Trevor T Hansel

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Microbes and mucosal immune responses in asthma
    Trevor T Hansel
    National Heart and Lung Institute, Centre for Respiratory Infection, MRC, London, UK
    Lancet 381:861-73. 2013
  2. doi request reprint The safety and side effects of monoclonal antibodies
    Trevor T Hansel
    Imperial Clinical Respiratory Research Unit, St Mary s Hospital, Paddington, London, UK
    Nat Rev Drug Discov 9:325-38. 2010
  3. doi request reprint New drugs for exacerbations of chronic obstructive pulmonary disease
    Trevor T Hansel
    National Heart and Lung Institute, Imperial College, London, UK
    Lancet 374:744-55. 2009
  4. ncbi request reprint A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma
    Trevor T Hansel
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    Clin Ther 28:906-20. 2006
  5. ncbi request reprint Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, Fulham Rd, London SW3 6HP, UK
    Chest 128:1974-9. 2005
  6. doi request reprint Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study
    Edward M Erin
    National Heart and Lung Institute Clinical Studies Unit, Imperial College, London, UK
    Chest 134:740-5. 2008
  7. ncbi request reprint Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants
    Edward M Erin
    NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Am J Respir Crit Care Med 177:132-41. 2008
  8. ncbi request reprint The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
    Edward M Erin
    National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Crit Care Med 174:753-62. 2006
  9. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
  10. ncbi request reprint Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?
    Rachel C Tennant
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, London, UK
    Curr Opin Pharmacol 3:270-6. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Microbes and mucosal immune responses in asthma
    Trevor T Hansel
    National Heart and Lung Institute, Centre for Respiratory Infection, MRC, London, UK
    Lancet 381:861-73. 2013
    ..On the basis of these new ideas, specific host biomarkers might then allow personalised treatment to become a reality for patients with asthma...
  2. doi request reprint The safety and side effects of monoclonal antibodies
    Trevor T Hansel
    Imperial Clinical Respiratory Research Unit, St Mary s Hospital, Paddington, London, UK
    Nat Rev Drug Discov 9:325-38. 2010
    ..Here, we review some of the adverse effects encountered with mAb therapies, and discuss advances in preclinical testing and antibody technology aimed at minimizing the risk of these events...
  3. doi request reprint New drugs for exacerbations of chronic obstructive pulmonary disease
    Trevor T Hansel
    National Heart and Lung Institute, Imperial College, London, UK
    Lancet 374:744-55. 2009
    ..Such concepts have been used to generate a range of molecular targets, and clinical trials are taking place to identify effective drugs for the prevention and treatment of COPD exacerbations...
  4. ncbi request reprint A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma
    Trevor T Hansel
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    Clin Ther 28:906-20. 2006
    ..It is important to compare new treatments with existing ICSs to obtain relative data concerning their efficacy and tolerability...
  5. ncbi request reprint Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, Fulham Rd, London SW3 6HP, UK
    Chest 128:1974-9. 2005
    ..Racemic glycopyrrolate is an anticholinergic drug that has been used orally to control gastric acidity, parenterally as an antisialogogue and to reverse neuromuscular blockade, and has been studied by inhalation for asthma and COPD...
  6. doi request reprint Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study
    Edward M Erin
    National Heart and Lung Institute Clinical Studies Unit, Imperial College, London, UK
    Chest 134:740-5. 2008
    ....
  7. ncbi request reprint Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants
    Edward M Erin
    NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Am J Respir Crit Care Med 177:132-41. 2008
    ..Dithiothreitol (DTT) is commonly used to liquefy induced sputum samples before assessment of cytology, but causes reduction of disulfide bonds and denaturation of proteins...
  8. ncbi request reprint The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
    Edward M Erin
    National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Crit Care Med 174:753-62. 2006
    ..Neutralization of tumor necrosis factor-alpha (TNF-alpha) is an effective antiinflammatory therapy for several chronic inflammatory diseases...
  9. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
    ..25 [0-91]%) or the "non-eosinophilic" group (27.5 [0-96] vs. 44 [9-96]%). In conclusion children with difficult asthma may benefit clinically from high-dose systemic corticosteroids even in the absence of sputum eosinophilia...
