J R Kerr

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Med Virol 74:147-55. 2004
  2. ncbi Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B
    Jonathan R Kerr
    Department of Paediatric Infectious Diseases, St Mary s Campus, Imperial College, London, United Kingdom
    J Infect Dis 192:276-86. 2005
  3. ncbi Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection
    J R Kerr
    Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London SW3 6NP, UK
    J Clin Pathol 56:725-7. 2003
  4. ncbi Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, Imperial College London, Sydney St, London SW3 6NP, United Kingdom
    Clin Infect Dis 36:e100-6. 2003
  5. ncbi Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, UK
    Curr Pain Headache Rep 7:333-41. 2003
  6. ncbi Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK
    J Gen Virol 82:3011-9. 2001
  7. ncbi Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 61:730-9. 2008
  8. ncbi Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, Imperial College London, Sydney Street, London SW3 6NP, UK
    J Clin Pathol 56:873-5. 2003
  9. ncbi Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 60:113-6. 2007
  10. ncbi Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae
    J R Kerr
    Department of Microbiology, Royal Brompton and Harefield NHS Trust, Imperial College School of Medicine, London, UK
    J Neurol Neurosurg Psychiatry 73:739-46. 2002

Collaborators

Detail Information

Publications19

  1. ncbi Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Med Virol 74:147-55. 2004
    ..The profile of circulating mediators may provide insights into the possible pathogenesis of particular clinical manifestations of this infection...
  2. ncbi Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B
    Jonathan R Kerr
    Department of Paediatric Infectious Diseases, St Mary s Campus, Imperial College, London, United Kingdom
    J Infect Dis 192:276-86. 2005
    ..Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections...
  3. ncbi Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection
    J R Kerr
    Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London SW3 6NP, UK
    J Clin Pathol 56:725-7. 2003
    ..Cytokines feature in the pathogenesis of parvovirus B19 infection, so inherited variability in cytokine responses to B19 infection might have a bearing on the symptomatology of parvovirus B19 infection...
  4. ncbi Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, Imperial College London, Sydney St, London SW3 6NP, United Kingdom
    Clin Infect Dis 36:e100-6. 2003
    ..IVIG therapy led to clearance of parvovirus B19 viremia, resolution of symptoms, and improvement in physical and functional ability in all patients, as well as resolution of cytokine dysregulation...
  5. ncbi Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, UK
    Curr Pain Headache Rep 7:333-41. 2003
    ....
  6. ncbi Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK
    J Gen Virol 82:3011-9. 2001
    ..0275). Prolonged upregulation of serum IFN-gamma and TNF-alpha appears to represent a consistent host response to symptomatic B19 virus infection...
  7. ncbi Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 61:730-9. 2008
    ..Clustering of quantitative PCR (qPCR) data from patients with CFS/ME revealed seven distinct subtypes with distinct differences in Medical Outcomes Survey Short Form-36 scores, clinical phenotypes and severity...
  8. ncbi Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, Imperial College London, Sydney Street, London SW3 6NP, UK
    J Clin Pathol 56:873-5. 2003
    ..To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia...
  9. ncbi Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments
    J R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London, UK
    J Clin Pathol 60:113-6. 2007
    ..Finally, clinical trials are being planned; novel treatments that we believe are important to trial in patients with CFS are interferon-beta and one of the anti-tumour necrosis factor-alpha drugs...
  10. ncbi Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae
    J R Kerr
    Department of Microbiology, Royal Brompton and Harefield NHS Trust, Imperial College School of Medicine, London, UK
    J Neurol Neurosurg Psychiatry 73:739-46. 2002
    ..To review the clinical and pathological features of parvovirus B19 meningoencephalitis and its sequelae in 12 previously published cases, and to perform additional tests to determine the pathogenesis of the disease...
  11. ncbi Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome
    N Kaushik
    Department of Paediatric Infectious Diseases, St Marys Campus, Imperial College, Norfolk Place, London W2 1PG, UK
    J Clin Pathol 58:826-32. 2005
    ..CONCLUSION: These results suggest that patients with CFS have reproducible alterations in gene regulation...
  12. ncbi Chronic fatigue syndrome and arthralgia following parvovirus B19 infection
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    J Rheumatol 29:595-602. 2002
    ..To determine the incidence of arthralgia and fatigue complicating B19 infection, along with associated B19 markers and autoantibodies...
  13. ncbi A case of persistent parvovirus B19 infection with bilateral cartilaginous and ligamentous damage to the wrists
    Susan M Lowry
    Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE 19713, USA
    Clin Infect Dis 41:e42-4. 2005
    ..Nineteen months after presentation, intravenous immunoglobulin therapy resulted in clearance of parvovirus B19 viremia and a significant improvement in the symptoms of fatigue and arthritis...
  14. ncbi Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Gen Virol 87:3567-75. 2006
    ..All of these aspects suggest a particular advantage to the viruses of the presence of these sequences...
  15. ncbi Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, United Kingdom
    Clin Infect Dis 46:e83-7. 2008
    ..Psychological stress is thought to be an important factor in the pathogenesis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Therefore, we sought to examine this relationship in the context of parvovirus B19 infection...
  16. ncbi Enterovirus infection of the stomach in chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    J Clin Pathol 61:1-2. 2008
  17. ncbi Neurological manifestations of human parvovirus B19 infection
    Faraj Barah
    Laboratory Medicine Academic Group, University of Manchester, Clinical Sciences Building 3rd Floor, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Rev Med Virol 13:185-99. 2003
    ..The outcome of the review supports an aetiological role of the virus in neurological disease. However, the pathogenesis remains unknown and elucidating this is a priority...
  18. ncbi Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, SW3 6NP London, United Kingdom
    J Infect Dis 186:447-52. 2002
    ..HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07...
  19. ncbi Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, London
    J Infect Dis 197:1171-84. 2008
    ..Clustering of quantitative polymerase chain reaction data from patients with CFS/ME revealed 7 subtypes with distinct differences in Medical Outcomes Survey Short Form-36 scores, clinical phenotypes, and severity...