K Ito

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, UK
    J Pharmacol Exp Ther 321:1-8. 2007
  2. doi request reprint Therapeutic targets for new therapy for corticosteroid refractory asthma
    Kazuhiro Ito
    National Heart and Lung Institute, Imperial College School of Medicine, Airways Disease Section, London SW3 6LY, UK
    Expert Opin Ther Targets 13:1053-67. 2009
  3. doi request reprint A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition
    Yoshiki Kobayashi
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Royal Brompton Campus, Dovehouse Street, London SW3 6LY
    J Pharmacol Exp Ther 345:76-84. 2013
  4. pmc Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Int J Chron Obstruct Pulmon Dis 7:641-52. 2012
  5. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
  6. pmc Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7
    Masako To
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, England
    Chest 141:1233-42. 2012
  7. pmc Epigenetics and airways disease
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
    Respir Res 7:21. 2006
  8. pmc New drugs targeting Th2 lymphocytes in asthma
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Occup Med Toxicol 3:S6. 2008
  9. pmc Differential patterns of histone acetylation in inflammatory bowel diseases
    Loukia G Tsaprouni
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
    J Inflamm (Lond) 8:1. 2011
  10. pmc Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
    Hannu Kankaanranta
    The Immunopharmacology Research Group, Medical School, FIN 33014, University of Tampere and Research Unit, Tampere University Hospital, Tampere, Finland
    J Inflamm (Lond) 7:9. 2010

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, UK
    J Pharmacol Exp Ther 321:1-8. 2007
    ..Encouraging data from animal models, primary cells and clinical studies in other diseases suggest that inhibitors of PI3K/Akt may prove to be useful novel therapies in the treatment of asthma and chronic obstructive pulmonary disease...
  2. doi request reprint Therapeutic targets for new therapy for corticosteroid refractory asthma
    Kazuhiro Ito
    National Heart and Lung Institute, Imperial College School of Medicine, Airways Disease Section, London SW3 6LY, UK
    Expert Opin Ther Targets 13:1053-67. 2009
    ....
  3. doi request reprint A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition
    Yoshiki Kobayashi
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Royal Brompton Campus, Dovehouse Street, London SW3 6LY
    J Pharmacol Exp Ther 345:76-84. 2013
    ..Thus, SOL showed better anti-inflammatory profiles compared with macrolides currently used in the clinic and may be a promising anti-inflammatory and antimicrobial macrolide for the treatment of COPD in future...
  4. pmc Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Int J Chron Obstruct Pulmon Dis 7:641-52. 2012
    ..Therefore, geroprotection for the lung might be an attractive approach for the treatment of COPD by preventing premature aging of lung...
  5. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
    ..abstract:..
  6. pmc Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7
    Masako To
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, England
    Chest 141:1233-42. 2012
    ..Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show that patients with COPD fail to induce HIF-1α and VEGF under hypoxic condition because of a reduction in histone deacetylase (HDAC) 7...
  7. pmc Epigenetics and airways disease
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
    Respir Res 7:21. 2006
    ..These changes, despite being heritable and stably maintained, are also potentially reversible and there is scope for the development of 'epigenetic therapies' for disease...
  8. pmc New drugs targeting Th2 lymphocytes in asthma
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Occup Med Toxicol 3:S6. 2008
    ..Some of these new Th2-oriented strategies may in the future not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease...
  9. pmc Differential patterns of histone acetylation in inflammatory bowel diseases
    Loukia G Tsaprouni
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
    J Inflamm (Lond) 8:1. 2011
    ..Enhanced acetylation of H4K5 and K16 was seen in the PP. These results demonstrate that histone acetylation is associated with inflammation and may provide a novel therapeutic target for mucosal inflammation...
  10. pmc Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
    Hannu Kankaanranta
    The Immunopharmacology Research Group, Medical School, FIN 33014, University of Tampere and Research Unit, Tampere University Hospital, Tampere, Finland
    J Inflamm (Lond) 7:9. 2010
    ..The aim of the present study was to explore the effects of HDAC inhibitors on apoptosis in human eosinophils and neutrophils...
