Affiliation: Imperial College
- A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regionsAnne Lingford-Hughes
Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
J Psychopharmacol 26:273-81. 2012..We speculate that the reduced limbic [(11)C]Ro15 4513 binding seen here results from the effects of alcohol, though we cannot currently distinguish whether they are compensatory in nature or evidence of brain toxicity...
- Neuropharmacology of addiction and how it informs treatmentAnne Lingford-Hughes
Department of Experimental Medicine, Imperial College, Burlington Danes Building, Hammersmith Hospital Site, 160 Du Cane Road, London, UK
Br Med Bull 96:93-110. 2010..In addition to modulating this reward pathway, alternative approaches in the future will target learning and memory, improving impulse control and decision-making...
- Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET studyTim M Williams
Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, UK
Eur Neuropsychopharmacol 19:740-8. 2009..This confirms previous work showing increased opioid receptor availability in early abstinence from substances of abuse and correlation with craving suggesting that the opioid system plays a fundamental role in this phase of addiction...
- Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography studyTim M Williams
Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
Br J Psychiatry 191:63-9. 2007..Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood...
- Socio-economic status in childhood and later alcohol use: a systematic reviewNicola J Wiles
Academic Unit of Psychiatry, Department of Community Based Medicine, University of Bristol, Bristol, UK
Addiction 102:1546-63. 2007..To conduct a systematic review of longitudinal studies that examined the association between childhood socio-economic status (SES) and alcohol use in later life...
- Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomographyAnne Lingford-Hughes
Psychopharmacology Unit, School of Medical Science, University of Bristol, UK
J Cereb Blood Flow Metab 22:878-89. 2002..The authors conclude that [11C]Ro15 4513 PET labels in vivo the GABA-benzodiazepine receptor containing the alpha5 subtype in limbic structures and can be used to further explore the functional role of this subtype in humans...
- Effects of cannabis use on outcomes of psychotic disorders: systematic reviewStanley Zammit
Academic Unit of Psychiatry, University of Bristol, UK
Br J Psychiatry 193:357-63. 2008..It is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors...
- A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patientsAviv Weinstein
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK
Addict Biol 8:229-32. 2003..Our results suggest that acamprosate may play a role in reduction of craving for alcohol after 6 weeks of treatment...
- Comparison of ethyl glucuronide in hair with self-reported alcohol consumptionRosemary Lees
Psychopharmacology Unit, University of Bristol, UK
Alcohol Alcohol 47:267-72. 2012..Ethyl glucuronide (EtG) in hair is a proposed biomarker for alcohol consumption. This study compares hair EtG concentrations with self-reported alcohol consumption data, in individuals with a range of alcohol use...
- GABAB receptors in addiction and its treatmentRobin J Tyacke
Neuropsychopharmacology Unit, Division of Experimental Medicine and Therapeutics, Imperial College London, London, UK
Adv Pharmacol 58:373-96. 2010..This potential is at present poorly understood or studied and warrants further investigation...
- Significant decreases in frontal and temporal [11C]-raclopride binding after THC challengePaul R A Stokes
MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
Neuroimage 52:1521-7. 2010..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
- Is there cognitive impairment in clinically 'healthy' abstinent alcohol dependence?Simon J C Davies
Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
Alcohol Alcohol 40:498-503. 2005....
- Does alcohol increase the risk of overdose death: the need for a translational approachMatt Hickman
Department of Social Medicine, University of Bristol, UK
Addiction 103:1060-2. 2008..We argue for a translational approach to addiction science, using an important current research question as a case study...
- Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studiesJan K Melichar
Psychopharmacology Unit, University of Bristol, Whitson St, Bristol, BS1 3NY, UK
J Pharmacol Exp Ther 312:309-15. 2005..This has implications for understanding the actions of methadone in comparison with other opioid drugs such as partial agonists and antagonists...
- Human functional neuroimaging connectivity research in dependenceMark Daglish
Psychopharmacology Unit, University of Bristol, Bristol, UK
Rev Neurosci 16:151-7. 2005..Studies of brain connectivity can now begin to help further unravel the tangle of disparate brain regions and their connections that underpin the psychopharmacological processes of dependence...
- Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients with alcohol dependenceClaire Taylor
Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Alcohol Alcohol 43:614-8. 2008..The aim of this study was to measure GABAA benzodiazepine receptor (GBzR) sensitivity in alcohol-dependent patients and compare with matched non-dependent drinkers...
- Human brain imaging and substance abuseAnne Lingford-Hughes
Academic Unit of Psychiatry, University of Bristol, Bristol BS6 6JL, UK
Curr Opin Pharmacol 5:42-6. 2005..g. methadone and buprenorphine) in opiate addicts...
- Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trialRahil Sanatinia
Centre for Mental Health, Imperial College, London, UK
Trials 13:149. 2012....
- The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography studyMaría Andreína Méndez
King s College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, PO Box 50, De Crespigny Park, London SE5 8AF, UK
Neuropharmacology 68:195-201. 2013..These results provide initial evidence of a GABAA α5 deficit in ASD and support further investigations of the GABA system in this disorder. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
- Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for PsychopharmacologyThomas R E Barnes
Centre for Mental Health, Imperial College, Charing Cross Campus, London, UK
J Psychopharmacol 25:567-620. 2011..They are accompanied by a more detailed qualitative review of the available evidence. The strength of supporting evidence for each recommendation is rated...
- Is socioeconomic status in early life associated with drug use? A systematic review of the evidenceJames Z Daniel
Academic Unit of Psychiatry, University of Bristol, Bristol, UK
Drug Alcohol Rev 28:142-53. 2009..To conduct a systematic review of longitudinal studies that examined the association between childhood socioeconomic status (SES) and illegal drug use in later life...
- Cannabis use and risk of psychotic or affective mental health outcomes: a systematic reviewTheresa H M Moore
Academic Unit of Psychiatry, University of Bristol, Bristol, UK
Lancet 370:319-28. 2007..We systematically reviewed the evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes...