Research Topics
| Peter JefferySummaryAffiliation: Imperial College Country: UK Publications
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Detail Information
Publications
Can HRCT be used as a marker of airway remodelling in children with difficult asthma?S Saglani
Respiratory Paediatrics, Royal Brompton Hospital, London, UK
Respir Res 7:46. 2006..A similar relationship in children with difficult asthma (DA), in whom RBM thickening is a known feature, may allow the use of HRCT as a non-invasive marker of airway remodelling. We evaluated this relationship in children with DA...
Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary diseasePeter K Jeffery
Lung Pathology Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Proc Am Thorac Soc 1:176-83. 2004..Importantly, a recent study of "eosinophilic bronchitis" demonstrates a thickened reticular basement membrane and challenges our current concept of the histopathologic distinctions between asthma and COPD...- Anti-inflammatory effects of inhaled corticosteroids in chronic obstructive pulmonary disease: similarities and differences to asthmaPeter Jeffery
Royal Brompton Hospital Lung Pathology, Sydney Street, London SW3 6NP, UK
Expert Opin Investig Drugs 14:619-32. 2005..Understanding the distinctive and, in exacerbations, the changing patterns of inflammation in COPD and asthma allows a better appreciation of the potential for ICS to target the unique pathophysiology of COPD... - Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPDPeter Jeffery
Lung Pathology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Pulm Pharmacol Ther 18:9-17. 2005..This review focuses on the nature of the inflammation in COPD and considers how selective PDE4 inhibitors may optimize and advance our treatment of this chronic condition... - Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatmentPeter Jeffery
Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Am J Respir Crit Care Med 168:S1-17. 2003 - Allergic rhinitis and asthma: inflammation in a one-airway conditionPeter K Jeffery
Lung Pathology, Imperial College at the Royal Brompton Hospital, London, SW3 6NP, UK
BMC Pulm Med 6:S5. 2006..Allergic rhinitis and asthma are conditions of airway inflammation that often coexist... - Mucin-producing elements and inflammatory cellsPeter Jeffery
Lung Pathology, Department of Gene Therapy, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Novartis Found Symp 248:51-68; discussion 68-75, 277-82. 2002..These considerations demonstrate the complexity of targets that need to be considered for the treatment of mucus hypersecretion... - Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthmaYusheng Qiu
Lung Pathology, Department of Gene Therapy, Imperial College, and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Thorax 62:475-82. 2007.... - Cigarette smoking alters bronchial mucosal immunity in asthmaMaria Tsoumakidou
Lung Pathology Unit, Department of Gene Therapy, Imperial College London, London, UK
Am J Respir Crit Care Med 175:919-25. 2007.... - Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosisNicolas Regamey
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
Chest 131:1710-7. 2007..We prospectively assessed how the quality of biopsy specimens obtained from children with CF compare with those from children with other airway diseases... - Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammationNathan W Bartlett
Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
Nat Med 14:199-204. 2008..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations... 
Nasal abnormalities in cystic fibrosis mice independent of infection and inflammationTom N Hilliard
Department of Gene Therapy, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK
Am J Respir Cell Mol Biol 39:19-25. 2008..There are significant histologic changes in the nasal mucosa of adult CF mice, not associated with increased lumenal inflammation or bacterial content, and which are not present perinatally. These may be novel therapeutic targets...- Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary diseaseJie Zhu
Lung Pathology Unit, Department of Gene Therapy, Imperial College London at the Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
Am J Respir Crit Care Med 175:1125-33. 2007..Airway wall inflammation, IL-4, and mucus hypersecretion are thought to be associated... - Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasisNicolas Regamey
Department of Gene Therapy, National Heart and Lung Institute, 1B Manresa Road, London SW3 6LR, UK
Am J Respir Crit Care Med 177:837-43. 2008..Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults... - Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezersSejal Saglani
Department of Respiratory Paediatrics, Imperial College London, United Kingdom
Am J Respir Crit Care Med 176:858-64. 2007..We hypothesized that eosinophilic airway inflammation and epithelial reticular basement membrane (RBM) thickening, absent in wheezy infants, would be present in preschool children with severe, recurrent wheeze... - Endobronchial biopsy in childhoodNicolas Regamey
Chest 133:312; author reply 313. 2008 - Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapiesNestor A Molfino
Otsuka Maryland Research Institute, Rockville, MD, USA
Pulm Pharmacol Ther 20:462-72. 2007..The present review will focus on what is known of the abnormal inflammatory response of COPD in different regions of the conducting airways and lung. Novel, potentially promising approaches to therapy are presented... - Early thickening of the reticular basement membrane in children with difficult asthmaDonald N R Payne
Department of Paediatrics, Imperial College at the Royal Brompton Hospital, London, United Kingdom
Am J Respir Crit Care Med 167:78-82. 2003..In addition, we find no association with age, symptom duration, lung function, or concurrent eosinophilic airway inflammation... - Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary diseaseElizabeth Gamble
Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
Am J Respir Crit Care Med 168:976-82. 2003..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease... - Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary diseaseYusheng Qiu
Lung Pathology, Department of Gene Therapy, Imperial College, Royal Brompton Hospital, London, United Kingdom
Am J Respir Crit Care Med 168:968-75. 2003..Thus, in COPD, in addition to CXCL8 and CXCR1, CXCL5 and CXCR2 appear to play important roles in the airway neutrophilia characteristic of severe exacerbations... - Airway remodeling and inflammation in symptomatic infants with reversible airflow obstructionSejal Saglani
Lung Pathology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Am J Respir Crit Care Med 171:722-7. 2005..001). CONCLUSION: RBM thickening and the eosinophilic inflammation characteristic of asthma in older children and adults are not present in symptomatic infants with reversible airflow obstruction, even in the presence of atopy... - Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosaJie Zhu
Lung Pathology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
Am J Respir Cell Mol Biol 33:531-40. 2005.... - Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung diseaseNeil C Barnes
Department of Respiratory Medicine, London Chest Hospital, London, UK
Am J Respir Crit Care Med 173:736-43. 2006.... - The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy studyKeith L Hattotuwa
Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
Am J Respir Crit Care Med 165:1592-6. 2002..The data indicate that inhaled fluticasone does affect selected aspects of airway inflammation in COPD, and this may explain, in part, the decrease in exacerbations seen in long-term studies with fluticasone propionate... - Safety of bronchoscopy, biopsy, and BAL in research patients with COPDKeith Hattotuwa
Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX UK
Chest 122:1909-12. 2002..CONCLUSIONS: Bronchoscopy, biopsy, and BAL can be performed safely in patients with COPD, including those with severe disease, provided careful assessment is performed and guidelines are adhered to... - Dendritic cells in chronic obstructive pulmonary disease: new players in an old gameMaria Tsoumakidou
Lung Pathology, Department of Gene Therapy, Imperial College London, London, United Kingdom
Am J Respir Crit Care Med 177:1180-6. 2008.... - Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitisJie Zhu
Lung Pathology, Department of Gene Therapy, Imperial College at the Royal Brompton Hospital, London, UK
Am J Respir Cell Mol Biol 27:666-77. 2002.... - Dendritic cell maturity and obstructive airway diseaseMaria Tsoumakidou
Am J Respir Crit Care Med 176:833; author reply 833-4. 2007 - Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 productionSimon D Message
Department of Respiratory Medicine, National Heart and Lung Institute and Medical Research Council and Asthma UK Center in Allergic Mechanisms of Asthma, London, United Kingdom
Proc Natl Acad Sci U S A 105:13562-7. 2008....