Lawrence A Kelley

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Discovering rules for protein-ligand specificity using support vector inductive logic programming
    Lawrence A Kelley
    Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, London, UK
    Protein Eng Des Sel 22:561-7. 2009
  2. doi request reprint Protein structure prediction on the Web: a case study using the Phyre server
    Lawrence A Kelley
    Structural Bioinformatics Group, Division of Molecular Biosciences, Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK
    Nat Protoc 4:363-71. 2009
  3. pmc 3DLigandSite: predicting ligand-binding sites using similar structures
    Mark N Wass
    Structural Bioinformatics Group, Centre for Bioinformatics, Imperial College London, London, SW7 2AZ, UK
    Nucleic Acids Res 38:W469-73. 2010
  4. doi request reprint Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe
    Daniel Chubb
    Department of Life Science, Imperial College London, London, UK
    Bioinformatics 26:2664-71. 2010
  5. ncbi request reprint Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre
    Riccardo M Bennett-Lovsey
    Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, London SW7 2AY, United Kingdom
    Proteins 70:611-25. 2008
  6. pmc Protein folding requires crowd control in a simulated cell
    Benjamin R Jefferys
    Division of Molecular Biosciences, Biochemistry Building, Imperial College London, South Kensington, London SW7 2AZ, UK
    J Mol Biol 397:1329-38. 2010
  7. ncbi request reprint Capturing expert knowledge with argumentation: a case study in bioinformatics
    Benjamin R Jefferys
    Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK
    Bioinformatics 22:924-33. 2006
  8. pmc Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains
    Tony E Lewis
    Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK
    Nucleic Acids Res 41:D499-507. 2013
  9. pmc The proteome: structure, function and evolution
    Keiran Fleming
    Structural Bioinformatics Group, Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Philos Trans R Soc Lond B Biol Sci 361:441-51. 2006
  10. doi request reprint A new structural model of the acid-labile subunit: pathogenetic mechanisms of short stature-causing mutations
    Alessia David
    Centre for Integrative Systems Biology and Bioinformatics, Division of Molecular Biosciences, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    J Mol Endocrinol 49:213-20. 2012

Collaborators

Detail Information

Publications11

  1. doi request reprint Discovering rules for protein-ligand specificity using support vector inductive logic programming
    Lawrence A Kelley
    Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, London, UK
    Protein Eng Des Sel 22:561-7. 2009
    ..The representation is sufficiently general to be applicable to any discriminatory binding problem. All programs and data sets are freely available to non-commercial users at http://www.sbg.bio.ic.ac.uk/svilp_ligand/...
  2. doi request reprint Protein structure prediction on the Web: a case study using the Phyre server
    Lawrence A Kelley
    Structural Bioinformatics Group, Division of Molecular Biosciences, Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK
    Nat Protoc 4:363-71. 2009
    ..Phyre is widely used by the biological community, with >150 submissions per day, and provides a simple interface to results. Phyre takes 30 min to predict the structure of a 250-residue protein...
  3. pmc 3DLigandSite: predicting ligand-binding sites using similar structures
    Mark N Wass
    Structural Bioinformatics Group, Centre for Bioinformatics, Imperial College London, London, SW7 2AZ, UK
    Nucleic Acids Res 38:W469-73. 2010
    ..68. The web server enables users to submit either a query sequence or structure. Predictions are visually displayed via an interactive Jmol applet. 3DLigandSite is available for use at http://www.sbg.bio.ic.ac.uk/3dligandsite...
  4. doi request reprint Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe
    Daniel Chubb
    Department of Life Science, Imperial College London, London, UK
    Bioinformatics 26:2664-71. 2010
    ..We interpret this trend as signalling our approach to a representative map of the protein universe and discuss its implications...
  5. ncbi request reprint Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre
    Riccardo M Bennett-Lovsey
    Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, London SW7 2AY, United Kingdom
    Proteins 70:611-25. 2008
    ..The results indicate greater coverage of sequence space and improved model quality, which can consequently lead to a reduction in the experimental workload of structural genomics initiatives...
  6. pmc Protein folding requires crowd control in a simulated cell
    Benjamin R Jefferys
    Division of Molecular Biosciences, Biochemistry Building, Imperial College London, South Kensington, London SW7 2AZ, UK
    J Mol Biol 397:1329-38. 2010
    ..Here, we discuss the possible implications regarding the relationship between protein expression level, protein size, chaperone activity and aggregation...
  7. ncbi request reprint Capturing expert knowledge with argumentation: a case study in bioinformatics
    Benjamin R Jefferys
    Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK
    Bioinformatics 22:924-33. 2006
    ..Often the process is laborious, goes unrecorded and may be biased. Argumentation is an established technique for reasoning about situations where absolute truth or precise probability is impossible to determine...
  8. pmc Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains
    Tony E Lewis
    Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK
    Nucleic Acids Res 41:D499-507. 2013
    ..This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs)...
  9. pmc The proteome: structure, function and evolution
    Keiran Fleming
    Structural Bioinformatics Group, Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Philos Trans R Soc Lond B Biol Sci 361:441-51. 2006
    ..The method is also able to identify the specific residues associated with the function of the protein family...
  10. doi request reprint A new structural model of the acid-labile subunit: pathogenetic mechanisms of short stature-causing mutations
    Alessia David
    Centre for Integrative Systems Biology and Bioinformatics, Division of Molecular Biosciences, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    J Mol Endocrinol 49:213-20. 2012
    ..The new model allowed us to analyse the ALS core and its caps and to interpret the potential structural effects of ALS mutations...
  11. pmc The extent and importance of intragenic recombination
    Eric de Silva
    Department of Biological Sciences, Imperial College London, Wolfson Building, South Kensington Campus, London SW7 2AZ, UK
    Hum Genomics 1:410-20. 2004
    ..This suggests that evolutionary analysis of the recombination process is greatly aided by considering nucleotide sequences and protein products jointly...