Frances Gotch

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens
    Rebecca C Robey
    Department of Immunology, Imperial College London, London, United Kingdom
    PLoS ONE 4:e5890. 2009
  2. pmc The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus
    Rebecca C Robey
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Adv Virol 2010:340356. 2010
  3. pmc Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011
    Nicolas Ruffin
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Transl Med 10:144. 2012
  4. pmc Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010
    Sarah Brinckmann
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg, Stockholm, 171 77, Sweden
    J Transl Med 9:40. 2011
  5. ncbi request reprint The importance of standardisation of laboratory evaluations in HIV vaccine trials
    Frances Gotch
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Microbes Infect 7:1424-32. 2005
  6. ncbi request reprint Science, medicine and research in the developing world: a perspective
    Frances Gotch
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Nat Immunol 8:1273-6. 2007
  7. ncbi request reprint Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects
    Anthony Kebba
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    J Leukoc Biol 78:37-42. 2005
  8. pmc Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
    Adel Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Proc Natl Acad Sci U S A 106:19940-5. 2009
  9. ncbi request reprint Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cell Res 14:251-6. 2004
  10. ncbi request reprint Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: concomitant assessment of perforin, IFN-gamma and IL-4 secretion
    Catherine T Burton
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Immunol Methods 308:216-30. 2006

Collaborators

Detail Information

Publications61

  1. pmc The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens
    Rebecca C Robey
    Department of Immunology, Imperial College London, London, United Kingdom
    PLoS ONE 4:e5890. 2009
    ..This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases...
  2. pmc The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus
    Rebecca C Robey
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Adv Virol 2010:340356. 2010
    ..In this paper we describe the current state of knowledge on the T-cell immune responses against KSHV...
  3. pmc Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011
    Nicolas Ruffin
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Transl Med 10:144. 2012
    ..These - necessarily overlapping topics - are comprehensively summarised by the Europrise students in the context of other recent exciting data...
  4. pmc Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010
    Sarah Brinckmann
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg, Stockholm, 171 77, Sweden
    J Transl Med 9:40. 2011
    ....
  5. ncbi request reprint The importance of standardisation of laboratory evaluations in HIV vaccine trials
    Frances Gotch
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Microbes Infect 7:1424-32. 2005
    ..Different well-validated assays must be used to quantitate specific responses, to determine which particular strategies may be efficacious...
  6. ncbi request reprint Science, medicine and research in the developing world: a perspective
    Frances Gotch
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Nat Immunol 8:1273-6. 2007
  7. ncbi request reprint Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects
    Anthony Kebba
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    J Leukoc Biol 78:37-42. 2005
    ..7, P = 0.015). Increased surface expression of CD91 on CD14(+) monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects...
  8. pmc Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
    Adel Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Proc Natl Acad Sci U S A 106:19940-5. 2009
    ....
  9. ncbi request reprint Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cell Res 14:251-6. 2004
    ..These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals...
  10. ncbi request reprint Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: concomitant assessment of perforin, IFN-gamma and IL-4 secretion
    Catherine T Burton
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Immunol Methods 308:216-30. 2006
    ....
  11. ncbi request reprint Thymic output during initial highly active antiretroviral therapy (HAART) and during HAART supplementation with interleukin 2 and/or with HIV type 1 immunogen (Remune)
    Jeffrey Pido-Lopez
    Department of Immunology, Faculty of Medicine, Imperial College of Science Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    AIDS Res Hum Retroviruses 19:103-9. 2003
    ....
  12. ncbi request reprint Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirs
    Antonio Pires
    Department of Immunology, Imperial College London, UK
    J Acquir Immune Defic Syndr 36:783-90. 2004
    ....
  13. ncbi request reprint Prospective study of the effects of antiretroviral therapy on Kaposi sarcoma--associated herpesvirus infection in patients with and without Kaposi sarcoma
    Jasjit Gill
    Chelsea and Westminster Hospital, London, England, United Kingdom
    J Acquir Immune Defic Syndr 31:384-90. 2002
    ..To investigate the effect of highly active antiretroviral therapy (HAART) on circulating Kaposi sarcoma (KS)-associated herpesvirus (KSHV) load in HIV-infected individuals with and without KS...
  14. ncbi request reprint Enhanced T-cell maturation, differentiation and function in HIV-1-infected individuals after growth hormone and highly active antiretroviral therapy
    Antonio Pires
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    Antivir Ther 9:67-75. 2004
    ..Administration of antiretroviral therapy (ART) during the chronic phases of HIV-1 infection fails to restore these responses in most patients...
