Nicholas S Kirkby
Affiliation: Imperial College
Kirkby N, Sampaio W, Etelvino G, Alves D, Anders K, Temponi R, et al
. Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway. Hypertension. 2018;71:297-305 pubmed publisher
..These findings have direct relevance to the renal and cardiovascular side effects of drugs that inhibit COX-2, as well as the potential of the COX-2/prostacyclin/PPARβ/δ axis as a therapeutic target in renal disease. ..
Kirkby N, Chan M, Zaiss A, Garcia Vaz E, Jiao J, Berglund L, et al
. Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-ÎºB and NFAT transcriptional pathways. Proc Natl Acad Sci U S A. 2016;113:434-9 pubmed publisher
Lee S, Chang W, Li Z, Kirkby N, Tsai W, Huang S, et al
. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018;38:183-191 pubmed publisher
..These findings indicate the therapeutic potential of AS-VI and CMG to accelerate wound healing; additionally, they suggest the mechanistic basis of this activity. ..
Kirkby N, Zaiss A, Wright W, Jiao J, Chan M, Warner T, et al
. Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochem Biophys Res Commun. 2013;438:249-56 pubmed publisher
..These observations suggest that a COX-2 selective inhibitor, given early in infection, may enhance and/or prolong endogenous interferon responses, and thereby increase anti-viral immunity. ..
Kirkby N, Tesfai A, Ahmetaj Shala B, Gashaw H, Sampaio W, Etelvino G, et al
. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. FASEB J. 2016;30:4172-4179 pubmed
..Ahmetaj-Shala, B., Gashaw, H. H., Sampaio, W., Etelvino, G., Leão, N. M., Santos, R. A., Mitchell, J. A. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. ..
Ahmetaj Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan M, Gashaw H, et al
. Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing. Biochem Biophys Res Commun. 2017;484:762-766 pubmed publisher
Kirkby N, Zaiss A, Urquhart P, Jiao J, Austin P, Al Yamani M, et al
. LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS ONE. 2013;8:e69524 pubmed publisher
..In doing so, we have identified the thymus, gut, brain and other tissues as target organs for consideration in developing a new understanding of how COX-2 protects the cardiovascular system. ..