Marina K Kuimova

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Determination of the triplet state energies of a series of conjugated porphyrin oligomers
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    Photochem Photobiol Sci 6:675-82. 2007
  2. ncbi request reprint Picosecond time-resolved infrared study of 2-aminopurine ionisation in solution
    Marina K Kuimova
    School of Chemistry, University of Nottingham, University Park, Nottingham, UK
    Photochem Photobiol Sci 6:949-55. 2007
  3. doi request reprint Molecular rheometry: direct determination of viscosity in Lo and Ld lipid phases via fluorescence lifetime imaging
    Yilei Wu
    Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
    Phys Chem Chem Phys 15:14986-93. 2013
  4. doi request reprint Mapping viscosity in cells using molecular rotors
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Phys Chem Chem Phys 14:12671-86. 2012
  5. doi request reprint Molecular rotors image intracellular viscosity
    Marina K Kuimova
    Chemistry Department, Imperial College, South Kensington SW7 2AZ, London, UK
    Chimia (Aarau) 66:159-65. 2012
  6. doi request reprint Imaging intracellular viscosity of a single cell during photoinduced cell death
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Nat Chem 1:69-73. 2009
  7. doi request reprint Molecular rotor measures viscosity of live cells via fluorescence lifetime imaging
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    J Am Chem Soc 130:6672-3. 2008
  8. doi request reprint Intramolecular rotation in a porphyrin dimer controls singlet oxygen production
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    J Am Chem Soc 131:7948-9. 2009
  9. doi request reprint One- and two-photon activated phototoxicity of conjugated porphyrin dimers with high two-photon absorption cross sections
    Emma Dahlstedt
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX13TA, UK
    Org Biomol Chem 7:897-904. 2009
  10. doi request reprint Singlet oxygen in a cell: spatially dependent lifetimes and quenching rate constants
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    J Am Chem Soc 131:332-40. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Determination of the triplet state energies of a series of conjugated porphyrin oligomers
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    Photochem Photobiol Sci 6:675-82. 2007
    ..Thus the conjugated porphyrin dimer is the most promising core structure for PDT applications via multiphoton excitation...
  2. ncbi request reprint Picosecond time-resolved infrared study of 2-aminopurine ionisation in solution
    Marina K Kuimova
    School of Chemistry, University of Nottingham, University Park, Nottingham, UK
    Photochem Photobiol Sci 6:949-55. 2007
    ..DFT calculations (EDF1/6-31+G*) were used to support the assignment of the intermediates observed in these spectroscopic experiments...
  3. doi request reprint Molecular rheometry: direct determination of viscosity in Lo and Ld lipid phases via fluorescence lifetime imaging
    Yilei Wu
    Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
    Phys Chem Chem Phys 15:14986-93. 2013
    ..Our study showcases the power of FLIM with molecular rotors to image microviscosity of heterogeneous microenvironments in complex biological systems, including membrane-localised lipid rafts. ..
  4. doi request reprint Mapping viscosity in cells using molecular rotors
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Phys Chem Chem Phys 14:12671-86. 2012
    ..Finally, it is discussed how the major advantage of molecular rotor imaging, fast signal acquisition, can be used to monitor changing viscosity during dynamic biological processes within cells, such as photoinduced cell death...
  5. doi request reprint Molecular rotors image intracellular viscosity
    Marina K Kuimova
    Chemistry Department, Imperial College, South Kensington SW7 2AZ, London, UK
    Chimia (Aarau) 66:159-65. 2012
    ..We have illustrated this advantage by monitoring changes in intracellular viscosity during photodynamic therapy, which is a clinically utilised modality for the treatment of neoplastic disease...
  6. doi request reprint Imaging intracellular viscosity of a single cell during photoinduced cell death
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Nat Chem 1:69-73. 2009
    ..Using these tools, we provide insight into the dynamics of diffusion in cells, which is pertinent to drug delivery, cell signalling and intracellular mass transport...
  7. doi request reprint Molecular rotor measures viscosity of live cells via fluorescence lifetime imaging
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    J Am Chem Soc 130:6672-3. 2008
    ..The high viscosity of intracellular compartments is likely to play an important role in vital intracellular processes, including the rate of diffusion of reactive oxygen species, causing programmed cell destruction...
