Ralph Knoll

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc MLP (muscle LIM protein) as a stress sensor in the heart
    Byambajav Buyandelger
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College, South Kensington Campus, Flowers Building, 4th Floor, London, SW7 2AZ, UK
    Pflugers Arch 462:135-42. 2011
  2. pmc Z-disc transcriptional coupling, sarcomeroptosis and mechanoptosis [corrected]
    Ralph Knoll
    Myocardial Genetics, British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College, Hammersmith Campus, London, UK
    Cell Biochem Biophys 66:65-71. 2013
  3. doi request reprint On mechanosensation, acto/myosin interaction, and hypertrophy
    Ralph Knoll
    Heart Science Section, National Heart and Lung Institute, Imperial College, London W12 0NN, UK
    Trends Cardiovasc Med 22:17-22. 2012
  4. doi request reprint Renal denervation and treatment of hypertension
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation Centre of Research Excellence, Imperial Centre for Translational and Experimental Medicine, London, UK
    High Blood Press Cardiovasc Prev 19:5-9. 2012
  5. pmc Myosin binding protein C: implications for signal-transduction
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation Centre for Research Excellence, Myocardial Genetics, London, UK
    J Muscle Res Cell Motil 33:31-42. 2012
  6. pmc The sarcomeric Z-disc and Z-discopathies
    Ralph Knoll
    Centre for Research Excellence, British Heart Foundation, National Heart and Lung Institute, Imperial College, South Kensington Campus, Flowers Building, 4th Floor, London SW72AZ, UK
    J Biomed Biotechnol 2011:569628. 2011
  7. pmc Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation, Centre for Research Excellence, Myocardial Genetics, London, UK
    Circ Res 109:758-69. 2011
  8. doi request reprint A common MLP (muscle LIM protein) variant is associated with cardiomyopathy
    Ralph Knoll
    Heart Centre, Georg August University, Götingen, Germany
    Circ Res 106:695-704. 2010
  9. pmc Genetics of mechanosensation in the heart
    Byambajav Buyandelger
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College, South Kensington Campus, London, UK
    J Cardiovasc Transl Res 4:238-44. 2011
  10. pmc Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients
    Valeria Palumbo
    Dipartimento di Genetica Biologia e Biochimica, Universita di Torino, Via Santena 19, Torino 10126, Italy
    BMC Med Genet 10:140. 2009

Collaborators

Detail Information

Publications11

  1. pmc MLP (muscle LIM protein) as a stress sensor in the heart
    Byambajav Buyandelger
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College, South Kensington Campus, Flowers Building, 4th Floor, London, SW7 2AZ, UK
    Pflugers Arch 462:135-42. 2011
    ..The focus of this review will be on the function of MLP in cardiac mechanosensation and we shall point to possible future directions in MLP research...
  2. pmc Z-disc transcriptional coupling, sarcomeroptosis and mechanoptosis [corrected]
    Ralph Knoll
    Myocardial Genetics, British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College, Hammersmith Campus, London, UK
    Cell Biochem Biophys 66:65-71. 2013
    ....
  3. doi request reprint On mechanosensation, acto/myosin interaction, and hypertrophy
    Ralph Knoll
    Heart Science Section, National Heart and Lung Institute, Imperial College, London W12 0NN, UK
    Trends Cardiovasc Med 22:17-22. 2012
    ..In this article, we introduce contractility per se as an important mechanosensory mechanism, and we differentiate extracellular from intracellular mechanosensory effects...
  4. doi request reprint Renal denervation and treatment of hypertension
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation Centre of Research Excellence, Imperial Centre for Translational and Experimental Medicine, London, UK
    High Blood Press Cardiovasc Prev 19:5-9. 2012
    ..This will include the discussion of previous attempts to denervate the renal arteries as well as the significant improvements achieved when catheter-based interventions are applied...
  5. pmc Myosin binding protein C: implications for signal-transduction
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation Centre for Research Excellence, Myocardial Genetics, London, UK
    J Muscle Res Cell Motil 33:31-42. 2012
    ..Here we shall discuss MYBPC interacting proteins and possible pathways linked to cardiomyopathy and heart failure...
  6. pmc The sarcomeric Z-disc and Z-discopathies
    Ralph Knoll
    Centre for Research Excellence, British Heart Foundation, National Heart and Lung Institute, Imperial College, South Kensington Campus, Flowers Building, 4th Floor, London SW72AZ, UK
    J Biomed Biotechnol 2011:569628. 2011
    ..This paper provides a brief overview of these novel aspects as well as points to future research directions...
  7. pmc Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart
    Ralph Knoll
    Imperial College, National Heart and Lung Institute, British Heart Foundation, Centre for Research Excellence, Myocardial Genetics, London, UK
    Circ Res 109:758-69. 2011
    ..In addition, a variety of telethonin mutations are associated with the development of several different diseases; however, little is known about the underlying molecular mechanisms and telethonin's in vivo function...
  8. doi request reprint A common MLP (muscle LIM protein) variant is associated with cardiomyopathy
    Ralph Knoll
    Heart Centre, Georg August University, Götingen, Germany
    Circ Res 106:695-704. 2010
    ..We previously discovered the human 10T-->C (Trp4Arg) missense mutation in exon 2 of the muscle LIM protein (MLP, CSRP3) gene...
  9. pmc Genetics of mechanosensation in the heart
    Byambajav Buyandelger
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College, South Kensington Campus, London, UK
    J Cardiovasc Transl Res 4:238-44. 2011
    ..However, our current knowledge regarding the genetic basis of impaired mechanosensation in the cardiovascular system is beginning to shed light on this subject and is at the centre of this brief review...
  10. pmc Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients
    Valeria Palumbo
    Dipartimento di Genetica Biologia e Biochimica, Universita di Torino, Via Santena 19, Torino 10126, Italy
    BMC Med Genet 10:140. 2009
    ..cardiomyopathies, we screened the ITGB1BP2 gene looking for genetic variations possibly associated to the pathological phenotype in three selected groups of patients affected by hypertension and dilated or hypertrophic cardiomyopathy..
  11. doi request reprint Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC
    Ralph Knoll
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College London, Flowers Building, 4th Floor, South Kensington Campus, London SW7 2AZ, UK
    Eur J Heart Fail 13:811-9. 2011
    ..We believe that this effort is the first step towards a much auspicated unification of the terminology between the experimental and the clinical cardiologists...