  15. ncbi request reprint Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 103:1791-5. 2004
    ..This approach, which offers an easy and effective protocol for the amplification of specific antiviral and antitumor CTLs, may offer significant advances for in vivo T-cell immunotherapeutic protocols...
  16. ncbi request reprint Human BDCA-1-positive blood dendritic cells differentiate into phenotypically distinct immature and mature populations in the absence of exogenous maturational stimuli: differentiation failure in HIV infection
    Steven Patterson
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    J Immunol 174:8200-9. 2005
    ..In HIV-infected individuals, there was a marked decrease in the viability of cultured blood mDC, a failure to differentiate into the two populations described for normal donors, and an impaired ability to stimulate T cell proliferation...
  17. ncbi request reprint Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor
    Justin Stebbing
    Department of Immunology, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 102:1806-14. 2003
    ..These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates...
  18. doi request reprint TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses
    Sai Suda Duraisingham
    Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    J Immunol 183:2242-51. 2009
    ..This study emphasizes the differences between human DC subsets and demonstrates that both the DC subset and the microbial stimulus influence the Th cell response...
  19. doi request reprint Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10
    Sandrine Buisson
    Department of Immunology, Faculty of Medicine, Imperial College, and Department of HIV GU Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    J Infect Dis 199:1862-71. 2009
    ..Our findings suggest that MDDCs used in therapeutic vaccination of HIV-infected individuals may show reduced potency...
  20. ncbi request reprint Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients
    Guglielmo Rosignoli
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
    AIDS 21:1379-81. 2007
    ..We found raised levels of PD-L1 in aviraemic chronically infected HIV-1-positive patients, which may contribute to incomplete immune reconstitution after treatment with HAART...
  21. pmc CD34-derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular-signal-regulated kinase phosphorylation
    Sai S Duraisingham
    Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
    Immunology 131:210-9. 2010
    ..Thus we have described differences in LC and moDC responses to TLR stimulation, and have identified key differences in ERK phosphorylation and the involvement of MAPK and PI3K...
  22. ncbi request reprint Activity of different vaccine-associated promoter elements in human dendritic cells
    Timoleon Papagatsias
    Department of Immunology, Imperial College London, 369 Fulham Road, Chelsea and Westminster Hospital, SW10 9NH London, UK
    Immunol Lett 115:117-25. 2008
    ..These findings demonstrate that the CMV promoter is the most effective of the three promoters tested in a range of different human DC populations...
  23. pmc Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients
    Adel Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 6:e17525. 2011
    ..Results from this study provide further insight into HIV-1 mediated suppression of innate immune functions...
  24. ncbi request reprint The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 101:4000-4. 2003
    ..The ability of CD91 to internalize alpha-defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8(+) responses in these patients...
  25. ncbi request reprint Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease
    Melanie Hart
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    J Immunol 178:8212-20. 2007
    ....
  26. ncbi request reprint Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:473-4. 2004
    ..015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis...
  27. doi request reprint T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness
    Jocelyn S Downey
    Section of Immunology, Department of Medicine, Imperial College London, UK
    AIDS 25:1981-6. 2011
    ..We sought to address whether aviraemic HIV-1 infection, therefore, contributed to long-term alterations in intracellular signalling events within the T cells of infected individuals that contributed to the exhausted phenotype...
  28. pmc Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands
    George Rozis
    Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
    Immunology 124:329-38. 2008
    ..Thus, in vitro-generated LC and dDC detect different pathogen-associated molecules and show different cytokine-secretion profiles in response to TLR ligands...
  29. ncbi request reprint Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    AIDS 17:1998-2000. 2003
    ..KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection...
  30. ncbi request reprint Immune reconstitution in HIV-1-infected patients
    Nesrina Imami
    Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
    Curr Opin Investig Drugs 3:1138-45. 2002
    ..Here, we review and discuss therapeutic immunization and immunotherapy with regard to their potential use in the treatment of chronic HIV-1 infection...
  31. ncbi request reprint Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully suppressive highly active antiretroviral therapy
    Ann K Sullivan
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    AIDS 17:628-9. 2003
    ..This immunotherapeutic approach, utilizing autologous virus as autovaccination, may be a viable, safer alternative to structured treatment interruption and potentially more efficacious than therapeutic vaccines...
