E W Lam

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology Imperial College School of Medicine at St Mary s, London, GB
    Eur J Immunol 29:3380-9. 1999
  2. ncbi request reprint Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 275:3479-84. 2000
  3. ncbi request reprint Modulation of E2F activity via signaling through surface IgM and CD40 receptors in WEHI-231 B lymphoma cells
    E W Lam
    Ludwig Institute for Cancer Research and Department of Medical Microbiology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 273:10051-7. 1998
  4. ncbi request reprint BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells
    L Banerji
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, UK
    Oncogene 20:7352-67. 2001
  5. ncbi request reprint BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression
    Y Parada
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 276:23572-80. 2001
  6. ncbi request reprint Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
    M Collado
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s Campus, London, United Kingdom
    J Biol Chem 275:21960-8. 2000
  7. ncbi request reprint Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor
    J Glassford
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 276:41040-8. 2001
  8. ncbi request reprint The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells
    J L Lewis
    LRF Centre for Adult Leukaemia, Department of Haematology, Imperial College School of Medicine, Hammersmith Campus, London, United Kingdom
    Blood 97:2604-10. 2001
  9. pmc Transcription regulation by murine B-myb is distinct from that by c-myb
    R J Watson
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Nucleic Acids Res 21:267-72. 1993
  10. ncbi request reprint Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
    N Solvason
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Int Immunol 12:631-8. 2000

Collaborators

  • N S Thomas
  • M Y Gordon
  • J M Goldman
  • M Turner
  • Marthe J Howard
  • N B La Thangue
  • M Serrano
  • N Solvason
  • L Banerji
  • J Glassford
  • Y Parada
  • J L Lewis
  • M Collado
  • N C Lea
  • M W Deininger
  • G G Klaus
  • C Rivas
  • R V Gopalkrishnan
  • L R Bandara
  • F X Mahon
  • W Chinswangwatanakul
  • N C Cross
  • G Peters
  • E Clayton
  • B Zheng
  • M Holman
  • S A Vieira
  • S B Marley
  • D X Nguyen
  • J V Melo
  • M Barradas
  • X F Hao
  • B M Burgering
  • M L Dubuisson
  • I Garcia-Cao
  • R H Medema
  • C Kedinger
  • R J Watson
  • D Glover
  • L Alphey
  • T S Sørensen
  • R Girling
  • M Zamanian
  • C Robinson

Detail Information

Publications17

  1. ncbi request reprint Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology Imperial College School of Medicine at St Mary s, London, GB
    Eur J Immunol 29:3380-9. 1999
    ..These results therefore indicate that the pRB/E2F pathway integrates proliferative signals emanating from the sIgM and CD40 receptors...
  2. ncbi request reprint Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 275:3479-84. 2000
    ....
  3. ncbi request reprint Modulation of E2F activity via signaling through surface IgM and CD40 receptors in WEHI-231 B lymphoma cells
    E W Lam
    Ludwig Institute for Cancer Research and Department of Medical Microbiology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 273:10051-7. 1998
    ....
  4. ncbi request reprint BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells
    L Banerji
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, UK
    Oncogene 20:7352-67. 2001
    ..These results indicate that BCR activation targets p27(Kip1) and cyclin D2 to mediate cell cycle arrest and apoptosis and that down-regulation of PI3-K/AKT activity post BCR stimulation is necessary for these to occur...
  5. ncbi request reprint BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression
    Y Parada
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 276:23572-80. 2001
    ..Furthermore, our data also suggest that cyclin D2 functions upstream of p27(Kip1), cyclin E, and cyclin D3, and therefore, plays an essential part in integrating the signals from IL-3 and BCR-ABL with the pRB/E2F pathway...
  6. ncbi request reprint Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
    M Collado
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s Campus, London, United Kingdom
    J Biol Chem 275:21960-8. 2000
    ..We show that this is due to a compensatory mechanism by which p130 functionally substitutes for the loss of p27(Kip1). This is the first description that p130 may have a role in inhibiting CDK activity during senescence...
  7. ncbi request reprint Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor
    J Glassford
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 276:41040-8. 2001
    ..We further demonstrate that intracellular calcium homeostasis is required for cyclin D2 induction, implicating a possible link with the defective calcium response of vav(-/-) B cells and their inability to induce cyclin D2...
  8. ncbi request reprint The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells
    J L Lewis
    LRF Centre for Adult Leukaemia, Department of Haematology, Imperial College School of Medicine, Hammersmith Campus, London, United Kingdom
    Blood 97:2604-10. 2001
    ....
  9. pmc Transcription regulation by murine B-myb is distinct from that by c-myb
    R J Watson
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Nucleic Acids Res 21:267-72. 1993
    ..Results obtained here demonstrate that the activities of B-Myb and c-Myb are clearly distinct and suggest that these related proteins may have different functions in regulation of target gene expression...
  10. ncbi request reprint Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
    N Solvason
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Int Immunol 12:631-8. 2000
    ....
  11. ncbi request reprint Cell-cycle regulation of human B-myb transcription
    E W Lam
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Gene 160:277-81. 1995
    ..In addition, complexes containing pRb were detected at both stages of the cell cycle...
  12. pmc DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein
    L R Bandara
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK
    EMBO J 13:3104-14. 1994
    ..We conclude that DP-1 is a frequent and cell cycle-regulated component of DRTF1/E2F, and that in the DP-1/E2F-1 heterodimer it is functionally important for recognition by pRb and the E4 orf 6/7 protein...
  13. pmc An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription
    E W Lam
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    EMBO J 12:2705-13. 1993
    ..These studies demonstrate for the first time a direct role for E2F in regulation of cell cycle gene expression by repression of transcription in G0/early G1...
  14. ncbi request reprint Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster
    X F Hao
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    J Cell Sci 108:2945-54. 1995
    ..The distinct expression patterns of DmDP and DmE2F-1 suggest that the formation of DP/E2F heterodimers, and hence DRTF1/E2F, is subject to complex regulatory cues...
  15. ncbi request reprint Characterization and cell cycle-regulated expression of mouse B-myb
    E W Lam
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Oncogene 7:1885-90. 1992
    ..Similarly, maximum B-myb mRNA levels were reached in G2/M synchronized cells prior to entry into S phase. These results are consistent with a role in G1/S transition as has been suggested for c-myb...
  16. ncbi request reprint The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter
    R V Gopalkrishnan
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS INSERM, University Louis Pasteur, F 67404 Illkirch Cedex C U de Strasbourg, France
    J Biol Chem 273:10972-8. 1998
    ..Inhibition of DP1 transcription has implications in one of the several possible mechanisms through which p53 induces cell cycle arrest...
  17. ncbi request reprint Direct relation between BCR-ABL tyrosine kinase activity and cyclin D2 expression in lymphoblasts
    M W Deininger
    Department of Haematology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Cancer Res 61:8005-13. 2001
    ..However, cell cycle progression in human Ph-positive lymphoid cells is not entirely dependent on Bcr-Abl PTK, and additional genetic lesions must be present...