A Barry Kay

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi Calcitonin gene-related peptide- and vascular endothelial growth factor-positive inflammatory cells in late-phase allergic skin reactions in atopic subjects
    A Barry Kay
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 127:232-7. 2011
  2. ncbi Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, SW3 6LY UK
    Immunol Allergy Clin North Am 24:645-66, vii. 2004
  3. ncbi Allergen immunotherapy with cat allergen peptides
    A Barry Kay
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK
    Springer Semin Immunopathol 25:391-9. 2004
  4. ncbi A role for eosinophils in airway remodelling in asthma
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, UK
    Trends Immunol 25:477-82. 2004
  5. ncbi The role of eosinophils in the pathogenesis of asthma
    A Barry Kay
    National Heart and Lung Institute, Imperial College London, and Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial College, South Kensington, London, SW7 2AZ, UK
    Trends Mol Med 11:148-52. 2005
  6. ncbi Immunomodulation in asthma: mechanisms and possible pitfalls
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Pharmacol 3:220-6. 2003
  7. ncbi The role of T lymphocytes in asthma
    A Barry Kay
    National Heart and Lung Institute, and Leukocyte Biology Section, Imperial College, London, UK
    Chem Immunol Allergy 91:59-75. 2006
  8. ncbi 100 years of 'Allergy': can von Pirquet's word be rescued?
    A B Kay
    Leukocyte Biology Section, NHLI Division, Imperial College, South Kensington Campus, London, UK
    Clin Exp Allergy 36:555-9. 2006
  9. ncbi Professor Robin Coombs FRS (1921-2006)
    A B Kay
    Emeritus Professor of Allergy and Clinical Immunology, Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ UK E mail
    Vox Sang 91:93-4. 2006
  10. doi An extract of Timothy-grass pollen used as sublingual immunotherapy for summer hay fever
    A B Kay
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 43:841-8. 2007

