Nicholas S Kirkby


Affiliation: Imperial College
Country: UK


  1. Kirkby N, Sampaio W, Etelvino G, Alves D, Anders K, Temponi R, et al. Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway. Hypertension. 2018;71:297-305 pubmed publisher
    ..These findings have direct relevance to the renal and cardiovascular side effects of drugs that inhibit COX-2, as well as the potential of the COX-2/prostacyclin/PPARβ/δ axis as a therapeutic target in renal disease. ..
  2. Kirkby N, Chan M, Zaiss A, Garcia Vaz E, Jiao J, Berglund L, et al. Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways. Proc Natl Acad Sci U S A. 2016;113:434-9 pubmed publisher
  3. Lee S, Chang W, Li Z, Kirkby N, Tsai W, Huang S, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018;38:183-191 pubmed publisher
    ..These findings indicate the therapeutic potential of AS-VI and CMG to accelerate wound healing; additionally, they suggest the mechanistic basis of this activity. ..
  4. Kirkby N, Zaiss A, Wright W, Jiao J, Chan M, Warner T, et al. Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochem Biophys Res Commun. 2013;438:249-56 pubmed publisher
    ..These observations suggest that a COX-2 selective inhibitor, given early in infection, may enhance and/or prolong endogenous interferon responses, and thereby increase anti-viral immunity. ..
  5. Kirkby N, Tesfai A, Ahmetaj Shala B, Gashaw H, Sampaio W, Etelvino G, et al. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. FASEB J. 2016;30:4172-4179 pubmed
    ..Ahmetaj-Shala, B., Gashaw, H. H., Sampaio, W., Etelvino, G., Leão, N. M., Santos, R. A., Mitchell, J. A. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. ..
  6. Ahmetaj Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan M, Gashaw H, et al. Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing. Biochem Biophys Res Commun. 2017;484:762-766 pubmed publisher
  7. Kirkby N, Zaiss A, Urquhart P, Jiao J, Austin P, Al Yamani M, et al. LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS ONE. 2013;8:e69524 pubmed publisher
    ..In doing so, we have identified the thymus, gut, brain and other tissues as target organs for consideration in developing a new understanding of how COX-2 protects the cardiovascular system. ..