P Karayiannis

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Hepatitis B virus: old, new and future approaches to antiviral treatment
    Peter Karayiannis
    Department of Medicine A, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, South Wharf Road, London W2 1NY, UK
    J Antimicrob Chemother 51:761-85. 2003
  2. ncbi request reprint Current status of hepatitis G virus (GBV-C) in transfusion: is it relevant?
    P Karayiannis
    Department of Medicine, Imperial College School of Medicine at St Mary s, London, UK
    Vox Sang 73:63-9. 1997
  3. ncbi request reprint Natural history and molecular biology of hepatitis G virus/GB virus C
    P Karayiannis
    Department of Medicine A, Imperial College School of Medicine at St Mary s, London, UK
    Clin Diagn Virol 10:103-11. 1998
  4. ncbi request reprint The hepatitis C virus NS3/4A protease complex interferes with pathways of the innate immune response
    P Karayiannis
    Department of Medicine A, Imperial College, St Mary s Hospital Campus, South Wharf Road, London W2 1NY, UK
    J Hepatol 43:743-5. 2005
  5. ncbi request reprint A recombinant vaccinia virus expressing hepatitis A virus structural polypeptides: characterization and demonstration of protective immunogenicity
    P Karayiannis
    Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, U K
    J Gen Virol 72:2167-72. 1991
  6. pmc Recombinant vaccinia viruses expressing hepatitis A virus structural polypeptides: detection of an anti-VP0 response in convalescent-phase sera
    P Karayiannis
    Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Clin Diagn Lab Immunol 2:708-11. 1995
  7. ncbi request reprint Purification of woodchuck hepatitis surface antigen using a monoclonal antibody raised against the antigen
    J A Waters
    Department of Medicine, Imperial College School of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Virol Methods 93:97-103. 2001
  8. ncbi request reprint In situ hybridization studies in hepatitis A infection
    G M Taylor
    Department of Histopathology, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London University, United Kingdom
    Hepatology 16:642-8. 1992
  9. ncbi request reprint Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient
    S Seddigh-Tonekaboni
    Department of Medicine A, Imperial College School of Medicine at St. Mary's, South Wharf Road, London W2 1NY, UK
    J Viral Hepat 8:154-8. 2001
  10. ncbi request reprint Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001

Collaborators

  • J A Waters
  • E C Holmes
  • G M Taylor
  • M Thursz
  • Howard Thomas
  • Juan Cristina
  • Irina Sominskaya
  • Paul Pumpens
  • Uga Dumpis
  • Daniel M Forton
  • M Roggendorf
  • A Alexopoulou
  • Rosa Zampino
  • Saffie Jammeh
  • Giuseppe Ruggiero
  • Michael Joseph McGarvey
  • Alejandro Schijman
  • Aldo Marrone
  • Grazia Cirillo
  • Riccardo Utili
  • Umesh Gaud
  • Emanuele Durante Mangoni
  • Jinlin Hou
  • S Seddigh-Tonekaboni
  • Theodoros Nastos
  • Mohammed Iqbal
  • Roger Watson
  • Fiona Tavner
  • Loredana Costagliola
  • Enrico Ragone
  • Rodney Colina
  • Olga Kalinina
  • Shobha Broor
  • Baldip Khan
  • Laura Garcia
  • Cristina Mogdasy
  • Sergey Mukomolov
  • Ajoy Varma Bhupatiraju
  • Theoni Petropoulou
  • Barbara Langer
  • Giovanni Rania
  • Jinjun Chen
  • Salvatore Lobello
  • Jiaji Jiang
  • Emanuele Miraglia del Giudice
  • Jia Min
  • Zhanhui Wang
  • Huiyu Liao
  • Carla Venturi-Pasini
  • Maria Chiaramonte
  • Kangxian Luo
  • Yulong Lin
  • J L Hou
  • K X Luo
  • W L Lim
  • B Young

