Research Topics
Species | Frances GotchSummaryAffiliation: Imperial College Country: UK Publications
| Collaborators
|
Detail Information
Publications
Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010Sarah Brinckmann
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg, Stockholm, 171 77, Sweden
J Transl Med 9:40. 2011....
The importance of standardisation of laboratory evaluations in HIV vaccine trialsFrances Gotch
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Microbes Infect 7:1424-32. 2005..Different well-validated assays must be used to quantitate specific responses, to determine which particular strategies may be efficacious...- Science, medicine and research in the developing world: a perspectiveFrances Gotch
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London SW10 9NH, UK
Nat Immunol 8:1273-6. 2007 - Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjectsAnthony Kebba
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
J Leukoc Biol 78:37-42. 2005..7, P = 0.015). Increased surface expression of CD91 on CD14(+) monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects... - Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1Adel Benlahrech
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
Proc Natl Acad Sci U S A 106:19940-5. 2009.... - Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: concomitant assessment of perforin, IFN-gamma and IL-4 secretionCatherine T Burton
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
J Immunol Methods 308:216-30. 2006.... - Thymic output during initial highly active antiretroviral therapy (HAART) and during HAART supplementation with interleukin 2 and/or with HIV type 1 immunogen (Remune)Jeffrey Pido-Lopez
Department of Immunology, Faculty of Medicine, Imperial College of Science Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
AIDS Res Hum Retroviruses 19:103-9. 2003.... - Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patientsJustin Stebbing
The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Cell Res 14:251-6. 2004..These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals... 
TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responsesSai Suda Duraisingham
Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
J Immunol 183:2242-51. 2009..This study emphasizes the differences between human DC subsets and demonstrates that both the DC subset and the microbial stimulus influence the Th cell response...- Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirsAntonio Pires
Department of Immunology, Imperial College London, UK
J Acquir Immune Defic Syndr 36:783-90. 2004.... - Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patientsGuglielmo Rosignoli
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
AIDS 21:1379-81. 2007..We found raised levels of PD-L1 in aviraemic chronically infected HIV-1-positive patients, which may contribute to incomplete immune reconstitution after treatment with HAART... - Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10Sandrine Buisson
Department of Immunology, Faculty of Medicine, Imperial College, and Department of HIV GU Medicine, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 199:1862-71. 2009..Our findings suggest that MDDCs used in therapeutic vaccination of HIV-infected individuals may show reduced potency... - Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal diseaseMelanie Hart
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
J Immunol 178:8212-20. 2007.... - Enhanced T-cell maturation, differentiation and function in HIV-1-infected individuals after growth hormone and highly active antiretroviral therapyAntonio Pires
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
Antivir Ther 9:67-75. 2004..This combination may represent a valuable immunotherapeutic intervention aiding in the treatment of chronic HIV-1 infection... - Human BDCA-1-positive blood dendritic cells differentiate into phenotypically distinct immature and mature populations in the absence of exogenous maturational stimuli: differentiation failure in HIV infectionSteven Patterson
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
J Immunol 174:8200-9. 2005..In HIV-infected individuals, there was a marked decrease in the viability of cultured blood mDC, a failure to differentiate into the two populations described for normal donors, and an impaired ability to stimulate T cell proliferation... - Activity of different vaccine-associated promoter elements in human dendritic cellsTimoleon Papagatsias
Department of Immunology, Imperial College London, 369 Fulham Road, Chelsea and Westminster Hospital, SW10 9NH London, UK
Immunol Lett 115:117-25. 2008..These findings demonstrate that the CMV promoter is the most effective of the three promoters tested in a range of different human DC populations... - Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcomaJustin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
AIDS 17:1998-2000. 2003..KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection... - Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligandsGeorge Rozis
Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
Immunology 124:329-38. 2008..Thus, in vitro-generated LC and dDC detect different pathogen-associated molecules and show different cytokine-secretion profiles in response to TLR ligands... - Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patientsAdel Benlahrech
