T Lawrence

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
    Nature 434:1138-43. 2005
  2. pmc Chronic inflammation: a failure of resolution?
    Toby Lawrence
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Int J Exp Pathol 88:85-94. 2007
  3. ncbi request reprint IKKalpha in the regulation of inflammation and adaptive immunity
    T Lawrence
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK
    Biochem Soc Trans 35:270-2. 2007
  4. pmc An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation
    Carol Ho Yan Fong
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, W6 8LH, UK
    J Exp Med 205:1269-76. 2008
  5. pmc Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection
    Arnaud Didierlaurent
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, England, UK
    J Exp Med 205:323-9. 2008
  6. pmc Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
    David H Broide
    Department of Medicine, Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:17723-8. 2005
  7. pmc I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
  8. ncbi request reprint Anti-inflammatory lipid mediators and insights into the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nat Rev Immunol 2:787-95. 2002
  9. ncbi request reprint Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    Michael Karin
    Laboratory of Gene Expression and Signal Transduction, Department of Pharmacology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 124:823-35. 2006
  10. pmc Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
    Sonya M Abraham
    Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, United Kingdom
    J Exp Med 203:1883-9. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
    Nature 434:1138-43. 2005
    ..Inactivation of IKKalpha in mice enhances inflammation and bacterial clearance. Hence, the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity...
  2. pmc Chronic inflammation: a failure of resolution?
    Toby Lawrence
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Int J Exp Pathol 88:85-94. 2007
    ..Here, we are going to discuss the key endogenous checkpoints necessary for mounting an effective yet limited inflammatory response and the crucial biochemical pathways necessary to prevent its persistence...
  3. ncbi request reprint IKKalpha in the regulation of inflammation and adaptive immunity
    T Lawrence
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK
    Biochem Soc Trans 35:270-2. 2007
    ..Here, we discuss the emerging roles for IKKalpha in the tight regulation of inflammation and the development of adaptive immune responses...
  4. pmc An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation
    Carol Ho Yan Fong
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, W6 8LH, UK
    J Exp Med 205:1269-76. 2008
    ..This establishes a new role for IKKbeta in the regulation of macrophage activation with important implications in chronic inflammatory disease, infection, and cancer...
  5. pmc Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection
    Arnaud Didierlaurent
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, England, UK
    J Exp Med 205:323-9. 2008
    ..Our data therefore suggests that post-viral desensitization to TLR signals may be one possible contributor to the common secondary bacterial pneumonia associated with pandemic and seasonal influenza infection...
  6. pmc Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
    David H Broide
    Department of Medicine, Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:17723-8. 2005
    ..Overall, these studies show an important role for NF-kappaB regulated genes in airway epithelium in allergen-induced airway remodeling, including peribronchial fibrosis and mucus production...
  7. pmc I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
    ..IKKbeta also protects osteoclasts and their progenitors from tumor necrosis factor alpha-induced apoptosis, and its loss in hematopoietic cells prevents inflammation-induced bone loss...
  8. ncbi request reprint Anti-inflammatory lipid mediators and insights into the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nat Rev Immunol 2:787-95. 2002
    ..This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines...
  9. ncbi request reprint Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    Michael Karin
    Laboratory of Gene Expression and Signal Transduction, Department of Pharmacology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 124:823-35. 2006
    ....
  10. pmc Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
    Sonya M Abraham
    Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, United Kingdom
    J Exp Med 203:1883-9. 2006
    ..Therefore, the expression of DUSP1 is required for the inhibition of proinflammatory signaling pathways by Dex in mouse macrophages. Furthermore, DUSP1 contributes to the antiinflammatory effects of Dex in vitro and in vivo...
  11. ncbi request reprint Air-pouch models of inflammation and modifications for the study of granuloma-mediated cartilage degradation
    Paul Colville-Nash
    The William Harvey Research Institute, London, UK
    Methods Mol Biol 225:181-9. 2003
  12. pmc Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor
    Nathan M Blackwell
    Bone and Joint Research Unit, William Harvey Research Institute, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Arthritis Rheum 50:2675-84. 2004
    ....
  13. ncbi request reprint Inflammation and cancer: a failure of resolution?
    Toby Lawrence
    Faculty of Medicine, Imperial College, 1 Aspenlea Road, London W6 8LH, UK
    Trends Pharmacol Sci 28:162-5. 2007
    ..There are clear opportunities for drug discovery and the development of new therapeutic approaches that target tumour-associated inflammation and the mechanisms of chronic inflammation...
  14. doi request reprint Investigating macrophage and malignant cell interactions in vitro
    Thorsten Hagemann
    Centre for Translational Oncology, Institute of Cancer and CR UK Clinical Cancer Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Methods Mol Biol 512:325-32. 2009
    ..There are several experimental approaches to study the interactions between macrophages and tumor cells in vitro, which we will describe here...
  15. ncbi request reprint Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    Andrew J Fleetwood
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 178:5245-52. 2007
    ....
  16. pmc The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    Chun Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:1019-27. 2008
    ..Our results suggest a dual function for p38 alpha in the regulation of inflammation and show mixed potential for its inhibition as a therapeutic strategy...
  17. ncbi request reprint Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis
    Derek W Gilroy
    Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, London EC1M 6BQ, UK
    FASEB J 17:2269-71. 2003
    ..These results provide insight into the mechanisms that switch off acute inflammation and prevent complications of wound healing and potentially the development of immune-mediated chronic inflammation...
  18. pmc Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2
    Ravindra Rajakariar
    Department of Experimental Medicine, Nephrology, and Critical Care, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 104:20979-84. 2007
    ..Here, we provide definitive proof that 15d-PGJ(2) is synthesized during mammalian inflammatory responses, and we highlight DP1 receptor activation as a potential antiinflammatory strategy...
  19. pmc "Re-educating" tumor-associated macrophages by targeting NF-kappaB
    Thorsten Hagemann
    Centre for Cancer and Inflammation, Institute of Cancer, Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, UK
    J Exp Med 205:1261-8. 2008
    ....
  20. ncbi request reprint Inflammatory resolution: new opportunities for drug discovery
    Derek W Gilroy
    William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Drug Discov 3:401-16. 2004
  21. pmc Novel biphasic role for lymphocytes revealed during resolving inflammation
    Ravindra Rajakariar
    Department of Experimental Medicine and Translational Therapeutics, William Harvey Research Institute, London, United Kingdom
    Blood 111:4184-92. 2008
    ....
  22. pmc Inflammation and cancer: a double-edged sword
    Thorsten Hagemann
    Centre for Translational Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Cancer Cell 12:300-1. 2007
    ..Apetoh et al. describe how activation of innate immunity after conventional radiation or chemotherapy can trigger protective antitumor immunity...
  23. ncbi request reprint Cancer. Sex, cytokines, and cancer
    Toby Lawrence
    Centre for Translational Oncology, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Science 317:51-2. 2007
  24. pmc Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense
    George Y Liu
    Department of Pediatrics, The Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:14491-6. 2004
    ..Together, these data suggest a mechanism by which the linked cylE-encoded phenotypes, betaH/C (sword) and carotenoid (shield), act in partnership to thwart the immune phagocytic defenses...
  25. ncbi request reprint Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha
    Panagiotis S Kabouridis
    Bone and Joint Research Unit and Department of Experimental Pathology, Barts and London School of Medicine and Dentistry, London, United Kingdom
    J Immunol 169:2587-93. 2002
    ..These results identify a novel way for direct regulation of NF-kappaB activity in diverse cell types that may be useful for therapeutic purposes...