Affiliation: Imperial College
- Hepatitis B virus: old, new and future approaches to antiviral treatmentPeter Karayiannis
Department of Medicine A, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, South Wharf Road, London W2 1NY, UK
J Antimicrob Chemother 51:761-85. 2003..It seems certain that combination therapies involving two or more nucleoside analogues, immunomodulators or gene therapies will be the future treatment regimens for chronic HBV infection...
- Current status of hepatitis G virus (GBV-C) in transfusion: is it relevant?P Karayiannis
Department of Medicine, Imperial College School of Medicine at St Mary s, London, UK
Vox Sang 73:63-9. 1997..The majority of long term carriers of the virus appear to have no liver, biochemical or histological abnormalities...
- Natural history and molecular biology of hepatitis G virus/GB virus CP Karayiannis
Department of Medicine A, Imperial College School of Medicine at St Mary s, London, UK
Clin Diagn Virol 10:103-11. 1998..Although the virus has been found in patients with acute and chronic hepatitis, evidence of disease association has not been forthcoming. The majority of patients carry the virus in the absence of liver enzyme abnormalities...
- The hepatitis C virus NS3/4A protease complex interferes with pathways of the innate immune responseP Karayiannis
Department of Medicine A, Imperial College, St Mary s Hospital Campus, South Wharf Road, London W2 1NY, UK
J Hepatol 43:743-5. 2005
- A recombinant vaccinia virus expressing hepatitis A virus structural polypeptides: characterization and demonstration of protective immunogenicityP Karayiannis
Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, U K
J Gen Virol 72:2167-72. 1991..Recombinant viruses expressing the above region of HAV or the proteins expressed by such viruses may be useful in the development of a vaccine suitable for use in man...
- Recombinant vaccinia viruses expressing hepatitis A virus structural polypeptides: detection of an anti-VP0 response in convalescent-phase seraP Karayiannis
Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
Clin Diagn Lab Immunol 2:708-11. 1995..The significance of this finding and the usefulness of these constructs in studying cell-mediated immunity during recovery from HAV infection are discussed...
- Purification of woodchuck hepatitis surface antigen using a monoclonal antibody raised against the antigenJ A Waters
Department of Medicine, Imperial College School of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
J Virol Methods 93:97-103. 2001..Both the antibody and the antigen are valuable reagents for the study of WHV infection...
- In situ hybridization studies in hepatitis A infectionG M Taylor
Department of Histopathology, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London University, United Kingdom
Hepatology 16:642-8. 1992..The hepatocyte appeared to be the only cell type showing staining. No hybridization was found in other organs, including the intestine (n = 4) and, in one animal, the kidney and spleen...
- Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patientS Seddigh-Tonekaboni
Department of Medicine A, Imperial College School of Medicine at St. Mary's, South Wharf Road, London W2 1NY, UK
J Viral Hepat 8:154-8. 2001..The present results indicate that HBsAg variants may exist in individuals other than vaccinated children...
- Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysisU Dumpis
Department of Medicine A, Imperial College School of Medicine, London, UK
J Hepatol 35:99-104. 2001..CONCLUSIONS: Phylogenetic tree analysis of sequences obtained from family members provided strong evidence of intrafamilial transmission of HBV in at least two-thirds of the families studied from Gambia...
- Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriersU Dumpis
Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
J Med Virol 65:664-70. 2001..Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes...
- Core promoter mutations 3 years after anti-hepatitis B e seroconversion in patients with chronic hepatitis B or hepatitis B and C infection and cancer remissionRosa Zampino
Department of Pediatrics, Second University of Naples, Italy
Am J Gastroenterol 97:2426-31. 2002....
- An outbreak of HBV and HCV infection in a paediatric oncology ward: epidemiological investigations and prevention of further spreadUga Dumpis
Biomedical Research and Study Centre, University of Latvia, Riga, Latvia
J Med Virol 69:331-8. 2003..The introduction and maintenance of strict prevention measures over a 2 year period, combined with HBV vaccination, reduced significantly the incidence of new HCV and HBV infections...
- Is lamivudine a safe and effective therapy for patients with chronic hepatitis B and advanced liver disease?Peter Karayiannis
Department of Medicine A, Imperial College, London, UK
Nat Clin Pract Gastroenterol Hepatol 2:138-9. 2005
- Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatmentRosa Zampino
Internal Medicine and Hepatology, Second University of Naples, and Unit of Infectious and Transplant Medicine Monaldi Hospital, Italy
Transplantation 80:1340-3. 2005..Immune suppression is crucial in the reactivation of previous inactive HBV infection and in the liver disease progression in heart recipients. Preemptive lamivudine treatment could be useful in the early management of these patients...