  32. doi request reprint Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials
    Harry Kaltsidis
    International AIDS Vaccine Initiative Human Immunology Laboratory IAVI HIL, London, UK
    J Immunol Methods 370:43-54. 2011
    ..Internal quality controls monitored over time, combined with the use of quality gating and standard operating procedures were used to demonstrate the generation of robust and reliable data...
  33. ncbi request reprint Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals
    Anthony Kebba
    Department of Immunology, Imperial College, London, Chelsea and Westminster Hospital, London, United Kingdom
    J Infect Dis 189:1705-13. 2004
    ..Immunodominant peptides recognized by SP subjects tended to be from relatively conserved regions, whereas peptides recognized by ESN individuals were associated with slow disease progression...
  34. ncbi request reprint Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women
    Manyu Prakash
    Department of Immunology, Faculty of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    J Infect Dis 190:246-50. 2004
    ..CCR5 and CXCR4 were detected on CD1a-positive and -negative cervical DCs. These findings suggest that DCs in the genital tract are potential targets for macrophage-tropic and lymphotropic strains of HIV...
  35. pmc A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection
    Nesrina Imami
    Department of Immunology, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom
    J Virol 76:9011-23. 2002
    ..These results suggest that a balanced type 1/type 2 profile correlates with successful long-term control of HIV-1...
  36. ncbi request reprint Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: implications for mucosal vaccines
    George Rozis
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    Eur J Immunol 35:2617-26. 2005
    ..These findings suggest that vaccine strategies that target LC with adenovirus vectors may be worthy of exploration...
  37. doi request reprint Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates
    Aggeliki Spentzou
    Human Immunology Laboratory, International AIDS Vaccine Initiative, Imperial College London, London SW10 9NH, United Kingdom
    J Infect Dis 201:720-9. 2010
    ..Assessment of direct antiviral T cell function by this assay provides additional information to guide vaccine design and the prioritizing of candidates for further clinical trials...
  38. ncbi request reprint Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1
    Heather Donaghy
    Department of Immunology, Imperial College of Science, Technology of Medicine, Westminster Hospital, London
    Blood 101:4505-11. 2003
    ..These findings suggest that infection, depletion, and dysfunction of dendritic cells may contribute to the immunosuppression associated with HIV-1 disease...
  39. ncbi request reprint Kaposi's sarcoma--an update
    Justin Stebbing
    Department of Immunology, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Int J STD AIDS 14:225-7. 2003
  40. ncbi request reprint Therapeutic vaccines and immunotherapy revisited
    Frances Gotch
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    J HIV Ther 10:48-50. 2005
    ....
  41. doi request reprint Reduced T(H)1/T(H)17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection
    Sally Clark
    Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    J Allergy Clin Immunol 128:838-846.e5. 2011
    ..Selective loss of T(H)1/T(H)17 cells in patients with HIV-1 infection might contribute to reduced tuberculosis-induced immune responses and an increased susceptibility to active tuberculosis...
  42. ncbi request reprint Mechanisms of loss of HIV-1-specific T-cell responses
    Nesrina Imami
    Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
    J HIV Ther 7:30-4. 2002
    ..The induction of virus-specific CD4 T-cell and, subsequently, CD8 T-cell responses may require different novel approaches based on an appreciation of the complex mechanisms involved in the loss of these responses...
  43. ncbi request reprint Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitus
    Manyu Prakash
    Department of Immunology, Imperial College of Science, Technology, and Medicine at Chelsea and Westminster Hospital, United Kingdom
    Am J Obstet Gynecol 188:376-81. 2003
    ..This study investigated the effect of sexual intercourse on cervical intraepithelial T lymphocytes and macrophages in healthy uninfected women...
  44. pmc Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretr
    John Wilkinson
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College School of Medicine, London, United Kingdom
    J Virol 76:2634-40. 2002
    ..Although these increases were modest in comparison to the number of SFC observed with the HIV-1 gag peptide SLYNTVATL, they represented a fourfold increase from the baseline, continuing an upward trend to week 52...
  45. pmc Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways
    Adel Benlahrech
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    Sensors (Basel) 9:386-403. 2009
    ..These factors act cumulatively to enhance cytotoxcity. Thus different parameters of pDC mediated NK cell activation are regulated by distinct pathways...
  46. ncbi request reprint New insights into the immunology and evolution of HIV
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SWIO 9NH, United Kingdom
    Cell Res 13:1-7. 2003
    ..Further delineation of the intimate interactions between the HIV and the immune system will be critical and recent advances in this direction are discussed...
