Ian F Godsland

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men
    I F Godsland
    Endocrinology and Metabolic Medicine, Imperial College School of Medicine, London, United Kingdom W2 1PG
    J Clin Endocrinol Metab 86:719-23. 2001
  2. ncbi request reprint Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000
    I F Godsland
    Endocrinology and Metabolic Medicine, Division of Medicine, Imperial College School of Medicine, London, United Kingdom
    Fertil Steril 75:898-915. 2001
  3. ncbi request reprint Maximizing the success rate of minimal model insulin sensitivity measurement in humans: the importance of basal glucose levels
    I F Godsland
    The Wynn Department of Metabolic Medicine, Division of Medicine, Imperial College School of Medicine St Mary s Campus, Norfolk Place, London W2 1PG, U K
    Clin Sci (Lond) 101:1-9. 2001
  4. ncbi request reprint Biology: risk factor modification by OCs and HRT lipids and lipoproteins
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Imperial College of Science, Technology and Medicine, St Mary s Hospital, Praed St, London W2 1NY, UK
    Maturitas 47:299-303. 2004
  5. ncbi request reprint Early metabolic defects following gestational diabetes in three ethnic groups of anti-GAD antibodies negative women with normal fasting glucose
    Eleni Kousta
    Section of Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine, St Mary s Hospital, Norfolk Place, London W2 1PG, UK
    Hormones (Athens) 6:138-47. 2007
  6. doi request reprint Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study
    Robert S Elkeles
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, London, UK
    Eur Heart J 29:2244-51. 2008
  7. doi request reprint Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in nonalcoholic fatty liver disease
    Sanjeev R Mehta
    Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
    J Clin Endocrinol Metab 97:2151-9. 2012
  8. doi request reprint Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up
    Wann J Loh
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Campus, Mint Wing, Praed Street, London, UK
    Cancer Causes Control 21:709-18. 2010
  9. ncbi request reprint Co-associations between insulin sensitivity and measures of liver function, subclinical inflammation, and hematology
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, W2 1NY London, UK
    Metabolism 57:1190-7. 2008
  10. pmc Adiposity measurements by BMI, skinfolds and dual energy X-ray absorptiometry in relation to risk markers for cardiovascular disease and diabetes in adult males
    Ahmad A Hariri
    Division of Diabetes, Endocrinology and Metabolic Medicine, Department of Medicine, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Dis Markers 35:753-64. 2013

Detail Information

Publications34

  1. ncbi request reprint Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men
    I F Godsland
    Endocrinology and Metabolic Medicine, Imperial College School of Medicine, London, United Kingdom W2 1PG
    J Clin Endocrinol Metab 86:719-23. 2001
    ..These measures were, nevertheless, highly intercorrelated. These findings strengthen the possibility that in healthy humans, homocysteine metabolism is not substantially affected by insulin action...
  2. ncbi request reprint Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000
    I F Godsland
    Endocrinology and Metabolic Medicine, Division of Medicine, Imperial College School of Medicine, London, United Kingdom
    Fertil Steril 75:898-915. 2001
    ..To establish reference estimates of the effects of different hormone replacement therapy (HRT) regimens on lipid and lipoprotein levels...
  3. ncbi request reprint Maximizing the success rate of minimal model insulin sensitivity measurement in humans: the importance of basal glucose levels
    I F Godsland
    The Wynn Department of Metabolic Medicine, Division of Medicine, Imperial College School of Medicine St Mary s Campus, Norfolk Place, London W2 1PG, U K
    Clin Sci (Lond) 101:1-9. 2001
    ....
  4. ncbi request reprint Biology: risk factor modification by OCs and HRT lipids and lipoproteins
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Imperial College of Science, Technology and Medicine, St Mary s Hospital, Praed St, London W2 1NY, UK
    Maturitas 47:299-303. 2004
    ..Accumulating evidence suggests that the clinical implications of steroid induced changes in the lipoprotein profile will need to be evaluated independently of population-based evidence...
  5. ncbi request reprint Early metabolic defects following gestational diabetes in three ethnic groups of anti-GAD antibodies negative women with normal fasting glucose
    Eleni Kousta
    Section of Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine, St Mary s Hospital, Norfolk Place, London W2 1PG, UK
    Hormones (Athens) 6:138-47. 2007
    ..To characterise early metabolic abnormalities and the impact of ethnicity following gestational diabetes mellitus (GDM)...
  6. doi request reprint Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study
    Robert S Elkeles
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, London, UK
    Eur Heart J 29:2244-51. 2008
    ..The PREDICT Study is a prospective cohort study designed to evaluate coronary artery calcification score (CACS) as a predictor of cardiovascular events in type 2 diabetes (T2DM)...
  7. doi request reprint Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in nonalcoholic fatty liver disease
    Sanjeev R Mehta
    Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
    J Clin Endocrinol Metab 97:2151-9. 2012
    ..Insulin is pivotal in regulating hepatic lipid synthesis, metabolism, and export...