- Established and emerging therapies for the treatment of viral hepatitisDaniel Forton
Department of Medicine A, Imperial College, St Mary s Campus, London, UK
Dig Dis 24:160-73. 2006..The efficacy of these treatments, reasons for treatment failure, drug resistance and future options are discussed in the present review...
- Detection of a hepatitis B surface antigen variant emerging in a patient with chronic lymphocytic leukaemia treated with fludarabineAlexandra Alexopoulou
Second Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Greece
J Med Virol 78:1043-6. 2006....
- Replicative competence of the T131I, K141E, and G145R surface variants of hepatitis B VirusSaffie Jammeh
Department of Medicine, Hepatology Section, Imperial College, St Mary s Campus, London, W2 1NY, UK
J Infect Dis 196:1010-3. 2007..The sT131I and sG145R variants replicated with efficiency equal to that of the wild type, whereas the sK141E variant was replication impaired...
- Effect of basal core promoter and pre-core mutations on hepatitis B virus replicationSaffie Jammeh
Department of Medicine, Imperial College, St Mary s Campus, London, UK
J Gen Virol 89:901-9. 2008..Thus, core promoter mutations other than those at 1762/1764 appear to upregulate viral DNA replication and, at the same time, greatly reduce HBeAg production...
- Current therapies for chronic hepatitis B virus infectionPeter Karayiannis
Imperial College London, Department of Medicine A, Hepatology Section, Faculty of Medicine, St Mary s Campus, South Wharf Road, London, W2 1NY, UK
Expert Rev Anti Infect Ther 2:745-60. 2004..An outline of future treatment perspectives is also included...
- Hepatitis vaccinesPeter Karayiannis
Department of Medicine A, Faculty of Medicine, Division of Medicine, St Mary s Campus, Imperial College, London W2 1NY, UK
Br Med Bull 70:29-49. 2004
- Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patientAlexandra Alexopoulou
Academic Department of Medicine, Hippokration General Hospital, Athens, Greece
J Clin Microbiol 42:2861-5. 2004..All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays...
- Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variantsDaniel M Forton
Hepatology Section, Division of Medicine, Faculty of Medicine, Imperial College London, 10th Floor, QEQM Building, St Mary s Hospital, South Wharf Road, London W2 1NY, United Kingdom
J Virol 78:5170-83. 2004....
- Comparison of hepatitis C viral loads in patients with or without coinfection with different genotypesAlejandro Schijman
Laboratorio de Biologia Molecular, Grupo CentraLab, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Buenos Aires, Argentina
Clin Diagn Lab Immunol 11:433-5. 2004..Twelve patients were coinfected with more than one genotype. Their median viral loads did not differ significantly from those observed for monoinfected patients, which in turn did not vary significantly among different genotypes...
- Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-alpha preparationsEmanuele Durante Mangoni
Department of Medicine A, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus QEQMW, London, United Kingdom
J Med Virol 70:62-73. 2003..A differential effect of different alpha-interferon preparations on HCV quasispecies kinetics may exist...
- Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defectsUmesh Gaud
Department of Medicine A, Imperial College School of Medicine, London, UK
J Med Virol 69:350-6. 2003..Amplicons of this region showed little or no variation at all over time, indicating that quasispecies variation in this region is driven by the host's humoral immune response...
- Detection and significance of a G1862T variant of hepatitis B virus in Chinese patients with fulminant hepatitisJinlin Hou
Department of Infectious Diseases, Nanfang Hospital, The First Medical College of PLA, Guangzhou 510515, China
J Gen Virol 83:2291-8. 2002..This suggests that, following HBV infection, the absence or reduced amounts of HBeAg may be a contributing factor in fulminant disease...
- Intra-familial transmission of hepatitis B virus in Italy: phylogenetic sequence analysis and amino-acid variation of the core geneRosa Zampino
Department of Medicine A, Imperial College School of Medicine at St Mary s, South Wharf Road, London W2 1NY, UK
J Hepatol 36:248-53. 2002..The index cases in such events have been assumed to come from within the family unit or from sources outside the immediate family, with whom the affected person is in close contact...
- Restricted quasispecies variation following infection with the GB virus BMichael Joseph McGarvey
Department of Medicine, Imperial College, Faculty of Medicine, St Mary s Campus, London, United Kingdom
Virus Res 135:181-6. 2008..This restricted sequence variation of GBV-B during acute hepatitis may explain the infrequent progression of the infection to a chronic stage...