  11. ncbi request reprint Impact of protein acetylation in inflammatory lung diseases
    Kazuhiro Ito
    Airway Disease, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    Pharmacol Ther 116:249-65. 2007
    ..Further appreciation of the role of these changes may lead to the development of novel therapeutic approaches to inflammatory lung diseases that are currently difficult to treat...
  12. ncbi request reprint Impact of post-translational modifications of proteins on the inflammatory process
    K Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Biochem Soc Trans 35:281-3. 2007
    ..Cross-talk of individual modifications on proteins deserves further evaluation in the future (as 'protein code')...
  13. pmc p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma
    Nicholas Mercado
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    Mol Pharmacol 80:1128-35. 2011
    ..In conclusion, p38 MAPK-γ activation impairs corticosteroid action and p38 MAPK-γ inhibition by LABAs has potential for the treatment of severe asthma...
  14. pmc Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, England, UK
    J Exp Med 203:7-13. 2006
    ..Thus, reduction of HDAC2 plays a critical role in glucocorticoid insensitivity in repressing NF-kappaB-mediated, but not GRE-mediated, gene expression...
  15. doi request reprint COPD as a disease of accelerated lung aging
    Kazuhiro Ito
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Chest 135:173-80. 2009
    ..Recent studies of the signal transduction mechanisms, such as protein acetylation pathways involved in aging, have identified novel antiaging molecules that may provide a new therapeutic approach to COPD...
  16. ncbi request reprint Mode of glucocorticoid actions in airway disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    ScientificWorldJournal 6:1750-69. 2006
    ....
  17. ncbi request reprint p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse St, London SW3 6LY, United Kingdom
    J Biol Chem 276:30208-15. 2001
    ..These data also suggest that pharmacological manipulation of specific histone acetylation status is a potentially useful approach for the treatment of inflammatory diseases...
  18. pmc Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
    ..This further suggests that pharmacological manipulation of of specific histone acetylation status is a potentially useful approach for the treatment of inflammatory diseases...
  19. ncbi request reprint Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation
    M Kagoshima
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 429:327-34. 2001
    ..These data suggest that the mechanism of glucocorticoid action in suppressing interleukin-1 beta-stimulated GM-CSF release in A549 cells may involve modulation of CBP-mediated histone-acetylase activity and DNA methylation...
  20. pmc Statistical parametric mapping with 18F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease
    K Ito
    MRC Cyclotron Unit, Hammersmith Hospital, London, UK
    J Neurol Neurosurg Psychiatry 66:754-8. 1999
    ..To apply statistical parametric mapping to 18F-dopa PET data sets, to examine the regional distribution of changes in dopaminergic metabolism in early asymmetric Parkinson's disease...
  21. ncbi request reprint Histone acetylation and deacetylation: importance in inflammatory lung diseases
    P J Barnes
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 25:552-63. 2005
    ..The reduction in histone deacetylase activity can be restored by theophylline, which may be able to reverse steroid resistance in chronic obstructive pulmonary disease and other inflammatory diseases...
  22. pmc Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
    Borja G Cosio
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, England, UK
    J Exp Med 200:689-95. 2004
    ..Therefore, theophylline might restore steroid responsiveness in COPD patients...
  23. ncbi request reprint Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 352:1967-76. 2005
    ..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
  24. pmc Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation
    L G Tsaprouni
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Clin Exp Immunol 150:151-7. 2007
    ..Changes in histone acetylation at the IL-8 are important in its regulation by proinflammatory and anti-inflammatory agents, and modulation of this activity may have therapeutic potential in inflammatory conditions...
  25. pmc Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
    Yasuo To
    Airway Disease Section, NHLI Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 182:897-904. 2010
    ..Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline...
  26. pmc A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
    Kazuhiro Ito
    Thoracic Medicine, Imperial College School of Science, Technology, and Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 99:8921-6. 2002
    ..Thus we have shown that low-dose theophylline exerts an anti-asthma effect through increasing activation of HDAC which is subsequently recruited by corticosteroids to suppress inflammatory genes...
  27. pmc Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition
    C Rossios
    Airway Disease Section, NHLI, Imperial College, London, UK
    Br J Pharmacol 167:775-86. 2012
    ..Here we show that the long-acting β(2) -agonist formoterol (FM) reversed corticosteroid insensitivity under oxidative stress via inhibition of phosphoinositide-3-kinase (PI3K) signalling...