  8. doi request reprint Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up
    Wann J Loh
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Campus, Mint Wing, Praed Street, London, UK
    Cancer Causes Control 21:709-18. 2010
    ..We evaluated whether insulinemia, indices of insulin resistance or a validated insulin resistance-related biomarker cluster, could predict cancer mortality independently of subclinical inflammation...
  9. ncbi request reprint Co-associations between insulin sensitivity and measures of liver function, subclinical inflammation, and hematology
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, W2 1NY London, UK
    Metabolism 57:1190-7. 2008
    ..In contrast, both GGT activity and uric acid concentrations correlated with insulin sensitivity and co-associated with insulin resistance-related risk factors and are therefore components of a true risk factor cluster...
  10. pmc Adiposity measurements by BMI, skinfolds and dual energy X-ray absorptiometry in relation to risk markers for cardiovascular disease and diabetes in adult males
    Ahmad A Hariri
    Division of Diabetes, Endocrinology and Metabolic Medicine, Department of Medicine, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Dis Markers 35:753-64. 2013
    ..Choice of adiposity measure may be important in the evaluation of relationships between adiposity and risk markers for cardiovascular disease and diabetes...
  11. doi request reprint Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism
    Nik Manassiev
    Goodrest Croft Surgery, Yardley Wood, London, UK
    Clin Endocrinol (Oxf) 78:297-302. 2013
    ..To determine the effects of tibolone or oestradiol (E(2) )/norethisterone acetate (NETA) hormone replacement therapy on glucose and insulin metabolism in postmenopausal women...
  12. pmc Ethnic variation in the activity of lipid desaturases and their relationships with cardiovascular risk factors in control women and an at-risk group with previous gestational diabetes mellitus: a cross-sectional study
    Robert G Gray
    Diabetes Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, St Mary s Campus, Room G1, Norfolk Place, London W2 1PG, UK
    Lipids Health Dis 12:25. 2013
    ..There are marked ethnic differences in risks of CHD and T2DM but little is known about ethnic differences in desaturase activities...
  13. pmc Cardiovascular outcomes in patients with locally advanced and metastatic prostate cancer treated with luteinising-hormone-releasing-hormone agonists or transdermal oestrogen: the randomised, phase 2 MRC PATCH trial (PR09)
    Ruth E Langley
    MRC Clinical Trials Unit, London, UK
    Lancet Oncol 14:306-16. 2013
    ..Use of parenteral oestrogen could avoid the long-term complications associated with LHRHa and the thromboembolic complications associated with oral oestrogen...
  14. ncbi request reprint The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects
    Klelia D Salpea
    Department of Medicine, Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Royal Free and University College Medical School, 5 University Street, London, WC1E 6JF, UK
    Nutr Metab Cardiovasc Dis 19:140-5. 2009
    ..The WNT5B gene has been reported to confer susceptibility to type 2 diabetes (T2D) in the Japanese population, and we therefore evaluated this in Caucasian subjects with respect to obesity status...
  15. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  16. pmc Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans
    Sophie V Eastwood
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 8:e75085. 2013
    ..Risk factors include visceral (VAT) and subcutaneous abdominal (SAT) adipose tissue, which vary with ethnicity and are difficult to quantify using anthropometry...
  17. ncbi request reprint Less than 50% of variation in HDL cholesterol between and within individuals, is explained by established predictors
    James A R Jeffs
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital, Mint Wing 2nd Floor, London W2 1NY, UK
    Atherosclerosis 184:178-87. 2006
    ..The majority of variation in HDL-C remains to be explained by influences other than the conventional variables: triglyceride and LDL cholesterol concentrations, insulin resistance, smoking and alcohol...
  18. ncbi request reprint Evaluation of nonlinear regression approaches to estimation of insulin sensitivity by the minimal model with reference to Bayesian hierarchical analysis
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, Mint Wing 2nd Floor, London W2 1PG, UK
    Am J Physiol Endocrinol Metab 291:E167-74. 2006
    ..S(I)(NLR) compared favorably with S(I)(BH) in the proportion of variance explained in known correlates of insulin sensitivity...
  19. doi request reprint A systematic evaluation of the insulin resistance syndrome as an independent risk factor for cardiovascular disease mortality and derivation of a clinical index
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London W2 1NY, London, UK
    Metabolism 60:1442-8. 2011
    ..The IRS is an independent risk factor for CVD mortality; and an effective, clinically usable index can be derived from readily measured variables...
  20. ncbi request reprint Rate of change and instability in body mass index, insulin resistance, and lipid metabolism as predictors of atherosclerotic vascular disease
    Annette Christen
    Endocrinology and Metabolic Medicine, Division of Medicine, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, London W2 1NY, United Kingdom
    J Clin Endocrinol Metab 92:3780-7. 2007
    ..By definition, levels of metabolic risk factors predict atherosclerotic vascular disease, but the effects of long-term adverse change and instability remain underresearched...
