Anthony P Goldstone

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Genetic obesity syndromes
    Anthony P Goldstone
    MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK
    Front Horm Res 36:37-60. 2008
  2. doi request reprint Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome
    A P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Int J Obes (Lond) 36:1564-70. 2012
  3. doi request reprint Fasting biases brain reward systems towards high-calorie foods
    Anthony P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
    Eur J Neurosci 30:1625-35. 2009
  4. doi request reprint The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Obesity (Silver Spring) 20:76-87. 2012
  5. doi request reprint Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task
    Alexander D Miras
    Imperial Weight Centre, Imperial College London, London, UK
    Am J Clin Nutr 96:467-73. 2012
  6. doi request reprint The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI
    Yu Ting Kuo
    Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College School of Medicine, Du Cane Road, London, W12 0HS, UK
    Neuroimage 50:1384-91. 2010
  7. doi request reprint Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment
    Jelena Anastasovska
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Obesity (Silver Spring) 20:1016-23. 2012
  8. pmc Impact of resistant starch on body fat patterning and central appetite regulation
    Po Wah So
    Biological Imaging Centre, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    PLoS ONE 2:e1309. 2007
  9. ncbi request reprint Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    Anthony P Goldstone
    Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 75:468-75. 2002
  10. pmc Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
    Samantha Scholtz
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Gut 63:891-902. 2014

Collaborators

Detail Information

Publications22

  1. doi request reprint Genetic obesity syndromes
    Anthony P Goldstone
    MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK
    Front Horm Res 36:37-60. 2008
    ....
  2. doi request reprint Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome
    A P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Int J Obes (Lond) 36:1564-70. 2012
    ..We investigated whether differences in appetite hormones may explain the development of abnormal eating behaviour in young children with PWS...
  3. doi request reprint Fasting biases brain reward systems towards high-calorie foods
    Anthony P Goldstone
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, UK
    Eur J Neurosci 30:1625-35. 2009
    ..These results demonstrate an interaction between homeostatic and hedonic aspects of feeding behaviour, with fasting biasing brain reward systems towards high-calorie foods...
  4. doi request reprint The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
    E Louise Thomas
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Obesity (Silver Spring) 20:76-87. 2012
    ..From these data we propose the thin-on-the-outside fat-on-the-inside (TOFI) as a subphenotype for individuals at increased metabolic risk...
  5. doi request reprint Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task
    Alexander D Miras
    Imperial Weight Centre, Imperial College London, London, UK
    Am J Clin Nutr 96:467-73. 2012
    ..There is increasing evidence that after gastric bypass surgery, patients and animal models show a decreased preference for sweet and fatty foods. The underlying mechanism may include alterations in taste function...
  6. doi request reprint The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI
    Yu Ting Kuo
    Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College School of Medicine, Du Cane Road, London, W12 0HS, UK
    Neuroimage 50:1384-91. 2010
    ..We conclude that MEMRI is able to detect the combined effects of the integrity of neuronal activity and blood-brain barrier permeability in the hypothalamus associated with dietary manipulation and aging...
  7. doi request reprint Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment
    Jelena Anastasovska
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Obesity (Silver Spring) 20:1016-23. 2012
    ....
  8. pmc Impact of resistant starch on body fat patterning and central appetite regulation
    Po Wah So
    Biological Imaging Centre, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    PLoS ONE 2:e1309. 2007
    ..This study was performed to investigate the impact of resistant starch (RS) on adipose tissue deposition and central regulation of appetite in mice...
  9. ncbi request reprint Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    Anthony P Goldstone
    Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 75:468-75. 2002
    ..Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR)...
  10. pmc Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
    Samantha Scholtz
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Gut 63:891-902. 2014
    ..We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations...
  11. ncbi request reprint The hypothalamus, hormones, and hunger: alterations in human obesity and illness
    Anthony P Goldstone
    Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London W12 0NN, UK
    Prog Brain Res 153:57-73. 2006
    ..Functional neuroimaging studies, using PET and fMRI, will also allow us to tease apart the hormonal and brain pathways responsible for controlling human appetite, and their defects in obesity...
  12. doi request reprint Ghrelin in obesity and endocrine diseases
    Miski Scerif
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Mol Cell Endocrinol 340:15-25. 2011
    ..Altered ghrelin levels have also been observed in Cushing's syndrome and thyroid disease probably due to the secondary insulin resistance in these subjects...
  13. ncbi request reprint Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification
    Sanjeev R Mehta
    Division of Medicine, St Mary s Hospital, Imperial College Healthcare NHS Trust, London, UK
    Hepatol Res 40:399-406. 2010
    ..There is a tendency of higher ultrasound grades to correlate with higher degrees of fatty infiltration, although some overlap exists. Our findings are still consistent with ultrasound being useful as a low cost screening tool...
  14. ncbi request reprint Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 58:743-55. 2003
    ..Prader-Willi syndrome (PWS) is a genetic obesity syndrome, with GH deficiency a feature independent of obesity. Reduced GH secretion may result from decreased hypothalamic release of GH-releasing hormone (GHRH)...
  15. ncbi request reprint Prader-Willi syndrome: advances in genetics, pathophysiology and treatment
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Trends Endocrinol Metab 15:12-20. 2004
    ..This could have benefits for a wide spectrum of endocrine, paediatric and neuropsychiatric diseases...
  16. ncbi request reprint Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects
    Anthony P Goldstone
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, 1105 AZ Amsterdam ZO, The Netherlands
    J Clin Endocrinol Metab 87:927-37. 2002
    ..The implications for pharmacological treatment of human obesity are discussed...
  17. ncbi request reprint Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    J Clin Endocrinol Metab 90:2681-90. 2005
    ....
  18. ncbi request reprint Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome
    Tricia M M Tan
    Department of Endocrinology, Royal Free and University College Hospital Medical School, Royal Free Hospital, Hampstead, London NW3 2QG, United Kingdom
    J Clin Endocrinol Metab 89:4162-5. 2004
    ..Somatostatin analogues may therefore not be an effective therapy for obesity in PWS. Larger chronic studies with long-acting somatostatin analogues will be needed to determine their benefits and risks in treating PWS obesity...
  19. ncbi request reprint Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:1718-26. 2004
    ..The hyperghrelinemia in PWS adults is therefore not solely explained by their reduced visceral adiposity and relative hypoinsulinemia. Its cause and consequences await further elucidation...
  20. ncbi request reprint Neurocognitive findings in Prader-Willi syndrome and early-onset morbid obesity
    Jennifer Miller
    Department of Pediatrics and the Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida 32610 0296, USA
    J Pediatr 149:192-8. 2006
    ..To examine whether early-onset morbid obesity is associated with cognitive impairment, neuropathologic changes, and behavioral problems...
  21. pmc Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome
    Jennifer L Miller
    Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida, USA
    J Neurol Neurosurg Psychiatry 78:615-9. 2007
    ..We hypothesised that the abnormal appetite in PWS results from aberrant reward processing of food stimuli in these neural pathways...
  22. ncbi request reprint Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity
    Jennifer L Miller
    Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida 32610 0296, USA
    Am J Med Genet A 146:570-7. 2008
    ....