Pascale V Guillot

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse
    P V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    J Pathol 214:627-36. 2008
  2. pmc Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice
    Maximilien Vanleene
    Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK
    Bone 50:1317-23. 2012
  3. ncbi request reprint Fetal stem cells: betwixt and between
    Pascale V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
    Semin Reprod Med 24:340-7. 2006
  4. ncbi request reprint Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC
    Pascale V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, U K
    Stem Cells 25:646-54. 2007
  5. ncbi request reprint Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources
    Pascale V Guillot
    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Differentiation 76:946-57. 2008
  6. ncbi request reprint Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice
    Pascale V Guillot
    Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, United Kingdom
    Blood 111:1717-25. 2008
  7. pmc Upregulating CXCR4 in human fetal mesenchymal stem cells enhances engraftment and bone mechanics in a mouse model of osteogenesis imperfecta
    Gemma N Jones
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, United Kingdom
    Stem Cells Transl Med 1:70-8. 2012
  8. ncbi request reprint Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics
    Dafni Moschidou
    The Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Stem Cells Dev 22:444-58. 2013
  9. doi request reprint Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties
    Maximilien Vanleene
    Department of Bioengineering, Imperial College, London, UK
    Blood 117:1053-60. 2011
  10. pmc Ontological differences in first compared to third trimester human fetal placental chorionic stem cells
    Gemma N Jones
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    PLoS ONE 7:e43395. 2012