Detail Information

Publications29

  1. ncbi request reprint Hepatitis B virus: old, new and future approaches to antiviral treatment
    Peter Karayiannis
    Department of Medicine A, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, South Wharf Road, London W2 1NY, UK
    J Antimicrob Chemother 51:761-85. 2003
    ..It seems certain that combination therapies involving two or more nucleoside analogues, immunomodulators or gene therapies will be the future treatment regimens for chronic HBV infection...
  2. ncbi request reprint Current status of hepatitis G virus (GBV-C) in transfusion: is it relevant?
    P Karayiannis
    Department of Medicine, Imperial College School of Medicine at St Mary s, London, UK
    Vox Sang 73:63-9. 1997
    ..The majority of long term carriers of the virus appear to have no liver, biochemical or histological abnormalities...
  3. ncbi request reprint Natural history and molecular biology of hepatitis G virus/GB virus C
    P Karayiannis
    Department of Medicine A, Imperial College School of Medicine at St Mary s, London, UK
    Clin Diagn Virol 10:103-11. 1998
    ..Although the virus has been found in patients with acute and chronic hepatitis, evidence of disease association has not been forthcoming. The majority of patients carry the virus in the absence of liver enzyme abnormalities...
  4. ncbi request reprint The hepatitis C virus NS3/4A protease complex interferes with pathways of the innate immune response
    P Karayiannis
    Department of Medicine A, Imperial College, St Mary s Hospital Campus, South Wharf Road, London W2 1NY, UK
    J Hepatol 43:743-5. 2005
  5. ncbi request reprint A recombinant vaccinia virus expressing hepatitis A virus structural polypeptides: characterization and demonstration of protective immunogenicity
    P Karayiannis
    Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, U K
    J Gen Virol 72:2167-72. 1991
    ..Recombinant viruses expressing the above region of HAV or the proteins expressed by such viruses may be useful in the development of a vaccine suitable for use in man...
  6. pmc Recombinant vaccinia viruses expressing hepatitis A virus structural polypeptides: detection of an anti-VP0 response in convalescent-phase sera
    P Karayiannis
    Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Clin Diagn Lab Immunol 2:708-11. 1995
    ..The significance of this finding and the usefulness of these constructs in studying cell-mediated immunity during recovery from HAV infection are discussed...
  7. ncbi request reprint Purification of woodchuck hepatitis surface antigen using a monoclonal antibody raised against the antigen
    J A Waters
    Department of Medicine, Imperial College School of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Virol Methods 93:97-103. 2001
    ..Both the antibody and the antigen are valuable reagents for the study of WHV infection...
  8. ncbi request reprint In situ hybridization studies in hepatitis A infection
    G M Taylor
    Department of Histopathology, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London University, United Kingdom
    Hepatology 16:642-8. 1992
    ..The hepatocyte appeared to be the only cell type showing staining. No hybridization was found in other organs, including the intestine (n = 4) and, in one animal, the kidney and spleen...
  9. ncbi request reprint Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient
    S Seddigh-Tonekaboni
    Department of Medicine A, Imperial College School of Medicine at St. Mary's, South Wharf Road, London W2 1NY, UK
    J Viral Hepat 8:154-8. 2001
    ..The present results indicate that HBsAg variants may exist in individuals other than vaccinated children...
  10. ncbi request reprint Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001
    ..CONCLUSIONS: Phylogenetic tree analysis of sequences obtained from family members provided strong evidence of intrafamilial transmission of HBV in at least two-thirds of the families studied from Gambia...
  11. ncbi request reprint Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
    J Med Virol 65:664-70. 2001
    ..Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes...
  12. ncbi request reprint Core promoter mutations 3 years after anti-hepatitis B e seroconversion in patients with chronic hepatitis B or hepatitis B and C infection and cancer remission
    Rosa Zampino
    Department of Pediatrics, Second University of Naples, Italy
    Am J Gastroenterol 97:2426-31. 2002
    ....
  13. ncbi request reprint An outbreak of HBV and HCV infection in a paediatric oncology ward: epidemiological investigations and prevention of further spread
    Uga Dumpis
    Biomedical Research and Study Centre, University of Latvia, Riga, Latvia
    J Med Virol 69:331-8. 2003
    ..The introduction and maintenance of strict prevention measures over a 2 year period, combined with HBV vaccination, reduced significantly the incidence of new HCV and HBV infections...
  14. ncbi request reprint Is lamivudine a safe and effective therapy for patients with chronic hepatitis B and advanced liver disease?
    Peter Karayiannis
    Department of Medicine A, Imperial College, London, UK
    Nat Clin Pract Gastroenterol Hepatol 2:138-9. 2005
  15. ncbi request reprint Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment
    Rosa Zampino
    Internal Medicine and Hepatology, Second University of Naples, and Unit of Infectious and Transplant Medicine Monaldi Hospital, Italy
    Transplantation 80:1340-3. 2005