  21. ncbi request reprint Insulin resistance and beta-cell dysfunction in normoglycaemic European women with a history of gestational diabetes
    Eleni Kousta
    Section of Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine, St Mary s Hospital, London, UK
    Clin Endocrinol (Oxf) 59:289-97. 2003
    ..Women with previous gestational diabetes (GDM) are at increased risk of subsequent type 2 diabetes. To characterize early metabolic abnormalities associated with this increased risk, we studied normoglycaemic women with a history of GDM...
  22. ncbi request reprint Procoagulant activities of plasma factor VIIc and factor Xc are positively and independently associated with concentrations of the high-density lipoprotein apolipoprotein, apo A-II
    Maria Atta
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Campus, Mint Wing, Praed Street, London W2 1PG, UK
    Thromb Haemost 100:391-6. 2008
    ..The independent and positive associations of apoA-II with FVIIc and FXc suggest a prothrombotic involvement for this apolipoprotein...
  23. ncbi request reprint Mechanisms of disease: lessons from ethnicity in the role of triglyceride metabolism in ischemic heart disease
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, London, UK
    Nat Clin Pract Endocrinol Metab 3:530-8. 2007
    ..These considerations re-endorse the potential importance of triglyceride metabolism in IHD and present opportunities for identifying useful areas in which drug targets for reducing IHD risk can be sought...
  24. pmc Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK
    Diabetes Care 36:383-93. 2013
    ..To determine the extent of, and reasons for, ethnic differences in type 2 diabetes incidence in the U.K...
  25. ncbi request reprint The minimal model: an evolving methodology
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, London W2 1NY, UK
    Clin Sci (Lond) 105:531-2. 2003
    ..This comment describes the study by Agbaje and colleagues in this issue of Clinical Science that exemplifies a new phase in the evolution of minimal model practice...
  26. ncbi request reprint Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  27. doi request reprint Lipoprotein separation in a novel iodixanol density gradient, for composition, density, and phenotype analysis
    Michael S Yee
    Section of Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital, London W2 1NY, United Kingdom
    J Lipid Res 49:1364-71. 2008
    ....
  28. ncbi request reprint The progress of coronary heart disease in Type 2 diabetes as measured by coronary calcium score from electron beam computed tomography (EBCT): the PREDICT study
    Robert S Elkeles
    Unit for Metabolic Medicine, St Mary s Hospital and Imperial College London, Praed Street, London W2 1NY, United Kingdom
    Atherosclerosis 197:777-83. 2008
    ....
  29. pmc Early hormonal data from a multicentre phase II trial using transdermal oestrogen patches as first-line hormonal therapy in patients with locally advanced or metastatic prostate cancer
    Ruth E Langley
    Endocrinology and Metabolic Medicine, Imperial College, London, UK
    BJU Int 102:442-5. 2008
    ..To assess the hormonal effects of Fem7 (Merck, KGaA, Darmstadt, Germany) 100 microg transdermal oestrogen patches on men undergoing first-line androgen-deprivation therapy for prostate cancer...
  30. pmc Type 2 diabetes is associated with reduced ATP-binding cassette transporter A1 gene expression, protein and function
    Dipesh C Patel
    Division of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 6:e22142. 2011
    ....
  31. pmc Insulin resistance and hyperinsulinaemia in the development and progression of cancer
    Ian F Godsland
    Endocrinology and Metabolic Medicine, Imperial College London, Praed Street, London W2 1PG, U K
    Clin Sci (Lond) 118:315-32. 2010
    ....
  32. ncbi request reprint Inflammation markers and erythrocyte sedimentation rate but not metabolic syndrome factor score predict coronary heart disease in high socioeconomic class males: the HDDRISC study
    Ian F Godsland
    Faculty of Medicine, Endocrinology and Metabolic Medicine, Imperial College London, London, UK
    Int J Cardiol 97:543-50. 2004
    ..To evaluate prediction of coronary heart disease (CHD) by quantitative measures of the metabolic syndrome and inflammation in a cohort of high socio-economic status males...
  33. ncbi request reprint Gender differences in the relationship between leptin, insulin resistance and the autonomic nervous system
    Daniel E Flanagan
    Department of Endocrinology, Derriford Hospital, Plymouth, UK
    Regul Pept 140:37-42. 2007
    ..9 years were studied. Insulin sensitivity was assessed using the IVGTT and minimal model with simultaneous measures of leptin. Cardiac autonomic activity was assessed using spectral analysis of heart rate variability...
  34. ncbi request reprint Impaired insulin secretion after prenatal exposure to the Dutch famine
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, The
    Diabetes Care 29:1897-901. 2006
    ..We aimed to determine whether this association is mediated through alterations in insulin secretion, insulin sensitivity, or a combination of both...