Affiliation: Imperial College
Griesenbach U, Vicente C, Roberts M, Meng C, Soussi S, Xenariou S, et al
. Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer. Biomaterials. 2011;32:2614-24 pubmed publisher
..This has allowed us to validate that GL67A, which is currently in clinical use, can generate significant amounts of recombinant protein in fully differentiated human air liquid interface cultures and the ovine lung in vivo. ..
Griesenbach U, Alton E. Progress in gene and cell therapy for cystic fibrosis lung disease. Curr Pharm Des. 2012;18:642-62 pubmed
..Recent studies in viral and non-viral vector developments, as well as cell therapy will be discussed and an update on clinical gene therapy studies will be provided here. ..
Griesenbach U, Meng C, Farley R, Cheng S, Scheule R, Davies M, et al
. In vivo imaging of gene transfer to the respiratory tract. Biomaterials. 2008;29:1533-40 pubmed
..45, p<0.05). To our knowledge these studies show for the first time that this non-invasive method of assessing pulmonary gene transfer is viable for evaluating non-viral gene transfer agents. ..
Alton E, Boyd A, Davies J, Gill D, Griesenbach U, Harrison P, et al
. Genetic medicines for CF: Hype versus reality. Pediatr Pulmonol. 2016;51:S5-S17 pubmed publisher
..We hope that this review will contribute to the ongoing discussion about the hype versus reality of genetic medicine-based treatment approaches in CF. Pediatr Pulmonol. 2016;51:S5-S17. © 2016 Wiley Periodicals, Inc. ..
Griesenbach U, Smith S, Farley R, Singh C, Alton E. Validation of nasal potential difference measurements in gut-corrected CF knockout mice. Am J Respir Cell Mol Biol. 2008;39:490-6 pubmed publisher
..These data should allow a more informed use of CF animals in future studies. ..