    ..Immune suppression is crucial in the reactivation of previous inactive HBV infection and in the liver disease progression in heart recipients. Preemptive lamivudine treatment could be useful in the early management of these patients...
  16. ncbi request reprint Established and emerging therapies for the treatment of viral hepatitis
    Daniel Forton
    Department of Medicine A, Imperial College, St Mary s Campus, London, UK
    Dig Dis 24:160-73. 2006
    ..The efficacy of these treatments, reasons for treatment failure, drug resistance and future options are discussed in the present review...
  17. ncbi request reprint Detection of a hepatitis B surface antigen variant emerging in a patient with chronic lymphocytic leukaemia treated with fludarabine
    Alexandra Alexopoulou
    Second Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Greece
    J Med Virol 78:1043-6. 2006
    ....
  18. ncbi request reprint Replicative competence of the T131I, K141E, and G145R surface variants of hepatitis B Virus
    Saffie Jammeh
    Department of Medicine, Hepatology Section, Imperial College, St Mary s Campus, London, W2 1NY, UK
    J Infect Dis 196:1010-3. 2007
    ..The sT131I and sG145R variants replicated with efficiency equal to that of the wild type, whereas the sK141E variant was replication impaired...
  19. doi request reprint Effect of basal core promoter and pre-core mutations on hepatitis B virus replication
    Saffie Jammeh
    Department of Medicine, Imperial College, St Mary s Campus, London, UK
    J Gen Virol 89:901-9. 2008
    ..Thus, core promoter mutations other than those at 1762/1764 appear to upregulate viral DNA replication and, at the same time, greatly reduce HBeAg production...
  20. ncbi request reprint Current therapies for chronic hepatitis B virus infection
    Peter Karayiannis
    Imperial College London, Department of Medicine A, Hepatology Section, Faculty of Medicine, St Mary s Campus, South Wharf Road, London, W2 1NY, UK
    Expert Rev Anti Infect Ther 2:745-60. 2004
    ..An outline of future treatment perspectives is also included...
  21. ncbi request reprint Hepatitis vaccines
    Peter Karayiannis
    Department of Medicine A, Faculty of Medicine, Division of Medicine, St Mary s Campus, Imperial College, London W2 1NY, UK
    Br Med Bull 70:29-49. 2004
  22. pmc Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient
    Alexandra Alexopoulou
    Academic Department of Medicine, Hippokration General Hospital, Athens, Greece
    J Clin Microbiol 42:2861-5. 2004
    ..All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays...
  23. pmc Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants
    Daniel M Forton
    Hepatology Section, Division of Medicine, Faculty of Medicine, Imperial College London, 10th Floor, QEQM Building, St Mary s Hospital, South Wharf Road, London W2 1NY, United Kingdom
    J Virol 78:5170-83. 2004
    ....
  24. pmc Comparison of hepatitis C viral loads in patients with or without coinfection with different genotypes
    Alejandro Schijman
    Laboratorio de Biologia Molecular, Grupo CentraLab, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Buenos Aires, Argentina
    Clin Diagn Lab Immunol 11:433-5. 2004
    ..Twelve patients were coinfected with more than one genotype. Their median viral loads did not differ significantly from those observed for monoinfected patients, which in turn did not vary significantly among different genotypes...
  25. ncbi request reprint Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-alpha preparations
    Emanuele Durante Mangoni
    Department of Medicine A, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus QEQMW, London, United Kingdom
    J Med Virol 70:62-73. 2003
    ..A differential effect of different alpha-interferon preparations on HCV quasispecies kinetics may exist...
  26. ncbi request reprint Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defects
    Umesh Gaud
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Med Virol 69:350-6. 2003
    ..Amplicons of this region showed little or no variation at all over time, indicating that quasispecies variation in this region is driven by the host's humoral immune response...
  27. ncbi request reprint Detection and significance of a G1862T variant of hepatitis B virus in Chinese patients with fulminant hepatitis
    Jinlin Hou
    Department of Infectious Diseases, Nanfang Hospital, The First Medical College of PLA, Guangzhou 510515, China
    J Gen Virol 83:2291-8. 2002
    ..This suggests that, following HBV infection, the absence or reduced amounts of HBeAg may be a contributing factor in fulminant disease...
  28. ncbi request reprint Intra-familial transmission of hepatitis B virus in Italy: phylogenetic sequence analysis and amino-acid variation of the core gene
    Rosa Zampino
    Department of Medicine A, Imperial College School of Medicine at St Mary s, South Wharf Road, London W2 1NY, UK
    J Hepatol 36:248-53. 2002
    ..The index cases in such events have been assumed to come from within the family unit or from sources outside the immediate family, with whom the affected person is in close contact...
  29. doi request reprint Restricted quasispecies variation following infection with the GB virus B
    Michael Joseph McGarvey
    Department of Medicine, Imperial College, Faculty of Medicine, St Mary s Campus, London, United Kingdom
    Virus Res 135:181-6. 2008
    ..This restricted sequence variation of GBV-B during acute hepatitis may explain the infrequent progression of the infection to a chronic stage...