Anne Lingford-Hughes

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images
    James F M Myers
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Cereb Blood Flow Metab 32:731-44. 2012
  2. doi request reprint A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions
    Anne Lingford-Hughes
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    J Psychopharmacol 26:273-81. 2012
  3. doi request reprint Neuropharmacology of addiction and how it informs treatment
    Anne Lingford-Hughes
    Department of Experimental Medicine, Imperial College, Burlington Danes Building, Hammersmith Hospital Site, 160 Du Cane Road, London, UK
    Br Med Bull 96:93-110. 2010
  4. ncbi request reprint Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study
    Tim M Williams
    Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
    Br J Psychiatry 191:63-9. 2007
  5. doi request reprint Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study
    Tim M Williams
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, UK
    Eur Neuropsychopharmacol 19:740-8. 2009
  6. ncbi request reprint Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography
    Anne Lingford-Hughes
    Psychopharmacology Unit, School of Medical Science, University of Bristol, UK
    J Cereb Blood Flow Metab 22:878-89. 2002
  7. doi request reprint Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
  8. ncbi request reprint Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies
    Jan K Melichar
    Psychopharmacology Unit, University of Bristol, Whitson St, Bristol, BS1 3NY, UK
    J Pharmacol Exp Ther 312:309-15. 2005
  9. ncbi request reprint The clinical effectiveness and cost-effectiveness of brief intervention for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial (SHEAR)
    Mike J Crawford
    Centre for Mental Health, Imperial College London, London, UK
    Health Technol Assess 18:1-48. 2014
  10. ncbi request reprint A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patients
    Aviv Weinstein
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK
    Addict Biol 8:229-32. 2003