Collaborators

Detail Information

Publications24

  1. doi request reprint Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse
    P V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    J Pathol 214:627-36. 2008
    ..We conclude that intrauterine transplantation of human fetal MSCs improves renal glomerulopathy in a collagen type I-deficient mouse model. These data support the feasibility of prenatal treatment for hereditary renal diseases...
  2. pmc Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice
    Maximilien Vanleene
    Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK
    Bone 50:1317-23. 2012
    ..Using a composite framework, we interpret the lower oim bone matrix elasticity observed as the result of a change in the aspect ratio of apatite crystals and a disruption of the crystal connectivity...
  3. ncbi request reprint Fetal stem cells: betwixt and between
    Pascale V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College, London, United Kingdom
    Semin Reprod Med 24:340-7. 2006
    ..They have also been implicated in fetomaternal trafficking in pregnancy, and in long-term microchimerism in postreproductive women...
  4. ncbi request reprint Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC
    Pascale V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, U K
    Stem Cells 25:646-54. 2007
    ..01). Compared with adult MSC, first-trimester fetal tissues constitute a source of MSC with characteristics that appear advantageous for cell therapy...
  5. ncbi request reprint Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources
    Pascale V Guillot
    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Differentiation 76:946-57. 2008
    ..Our findings suggest that stem cell therapy for bone dysplasias such as osteogenesis imperfecta may benefit from preferentially using first trimester fetal blood or bone marrow MSC over fetal liver or adult bone marrow MSC...
  6. ncbi request reprint Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice
    Pascale V Guillot
    Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, United Kingdom
    Blood 111:1717-25. 2008
    ....
  7. pmc Upregulating CXCR4 in human fetal mesenchymal stem cells enhances engraftment and bone mechanics in a mouse model of osteogenesis imperfecta
    Gemma N Jones
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, United Kingdom
    Stem Cells Transl Med 1:70-8. 2012
    ..Higher engraftment in oim bones was associated with decreased bone brittleness. This strategy represents a step to improve the therapeutic benefits of fetal cell therapy toward being curative...
  8. ncbi request reprint Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics
    Dafni Moschidou
    The Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Stem Cells Dev 22:444-58. 2013
    ..Our data suggest that this medium-dependant approach to pluripotent mid-trimester AFSC reflects true reprogramming and not the selection of prepluripotent cells...
  9. doi request reprint Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties
    Maximilien Vanleene
    Department of Bioengineering, Imperial College, London, UK
    Blood 117:1053-60. 2011
    ..In conclusion, expression of normal collagen from mature osteoblast of donor origin significantly decreased bone brittleness by improving the mechanical integrity of the bone at the molecular, tissue, and whole bone levels...
  10. pmc Ontological differences in first compared to third trimester human fetal placental chorionic stem cells
    Gemma N Jones
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    PLoS ONE 7:e43395. 2012
    ....
  11. doi request reprint A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells
    Cosimo De Bari
    King s College London, London, UK
    Arthritis Rheum 58:240-50. 2008
    ..To develop a biomarker-based model to predict osteogenic potency of human mesenchymal stem cells (MSCs) from synovial membrane and periosteum...
  12. pmc Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach
    Dafni Moschidou
    Imperial College London, London, UK
    Mol Ther 20:1953-67. 2012
    ..We conclude that AFSC can be utilized for cell banking of patient-specific pluripotent cells for potential applications in allogeneic cellular replacement therapies, pharmaceutical screening, and disease modeling...
  13. ncbi request reprint Molecular signature of human amniotic fluid stem cells during fetal development
    Dafni Moschidou
    Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, United Kingdom
    Curr Stem Cell Res Ther 8:73-81. 2013
    ..We conclude that both populations are related but distinct to each other as well as to hESC...
  14. ncbi request reprint Osterix induces osteogenic gene expression but not differentiation in primary human fetal mesenchymal stem cells
    Hitoshi Kurata
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, UK
    Tissue Eng 13:1513-23. 2007
    ..In conclusion, Osx regulates osteogenic gene expression in hfMSCs but is insufficient to induce terminal osteogenic differentiation...
  15. ncbi request reprint Therapeutic potential of amniotic fluid stem cells
    Hassan Abdulrazzak
    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Curr Stem Cell Res Ther 8:117-24. 2013
    ..These characteristics, together with absence of ethical issues concerning their employment, have made stem cells from amniotic fluid a promising candidate for cell therapy and tissue engineering...
  16. ncbi request reprint Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse
    Jerry Chan
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London, United Kingdom
    Stem Cells 25:875-84. 2007
    ..Although the low-level of chimerism achieved is not curative for DMD, this approach may be useful in other severe mesenchymal or enzyme deficiency syndromes, where low-level protein expression may ameliorate disease pathology...
  17. doi request reprint Placenta as a reservoir of stem cells: an underutilized resource?
    Caterina Pipino
    University College London, 30 Guilford Street, London, UK
    Br Med Bull 105:43-68. 2013
    ..As an alternative, the placenta is a foetal tissue that can be obtained during gestation and at term, and it represents a reservoir of stem cells with various potential...
  18. pmc Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues
    Hassan Abdulrazzak
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK
    J R Soc Interface 7:S689-706. 2010
    ..Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status...
  19. pmc Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta
    Gemma N Jones
    1 Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    Stem Cells Dev 23:262-76. 2014
    ..In conclusion, the placenta is a practical source of stem cells for the treatment of OI. ..
  20. pmc The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells
    Jennifer Frost
    Institute of Reproductive and Developmental Biology, Imperial Colleg, London, UK
    Epigenetics 6:52-62. 2011
    ..Since DMR integrity was maintained in fMSC but not hES cells, we postulate that specific hES cell derivation and culturing practices result in changes in methylation at DMRs...
  21. pmc Induced pluripotent stem (iPS) cells from human fetal stem cells (hFSCs)
    Valentina Spinelli
    Surgery Unit, Institute of Child Health, University College London and Great Ormond Street Hospital, London, UK
    Organogenesis 9:101-10. 2013
    ..4) Hurdles to overcome include i.e stability of the phenotype in relation to epigenetic memory...
  22. ncbi request reprint Stem cell differentiation and expansion for clinical applications of tissue engineering
    Pascale V Guillot
    Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, London, UK
    J Cell Mol Med 11:935-44. 2007
    ....
  23. pmc Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain
    Sheila Q Xie
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, United Kingdom
    Mol Biol Cell 17:1723-33. 2006
    ..We find that paraspeckles are transcriptionally inactive but contain polymerase II, which remains stably associated upon transcriptional inhibition, when paraspeckles reorganize around nucleoli in the form of caps...
  24. ncbi request reprint Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells
    Pascale V Guillot
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Exp Cell Res 295:460-8. 2004
    ..A minor proportion of the total amount of the phospho-Ser(2) form is present in these domains...