T T Hansel

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
    Respir Res 8:25. 2007
  2. ncbi request reprint New treatments for asthma: current and future aspects
    T T Hansel
    National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College, and Royal Brompton Hospital, London, UK
    Curr Opin Pulm Med 7:S3-6. 2001
  3. ncbi request reprint Novel drugs for treating asthma
    T T Hansel
    National Heart and Lung Institute NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Curr Allergy Asthma Rep 1:164-73. 2001
  4. ncbi request reprint How do we measure the effectiveness of inhaled corticosteroids in clinical studies?
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:S9-15. 2004
  5. ncbi request reprint Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD
    Trevor T Hansel
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 38:585-600. 2002
  6. ncbi request reprint A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute NHLI, Imperial College, London, UK
    FASEB J 17:1298-300. 2003
  7. ncbi request reprint Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses
    E M Erin
    Clinical Studies Unit, National Heart and Lung Institute NHLI, Imperial College, London, UK
    Clin Exp Allergy 36:458-64. 2006
  8. ncbi request reprint Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Clin Exp Allergy 35:1608-14. 2005
  9. ncbi request reprint Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Allergy 60:1524-9. 2005
  10. pmc Automated quantitation of circulating neutrophil and eosinophil activation in asthmatic patients
    M J Leckie
    National Heart and Lung Institute NHLI, Royal Brompton Clinical Studies Unit, Royal Brompton Hospital, London SW3 6HP, UK
    Thorax 55:471-7. 2000