Collaborators

Detail Information

Publications48

  1. doi Calcitonin gene-related peptide- and vascular endothelial growth factor-positive inflammatory cells in late-phase allergic skin reactions in atopic subjects
    A Barry Kay
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 127:232-7. 2011
    ....
  2. ncbi Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, SW3 6LY UK
    Immunol Allergy Clin North Am 24:645-66, vii. 2004
    ..This article discusses the rationale for the use of anti-IL-5 therapy in asthma and hypereosinophilic syndrome and summarizes the available clinical data on the use of anti-IL-5 to treat these disorders...
  3. ncbi Allergen immunotherapy with cat allergen peptides
    A Barry Kay
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK
    Springer Semin Immunopathol 25:391-9. 2004
    ..This review discusses recent advances in our understanding of the mechanisms and potential efficacy of this form of therapy...
  4. ncbi A role for eosinophils in airway remodelling in asthma
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, UK
    Trends Immunol 25:477-82. 2004
    ..However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established...
  5. ncbi The role of eosinophils in the pathogenesis of asthma
    A Barry Kay
    National Heart and Lung Institute, Imperial College London, and Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial College, South Kensington, London, SW7 2AZ, UK
    Trends Mol Med 11:148-52. 2005
    ..The results, although largely confirmatory of previous studies both in mice and humans, put the eosinophil firmly back on the asthma stage and strengthen the case for developing effective eosinophil-depleting agents for clinical use...
  6. ncbi Immunomodulation in asthma: mechanisms and possible pitfalls
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Pharmacol 3:220-6. 2003
    ..Failure to stimulate regulatory responses could explain the rising trends in allergy and autoimmunity, and also partly explain the mode of action of allergen-injection immunotherapy and new immunomodulatory approaches...
  7. ncbi The role of T lymphocytes in asthma
    A Barry Kay
    National Heart and Lung Institute, and Leukocyte Biology Section, Imperial College, London, UK
    Chem Immunol Allergy 91:59-75. 2006
    ....
  8. ncbi 100 years of 'Allergy': can von Pirquet's word be rescued?
    A B Kay
    Leukocyte Biology Section, NHLI Division, Imperial College, South Kensington Campus, London, UK
    Clin Exp Allergy 36:555-9. 2006
    ..Although the word is no longer used in the way he intended, his concept of 'changed reactivity' laid the foundation for the modern science of immunology...
  9. ncbi Professor Robin Coombs FRS (1921-2006)
    A B Kay
    Emeritus Professor of Allergy and Clinical Immunology, Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ UK E mail
    Vox Sang 91:93-4. 2006
  10. doi An extract of Timothy-grass pollen used as sublingual immunotherapy for summer hay fever
    A B Kay
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 43:841-8. 2007
    ..There have been no instances of anaphylaxis. In randomized double-blind placebo controlled trials Grazax reduces symptoms and medication scores in adults with hay fever. The long-term effects of Grazax are currently being investigated...
  11. pmc Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    Patrick Flood-Page
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Clin Invest 112:1029-36. 2003
    ..Therefore eosinophils may contribute to tissue remodeling processes in asthma by regulating the deposition of ECM proteins...
  12. doi Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 124:454-62. 2009
    ..Both transforming growth factor (TGF)-beta(1) and activin-A have been implicated in airway remodeling in asthma, but the modulation of their specific signaling pathways after disease activation remains undefined...
  13. ncbi Anti-IgE (omalizumab) inhibits late-phase reactions and inflammatory cells after repeat skin allergen challenge
    Yee Ean Ong
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, South Kensington, London, UK
    J Allergy Clin Immunol 116:558-64. 2005
    ..The effect of chronic allergen exposure on these outcomes is unknown. Repeat allergen challenge in human skin represents a suitable model to address this question...
  14. pmc T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
    Adrienne Verhoef
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    PLoS Med 2:e78. 2005
    ..Treatment of allergic diseases with peptides may offer substantial advantages over treatment with native allergen molecules because of the reduced potential for cross-linking IgE bound to the surface of mast cells and basophils...
  15. doi Basal expression of bone morphogenetic protein receptor is reduced in mild asthma
    Harsha H Kariyawasam
    Emeritus Professor of Allergy and Clinical Immunology, Sir Alexander Fleming Building, Leukocyte Biology Section, Imperial College, South Kensington Campus, London, SW7 2AZ UK
    Am J Respir Crit Care Med 177:1074-81. 2008
    ..Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway...
  16. pmc Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF)
    Sophie Pegorier
    Leukocyte Biology Section, Faculty of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:85. 2010
    ..However, the role of BMPs in lung remodelling remains unclear. BMPs may regulate tissue remodelling in asthma by controlling TGF-beta-induced profibrotic functions in lung fibroblasts...
  17. doi Expression of functional receptor activity modifying protein 1 by airway epithelial cells with dysregulation in asthma
    Kandace Bonner
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom
    J Allergy Clin Immunol 126:1277-83.e3. 2010
    ..Epithelial cell expression of calcitonin gene-related peptide (CGRP) is a feature of provoked asthma. Receptor activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor combine to form the CGRP1 receptor...
  18. ncbi Acute allergen-induced airway remodeling in atopic asthma
    Simon Phipps
    Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Cell Mol Biol 31:626-32. 2004
    ..Airway remodeling in asthma may, in part, result from repeated acute activation of the EMTU by allergen exposure...
  19. ncbi The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin
    Simon Phipps
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, UK, SW3 6LY
    J Immunol 169:4604-12. 2002
    ..TGF-beta1 and IL-13 also induced tenascin expression. We conclude that TGF-beta1 and IL-13, provided partially by eosinophils, contribute to repair and remodeling events in allergic inflammation in human atopic skin...
  20. pmc Airway hyperresponsiveness and bronchial mucosal inflammation in T cell peptide-induced asthmatic reactions in atopic subjects
    F Runa Ali
    Department of Allergy and Clinical Immunology, Imperial College, London, UK
    Thorax 62:750-57. 2007
    ..Animal experiments have shown that airway hyperresponsiveness (AHR) is CD4+ cell-dependent. It is hypothesised that peptide inhalation produces increases in non-specific AHR and a T cell-dominant bronchial mucosal inflammatory response...
  21. ncbi The role of T lymphocytes in the pathogenesis of asthma
    Mark Larché
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Allergy Clin Immunol 111:450-63; quiz 464. 2003
    ....