  28. ncbi request reprint Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration
    K Ito
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Biochem Biophys Res Commun 315:240-5. 2004
    ..This novel mechanism of inflammation may be important in increasing the severity and chronicity of inflammatory diseases...
  29. ncbi request reprint Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications
    M Kagoshima
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Biochem Soc Trans 31:60-5. 2003
    ..Understanding how corticosteroids work in asthma may help in designing novel corticosteroids with fewer systemic effects, as well as novel anti-inflammatory approaches...
  30. ncbi request reprint Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies
    G Caramori
    Dept of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur Respir J 18:466-73. 2001
    ..Finally, no evidence was found for an increased expression of GATA-4 and GATA-6 in asthma...
  31. doi request reprint Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients
    Caterina Brindicci
    Section of Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Chest 135:353-67. 2009
    ..NO production is increased in patients with COPD, and the production of NO under oxidative stress conditions generates reactive nitrogen species that may amplify the inflammatory response in COPD...
  32. ncbi request reprint Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
    Omar S Usmani
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:704-12. 2005
    ..Together, our data confirm that GR nuclear translocation may underlie the complementary interactions between LABAs and corticosteroids, although the precise signal transduction mechanisms remain to be determined...
  33. doi request reprint Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine
    Grace O Osoata
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Chest 135:1513-20. 2009
    ..Nitrative stress is implicated in COPD pathogenesis, but PN has not been detected due to a short half-life (< 1 s) at physiologic condition. Instead, 3-nitrotyrosine has been measured as a footprint of PN release...
  34. ncbi request reprint Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance
    Matthew J Walters
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Imperial College London, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Mol Pharmacol 68:1343-53. 2005
    ..These observations add significantly to our understanding of smoke as an inflammatory stimulus that has implications for potential the development of treatments of smoking or related disease...
  35. ncbi request reprint 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene
    Hiroo Wada
    Airway Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Biochem Biophys Res Commun 331:93-9. 2005
    ....
  36. ncbi request reprint NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription
    Kang Yun Lee
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Immunol 176:603-15. 2006
    ..Our results suggest that IL-1beta-stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites...
  37. pmc Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 39:543-50. 2008
    ..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity...
  38. ncbi request reprint Expression and activity of histone deacetylases in human asthmatic airways
    Kazuhiro Ito
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY UK
    Am J Respir Crit Care Med 166:392-6. 2002
    ..The increase in HAT activity and reduced HDAC activity in asthma may underlie the increased expression of multiple inflammatory genes, and this is reversed, at least in part, by treatment with inhaled steroids...
  39. ncbi request reprint Effects of glucocorticoids on gene transcription
    Ryuji Hayashi
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London, SW3 6LY, UK
    Eur J Pharmacol 500:51-62. 2004
    ..In addition, dissociated glucocorticoids that target NF-kappaB preferentially have also been successful in the treatment of allergic disease...
  40. ncbi request reprint Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo
    D M Vigushin
    Department of Cancer Medicine, Cancer Research Campaign Laboratories, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom
    Clin Cancer Res 7:971-6. 2001
    ....
  41. ncbi request reprint Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity
    Caterina Brindicci
    Section of Airway Disease, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, UK
    Chest 131:1353-62. 2007
    ..The majority of asthmatic patients achieve control of their illness; others do not. It is therefore crucial to validate/develop strategies that help the clinician monitor the disease, improving the response to treatment...
  42. ncbi request reprint Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
    John G Matthews
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    J Allergy Clin Immunol 113:1100-8. 2004
    ..Most chronic inflammatory diseases are well controlled by glucocorticoids. However, a minority of patients fails to respond adequately to this treatment...
  43. pmc Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease
    Kittipong Maneechotesuwan
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS Med 6:e1000076. 2009
    ..We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo...
  44. doi request reprint A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
    Yuji Nakamaru
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    FASEB J 23:2810-9. 2009
    ..Thus, SIRT1 is a negative regulator of MMP9 expression, and SIRT1 activation is implicated as a novel therapeutic approach to treating chronic inflammatory diseases, in which MMP9 is abundant...
