G Gregory
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Clin Exp Allergy 39:1597-610. 2009
    ..Inhaled house dust mite (HDM) results in T-helper (TH) 2 type pathology in unsensitized mice, in conjunction with airway hyperreactivity and airway remodelling. However, the pulmonary cytokine and chemokine profile has not been reported...
  21. pmc Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine
    J W Wells
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Guy s Hospital, London, UK
    Mucosal Immunol 2:54-62. 2009
    ..Airway hyperreactivity was prevented by vaccination in an allergen-specific fashion. Class I peptide vaccines might therefore represent a robust and long-lasting immunotherapeutic strategy in allergic disease...
  22. pmc CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses
    G Banfield
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK
    Allergy 65:1126-33. 2010
    ..CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation...
  23. pmc Prolonged allergen challenge in mice leads to persistent airway remodelling
    S J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, UK
    Clin Exp Allergy 34:497-507. 2004
    ..Current animal models of allergen-induced airway inflammation generally concentrate on the acute inflammation following allergen exposure and fail to mimic all of these features...
  24. pmc Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK
    Am J Respir Crit Care Med 179:772-81. 2009
    ..This represents an important consideration because failure to resolve allergen driven inflammation potentially leads to irreversible airway remodeling, characteristic of chronic asthma...
  25. pmc Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung
    M Habibzay
    Imperial College London, Leukocyte Biology Section, National Heart and Lung Institute, London, UK
    Mucosal Immunol 5:524-34. 2012
    ..A background of allergic airway disease therefore exacerbates bacterial infection by altering key antibacterial innate immune pathways that are amenable to therapeutic intervention...
  26. ncbi request reprint Animal models to study chemokine receptor function: in vivo mouse models of allergic airway inflammation
    Clare M Lloyd
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, U K
    Methods Mol Biol 239:199-210. 2004
  27. pmc Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
    Jennifer Kearley
    Leukocyte Biology Section, Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, SW7 2AZ London, England, UK
    J Exp Med 202:1539-47. 2005
    ..These data suggest that CD4+CD25+ T cells can suppress the Th2 cell-driven response to allergen in vivo by an IL-10-dependent mechanism but that IL-10 production by the regulatory T cells themselves is not required for such suppression...
  28. ncbi request reprint CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease
    Benjamin Bishop
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 170:4810-7. 2003
    ..In summary, our results indicate that CCL1 is important for the pulmonary recruitment of eosinophils, rather than allergen-specific Th2 cells, following allergen challenge...
  29. pmc T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy
    J N Francis
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK
    Allergy 62:59-65. 2007
    ..The aim of this study was to assess differential chemokine receptor expression from symptomatic atopic grass pollen-sensitive subjects, compared with patients on high-dose allergen injection immunotherapy (IT) and healthy controls...
  30. ncbi request reprint Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway
    Sarah J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine Imperial College, London, United Kingdom
    J Immunol 174:5774-80. 2005
    ..Moreover, the molecular mechanism behind this effect may involve regulation of active TGF-beta signaling...
  31. ncbi request reprint Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 124:454-62. 2009
    ..Both transforming growth factor (TGF)-beta(1) and activin-A have been implicated in airway remodeling in asthma, but the modulation of their specific signaling pathways after disease activation remains undefined...
  32. ncbi request reprint CCR4 in human allergen-induced late responses in the skin and lung
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:1933-8. 2002
    ..CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner...
  33. pmc Eosinophils in the pathogenesis of allergic airways disease
    S G Trivedi
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Cell Mol Life Sci 64:1269-89. 2007
    ..Here we review the highly co-ordinated nature of eosinophil development and trafficking and the evolution of the eosinophil as a multi-factoral leukocyte with diverse functions in asthma...
  34. pmc Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors
    D Ahern
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK
    Allergy 64:1121-9. 2009
    ..Both express chemokine receptors (CCR) 4 and CCR8, but the dynamics of expression and effect of atopic status are unknown...