  47. pmc Gene expression profiling in male genital lichen sclerosus
    Emma Edmonds
    Dermatology Chelsea and Westminster Campus, Imperial College School of Medicine, London, UK
    Int J Exp Pathol 92:320-5. 2011
    ..No specific HPV, autoimmune or squamous carcinogenesis-associated gene expression patterns were found. ECM1 and CABLES1 expression were significantly reduced in paediatric and adult samples respectively...
  48. ncbi request reprint Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women
    Manyu Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine ICSTM at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Reprod Immunol 54:117-31. 2002
    ..Furthermore, the cell surface density of CCR5 is increased on both CD4(+) and CD8(+) T lymphocyte subsets. These findings suggest a mechanism by which oral contraceptive use can increase the risk of HIV-1 transmission...
  49. pmc Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes
    Justin Stebbing
    Cancer Research U K Viral Oncology Group, The Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Virol 77:4306-14. 2003
    ..Furthermore, these epitopes are highly conserved sequences within KSHV isolates from a specific strain but are not conserved between different strains. We conclude that CTL recognition contributes to K1, and therefore to KSHV, evolution...
  50. ncbi request reprint Twenty years of HIV-1 research: what the future holds
    Nesrina Imami
    Nat Immunol 4:501. 2003
  51. ncbi request reprint HIV/AIDS cohorts in Uganda. An interview with Frances Gotch
    Frances Gotch
    IAVI Rep 9:14-7. 2005
  52. ncbi request reprint Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trials
    Anthony Kebba
    Medical Research Council Research Unit on AIDS, Uganda Virus Research Institute, Plot 51 59, Nakiwogo Road, PO Box 49, Entebbe, Uganda
    Pharmacogenomics 8:409-14. 2007
    ..Data also suggest that efficacy on post-infection end points may depend on whether transmission pairs are matched or mismatched for HLA class I alleles...
  53. ncbi request reprint Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women using oral contraceptives
    Manyu Prakash
    Department of GU HIV Medicine, Imperial College of Science, Technology and Medicine, Northwick Park Hospital, Harrow, Middlesex, UK
    BJOG 111:1468-70. 2004
    ..Up-regulation of CCR5 on cervical intraepithelial CD4+ T lymphocytes offers a potential explanation by which women receiving combined oral contraceptives may be at increased risk of HIV transmission...
  54. ncbi request reprint Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivo
    Justin Stebbing
    AIDS 18:2099-101. 2004
  55. ncbi request reprint Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease
    Assia Samri
    Laboratoire d Immunologie Cellulaire, AP HP, Hopital Pitie Salpetriere, Paris, France
    Antivir Ther 12:553-8. 2007
    ..The long-term immunological benefit of protease inhibitor (PI)-sparing antiretroviral therapy (ART) using non-nucleoside reverse transcriptase inhibitors (NNRTIs) remains poorly investigated...
  56. ncbi request reprint HIV type 1-specific inter- and intrasubtype cellular immune responses in HIV type 1-infected Ugandans
    Alleluiah Rutebemberwa
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 20:763-71. 2004
    ....
  57. ncbi request reprint Support for the RV144 HIV vaccine trial
    Robert Belshe
    Science 305:177-80; author reply 177-80. 2004
  58. ncbi request reprint HIV type 1 antigen-responsive CD4+ T-lymphocytes in exposed yet HIV Type 1 seronegative Ugandans
    Anthony Kebba
    Medical Research Council s Programme on AIDS in Uganda, UVRI, Entebbe, Uganda
    AIDS Res Hum Retroviruses 20:67-75. 2004
    ....
  59. ncbi request reprint European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research
    Thomas Lehner
    Mucosal Immunology Unit, Kings College at Guy s Hospital, Guy s Tower, London SE1 9RT, UK
    Vaccine 23:5551-6. 2005
    ..The resulting consensus paper will guide the EC and EDCTP in developing HIV vaccine strategy and recommendations...
  60. ncbi request reprint Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine
    Mark Page
    Division of Retrovirology, National Institute for Biological Standards and Control, Potters Bar EN6 3QG, UK
    AIDS 21:375-7. 2007
    ..These responses were not detected in HLA-B62 and HLA-DR4-positive individuals indicating that immunotherapy did not break tolerance to self-antigens...
  61. ncbi request reprint An anniversary without celebration?
    Nesrina Imami
    Nat Immunol 7:893. 2006