Affiliation: Imperial College
- Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactionsA J Godkin
Nuffield Department of Medicine, Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 166:6720-7. 2001..Recognition of these allele-transcending patterns in the PFRs may prove useful in epitope identification and vaccine design...
- Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patientsA Godkin
Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
Eur J Immunol 31:1438-46. 2001..The frequency and phenotype of memory cells is likely to reflect the magnitude of the initial immune response, and suggests that a high frequency of IFN-gamma-secreting CD4+ T cells to multiple epitopes are important in clearance of HCV...
- Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplantA Godkin
Department of Medicine A, Imperial College of Science, Technology and Medicine, St Mary s Hospital, Paddington, London, UK
J Viral Hepat 12:604-8. 2005..From the above observations, it is plausible that the introduction of foreign viral antigen into the thymus may lead to subsequent acquired central tolerance...
- Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selectionA J Godkin
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 161:850-8. 1998..Thus, the use of complete eluted peptide sequence data offers a powerful approach to the prediction of HLA-DQ and -DR peptide ligands and T cell epitopes...
- In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitopeR P Anderson
Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Nat Med 6:337-42. 2000..Discovery of this dominant epitope may allow development of antigen-specific immunotherapy for CD...