  8. doi request reprint Intramolecular rotation in a porphyrin dimer controls singlet oxygen production
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, SW7 2AZ, UK
    J Am Chem Soc 131:7948-9. 2009
    ..This property may be beneficial for many applications requiring the controlled release of an oxidizing species, e.g., microfabrication and singlet oxygen-mediated cell death...
  9. doi request reprint One- and two-photon activated phototoxicity of conjugated porphyrin dimers with high two-photon absorption cross sections
    Emma Dahlstedt
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX13TA, UK
    Org Biomol Chem 7:897-904. 2009
    ..We conclude that the in vitro two-photon PDT efficacy of P2C2-NMeI is about twice that of Visudyne. This result highlights the potential of this series of porphyrin dimers for two-photon PDT...
  10. doi request reprint Singlet oxygen in a cell: spatially dependent lifetimes and quenching rate constants
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    J Am Chem Soc 131:332-40. 2009
    ..Thus, despite a relatively long intracellular lifetime, singlet oxygen does not diffuse a great distance from its site of production. This is a consequence of an apparent intracellular viscosity that is comparatively large...
  11. doi request reprint Photophysical properties and intracellular imaging of water-soluble porphyrin dimers for two-photon excited photodynamic therapy
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW72AZ, UK
    Org Biomol Chem 7:889-96. 2009
    ..Analysis of the photophysical parameters and intracellular imaging data indicates that these dimers are promising candidates for one-photon and two-photon excited PDT...
  12. ncbi request reprint Fluorescence characterisation of multiply-loaded anti-HER2 single chain Fv-photosensitizer conjugates suitable for photodynamic therapy
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, UK
    Photochem Photobiol Sci 6:933-9. 2007
    ..The present study highlights the usefulness of photosensitizer immunoconjugates with scFvs for targeted PDT...
  13. doi request reprint Fluorescence anisotropy of molecular rotors
    James A Levitt
    Department of Physics, King s College London, Strand, London, WC2R 2LS, UK
    Chemphyschem 12:662-72. 2011
    ....
  14. pmc Monitoring the direct and indirect damage of DNA bases and polynucleotides by using time-resolved infrared spectroscopy
    Marina K Kuimova
    School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Proc Natl Acad Sci U S A 103:2150-3. 2006
    ..The ability to use time-resolved infrared spectroscopy in this way paves the way for developing solution-phase studies to investigate both direct and indirect radiation chemistry of DNA...
  15. ncbi request reprint Picosecond time-resolved infrared spectroscopic investigation into electron localisation in the excited states of Re(i) polypyridyl complexes with bridging ligands
    Marina K Kuimova
    School of Chemistry, University of Nottingham, University Park, Nottingham, UK
    Photochem Photobiol Sci 5:82-7. 2006
    ..The nu(CO) bands of the adjacent Re centre are affected by the reduction of the bridging ligand. On the IR timescale the excited state structure is best formulated as [Cl(CO)3Re(II)(micro-ppbMe2 *-)Re(I)(CO)3Cl]...
  16. doi request reprint Novel photosensitisers derived from pyropheophorbide-a: uptake by cells and photodynamic efficiency in vitro
    Ioanna Stamati
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, Exhibition Road, SW7 2AZ, UK
    Photochem Photobiol Sci 9:1033-41. 2010
    ..These studies highlight the underlying factors behind creating more potent photosensitisers through synthetic manipulation...
  17. doi request reprint Chemical imaging of live cancer cells in the natural aqueous environment
    Marina K Kuimova
    Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom
    Appl Spectrosc 63:164-71. 2009
    ....
  18. doi request reprint A cyclometallated platinum complex as a selective optical switch for quadruplex DNA
    Kogularamanan Suntharalingam
    Department of Chemistry, Imperial College London, London SW7 2AZ, UK
    Chemistry 18:16277-82. 2012
    ..By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli...
  19. pmc Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors
    Neveen A Hosny
    Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 110:9225-30. 2013
    ..We also demonstrate that heterogeneous viscosity distributions exist within individual microbubble shells even with a single surfactant component...