S J Fuller

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Oncogenic src, raf, and ras stimulate a hypertrophic pattern of gene expression and increase cell size in neonatal rat ventricular myocytes
    S J Fuller
    Section of Cardiac Medicine, National Heart and Lung Institute Division, Imperial College School of Medicine, London SW3 6LY, United Kingdom
    J Biol Chem 273:18146-52. 1998
  2. pmc Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf
    S J Fuller
    NHLI Division Cardiac Medicine, Imperial College School of Medicine, London SW3 6LY, UK
    Biochem J 335:241-6. 1998
  3. ncbi request reprint G alpha 13 stimulates gene expression and increases cell size in cultured neonatal rat ventricular myocytes
    S G Finn
    NHL1 Division, Imperial College School of Medicine, London, UK
    Cardiovasc Res 42:140-8. 1999
  4. pmc Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1
    A Clerk
    Division of Biomedical Sciences Molecular Pathology Section, Imperial College School of Medicine, London SW7 2AZ, United Kingdom
    Mol Cell Biol 21:1173-84. 2001
  5. pmc c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes
    S G Finn
    NHLI Division (Cardiac Medicine, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Biochem J 358:489-95. 2001
  6. pmc Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    P H Sugden
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 153:S137-53. 2008
  7. ncbi request reprint Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
    A Clerk
    National Heart and Lung Institute Division, Imperial College School of Medicine, Royal Brompton Campus, London SW3 6LY, United Kingdom
    J Biol Chem 273:7228-34. 1998
  8. ncbi request reprint Beta-adrenoceptor subtype dependence of chronotropy in mouse embryonic stem cell-derived cardiomyocytes
    N N Ali
    NHLI Division, Imperial College London, Dovehouse St, London SW3 6LY, UK
    Basic Res Cardiol 99:382-91. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Oncogenic src, raf, and ras stimulate a hypertrophic pattern of gene expression and increase cell size in neonatal rat ventricular myocytes
    S J Fuller
    Section of Cardiac Medicine, National Heart and Lung Institute Division, Imperial College School of Medicine, London SW3 6LY, United Kingdom
    J Biol Chem 273:18146-52. 1998
    ..We conclude that members of the Src family of tyrosine kinases may be important in mediating the transcriptional changes occurring during cardiac myocyte hypertrophy and that Ras and Raf may be downstream effectors...
  2. pmc Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf
    S J Fuller
    NHLI Division Cardiac Medicine, Imperial College School of Medicine, London SW3 6LY, UK
    Biochem J 335:241-6. 1998
    ..9-fold). These results suggest that Raf, Ral.GDS and PI-3-K can all transduce transcriptional responses to V12HRas, but that the specific induction of genes associated with the hypertrophic response is not mediated through PI-3-K...
  3. ncbi request reprint G alpha 13 stimulates gene expression and increases cell size in cultured neonatal rat ventricular myocytes
    S G Finn
    NHL1 Division, Imperial College School of Medicine, London, UK
    Cardiovasc Res 42:140-8. 1999
    ..The objective of this study was to determine whether constitutively-active G alpha 13 is able to induce a hypertrophic phenotype in cardiac myocytes...
  4. pmc Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1
    A Clerk
    Division of Biomedical Sciences Molecular Pathology Section, Imperial College School of Medicine, London SW7 2AZ, United Kingdom
    Mol Cell Biol 21:1173-84. 2001
    ..We conclude that activation of Rac1 by hypertrophic stimuli contributes to the hypertrophic response by modulating the ERK and/or possibly the JNK (but not the p38-MAPK) cascades...
  5. pmc c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes
    S G Finn
    NHLI Division (Cardiac Medicine, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Biochem J 358:489-95. 2001
    ..These results suggest that activation of the JNK pathway contributes to the transcriptional and morphological responses to G(q) receptor-coupled hypertrophic agonists...
  6. pmc Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    P H Sugden
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 153:S137-53. 2008
    ..We discuss whether cardiac pathologies could be treated by therapeutic intervention at the GSK3 level but conclude that any intervention would be premature without greater understanding of the precise role of GSK3 in cardiac processes...
  7. ncbi request reprint Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
    A Clerk
    National Heart and Lung Institute Division, Imperial College School of Medicine, Royal Brompton Campus, London SW3 6LY, United Kingdom
    J Biol Chem 273:7228-34. 1998
    ..These data are consistent with a role for reactive oxygen species in the activation of SR-MAPKs during ischemia/reperfusion...
  8. ncbi request reprint Beta-adrenoceptor subtype dependence of chronotropy in mouse embryonic stem cell-derived cardiomyocytes
    N N Ali
    NHLI Division, Imperial College London, Dovehouse St, London SW3 6LY, UK
    Basic Res Cardiol 99:382-91. 2004
    ..This study extends the characterisation of ESCM as a preparation for studying receptor pharmacology, and indicates that the beta1AR is the predominant subtype mediating increases in contraction rate in murine ESCM...