Affiliation: Imperial College
- VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2Serafim Kiriakidis
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, UK
J Cell Sci 116:665-74. 2003..NF-kappaB regulates many of the genes involved in immune and inflammatory responses, and our study adds the angiogenic cytokine VEGF to the list of NF-kappaB-dependent cytokines...
- Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAPEvangelos Andreakos
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
Blood 103:2229-37. 2004....
- Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapyEvangelos Andreakos
Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
Arthritis Rheum 48:1901-12. 2003....
- Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaBJennifer Grosjean
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
Biochem Biophys Res Commun 340:984-94. 2006..This study highlights that different molecular mechanisms of NFkappaB activation may be involved downstream of stimuli which activate the endothelial lining of blood vessels...
- Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophagesMagdalena Pertyńska-Marczewska
Kennedy Institute of Rheumatology, Arthritis Research Campaign Building, Faculty of Medicine, Imperial College, 1, Aspenlea Road, Hammersmith, London W6 8LH, UK
Cytokine 28:35-47. 2004....
- T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseasesClaudia Monaco
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
Curr Drug Targets Inflamm Allergy 3:35-42. 2004..This cascade of events is discussed in the context of disease initiation/progression, with particular reference to atherosclerosis and rheumatoid arthritis, and to potential novel therapeutic targets for their treatment...
- Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritisNasser M Malik
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Arthritis Research Campaign Building, London, UK
Rheumatology (Oxford) 49:1828-39. 2010....
- Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritisSofia Konisti
Department of Medicine, Charing Cross Hospital Campus, Imperial College, London W6 8LH, UK
Nat Rev Rheumatol 8:153-62. 2012..These processes emphasise the close links between hypoxia, angiogenesis and inflammation in this disease and supports the concept that angiogenesis blockade could be of therapeutic benefit in RA...
- Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritisBarbara Muz
Kennedy Institute of Rheumatology, Charing Cross Campus, Faculty of Medicine, Imperial College, Aspenlea Road, London W68LH, UK
Arthritis Res Ther 11:201. 2009....
- Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experienceNgayu Thairu
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK
Angiogenesis 14:223-34. 2011..This review focuses on our current understanding of the importance of angiogenesis in RA, and on the lessons which may be learnt from the clinical experiences of angiogenesis blockade, particularly in colorectal cancer...
- Colorectal carcinoma cells (Caco-2) secrete stroma-inducing growth factors in a stroma-oriented directionEva Wardelmann
Department of Pathology, University of Bonn, P.O. Box 2120, 53011 Bonn, Germany
Anticancer Res 23:137-41. 2003..We conclude that the directed secretion of stroma-regulating factors might play a central role in the regulation of both tumor angiogenesis and tumor invasion in carcinomas with a polarized growth pattern...
- Targeting rheumatoid tenosynovial angiogenesis with cytokine inhibitorsAbhilash Jain
Department of Musculoskeletal Surgery, Imperial College London, The Charing Cross Hospital Campus, London, UK
Clin Orthop Relat Res 446:268-77. 2006..Level of Evidence: Therapeutic study. Level II (Prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence...
- Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosisClaudia Monaco
Kennedy Institute of Rheumatology, Imperial College, Charing Cross Campus, London W6 8LH, United Kingdom
Proc Natl Acad Sci U S A 101:5634-9. 2004....
- Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assaySerafim Kiriakidis
Institute of Pathology, University of Bonn, Bonn, Germany
Br J Nutr 93:317-23. 2005..Our present findings suggest that the new isoflavones might be added to the list of low molecular mass therapeutic agents for the inhibition of angiogenesis...
- The transcription factor ETS-1: its role in tumour development and strategies for its inhibitionJens Claus Hahne
Institute of Pathology, University of Bonn, P O Box 2120, 53011 Bonn, Germany
Mini Rev Med Chem 8:1095-105. 2008..We then discuss specific strategies for Ets-1 inhibition as a potential tool for cancer treatment...
- The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritisSandra M Sacre
Kennedy Institute of Rheumatology, Imperial College London, and the Department of Orthopedics, Royal United Hospital, Bath, UK
Am J Pathol 170:518-25. 2007..Thus, TLRs not only protect against infection but may also promote the inflammatory and destructive process in RA...