  22. ncbi Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London
    J Allergy Clin Immunol 111:714-9. 2003
    ..We have previously reported that anti-IL-5 monoclonal antibody treatment decreases total bone marrow and bronchial mucosal eosinophil numbers in asthma...
  23. ncbi Peptide-based vaccines in the treatment of specific allergy
    Clare Alexander
    Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Curr Drug Targets Inflamm Allergy 1:353-61. 2002
    ..Whether this strategy can be used for allergy to complex allergen mixtures such as dust mites will need further evaluation...
  24. ncbi Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides
    F Runa Ali
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK
    Am J Respir Crit Care Med 169:20-6. 2004
    ..Thus, isolated LAR induced by inhaled, allergen-derived peptides represent a novel model of provoked asthma and are not associated with the induction of hyporesponsiveness ("tolerance") in the skin or lung...
  25. ncbi Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology, Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial College London, London, UK
    Am J Respir Crit Care Med 175:896-904. 2007
    ..Cellular inflammation and airway remodeling are increased 24 hours after allergen challenge...
  26. doi CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4
    Kandace Bonner
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 132:942-50.e1-3. 2013
    ..Increased airway epithelial cell expression of CGRP, together with increased CCL17 expression, was previously observed in a model of provoked asthma in atopic human subjects...
  27. ncbi TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction
    Sun Ying
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
    J Allergy Clin Immunol 109:694-700. 2002
    ....
  28. ncbi The potential of peptide immunotherapy in allergy and asthma
    F Runa Ali
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Curr Allergy Asthma Rep 2:151-8. 2002
    ..This review evaluates the scientific basis of peptide immunotherapy and clinical experience in allergy up to the present time...
  29. ncbi Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 169:2712-8. 2002
    ..Thus, intradermal injection of eotaxin and eotaxin-2 in humans induced infiltration of eosinophils and other inflammatory cells as well as changes consistent with CC chemokine-induced mast cell degranulation...
  30. ncbi Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    Patrick T Flood-Page
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 167:199-204. 2003
    ..Anti-IL-5 treatment reduces but does not deplete airway or bone marrow eosinophils. The role of the eosinophil remains uncertain. Further clinical studies in asthma with more effective antieosinophil strategies are required...
  31. doi Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses
    Chris J Corrigan
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    J Allergy Clin Immunol 128:116-24. 2011
    ..IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses...
  32. ncbi Eosinophils
    Douglas S Robinson
    Imperial College School of Medicine, National Heart and Lung Institute, London, England
    Clin Allergy Immunol 16:43-75. 2002
  33. ncbi Proliferation and release of IL-5 and IFN-gamma by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non-cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1
    B M Haselden
    Department of Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    J Allergy Clin Immunol 108:349-56. 2001
    ....
  34. ncbi Cat allergen peptide immunotherapy reduces CD4(+) T cell responses to cat allergen but does not alter suppression by CD4(+) CD25(+) T cells: a double-blind placebo-controlled study
    T R F Smith
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute and Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, UK
    Allergy 59:1097-101. 2004
    ..It has been suggested that allergen immunotherapy induces regulatory T cell activity: we hypothesized that allergen peptide immunotherapy might increase suppressive activity of CD4(+) CD25(+) T cells...
  35. ncbi Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial
    W L G Oldfield
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London SW3 6LY, UK
    Lancet 360:47-53. 2002
    ..We aimed to ascertain the effect of multiple injections on the magnitude of the early and late phase skin reactions to intact allergens...
  36. ncbi The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects
    C Alexander
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
    Allergy 60:1269-74. 2005
    ..The present pilot study was designed to determine whether this treatment affected clinically relevant outcome measurements such as the allergen-induced nasal and bronchial reactions, and asthma/rhinitis quality of life (QOL)...
  37. ncbi Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin
    Simon Phipps
    Department of Allergy and Clinical Immunology, Imperial College London, NHLI Division, London, UK
    J Invest Dermatol 122:1406-12. 2004
    ....
  38. ncbi Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma
    S Ying
    Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse St, London SW3 6LY, UK
    J Allergy Clin Immunol 107:686-92. 2001
    ..These changes appear to relate to asthma rather than atopy per se and, at least in part, may be under the regulation of IL-4...
  39. ncbi Mechanisms of T cell peptide epitope-dependent late asthmatic reactions
    M Larche
    Allergy and Clinical Immunology, Imperial College School of Medicine, London, UK
    Int Arch Allergy Immunol 124:272-5. 2001
    ..The precise mechanisms whereby MHC-restricted activation of allergen-specific T cells gives rise to bronchoconstriction are currently under investigation...
  40. ncbi Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects
    W L Oldfield
    Department of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, United Kingdom
    J Immunol 167:1734-9. 2001
    ..Thus, allergen-derived peptides induce tolerance to subsequent peptide injection in the target organ (the lung), reduce late-phase cutaneous responsiveness to whole allergen, and alter in vitro T cell reactivity...
  41. ncbi Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or T(H)2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar
    B M Haselden
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Allergy Clin Immunol 108:394-401. 2001
    ..043). CONCLUSION: Part of the asthma process might involve T cell-dependent airway narrowing with no requirement for IgE, mast cells, or infiltrating inflammatory cells...
  42. pmc Adhesion to fibronectin prolongs eosinophil survival
    A R Anwar
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, United Kingdom
    J Exp Med 177:839-43. 1993
    ....
  43. ncbi Peptide therapy and asthma
    Mark Larché
    Am J Respir Crit Care Med 169:1331; author reply 1331-2. 2004
  44. ncbi Natural killer T cells and asthma
    A Barry Kay
    N Engl J Med 354:1186-8. 2006
  45. ncbi Eosinophils and interleukin-5: the debate continues
    A Barry Kay
    Am J Respir Crit Care Med 167:1586-7. 2003
  46. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  47. doi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  48. pmc Safety and tolerability of three consecutive bronchoscopies after allergen challenge in volunteers with mild asthma
    H H Kariyawasam
    Thorax 62:557-8. 2007