William Paul Hanage

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Assessing the reliability of eBURST using simulated populations with known ancestry
    Katherine M E Turner
    Department of Infectious Disease Epidemiology, Imperial College, St Mary s Hospital Campus, Norfolk Place, London, UK
    BMC Microbiol 7:30. 2007
  2. pmc Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era
    Grace M Lee
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    BMC Infect Dis 9:110. 2009
  3. pmc Assigning strains to bacterial species via the internet
    Cynthia J Bishop
    Department of Infectious Disease Epidemiology, Imperial College London, St, Mary s Hospital Campus, London, UK
    BMC Biol 7:3. 2009
  4. pmc Bayesian modeling of recombination events in bacterial populations
    Pekka Marttinen
    Department of Mathematics and Statistics, University of Helsinki, FIN 00014, Finland
    BMC Bioinformatics 9:421. 2008
  5. pmc Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Epidemics 2:80-4. 2010
  6. ncbi request reprint Serotype replacement in invasive pneumococcal disease: where do we go from here?
    W P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    J Infect Dis 196:1282-4. 2007
  7. doi request reprint Serotype-specific problems associated with pneumococcal conjugate vaccination
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Future Microbiol 3:23-30. 2008
  8. pmc A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus
    W P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    J Clin Microbiol 44:743-9. 2006
  9. ncbi request reprint The impact of homologous recombination on the generation of diversity in bacteria
    William P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital Campus, Imperial College London, London W2 1PG, UK
    J Theor Biol 239:210-9. 2006
  10. pmc Using multilocus sequence data to define the pneumococcus
    William P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    J Bacteriol 187:6223-30. 2005