Collaborators

Detail Information

Publications25

  1. pmc Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images
    James F M Myers
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Cereb Blood Flow Metab 32:731-44. 2012
    ..The proposed method for [(11)C]Ro15-4513 analysis may allow more accurate selective binding assays and estimation of drug occupancy for other nonselective ligands...
  2. doi request reprint A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions
    Anne Lingford-Hughes
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    J Psychopharmacol 26:273-81. 2012
    ..We speculate that the reduced limbic [(11)C]Ro15 4513 binding seen here results from the effects of alcohol, though we cannot currently distinguish whether they are compensatory in nature or evidence of brain toxicity...
  3. doi request reprint Neuropharmacology of addiction and how it informs treatment
    Anne Lingford-Hughes
    Department of Experimental Medicine, Imperial College, Burlington Danes Building, Hammersmith Hospital Site, 160 Du Cane Road, London, UK
    Br Med Bull 96:93-110. 2010
    ..In addition to modulating this reward pathway, alternative approaches in the future will target learning and memory, improving impulse control and decision-making...
  4. ncbi request reprint Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study
    Tim M Williams
    Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
    Br J Psychiatry 191:63-9. 2007
    ..Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood...
  5. doi request reprint Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study
    Tim M Williams
    Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, UK
    Eur Neuropsychopharmacol 19:740-8. 2009
    ..This confirms previous work showing increased opioid receptor availability in early abstinence from substances of abuse and correlation with craving suggesting that the opioid system plays a fundamental role in this phase of addiction...
  6. ncbi request reprint Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography
    Anne Lingford-Hughes
    Psychopharmacology Unit, School of Medical Science, University of Bristol, UK
    J Cereb Blood Flow Metab 22:878-89. 2002
    ..The authors conclude that [11C]Ro15 4513 PET labels in vivo the GABA-benzodiazepine receptor containing the alpha5 subtype in limbic structures and can be used to further explore the functional role of this subtype in humans...
  7. doi request reprint Effects of cannabis use on outcomes of psychotic disorders: systematic review
    Stanley Zammit
    Academic Unit of Psychiatry, University of Bristol, UK
    Br J Psychiatry 193:357-63. 2008
    ..It is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors...
  8. ncbi request reprint Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies
    Jan K Melichar
    Psychopharmacology Unit, University of Bristol, Whitson St, Bristol, BS1 3NY, UK
    J Pharmacol Exp Ther 312:309-15. 2005
    ..This has implications for understanding the actions of methadone in comparison with other opioid drugs such as partial agonists and antagonists...
  9. ncbi request reprint The clinical effectiveness and cost-effectiveness of brief intervention for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial (SHEAR)
    Mike J Crawford
    Centre for Mental Health, Imperial College London, London, UK
    Health Technol Assess 18:1-48. 2014
    ..Excessive use of alcohol is associated with poor sexual health, but the clinical effectiveness and cost-effectiveness of brief alcohol intervention in this setting has not been investigated...
  10. ncbi request reprint A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patients
    Aviv Weinstein
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK
    Addict Biol 8:229-32. 2003
    ..Our results suggest that acamprosate may play a role in reduction of craving for alcohol after 6 weeks of treatment...
  11. ncbi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  12. doi request reprint Comparison of ethyl glucuronide in hair with self-reported alcohol consumption
    Rosemary Lees
    Psychopharmacology Unit, University of Bristol, UK
    Alcohol Alcohol 47:267-72. 2012
    ..Ethyl glucuronide (EtG) in hair is a proposed biomarker for alcohol consumption. This study compares hair EtG concentrations with self-reported alcohol consumption data, in individuals with a range of alcohol use...
  13. ncbi request reprint GABAB receptors in addiction and its treatment
    Robin J Tyacke
    Neuropsychopharmacology Unit, Division of Experimental Medicine and Therapeutics, Imperial College London, London, UK
    Adv Pharmacol 58:373-96. 2010
    ..This potential is at present poorly understood or studied and warrants further investigation...
  14. ncbi request reprint Is there cognitive impairment in clinically 'healthy' abstinent alcohol dependence?
    Simon J C Davies
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Alcohol Alcohol 40:498-503. 2005
    ....
  15. ncbi request reprint Does alcohol increase the risk of overdose death: the need for a translational approach
    Matt Hickman
    Department of Social Medicine, University of Bristol, UK
    Addiction 103:1060-2. 2008
    ..We argue for a translational approach to addiction science, using an important current research question as a case study...
  16. ncbi request reprint Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
    Theresa H M Moore
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Lancet 370:319-28. 2007
    ..We systematically reviewed the evidence pertaining to cannabis use and occurrence of psychotic or affective mental health outcomes...
  17. ncbi request reprint Human brain imaging and substance abuse
    Anne Lingford-Hughes
    Academic Unit of Psychiatry, University of Bristol, Bristol BS6 6JL, UK
    Curr Opin Pharmacol 5:42-6. 2005
    ..g. methadone and buprenorphine) in opiate addicts...
  18. ncbi request reprint Human functional neuroimaging connectivity research in dependence
    Mark Daglish
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    Rev Neurosci 16:151-7. 2005
    ..Studies of brain connectivity can now begin to help further unravel the tangle of disparate brain regions and their connections that underpin the psychopharmacological processes of dependence...
  19. doi request reprint Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients with alcohol dependence
    Claire Taylor
    Psychopharmacology Unit, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Alcohol Alcohol 43:614-8. 2008
    ..The aim of this study was to measure GABAA benzodiazepine receptor (GBzR) sensitivity in alcohol-dependent patients and compare with matched non-dependent drinkers...
  20. ncbi request reprint Functional connectivity analysis of the neural circuits of opiate craving: "more" rather than "different"?
    Mark R C Daglish
    Psychopharmacology Unit, University of Bristol, UK
    Neuroimage 20:1964-70. 2003
    ..This argues that neural circuits of dependence and craving are not specific "craving" or "addiction" brain regions but are "normal" circuits activated to a greater degree...
  21. ncbi request reprint Socio-economic status in childhood and later alcohol use: a systematic review
    Nicola J Wiles
    Academic Unit of Psychiatry, Department of Community Based Medicine, University of Bristol, Bristol, UK
    Addiction 102:1546-63. 2007
    ..To conduct a systematic review of longitudinal studies that examined the association between childhood socio-economic status (SES) and alcohol use in later life...
  22. pmc Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial
    Rahil Sanatinia
    Centre for Mental Health, Imperial College, London, UK
    Trials 13:149. 2012
    ....
  23. doi request reprint The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study
    María Andreína Méndez
    King s College London, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, PO Box 50, De Crespigny Park, London SE5 8AF, UK
    Neuropharmacology 68:195-201. 2013
    ..These results provide initial evidence of a GABAA α5 deficit in ASD and support further investigations of the GABA system in this disorder. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
  24. doi request reprint Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology
    Thomas R E Barnes
    Centre for Mental Health, Imperial College, Charing Cross Campus, London, UK
    J Psychopharmacol 25:567-620. 2011
    ..They are accompanied by a more detailed qualitative review of the available evidence. The strength of supporting evidence for each recommendation is rated...
  25. doi request reprint Is socioeconomic status in early life associated with drug use? A systematic review of the evidence
    James Z Daniel
    Academic Unit of Psychiatry, University of Bristol, Bristol, UK
    Drug Alcohol Rev 28:142-53. 2009
    ..To conduct a systematic review of longitudinal studies that examined the association between childhood socioeconomic status (SES) and illegal drug use in later life...