Peter Jeffery

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    S Saglani
    Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Respir Res 7:46. 2006
  2. ncbi request reprint Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease
    Peter K Jeffery
    Lung Pathology Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Proc Am Thorac Soc 1:176-83. 2004
  3. ncbi request reprint Anti-inflammatory effects of inhaled corticosteroids in chronic obstructive pulmonary disease: similarities and differences to asthma
    Peter Jeffery
    Royal Brompton Hospital Lung Pathology, Sydney Street, London SW3 6NP, UK
    Expert Opin Investig Drugs 14:619-32. 2005
  4. ncbi request reprint Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPD
    Peter Jeffery
    Lung Pathology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Pulm Pharmacol Ther 18:9-17. 2005
  5. ncbi request reprint Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment
    Peter Jeffery
    Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 168:S1-17. 2003
  6. pmc Allergic rhinitis and asthma: inflammation in a one-airway condition
    Peter K Jeffery
    Lung Pathology, Imperial College at the Royal Brompton Hospital, London, SW3 6NP, UK
    BMC Pulm Med 6:S5. 2006
  7. ncbi request reprint Mucin-producing elements and inflammatory cells
    Peter Jeffery
    Lung Pathology, Department of Gene Therapy, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Novartis Found Symp 248:51-68; discussion 68-75, 277-82. 2002
  8. pmc Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma
    Yusheng Qiu
    Lung Pathology, Department of Gene Therapy, Imperial College, and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 62:475-82. 2007
  9. ncbi request reprint Cigarette smoking alters bronchial mucosal immunity in asthma
    Maria Tsoumakidou
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London, London, UK
    Am J Respir Crit Care Med 175:919-25. 2007
  10. ncbi request reprint Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis
    Nicolas Regamey
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Chest 131:1710-7. 2007