  35. pmc Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells
    Jenna R Murdoch
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 182:464-76. 2010
    ..Although regulation of allergic airway disease has been attributed to IL-17-producing T helper (Th) 17 cells, we have found that gammadeltaT cells represent the major source of IL-17 in the allergic lung...
  36. pmc Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25
    Lisa G Gregory
    Leukocyte Biology Section, NHLI, Imperial College London, London SW7 2AZ, UK
    Am J Respir Crit Care Med 182:143-54. 2010
    ..Moreover, we have identified novel roles for IL-25 and activin A in driving airway hyperreactivity and remodeling...
  37. pmc Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice
    Sejal Saglani
    Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Cell Mol Biol 41:281-9. 2009
    ..Importantly, all abnormalities developed in parallel, not sequentially, between 2 and 3 weeks of age...
  38. pmc CCR4 blockade does not inhibit allergic airways inflammation
    Dolores M Conroy
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Leukoc Biol 74:558-63. 2003
    ..This study casts doubts on the validity of CCR4 as a therapeutic target in the treatment of asthma...
  39. ncbi request reprint CXCR1+CD4+ T cells in human allergic disease
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
    J Immunol 172:268-73. 2004
    ..Phenotypic analysis reveals that IFN-gamma expression was lower in the CXCR1+CD4+ cells. The identification of CXCR1 as a marker of allergic rhinitis reveals a possible target for therapeutic intervention in atopic disease...
  40. ncbi request reprint Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model
    L G Gregory
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, UK
    Allergy 68:1579-88. 2013
    ..Therefore, we aimed to determine the role of altered pulmonary gene expression in disease inception and identify proremodeling mediators...
  41. ncbi request reprint Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4
    Miles E Banwell
    Leukocyte Biology Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 112:1155-61. 2003
    ..However, whether selective recruitment of allergen-specific T(H)2 cells to the airways occurs through CCR4 or other chemokine receptors remains controversial...
  42. pmc Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, England, UK
    J Exp Med 204:1289-94. 2007
    ..Thus, blocking Tim-3 function has a beneficial effect during pulmonary inflammation by skewing the Th2 response toward that of a Th1 type, suggesting an important role for Tim-3 in the regulation of allergic disease...
  43. pmc The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity
    Sarah J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, England
    J Exp Med 195:51-7. 2002
    ..These findings indicate that IL-9 is not obligatory for the development of eosinophilia and AHR, and imply that other Th2 cytokines can act in a compensatory fashion...
  44. pmc Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization
    Jamie A Leggat
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Allergy Clin Immunol 122:1014-1021.e4. 2008
    ..Infection or stimulation of the innate immune system by nonspecific microbial antigens is thought to educate the immune system to respond appropriately to allergens, preventing allergy...
  45. pmc Asthma: T-bet--a master controller?
    Douglas S Robinson
    Department of Allergy, National Heart and Lung Institute, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Curr Biol 12:R322-4. 2002
    ..The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma...
  46. ncbi request reprint Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation
    Sarah J McMillan
    Division of Biomedical Sciences, Faculty of Medicine Imperial College, London, United Kingdom
    J Immunol 172:2586-94. 2004
    ..Our results indicate that MMP-9 is critically involved in the recruitment of eosinophils and Th2 cells to the lung following allergen challenge, and suggest that MMP-9 plays a role in the development of Th2 responses to allergen...
  47. pmc Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets
    Georgina Xanthou
    Cellular Immunology Laboratory, Division of Cell Biology, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, 4 Soranou Efessiou Street, 115 27 Athens, Greece
    Nat Med 13:570-8. 2007
    ..These effects on T(H)2 allergic responses suggest that Opn-s is an important therapeutic target and provide new insight into its role in immunity...
  48. ncbi request reprint A critical role for eosinophils in allergic airways remodeling
    Alison A Humbles
    Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 305:1776-9. 2004
    ..These data suggest that eosinophils contribute substantially to airway remodeling but are not obligatory for allergen-induced lung dysfunction, and support an important role for eosinophil-targeted therapies in chronic asthma...