  10. ncbi request reprint Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?
    Rachel C Tennant
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, London, UK
    Curr Opin Pharmacol 3:270-6. 2003
    ..However, because LABAs are given twice daily but tiotropium bromide is required only once daily, the challenge is to develop a combined inhaler that can be employed on a daily basis...
  11. ncbi request reprint Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 40:55-69. 2004
    ..Furthermore, the reversal of the steroid resistance induced by oxidative stress suggests that theophylline may increase responsiveness to corticosteroids...
  12. ncbi request reprint A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute NHLI, Imperial College, London, UK
    FASEB J 17:1298-300. 2003
    ....
  13. pmc A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
    Respir Res 8:25. 2007
    ..We therefore prospectively investigated the impact of disease severity, exacerbation frequency and treatment with corticosteroids on change in body composition and maximum isometric quadriceps strength (QMVC) over one year...
  14. ncbi request reprint How do we measure the effectiveness of inhaled corticosteroids in clinical studies?
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:S9-15. 2004
    ..Since ICSs are the mainstay of asthma management guidelines, it is important that novel therapies should be judged against ICSs in future clinical trials. There are many potential designs for these comparative studies...
  15. doi request reprint The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
    Grant C Nicholson
    NHLI, Imperial College, London, UK
    J Allergy Clin Immunol 128:800-807.e9. 2011
    ..IL-13 is a key T(H)2 cytokine that is implicated in allergic responses...
  16. doi request reprint A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies
    Lucy Bailey
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, London, UK
    J Pharmacol Toxicol Methods 68:231-9. 2013
    ..These types of protocols rely on different donor cells and therefore have limitations as bioassays for pre-clinical testing...
  17. ncbi request reprint Prospects for new drugs for chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Lancet 364:985-96. 2004
    ..Effective delivery of drugs to the sites of disease in the peripheral lung is an important consideration, and there is a need for validated biomarkers and monitoring techniques in early clinical studies with new therapies for COPD...
  18. ncbi request reprint Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD
    Trevor T Hansel
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 38:585-600. 2002
    ..Based on these promising features, it is likely that tiotropium used alone or in combination with other bronchodilators will emerge as first-line maintenance treatment for patients with airway obstruction due to COPD...
  19. ncbi request reprint A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist
    Grant C Nicholson
    National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College London, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Pulm Pharmacol Ther 20:52-9. 2007
    ..Cellular activation can also trigger chemotaxis and shape change, the activation itself being caused by the binding of chemokines to cell surface receptors...
  20. ncbi request reprint Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern
    Christiane Lex
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:318-24. 2005
    ..Raised nitric oxide is only poorly predictive of sputum eosinophilia in these children...
  21. doi request reprint Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes
    Guy W Scadding
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK
    J Immunol Methods 384:25-32. 2012
    ..Our model allows correlation between clinical responses and local biomarkers following nasal allergen challenge...
  22. pmc Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells
    Rekha Badiger
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, London, United Kingdom
    PLoS ONE 7:e46779. 2012
    ..Although rare, these adverse events can be severe and potentially life-threatening, emphasizing the need for simple biomarkers of IFN-induced lung toxicity...
  23. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  24. ncbi request reprint A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    Patrick Flood-Page
    F R C P, London Chest Hospital, Bonner Road, London E2 9JX, UK
    Am J Respir Crit Care Med 176:1062-71. 2007
    ..A previous small dose-finding study found that mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, had no effect on allergen challenge in humans...
  25. doi request reprint Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial
    Brian R Leaker
    Pulmonology, Heart and Lung Centre, London, England
    J Nucl Cardiol 15:329-36. 2008
    ..Patients with reactive airways are at risk for adenosine-induced bronchoconstriction, mediated via A(2B) and/or A(3) adenosine receptors...
  26. ncbi request reprint Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
    Roy Pettipher
    Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
    Nat Rev Drug Discov 6:313-25. 2007
    ..We also discuss recent progress in the discovery and development of selective antagonists of these receptors...
  27. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
    ....
  28. ncbi request reprint The trials and tribulations of anti-IL-5 em leader
    Trevor T Hansel
    J Allergy Clin Immunol 109:575-6. 2002