Serafim Kiriakidis

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
    Serafim Kiriakidis
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, UK
    J Cell Sci 116:665-74. 2003
  2. ncbi request reprint Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
    Blood 103:2229-37. 2004
  3. ncbi request reprint Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy
    Evangelos Andreakos
    Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
    Arthritis Rheum 48:1901-12. 2003
  4. ncbi request reprint Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB
    Jennifer Grosjean
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
    Biochem Biophys Res Commun 340:984-94. 2006
  5. ncbi request reprint Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages
    Magdalena Pertyńska-Marczewska
    Kennedy Institute of Rheumatology, Arthritis Research Campaign Building, Faculty of Medicine, Imperial College, 1, Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cytokine 28:35-47. 2004
  6. ncbi request reprint T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases
    Claudia Monaco
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
    Curr Drug Targets Inflamm Allergy 3:35-42. 2004
  7. doi request reprint Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis
    Nasser M Malik
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Arthritis Research Campaign Building, London, UK
    Rheumatology (Oxford) 49:1828-39. 2010
  8. doi request reprint Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis
    Sofia Konisti
    Department of Medicine, Charing Cross Hospital Campus, Imperial College, London W6 8LH, UK
    Nat Rev Rheumatol 8:153-62. 2012
  9. doi request reprint Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer
    Tak L Khong
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
    BMC Cancer 13:518. 2013
  10. pmc Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis
    Barbara Muz
    Kennedy Institute of Rheumatology, Charing Cross Campus, Faculty of Medicine, Imperial College, Aspenlea Road, London W68LH, UK
    Arthritis Res Ther 11:201. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
    Serafim Kiriakidis
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, UK
    J Cell Sci 116:665-74. 2003
    ..NF-kappaB regulates many of the genes involved in immune and inflammatory responses, and our study adds the angiogenic cytokine VEGF to the list of NF-kappaB-dependent cytokines...
  2. ncbi request reprint Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
    Blood 103:2229-37. 2004
    ....
  3. ncbi request reprint Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy
    Evangelos Andreakos
    Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
    Arthritis Rheum 48:1901-12. 2003
    ....
  4. ncbi request reprint Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB
    Jennifer Grosjean
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
    Biochem Biophys Res Commun 340:984-94. 2006
    ..This study highlights that different molecular mechanisms of NFkappaB activation may be involved downstream of stimuli which activate the endothelial lining of blood vessels...
  5. ncbi request reprint Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages
    Magdalena Pertyńska-Marczewska
    Kennedy Institute of Rheumatology, Arthritis Research Campaign Building, Faculty of Medicine, Imperial College, 1, Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cytokine 28:35-47. 2004
    ....
  6. ncbi request reprint T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases
    Claudia Monaco
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
    Curr Drug Targets Inflamm Allergy 3:35-42. 2004
    ..This cascade of events is discussed in the context of disease initiation/progression, with particular reference to atherosclerosis and rheumatoid arthritis, and to potential novel therapeutic targets for their treatment...
  7. doi request reprint Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis
    Nasser M Malik
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Arthritis Research Campaign Building, London, UK
    Rheumatology (Oxford) 49:1828-39. 2010
    ....
  8. doi request reprint Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis
    Sofia Konisti
    Department of Medicine, Charing Cross Hospital Campus, Imperial College, London W6 8LH, UK
    Nat Rev Rheumatol 8:153-62. 2012
    ..These processes emphasise the close links between hypoxia, angiogenesis and inflammation in this disease and supports the concept that angiogenesis blockade could be of therapeutic benefit in RA...
  9. doi request reprint Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer
    Tak L Khong
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
    BMC Cancer 13:518. 2013
    ..Although EGF has been demonstrated to induce expression of angiogenic mediators, potential interactions in CRC between EGF-mediated signalling and the hypoxia/HIF pathway remain uncharacterised...
  10. pmc Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis
    Barbara Muz
    Kennedy Institute of Rheumatology, Charing Cross Campus, Faculty of Medicine, Imperial College, Aspenlea Road, London W68LH, UK
    Arthritis Res Ther 11:201. 2009
    ....
  11. doi request reprint Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience
    Ngayu Thairu
    Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK
    Angiogenesis 14:223-34. 2011
    ..This review focuses on our current understanding of the importance of angiogenesis in RA, and on the lessons which may be learnt from the clinical experiences of angiogenesis blockade, particularly in colorectal cancer...
  12. ncbi request reprint Targeting rheumatoid tenosynovial angiogenesis with cytokine inhibitors
    Abhilash Jain
    Department of Musculoskeletal Surgery, Imperial College London, The Charing Cross Hospital Campus, London, UK
    Clin Orthop Relat Res 446:268-77. 2006
    ..Level of Evidence: Therapeutic study. Level II (Prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence...
  13. ncbi request reprint Colorectal carcinoma cells (Caco-2) secrete stroma-inducing growth factors in a stroma-oriented direction
    Eva Wardelmann
    Department of Pathology, University of Bonn, P O Box 2120, 53011 Bonn, Germany
    Anticancer Res 23:137-41. 2003
    ..We conclude that the directed secretion of stroma-regulating factors might play a central role in the regulation of both tumor angiogenesis and tumor invasion in carcinomas with a polarized growth pattern...
  14. pmc Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis
    Claudia Monaco
    Kennedy Institute of Rheumatology, Imperial College, Charing Cross Campus, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 101:5634-9. 2004
    ....
  15. ncbi request reprint The transcription factor ETS-1: its role in tumour development and strategies for its inhibition
    Jens Claus Hahne
    Institute of Pathology, University of Bonn, P O Box 2120, 53011 Bonn, Germany
    Mini Rev Med Chem 8:1095-105. 2008
    ..We then discuss specific strategies for Ets-1 inhibition as a potential tool for cancer treatment...
  16. ncbi request reprint Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay
    Serafim Kiriakidis
    Institute of Pathology, University of Bonn, Bonn, Germany
    Br J Nutr 93:317-23. 2005
    ..Our present findings suggest that the new isoflavones might be added to the list of low molecular mass therapeutic agents for the inhibition of angiogenesis...
  17. pmc The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology, Imperial College London, and the Department of Orthopedics, Royal United Hospital, Bath, UK
    Am J Pathol 170:518-25. 2007
    ..Thus, TLRs not only protect against infection but may also promote the inflammatory and destructive process in RA...