  45. pmc Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription
    Catherine E Charron
    Section of Airway Disease, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:36047-54. 2009
    ..Our results suggest that activation of HIF-1alpha by hypoxia decreases HDAC2 levels, resulting in amplified inflammation and corticosteroid resistance...
  46. ncbi request reprint Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers
    Caterina Brindicci
    Section of Airway Disease, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Chest 132:581-8. 2007
    ....
  47. doi request reprint Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
    John A Marwick
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 179:542-8. 2009
    ..Recent studies have shown that histone deacetylase activity, which is critical to glucocorticoid function, is altered by oxidant stress and may be involved in the development of glucocorticoid insensitivity...
  48. pmc Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ
    Nicolas Mercado
    Airway Disease Section, National Heart and Lung Institute, Dovehouse St, London, SW3 6LY, United Kingdom
    J Pharmacol Exp Ther 337:465-70. 2011
    ..Nortriptyline restores corticosteroid sensitivity induced by oxidative stress via direct inhibition of PI3Kδ and is a potential treatment for corticosteroid-insensitive diseases such as COPD and severe asthma...
  49. doi request reprint Oxidative stress modulates theophylline effects on steroid responsiveness
    John A Marwick
    National Heart and Lung Institute, Airways Disease Section, Imperial College London, Guy Scadding Building, Dovehouse Steet, London SW3 6LY, UK
    Biochem Biophys Res Commun 377:797-802. 2008
    ..In conclusion, oxidative stress alters theophylline binding profile and gene expression which may result in restoration of corticosteroid function...
  50. doi request reprint Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease
    Caterina Brindicci
    National Heart and Lung Institute, Imperial College London, UK
    Am J Respir Crit Care Med 181:21-30. 2010
    ..However, expression of the NO synthase(s) responsible for elevated NO has not been identified in the peripheral lung tissue of patients with COPD of varying severity...
  51. doi request reprint Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2
    Grace O Osoata
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Biochem Biophys Res Commun 384:366-71. 2009
    ..Thus, nitration of distinct tyrosine residues modifies both the expression and activity of HDAC2, having an impact on epigenetic regulation...
  52. ncbi request reprint Epigenetic regulation of airway inflammation
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Curr Opin Immunol 19:694-700. 2007
    ..Targeting specific enzymes involved in this process may lead to new therapeutic agents, in particular, in situations where current anti-inflammatory therapies are currently suboptimal...
  53. ncbi request reprint Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
    Peter J Barnes
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Lancet 363:731-3. 2004
    ..This hypothesis raises the possibility that novel therapeutic approaches might unlock this corticosteroid resistance, leading to more effective anti-inflammatory treatments for COPD and other severe inflammatory diseases...
  54. ncbi request reprint Kinase inhibitors and airway inflammation
    Ian M Adcock
    Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, United Kingdom
    Eur J Pharmacol 533:118-32. 2006
    ....
  55. ncbi request reprint Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?
    Ian M Adcock
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Pharmacol 4:257-62. 2004
    ..However, management of those few patients with true steroid resistance will require novel therapies tailored to specific subgroups of patients...
  56. ncbi request reprint Update on glucocorticoid action and resistance
    Kazuhiro Ito
    Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
    J Allergy Clin Immunol 117:522-43. 2006
    ....
  57. ncbi request reprint Glucocorticoid pathways in chronic obstructive pulmonary disease therapy
    Ian M Adcock
    Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 2:313-9; discussion 340-1. 2005
    ..Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease...
  58. ncbi request reprint New insights into the molecular mechanisms of corticosteroids actions
    Ian M Adcock
    Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
    Curr Drug Targets 7:649-60. 2006
    ..Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease...
  59. ncbi request reprint Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms
    Louise E Donnelly
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Am J Physiol Lung Cell Mol Physiol 287:L774-83. 2004
    ..3 microM), and cyclooxygenase-2 expression in these cells. This study demonstrates that resveratrol and quercetin have novel nonsteroidal anti-inflammatory activity that may have applications for the treatment of inflammatory diseases...
  60. ncbi request reprint IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter
    Silvana Morello
    Airways Disease Section, NHLI Imperial College London, London, United Kingdom
    J Immunol 177:7173-83. 2006
    ....