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
PLoS ONE 6:e17525. 2011..Results from this study provide further insight into HIV-1 mediated suppression of innate immune functions... - CD34-derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular-signal-regulated kinase phosphorylationSai S Duraisingham
Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
Immunology 131:210-9. 2010..Thus we have described differences in LC and moDC responses to TLR stimulation, and have identified key differences in ERK phosphorylation and the involvement of MAPK and PI3K... - A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infectionNesrina Imami
Department of Immunology, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom
J Virol 76:9011-23. 2002..These results suggest that a balanced type 1/type 2 profile correlates with successful long-term control of HIV-1... - Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: implications for mucosal vaccinesGeorge Rozis
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
Eur J Immunol 35:2617-26. 2005..These findings suggest that vaccine strategies that target LC with adenovirus vectors may be worthy of exploration... - Immune reconstitution in HIV-1-infected patientsNesrina Imami
Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
Curr Opin Investig Drugs 3:1138-45. 2002..Here, we review and discuss therapeutic immunization and immunotherapy with regard to their potential use in the treatment of chronic HIV-1 infection... - Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully suppressive highly active antiretroviral therapyAnn K Sullivan
St Stephen's Centre, Chelsea and Westminster Hospital, London, UK
AIDS 17:628-9. 2003..This immunotherapeutic approach, utilizing autologous virus as autovaccination, may be a viable, safer alternative to structured treatment interruption and potentially more efficacious than therapeutic vaccines... - Therapeutic vaccines and immunotherapy revisitedFrances Gotch
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
J HIV Ther 10:48-50. 2005.... - Kaposi's sarcoma--an updateJustin Stebbing
Department of Immunology, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Int J STD AIDS 14:225-7. 2003 - Reduced T(H)1/T(H)17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infectionSally Clark
Immunology Section, Division of Infectious Diseases, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
J Allergy Clin Immunol 128:838-846.e5. 2011..Selective loss of T(H)1/T(H)17 cells in patients with HIV-1 infection might contribute to reduced tuberculosis-induced immune responses and an increased susceptibility to active tuberculosis... - Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptorJustin Stebbing
Department of Immunology, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
Blood 102:1806-14. 2003..These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates... - Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individualsAnthony Kebba
Department of Immunology, Imperial College, London, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 189:1705-13. 2004..Immunodominant peptides recognized by SP subjects tended to be from relatively conserved regions, whereas peptides recognized by ESN individuals were associated with slow disease progression... - Mechanisms of loss of HIV-1-specific T-cell responsesNesrina Imami
Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
J HIV Ther 7:30-4. 2002..The induction of virus-specific CD4 T-cell and, subsequently, CD8 T-cell responses may require different novel approaches based on an appreciation of the complex mechanisms involved in the loss of these responses... - Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different PathwaysAdel Benlahrech
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
Sensors (Basel) 9:386-403. 2009..These factors act cumulatively to enhance cytotoxcity. Thus different parameters of pDC mediated NK cell activation are regulated by distinct pathways... - Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcomaJustin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
Int J Cancer 108:473-4. 2004..015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis... - Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy womenManyu Prakash
Department of Immunology, Faculty of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 190:246-50. 2004..CCR5 and CXCR4 were detected on CD1a-positive and -negative cervical DCs. These findings suggest that DCs in the genital tract are potential targets for macrophage-tropic and lymphotropic strains of HIV... - Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretrJohn Wilkinson
Department of Immunology, Chelsea and Westminster Hospital, Imperial College School of Medicine, London, United Kingdom
J Virol 76:2634-40. 2002..Although these increases were modest in comparison to the number of SFC observed with the HIV-1 gag peptide SLYNTVATL, they represented a fourfold increase from the baseline, continuing an upward trend to week 52... - New insights into the immunology and evolution of HIVJustin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SWIO 9NH, United Kingdom
Cell Res 13:1-7. 2003..Further delineation of the intimate interactions between the HIV and the immune system will be critical and recent advances in this direction are discussed... - Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy womenManyu Prakash
Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
J Reprod Immunol 54:117-31. 2002..Furthermore, the cell surface density of CCR5 is increased on both CD4(+) and CD8(+) T lymphocyte subsets. These findings suggest a mechanism by which oral contraceptive use can increase the risk of HIV-1 transmission... - Twenty years of HIV-1 research: what the future holdsNesrina Imami
Nat Immunol 4:501. 2003 - Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivoJustin Stebbing
AIDS 18:2099-101. 2004 - Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopesJustin Stebbing
Cancer Research U.K. Viral Oncology Group, The Wolfson Institute for Biomedical Research, University College London, United Kingdom
J Virol 77:4306-14. 2003..Furthermore, these epitopes are highly conserved sequences within KSHV isolates from a specific strain but are not conserved between different strains. We conclude that CTL recognition contributes to K1, and therefore to KSHV, evolution... - Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1Heather Donaghy
Department of Immunology, Imperial College of Science, Technology of Medicine, Westminster Hospital, London
Blood 101:4505-11. 2003..These findings suggest that infection, depletion, and dysfunction of dendritic cells may contribute to the immunosuppression associated with HIV-1 disease... - The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressorsJustin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
Blood 101:4000-4. 2003..The ability of CD91 to internalize alpha-defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8(+) responses in these patients... - Prospective study of the effects of antiretroviral therapy on Kaposi sarcoma--associated herpesvirus infection in patients with and without Kaposi sarcomaJasjit Gill
Chelsea and Westminster Hospital, London, England, United Kingdom
J Acquir Immune Defic Syndr 31:384-90. 2002..There was no clear association between CD4 cell count response and KS response to HAART, but there was a significant relationship between HIV load response to HAART and clinical improvement of KS... - Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccinationJustin Stebbing
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
Blood 103:1791-5. 2004..This approach, which offers an easy and effective protocol for the amplification of specific antiviral and antitumor CTLs, may offer significant advances for in vivo T-cell immunotherapeutic protocols... - HIV type 1 antigen-responsive CD4+ T-lymphocytes in exposed yet HIV Type 1 seronegative UgandansAnthony Kebba
Medical Research Council's Programme on AIDS in Uganda, UVRI, Entebbe, Uganda
AIDS Res Hum Retroviruses 20:67-75. 2004.... - Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 diseaseAssia Samri
Laboratoire d Immunologie Cellulaire, AP HP, Hopital Pitie Salpetriere, Paris, France
Antivir Ther 12:553-8. 2007..The long-term immunological benefit of protease inhibitor (PI)-sparing antiretroviral therapy (ART) using non-nucleoside reverse transcriptase inhibitors (NNRTIs) remains poorly investigated... - European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines researchThomas Lehner
Mucosal Immunology Unit, Kings College at Guy's Hospital, Guy's Tower, London SE1 9RT, UK
Vaccine 23:5551-6. 2005..The resulting consensus paper will guide the EC and EDCTP in developing HIV vaccine strategy and recommendations... - Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women using oral contraceptivesManyu Prakash
Department of GU/HIV Medicine, Imperial College of Science, Technology and Medicine, Northwick Park Hospital, Harrow, Middlesex, UK
BJOG 111:1468-70. 2004..Up-regulation of CCR5 on cervical intraepithelial CD4+ T lymphocytes offers a potential explanation by which women receiving combined oral contraceptives may be at increased risk of HIV transmission... - HIV/AIDS cohorts in Uganda. An interview with Frances GotchFrances Gotch
IAVI Rep 9:14-7. 2005 - Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trialsAnthony Kebba
Medical Research Council Research Unit on AIDS, Uganda Virus Research Institute, Plot 51 59, Nakiwogo Road, PO Box 49, Entebbe, Uganda
Pharmacogenomics 8:409-14. 2007..Data also suggest that efficacy on post-infection end points may depend on whether transmission pairs are matched or mismatched for HLA class I alleles... - HIV type 1-specific inter- and intrasubtype cellular immune responses in HIV type 1-infected UgandansAlleluiah Rutebemberwa
Henry M Jackson Foundation, Rockville, Maryland 20850, USA
AIDS Res Hum Retroviruses 20:763-71. 2004.... - Support for the RV144 HIV vaccine trialRobert Belshe
Science 305:177-80; author reply 177-80. 2004 - Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccineMark Page
Division of Retrovirology, National Institute for Biological Standards and Control, Potters Bar EN6 3QG, UK
AIDS 21:375-7. 2007..These responses were not detected in HLA-B62 and HLA-DR4-positive individuals indicating that immunotherapy did not break tolerance to self-antigens... - An anniversary without celebration?Nesrina Imami
Nat Immunol 7:893. 2006 - Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitusManyu Prakash
Department of Immunology, Imperial College of Science, Technology, and Medicine at Chelsea and Westminster Hospital, United Kingdom
Am J Obstet Gynecol 188:376-81. 2003....