Collaborators

Detail Information

Publications29

  1. pmc A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
    Respir Res 8:25. 2007
    ..We therefore prospectively investigated the impact of disease severity, exacerbation frequency and treatment with corticosteroids on change in body composition and maximum isometric quadriceps strength (QMVC) over one year...
  2. ncbi request reprint New treatments for asthma: current and future aspects
    T T Hansel
    National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College, and Royal Brompton Hospital, London, UK
    Curr Opin Pulm Med 7:S3-6. 2001
    ..These biotechnological therapies may eventually provide the opportunity to tailor treatment to the needs of individual patients, and to manipulate the immune system away from allergic responses...
  3. ncbi request reprint Novel drugs for treating asthma
    T T Hansel
    National Heart and Lung Institute NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Curr Allergy Asthma Rep 1:164-73. 2001
    ..Thanks to the extensive efforts of the pharmaceutical industry, we can expect the introduction of a range of novel therapies for asthma in the near future...
  4. ncbi request reprint How do we measure the effectiveness of inhaled corticosteroids in clinical studies?
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:S9-15. 2004
    ..Since ICSs are the mainstay of asthma management guidelines, it is important that novel therapies should be judged against ICSs in future clinical trials. There are many potential designs for these comparative studies...
  5. ncbi request reprint Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD
    Trevor T Hansel
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 38:585-600. 2002
    ..Based on these promising features, it is likely that tiotropium used alone or in combination with other bronchodilators will emerge as first-line maintenance treatment for patients with airway obstruction due to COPD...
  6. ncbi request reprint A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute NHLI, Imperial College, London, UK
    FASEB J 17:1298-300. 2003
    ....
  7. ncbi request reprint Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses
    E M Erin
    Clinical Studies Unit, National Heart and Lung Institute NHLI, Imperial College, London, UK
    Clin Exp Allergy 36:458-64. 2006
    ..beta-Tryptase is a multifunctional mast cell serine protease released during mast cell degranulation and tryptase/trypsin inhibitors are a novel potential therapeutic approach for allergic inflammatory diseases...
  8. ncbi request reprint Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Clin Exp Allergy 35:1608-14. 2005
    ..Cytokines and chemokines produced by allergen-reactive T-helper type 2 (Th2) cells may be pivotal to the pathophysiology of allergic disorders...
  9. ncbi request reprint Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Allergy 60:1524-9. 2005
    ..Objective: To determine the effects of a single dose of topical steroid on eosinophils and levels of chemokines and cytokines in nasal lavage fluid following NAC in patients with allergic rhinitis...
  10. pmc Automated quantitation of circulating neutrophil and eosinophil activation in asthmatic patients
    M J Leckie
    National Heart and Lung Institute NHLI, Royal Brompton Clinical Studies Unit, Royal Brompton Hospital, London SW3 6HP, UK
    Thorax 55:471-7. 2000
    ..In addition, cells stimulated with interleukin (IL)-8 were examined by electron microscopy...
  11. ncbi request reprint Eotaxin receptor (CCR3) antagonism in asthma and allergic disease
    E M Erin
    NHLI Clinical Studies Unit, Imperial College, London, UK
    Curr Drug Targets Inflamm Allergy 1:201-14. 2002
    ..CCR3 antagonists are likely to be safe and effective therapies for allergic diseases, and their clinical pharmacology can readily be defined within phase I/II studies in patients with allergy and asthma...
  12. pmc Sputum T lymphocytes in asthma, COPD and healthy subjects have the phenotype of activated intraepithelial T cells (CD69+ CD103+)
    M J Leckie
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Thorax 58:23-9. 2003
    ....
  13. ncbi request reprint A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    Patrick Flood-Page
    F R C P, London Chest Hospital, Bonner Road, London E2 9JX, UK
    Am J Respir Crit Care Med 176:1062-71. 2007
    ..A previous small dose-finding study found that mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, had no effect on allergen challenge in humans...
  14. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
    ....
  15. ncbi request reprint A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma
    Trevor T Hansel
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    Clin Ther 28:906-20. 2006
    ..It is important to compare new treatments with existing ICSs to obtain relative data concerning their efficacy and tolerability...
  16. ncbi request reprint The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
    Edward M Erin
    National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Crit Care Med 174:753-62. 2006
    ..Neutralization of tumor necrosis factor-alpha (TNF-alpha) is an effective antiinflammatory therapy for several chronic inflammatory diseases...
  17. doi request reprint Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study
    Edward M Erin
    National Heart and Lung Institute Clinical Studies Unit, Imperial College, London, UK
    Chest 134:740-5. 2008
    ....
  18. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  19. ncbi request reprint Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, Fulham Rd, London SW3 6HP, UK
    Chest 128:1974-9. 2005
    ..Racemic glycopyrrolate is an anticholinergic drug that has been used orally to control gastric acidity, parenterally as an antisialogogue and to reverse neuromuscular blockade, and has been studied by inhalation for asthma and COPD...
  20. ncbi request reprint Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease
    Trevor T Hansel
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, London, UK
    Drugs Today (Barc) 40:55-69. 2004
    ..Furthermore, the reversal of the steroid resistance induced by oxidative stress suggests that theophylline may increase responsiveness to corticosteroids...
  21. ncbi request reprint Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?
    Rachel C Tennant
    Clinical Studies Unit, National Heart and Lung Institute, Imperial College, London, UK
    Curr Opin Pharmacol 3:270-6. 2003
    ..However, because LABAs are given twice daily but tiotropium bromide is required only once daily, the challenge is to develop a combined inhaler that can be employed on a daily basis...
  22. ncbi request reprint The trials and tribulations of anti-IL-5 em leader
    Trevor T Hansel
    J Allergy Clin Immunol 109:575-6. 2002
  23. ncbi request reprint Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants
    Edward M Erin
    NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Am J Respir Crit Care Med 177:132-41. 2008
    ..Dithiothreitol (DTT) is commonly used to liquefy induced sputum samples before assessment of cytology, but causes reduction of disulfide bonds and denaturation of proteins...
  24. ncbi request reprint Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
    Roy Pettipher
    Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
    Nat Rev Drug Discov 6:313-25. 2007
    ..We also discuss recent progress in the discovery and development of selective antagonists of these receptors...
  25. ncbi request reprint A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist
    Grant C Nicholson
    National Heart and Lung Institute NHLI, Clinical Studies Unit, Imperial College London, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK
    Pulm Pharmacol Ther 20:52-9. 2007
    ..Cellular activation can also trigger chemotaxis and shape change, the activation itself being caused by the binding of chemokines to cell surface receptors...
  26. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
    ..25 [0-91]%) or the "non-eosinophilic" group (27.5 [0-96] vs. 44 [9-96]%). In conclusion children with difficult asthma may benefit clinically from high-dose systemic corticosteroids even in the absence of sputum eosinophilia...
  27. ncbi request reprint Prospects for new drugs for chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Lancet 364:985-96. 2004
    ..Effective delivery of drugs to the sites of disease in the peripheral lung is an important consideration, and there is a need for validated biomarkers and monitoring techniques in early clinical studies with new therapies for COPD...
  28. ncbi request reprint Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern
    Christiane Lex
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:318-24. 2005
    ..Raised nitric oxide is only poorly predictive of sputum eosinophilia in these children...
  29. doi request reprint Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial
    Brian R Leaker
    Pulmonology, Heart and Lung Centre, London, England
    J Nucl Cardiol 15:329-36. 2008
    ..Patients with reactive airways are at risk for adenosine-induced bronchoconstriction, mediated via A(2B) and/or A(3) adenosine receptors...