  61. ncbi request reprint Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response
    Ian M Adcock
    Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Antioxid Redox Signal 7:144-52. 2005
    ..This may account for the lack of glucocorticoid sensitivity in patients with chronic obstructive pulmonary disease. Antioxidants should reduce the inflammation and restore glucocorticoid sensitivity in these subjects...
  62. ncbi request reprint Histone deacetylation: an important mechanism in inflammatory lung diseases
    Ian M Adcock
    National Heart and Lung Institute, Imperial College London, UK
    COPD 2:445-55. 2005
    ..The modulation of HAT/HDAC activity may lead to the development of novel anti-inflammatory approaches to inflammatory lung diseases that are currently difficult to treat...
  63. ncbi request reprint Molecular mechanisms of corticosteroid actions
    I M Adcock
    Dept of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Monaldi Arch Chest Dis 55:256-66. 2000
    ..Many of the detrimental side-effects of corticosteroids are believed to be due to gene induction, leading to the search for novel corticosteroids which can repress inflammatory genes without inducing gene transcription...
  64. ncbi request reprint Exhaled nitric oxide from lung periphery is increased in COPD
    C Brindicci
    Section of Airway Disease, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Eur Respir J 26:52-9. 2005
    ..Measurements of nitric oxide at multiple expired flows may be useful in monitoring inflammation and progression of chronic obstructive pulmonary disease, and the response to anti-inflammatory treatment...
  65. ncbi request reprint Regulation of human lung epithelial cell numbers by diesel exhaust particles
    H Bayram
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 27:705-13. 2006
    ..Therefore, low-dose diesel exhaust particle exposure may lead to lung epithelial cell hyperplasia...
  66. ncbi request reprint Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD
    Gaetano Caramori
    Airways Disease Section, National Heart and Lung Institute, Imperal College London, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Investig Drugs 5:1141-7. 2004
    ..Here, we review some of the major NFkappaB activating pathways, their role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD), and their potential as targets in the treatment of asthma and COPD...
  67. ncbi request reprint Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma
    Borja G Cosio
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 170:141-7. 2004
    ..Glucocorticoids and theophylline may downregulate the inflammatory response by modulating HAT and HDAC activity, and nuclear factor-kappaB activation...
  68. doi request reprint Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms
    Karine Enesa
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, W12 ONN, United Kingdom
    J Biol Chem 283:18582-90. 2008
    ..We conclude that H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha...
  69. ncbi request reprint Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding
    Matthew C Catley
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
    J Biol Chem 279:18457-66. 2004
    ....
  70. ncbi request reprint Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers
    Katsuyuki Tomita
    Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, London, United Kingdom
    Am J Respir Crit Care Med 166:724-31. 2002
    ..Thus, oxidative stress induced by cigarette smoking may contribute to the chronicity of inflammation in the airway, through a reduction of apoptosis...
  71. pmc A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition
    Y Kobayashi
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Br J Pharmacol 169:1024-34. 2013
    ..The aim of this study is to evaluate effects of a novel macrolide/fluoroketolide, solithromycin (SOL, CEM-101), on corticosteroid sensitivity induced by oxidative stress...
  72. ncbi request reprint Histone acetylation and histone deacetylation
    Kazuhiro Ito
    Thoracic Medicine, Imperial College Sch Medicine, National Heart and Lung Institute, London, UK
    Mol Biotechnol 20:99-106. 2002
    ..These methods can also be applied to protein extracts from primary cells and from biopsy samples...
  73. ncbi request reprint Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
    Kittipong Maneechotesuwan
    Section of Airway Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 178:2491-8. 2007
    ..This provides a means whereby allergen exposure leads to the expression of Th2 cytokines, and this novel mechanism may provide new approaches to treating allergic diseases...
  74. ncbi request reprint Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study
    J S Rakshi
    MRC Cyclotron Unit, Hammersmith Hospital, The Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
    Brain 122:1637-50. 1999
    ..This suggests, therefore, that Parkinson's disease is a monoaminergic neurodegenerative disorder...