Collaborators

Detail Information

Publications29

  1. pmc Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    S Saglani
    Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Respir Res 7:46. 2006
    ..A similar relationship in children with difficult asthma (DA), in whom RBM thickening is a known feature, may allow the use of HRCT as a non-invasive marker of airway remodelling. We evaluated this relationship in children with DA...
  2. ncbi request reprint Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease
    Peter K Jeffery
    Lung Pathology Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Proc Am Thorac Soc 1:176-83. 2004
    ..Importantly, a recent study of "eosinophilic bronchitis" demonstrates a thickened reticular basement membrane and challenges our current concept of the histopathologic distinctions between asthma and COPD...
  3. ncbi request reprint Anti-inflammatory effects of inhaled corticosteroids in chronic obstructive pulmonary disease: similarities and differences to asthma
    Peter Jeffery
    Royal Brompton Hospital Lung Pathology, Sydney Street, London SW3 6NP, UK
    Expert Opin Investig Drugs 14:619-32. 2005
    ..Understanding the distinctive and, in exacerbations, the changing patterns of inflammation in COPD and asthma allows a better appreciation of the potential for ICS to target the unique pathophysiology of COPD...
  4. ncbi request reprint Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPD
    Peter Jeffery
    Lung Pathology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Pulm Pharmacol Ther 18:9-17. 2005
    ..This review focuses on the nature of the inflammation in COPD and considers how selective PDE4 inhibitors may optimize and advance our treatment of this chronic condition...
  5. ncbi request reprint Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment
    Peter Jeffery
    Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 168:S1-17. 2003
  6. pmc Allergic rhinitis and asthma: inflammation in a one-airway condition
    Peter K Jeffery
    Lung Pathology, Imperial College at the Royal Brompton Hospital, London, SW3 6NP, UK
    BMC Pulm Med 6:S5. 2006
    ..Allergic rhinitis and asthma are conditions of airway inflammation that often coexist...
  7. ncbi request reprint Mucin-producing elements and inflammatory cells
    Peter Jeffery
    Lung Pathology, Department of Gene Therapy, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Novartis Found Symp 248:51-68; discussion 68-75, 277-82. 2002
    ..These considerations demonstrate the complexity of targets that need to be considered for the treatment of mucus hypersecretion...
  8. pmc Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma
    Yusheng Qiu
    Lung Pathology, Department of Gene Therapy, Imperial College, and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 62:475-82. 2007
    ....
  9. ncbi request reprint Cigarette smoking alters bronchial mucosal immunity in asthma
    Maria Tsoumakidou
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London, London, UK
    Am J Respir Crit Care Med 175:919-25. 2007
    ....
  10. ncbi request reprint Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis
    Nicolas Regamey
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Chest 131:1710-7. 2007
    ..We prospectively assessed how the quality of biopsy specimens obtained from children with CF compare with those from children with other airway diseases...
  11. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
    ..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations...
  12. doi request reprint Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation
    Tom N Hilliard
    Department of Gene Therapy, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK
    Am J Respir Cell Mol Biol 39:19-25. 2008
    ..There are significant histologic changes in the nasal mucosa of adult CF mice, not associated with increased lumenal inflammation or bacterial content, and which are not present perinatally. These may be novel therapeutic targets...
  13. ncbi request reprint Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease
    Jie Zhu
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London at the Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
    Am J Respir Crit Care Med 175:1125-33. 2007
    ..Airway wall inflammation, IL-4, and mucus hypersecretion are thought to be associated...
  14. doi request reprint Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis
    Nicolas Regamey
    Department of Gene Therapy, National Heart and Lung Institute, 1B Manresa Road, London SW3 6LR, UK
    Am J Respir Crit Care Med 177:837-43. 2008
    ..Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults...
  15. ncbi request reprint Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
    Sejal Saglani
    Department of Respiratory Paediatrics, Imperial College London, United Kingdom
    Am J Respir Crit Care Med 176:858-64. 2007
    ..We hypothesized that eosinophilic airway inflammation and epithelial reticular basement membrane (RBM) thickening, absent in wheezy infants, would be present in preschool children with severe, recurrent wheeze...
  16. doi request reprint Endobronchial biopsy in childhood
    Nicolas Regamey
    Chest 133:312; author reply 313. 2008
  17. ncbi request reprint Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies
    Nestor A Molfino
    Otsuka Maryland Research Institute, Rockville, MD, USA
    Pulm Pharmacol Ther 20:462-72. 2007
    ..The present review will focus on what is known of the abnormal inflammatory response of COPD in different regions of the conducting airways and lung. Novel, potentially promising approaches to therapy are presented...
  18. ncbi request reprint Early thickening of the reticular basement membrane in children with difficult asthma
    Donald N R Payne
    Department of Paediatrics, Imperial College at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 167:78-82. 2003
    ..In addition, we find no association with age, symptom duration, lung function, or concurrent eosinophilic airway inflammation...
  19. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  20. ncbi request reprint Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease
    Yusheng Qiu
    Lung Pathology, Department of Gene Therapy, Imperial College, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 168:968-75. 2003
    ..Thus, in COPD, in addition to CXCL8 and CXCR1, CXCL5 and CXCR2 appear to play important roles in the airway neutrophilia characteristic of severe exacerbations...
  21. ncbi request reprint Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
    Sejal Saglani
    Lung Pathology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:722-7. 2005
    ..We hypothesized that the epithelial reticular basement membrane (RBM) thickening and eosinophilic inflammation characteristic of asthma would be present in symptomatic infants with reversible airflow obstruction...
  22. ncbi request reprint Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa
    Jie Zhu
    Lung Pathology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
    Am J Respir Cell Mol Biol 33:531-40. 2005
    ....
  23. ncbi request reprint Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  24. ncbi request reprint The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study
    Keith L Hattotuwa
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1592-6. 2002
    ..The data indicate that inhaled fluticasone does affect selected aspects of airway inflammation in COPD, and this may explain, in part, the decrease in exacerbations seen in long-term studies with fluticasone propionate...
  25. ncbi request reprint Safety of bronchoscopy, biopsy, and BAL in research patients with COPD
    Keith Hattotuwa
    Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX UK
    Chest 122:1909-12. 2002
    ..Bronchoscopy with biopsy and BAL is being performed increasingly in patients with COPD as a research tool. Previous reports have shown these procedures to be safe in asthmatic patients, but there is little safety data specific to COPD...
  26. doi request reprint Dendritic cells in chronic obstructive pulmonary disease: new players in an old game
    Maria Tsoumakidou
    Lung Pathology, Department of Gene Therapy, Imperial College London, London, United Kingdom
    Am J Respir Crit Care Med 177:1180-6. 2008
    ....
  27. ncbi request reprint Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitis
    Jie Zhu
    Lung Pathology, Department of Gene Therapy, Imperial College at the Royal Brompton Hospital, London, UK
    Am J Respir Cell Mol Biol 27:666-77. 2002
    ....
  28. ncbi request reprint Dendritic cell maturity and obstructive airway disease
    Maria Tsoumakidou
    Am J Respir Crit Care Med 176:833; author reply 833-4. 2007
  29. pmc Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
    Simon D Message
    Department of Respiratory Medicine, National Heart and Lung Institute and Medical Research Council and Asthma UK Center in Allergic Mechanisms of Asthma, London, United Kingdom
    Proc Natl Acad Sci U S A 105:13562-7. 2008
    ....