Detail Information

Publications29

  1. pmc Assessing the reliability of eBURST using simulated populations with known ancestry
    Katherine M E Turner
    Department of Infectious Disease Epidemiology, Imperial College, St Mary s Hospital Campus, Norfolk Place, London, UK
    BMC Microbiol 7:30. 2007
    ..The reliability of eBURST was evaluated using populations simulated with different levels of recombination in which the ancestry of all strains was known...
  2. pmc Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era
    Grace M Lee
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    BMC Infect Dis 9:110. 2009
    ..aureus and MRSA colonization in young children in the context of widespread use of PCV7; and (2) examine risk factors for S. aureus colonization in the post-PCV7 era, including the absence of vaccine-type S. pneumoniae colonization...
  3. pmc Assigning strains to bacterial species via the internet
    Cynthia J Bishop
    Department of Infectious Disease Epidemiology, Imperial College London, St, Mary s Hospital Campus, London, UK
    BMC Biol 7:3. 2009
    ....
  4. pmc Bayesian modeling of recombination events in bacterial populations
    Pekka Marttinen
    Department of Mathematics and Statistics, University of Helsinki, FIN 00014, Finland
    BMC Bioinformatics 9:421. 2008
    ..The currently available methods for recombination detection capable of probabilistic characterization of uncertainty have a limited applicability in practice as the number of strains in a data set increases...
  5. pmc Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Epidemics 2:80-4. 2010
    ..For other serotypes, the future course of replacement disease remains to be determined...
  6. ncbi request reprint Serotype replacement in invasive pneumococcal disease: where do we go from here?
    W P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    J Infect Dis 196:1282-4. 2007
  7. doi request reprint Serotype-specific problems associated with pneumococcal conjugate vaccination
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Future Microbiol 3:23-30. 2008
    ..Finally, lessons from the US experience for conjugate vaccination in other settings including sub-Saharan Africa are drawn...
  8. pmc A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus
    W P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    J Clin Microbiol 44:743-9. 2006
    ..The diversification and geographic spread of this lineage suggest that loss of capsule is not inconsistent with long-term persistence and raise questions about the capsule's role in pneumococcal transmission...
  9. ncbi request reprint The impact of homologous recombination on the generation of diversity in bacteria
    William P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital Campus, Imperial College London, London W2 1PG, UK
    J Theor Biol 239:210-9. 2006
    ..We also demonstrate that by fitting the neutral model to experimental data, more informative and precise estimates of the relative roles of recombination and mutation may be obtained...
  10. pmc Using multilocus sequence data to define the pneumococcus
    William P Hanage
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    J Bacteriol 187:6223-30. 2005
    ....
  11. pmc Fuzzy species among recombinogenic bacteria
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    BMC Biol 3:6. 2005
    ....
  12. pmc Invasiveness of serotypes and clones of Streptococcus pneumoniae among children in Finland
    William P Hanage
    Department of Infectious Disease Epidemiology, Old Medical School Building, St Mary s Hospital, Imperial College London, London W2 1PG, United Kingdom
    Infect Immun 73:431-5. 2005
    ..These results demonstrate the invasive phenotype of the serotype 14 variant of the Spain(9V)-3 clone and differences between members of the same serogroup in invasive disease potential...
  13. doi request reprint Hyper-recombination, diversity, and antibiotic resistance in pneumococcus
    William Paul Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Science 324:1454-7. 2009
    ..This could have consequences for the reemergence of drug resistance after pneumococcal vaccination and also for our understanding of diversification and speciation in recombinogenic bacteria...
  14. ncbi request reprint Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College, London, UK
    J Infect Dis 195:347-52. 2007
    ..Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clones, and expansion of existing clones...
  15. pmc Ability of pneumococcal serotypes and clones to cause acute otitis media: implications for the prevention of otitis media by conjugate vaccines
    William P Hanage
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, London W2 1PG, United Kingdom
    Infect Immun 72:76-81. 2004
    ..We conclude that serotype replacement may reduce the long-term efficacy of these vaccines against AOM...
  16. pmc Sequences, sequence clusters and bacterial species
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital Campus, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 361:1917-27. 2006
    ..The advantages and problems in using sequence clusters as the basis of species assignments are discussed...
  17. pmc Modelling bacterial speciation
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital Campus, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 361:2039-44. 2006
    ....
  18. pmc HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda
    T Deirdre Hollingsworth
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Pathog 6:e1000876. 2010
    ..The most parsimonious explanation is that this is due to shared characteristics of the transmitted virus, a finding which sheds light on both the role of viral factors in HIV-1 pathogenesis and on the evolution of the virus...
  19. ncbi request reprint Displaying the relatedness among isolates of bacterial species -- the eBURST approach
    Brian G Spratt
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, Old Medical School Building, London W2 1PG, UK
    FEMS Microbiol Lett 241:129-34. 2004
    ..We discuss the advantages of this approach and describe its use to explore patterns of descent within clonal complexes identified using multilocus sequence typing...
  20. doi request reprint The bacterial species challenge: making sense of genetic and ecological diversity
    Christophe Fraser
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Science 323:741-6. 2009
    ..The resulting data may help to discriminate among the many theories of prokaryotic species that have been produced to date...
  21. pmc Neutral microepidemic evolution of bacterial pathogens
    Christophe Fraser
    Department of Infectious Disease Epidemiology, St Mary s Hospital Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 102:1968-73. 2005
    ..These findings challenge the assumption that strains of bacterial pathogens differ markedly in relative fitness...
  22. ncbi request reprint Modelling infectious disease - time to think outside the box?
    Siouxsie Wiles
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nat Rev Microbiol 4:307-12. 2006
    ..Focusing on mouse models of bacterial pathogens, we discuss some of these discrepancies and suggest ways of improving model systems in the future...
  23. pmc Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis
    Christophe Fraser
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 104:17441-6. 2007
    ..We discuss how this evolutionary hypothesis can be tested, review the evidence available to date, and highlight directions for future research...
  24. pmc Recombination and the nature of bacterial speciation
    Christophe Fraser
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Science 315:476-80. 2007
    ..Hence, to make sense of bacterial diversity, we need data not only from genetic surveys but also from experimental determination of selection pressures and recombination rates and from theoretical models...
  25. pmc Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers
    Merit M Melin
    National Public Health Institute KTL, Department of Vaccines, Mannerheimintie 166, 00300 Helsinki, Finland
    Clin Vaccine Immunol 15:1555-63. 2008
    ..The majority of the isolates (97%) belonged to either PspA family 1 or family 2, suggesting that a combination including the two main PspA families would make a good vaccine candidate...
  26. ncbi request reprint The important role of nontypable Streptococcus pneumoniae international clones in acute conjunctivitis
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel
    J Infect Dis 194:689-96. 2006
    ..The purpose of the present study was to evaluate the relative importance in causing AC of the absence of capsule versus genotype properties...
  27. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
    ..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria meningitidis...
  28. ncbi request reprint Emergence of 19A as virulent and multidrug resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine
    Stephen I Pelton
    Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Boston, MA, USA
    Pediatr Infect Dis J 26:468-72. 2007
    ..Ongoing surveillance is necessary to identify emerging invasive serotypes and antimicrobial susceptibilities...
  29. doi request reprint Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
    Monica Moschioni
    Novartis Vaccines, Siena, Italy
    J Infect Dis 197:888-96. 2008
    ..Limited data are available on the prevalence of the rlrA operon in pneumococci; therefore, we investigated its distribution and its antigenic variation among disease-causing strains...