  75. ncbi request reprint Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines
    Masashi Yanada
    Department of Cardiovascular and Thoracic Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Oncol Rep 14:817-22. 2005
    ..These results suggest that a comprehensive study on RUNX3 using real-time RT-PCR, MSP, and FISH could be beneficial in understanding the pathogenetic mechanisms of human lung cancer at the molecular level...
  76. ncbi request reprint Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease
    Fabio L M Ricciardolo
    Unit of Respiratory Disease, Istituto di Ricovero e Cura a Carattere Scientifico Gaslini Institute, Genoa, Italy
    J Allergy Clin Immunol 116:1028-35. 2005
    ..Reactive nitrogen species formation and nitrosative stress are potentially involved in chronic obstructive pulmonary disease (COPD) pathogenesis...
  77. ncbi request reprint Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy
    John A Marwick
    Novartis Institute for Biomedical Research, Respiratory Disease Area, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, UK
    Expert Opin Ther Targets 11:745-55. 2007
    ..Once their mechanisms of action are established, it is likely that derivatives of these compounds may be used as a therapeutic strategy to restore corticosteroid insensitivity in the future...
  78. ncbi request reprint Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Italy
    Curr Med Chem 13:2267-90. 2006
    ..Clearly this is an exciting new area of ongoing research with promising therapeutic potential...
  79. ncbi request reprint Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells
    Loukia G Tsaprouni
    Department of Biology Health Science, University of Luton, Luton LU1 3JU, UK
    Ann N Y Acad Sci 973:481-3. 2002
  80. ncbi request reprint Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages
    Andrea Koch
    University of Cologne, Medizinische Klinik III, Department of Pneumology, Joseph Stelzmann Str 9, 50924 Köln Cologne, Germany
    Am J Respir Cell Mol Biol 30:342-9. 2004
    ..GM-CSF expression and release in AM is controlled by NF-kappaB activation, and this is modulated by phosphorylation of MKK-1 and p38 MAP kinase acting on histone acetylation...
  81. ncbi request reprint Aurones serve as probes of beta-amyloid plaques in Alzheimer's disease
    Masahiro Ono
    Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Biochem Biophys Res Commun 361:116-21. 2007
    ..11-0.26% ID/g at 60 min), which is highly desirable for amyloid imaging agents. The results in this study suggest that novel radiolabeled aurones may be useful amyloid imaging agents for detecting beta-amyloid plaques in the brain of AD...
  82. ncbi request reprint Castleman's disease or angiofollicular hyperplasia as a solitary pulmonary nodule: case report
    Guilherme Andrade Krawczun
    Universidade Estadual de Londrina, Londrina, PR, Brasil
    J Bras Pneumol 33:226-8. 2007
    ..This article emphasizes the importance of adding this disease to the list of morbidities in the differential diagnosis of pulmonary solitary nodules...
  83. doi request reprint Quadrilateral space syndrome: a rare complication of thoracic surgery
    Motohiro Nishimura
    Department of Surgery, Social Insurance Kyoto Hospital, Kyoto, Japan
    Ann Thorac Surg 86:1350-1. 2008
    ..This is a rare complication, but it interferes with the activities of daily living, and thus one should pay attention to this syndrome...
  84. ncbi request reprint Protective effects of preischemic treatment with pioglitazone, a peroxisome proliferator-activated receptor-gamma ligand, on lung ischemia-reperfusion injury in rats
    Kazuhiro Ito
    Department of Cardiovascular and Thoracic Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Eur J Cardiothorac Surg 25:530-6. 2004
    ..We examined the effects of pioglitazone, a synthetic ligand of PPAR-gamma, against lung ischemia-reperfusion injury in rats...
  85. ncbi request reprint Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease
    Katia Varani
    Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Am J Respir Crit Care Med 173:398-406. 2006
    ..Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality worldwide. Adenosine is an inflammatory regulator that acts through four distinct receptors to mediate pro- and antiinflammatory effects...
  86. ncbi request reprint Transcription factors in asthma and COPD
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, Italy
    IDrugs 7:764-70. 2004
    ..Several new compounds based on interactions with specific transcription factors or their activation pathways are now in development for the treatment of asthma and COPD...
  87. ncbi request reprint Targeting Th2 cells in asthmatic airways
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Italy
    Curr Drug Targets Inflamm Allergy 3:243-55. 2004
    ..Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease...