Stephen Franks

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom W12 0NN
    J Clin Endocrinol Metab 91:786-9. 2006
  2. doi request reprint Investigations of TGF-β signaling in preantral follicles of female mice reveal differential roles for bone morphogenetic protein 15
    Mark A Fenwick
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 154:3423-36. 2013
  3. ncbi request reprint Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro
    Ruth Roberts
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Biol Reprod 72:107-18. 2005
  4. doi request reprint Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary
    Patricia Da Silva-Buttkus
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Cell Sci 121:3890-900. 2008
  5. doi request reprint Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 93:3396-402. 2008
  6. doi request reprint Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, London, W12 0NN, United Kingdom
    J Clin Endocrinol Metab 98:3298-305. 2013
  7. ncbi request reprint Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:4418-26. 2007
  8. doi request reprint Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles
    Jocelyn M Mora
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    Biol Reprod 86:153, 1-14. 2012
  9. doi request reprint Follicle dynamics and anovulation in polycystic ovary syndrome
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Hum Reprod Update 14:367-78. 2008
  10. ncbi request reprint Prolonged survival in culture of preantral follicles from polycystic ovaries
    Lisa J Webber
    Imperial College School of Medicine, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:1975-8. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom W12 0NN
    J Clin Endocrinol Metab 91:786-9. 2006
    ..Polycystic ovary syndrome (PCOS) is a very common endocrinopathy with a heterogeneous presentation whose etiology is still uncertain. Not surprisingly, therefore, the definition of, and diagnostic criteria for, PCOS remain controversial...
  2. doi request reprint Investigations of TGF-β signaling in preantral follicles of female mice reveal differential roles for bone morphogenetic protein 15
    Mark A Fenwick
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 154:3423-36. 2013
    ..Overall results highlight differential effects of the 2 main TGF-β signaling pathways during preantral follicle growth. ..
  3. ncbi request reprint Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro
    Ruth Roberts
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Biol Reprod 72:107-18. 2005
    ..These results demonstrate that exposure to high levels of FSH during IVM can accelerate nuclear maturation and induce chromosomal abnormalities and highlights the importance of the judicious use of FSH during IVM...
  4. doi request reprint Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary
    Patricia Da Silva-Buttkus
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Cell Sci 121:3890-900. 2008
    ....
  5. doi request reprint Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 93:3396-402. 2008
    ..Polycystic ovary syndrome (PCOS) is a common endocrinopathy of uncertain etiology but with strong evidence for a genetic contribution...
  6. doi request reprint Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, London, W12 0NN, United Kingdom
    J Clin Endocrinol Metab 98:3298-305. 2013
    ..Data from experimental animals and preliminary results from studies of human ovarian tissue suggest that IGFs affect preantral follicle development...
  7. ncbi request reprint Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:4418-26. 2007
    ..We have recently found that in PCOS the proportion of primordial follicles is decreased with a reciprocal increase in the proportion of primary follicles...
  8. doi request reprint Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles
    Jocelyn M Mora
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    Biol Reprod 86:153, 1-14. 2012
    ..Lack of classic markers suggests that GCs are not epithelial. Identification of AJs during GC cuboidalization highlights the importance of AJs in regulating initiation of follicle growth...
  9. doi request reprint Follicle dynamics and anovulation in polycystic ovary syndrome
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Hum Reprod Update 14:367-78. 2008
    ..Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility and menstrual cycle abnormalities, but the factors responsible for failure to select a dominant follicle remain unclear...
  10. ncbi request reprint Prolonged survival in culture of preantral follicles from polycystic ovaries
    Lisa J Webber
    Imperial College School of Medicine, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:1975-8. 2007
    ..However, there is little evidence for a reduced reproductive life span (early menopause) in women with PCOS, suggesting that the dynamics of follicle growth, and of follicle loss by atresia, is altered in PCOS...
  11. ncbi request reprint Disordered follicle development in ovaries of prenatally androgenized ewes
    Rachel A Forsdike
    Department of Mathematics, Imperial College London, London, UK
    J Endocrinol 192:421-8. 2007
    ....
  12. ncbi request reprint Anti-müllerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 90:5536-43. 2005
    ..This ovarian phenotype is similar to that observed in mice lacking anti-müllerian hormone (AMH)...
  13. doi request reprint The investigation and management of hirsutism
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    J Fam Plann Reprod Health Care 38:182-6. 2012
    ..However, endocrine therapy to suppress androgen production and/or action is desirable in many, if not most, cases...
  14. ncbi request reprint Genetic and environmental origins of obesity relevant to reproduction
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Reprod Biomed Online 12:526-31. 2006
    ..Understanding the genetic basis of PCOS is important but improvements in diet and lifestyle are the best means of improving reproductive function...
  15. doi request reprint Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters
    Jalini Joharatnam
    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    Clin Endocrinol (Oxf) 74:714-9. 2011
    ..Our objective was to assess the importance of familial dyslipidaemia in PCOS by comparing fasting lipids between probands and their (affected and nonaffected) sisters...
  16. doi request reprint The link between polycystic ovary syndrome and both Type 1 and Type 2 diabetes mellitus: what do we know today?
    Thomas M Barber
    Institute of Reproductive and Developmental Biology, Imperial College Hammersmith Campus, London, W12 0NN, UK
    Womens Health (Lond Engl) 8:147-54. 2012
    ..Research to gain a clearer understanding of the mechanisms linking each condition should be a priority...
  17. ncbi request reprint Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment
    Anwen Gorry
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Endocrine 30:27-33. 2006
    ..Insulin-sensitizing drugs such as metformin may also have a place in treatment of PCOS...
  18. ncbi request reprint Energy substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation
    Ruth Roberts
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Biol Reprod 71:199-209. 2004
    ....
  19. doi request reprint When should an insulin sensitizing agent be used in the treatment of polycystic ovary syndrome?
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK
    Clin Endocrinol (Oxf) 74:148-51. 2011
    ..Metformin at least has an assured safety record whereas both efficacy and safety of other insulin sensitizing agents in women of reproductive age, such as thiazolidinediones and glucagon-like peptide analogues, remains to be established...
  20. doi request reprint Identification and regulation of bone morphogenetic protein antagonists associated with preantral follicle development in the ovary
    Mark A Fenwick
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 152:3515-26. 2011
    ....
  21. pmc Does PCOS have developmental origins?
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Fertil Steril 97:2-6. 2012
    ..CON--While one would not exclude altogether developmental determinants of PCOS, it is difficult to view PCOS as purely developmental or resulting only from intrauterine exposures or simply an adaptation gone astray...
  22. ncbi request reprint Development of polycystic ovary syndrome: involvement of genetic and environmental factors
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, UK
    Int J Androl 29:278-85; discussion 286-90. 2006
    ..In this review, this hypothesis is explored in the light of clinical, biochemical and genetic research...
  23. ncbi request reprint Candidate genes in women with polycystic ovary syndrome
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Fertil Steril 86:S15. 2006
    ..As yet, however, none of the potential candidate loci have withstood the scrutiny of large case-control studies, although studies of a locus close to the insulin receptor gene on chromosome 19p are emerging as promising...
  24. ncbi request reprint Genetics of ovarian disorders: polycystic ovary syndrome
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Rev Endocr Metab Disord 5:69-76. 2004
  25. ncbi request reprint Assessment and management of anovulatory infertility in polycystic ovary syndrome
    Stephen Franks
    Division of Pediatrics, Obstetrics, and Gynecology, Faculty of Medicine, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Endocrinol Metab Clin North Am 32:639-51. 2003
    ..Fertility can usually be restored by appropriate choice of induction of ovulation, but careful monitoring is required, even when using clomiphene alone...
  26. ncbi request reprint Determination of androgen bioactivity in human serum samples using a recombinant cell based in vitro bioassay
    Partha Roy
    Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 ONN, UK
    J Steroid Biochem Mol Biol 101:68-77. 2006
    ..The 96-well plate format makes the assay suitable for high throughput measurements...
  27. pmc Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome
    Fabio V Comim
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom Federal University of Santa Maria UFSM, Santa Maria, Brazil
    PLoS ONE 8:e80416. 2013
    ..These results provide evidence for a direct link between fat cell metabolism and ovarian steroidogenesis, suggesting that disruption of adiponectin and/or its receptors plays a key role in pathogenesis of hyperandrogenism in PCOS...
  28. ncbi request reprint Adult polycystic ovary syndrome begins in childhood
    Stephen Franks
    Department of Reproductive Science and Medicine, Institute of Reproductive and Developmental Biology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, W12 0NN, UK
    Best Pract Res Clin Endocrinol Metab 16:263-72. 2002
    ..The aetiology of PCOS is uncertain but there is evidence for a primary abnormality of ovarian androgen production which is manifest at puberty but may have its origins in childhood or even during fetal development...
  29. ncbi request reprint Gonadotrophin regimens and oocyte quality in women with polycystic ovaries
    Stephen Franks
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Reprod Biomed Online 6:181-4. 2003
    ..In some reports however, specific endocrine abnormalities, such as hyperinsulinaemia/insulin resistance, have been noted to be associated with reduced fertilization rates and abnormal early embryonic development...
  30. ncbi request reprint Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy
    Stephen Franks
    Reproductive Endocrinology, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Hum Reprod 23:231-2. 2008
    ....
  31. ncbi request reprint Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors
    Morten B Sorensen
    CMR Unit and Department of Cardiac Medicine, Imperial College London, Royal Brompton Hospital, London, UK
    Clin Endocrinol (Oxf) 65:655-9. 2006
    ..Endothelial function, a recognized composite marker of CVDr, may be reduced in PCOS and can be precisely and noninvasively assessed by cardiovascular magnetic resonance (CMR)...
  32. ncbi request reprint Culture environment modulates maturation and metabolism of human oocytes
    Ruth Roberts
    Department of Reproductive Science and Medicine, Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Hum Reprod 17:2950-6. 2002
    ..The clinical use of oocytes matured in vitro for IVF is increasing, but little is known about the effect of culture conditions on oocyte maturation...
  33. ncbi request reprint Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome
    Thomas M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
    Clin Endocrinol (Oxf) 66:513-7. 2007
    ..We characterized the metabolic and endocrine profiles of PCOS women who are oligomenorrhoeic but normoandrogenaemic, and compared these to other PCOS women and controls...
  34. ncbi request reprint Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study
    Saara Taponen
    Departments of Clinical Chemistry, University of Oulu and Oulu University Hospital, Oulu, Finland
    J Clin Endocrinol Metab 89:2114-8. 2004
    ....
  35. ncbi request reprint Luteal phase progesterone excretion in ovulatory women with polycystic ovaries
    Rosanne Joseph-Horne
    Department of Reproductive Science and Medicine, Imperial College Faculty of Medicine, St Mary s Hospital, Paddington, London W2 1PG, UK
    Hum Reprod 17:1459-63. 2002
    ....
  36. ncbi request reprint Polycystic ovary syndrome. Revised diagnostic criteria and long-term health consequences
    Eleni Kousta
    Ippokration Hospital, Athens, Greece, and Institute of Reprodcutive and Developmental Biology Imperial College London, UK
    Hormones (Athens) 4:133-47. 2005
    ....
  37. ncbi request reprint Three-dimensional assessment of ultrasound features in women with clomiphene citrate-resistant polycystic ovarian syndrome (PCOS): ovarian stromal volume does not correlate with biochemical indices
    Luciano G Nardo
    Department of Reproductive Medicine and Science, Imperial College, St Mary s Hospital, Mint Wing, Praed Street, London W2 1PG, UK
    Hum Reprod 17:1052-5. 2002
    ....
  38. ncbi request reprint Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study
    Saara Taponen
    Department of Clinical Chemistry, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland
    J Clin Endocrinol Metab 88:141-7. 2003
    ..These symptoms are markers of the underlying metabolic alterations possibly associated with increased health risks in later life...
  39. ncbi request reprint Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse
    Irina Neganova
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    Biol Reprod 76:1045-53. 2007
    ..Our data suggest that ovarian rather than central nervous system IRS2 signaling is important in the regulation of female reproductive function...
  40. ncbi request reprint Prevalence of polycystic ovaries in women with androgenic alopecia
    Ester Cela
    Department of Obstetrics and Gynaecology, St Mary s Hospital, London W2 1PG, Hammersmith Hospital, London W12 0NN, UK
    Eur J Endocrinol 149:439-42. 2003
    ..We examined the prevalence of ultrasound-based polycystic ovarian morphology and associated clinical and biochemical features in a large multiethnic group of women whose presenting complaint was of alopecia, and in a control group...
  41. ncbi request reprint Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels
    Thomas M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, UK
    Eur J Hum Genet 15:679-84. 2007
    ..In conclusion, these data (involving >4600 subjects) provide no evidence that common variants of the KCNJ11 E23K polymorphism have a major influence on PCOS susceptibility, though modest effect sizes (OR<1.25) cannot be excluded...
  42. doi request reprint Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition
    Thomas M Barber
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
    J Clin Endocrinol Metab 93:2859-65. 2008
    ..Insulin resistance, which associates with levels of retinol-binding protein 4 (RBP4) and adiponectin, is implicated in the development of polycystic ovary syndrome (PCOS)...
  43. doi request reprint Ghrelin levels are suppressed and show a blunted response to oral glucose in women with polycystic ovary syndrome
    Thomas M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
    Eur J Endocrinol 158:511-6. 2008
    ..Abnormal ghrelin regulation may influence the development of obesity-associated conditions including polycystic ovary syndrome (PCOS). Our aim was to compare ghrelin regulation between PCOS cases and controls...
  44. ncbi request reprint Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome
    Roger Hart
    UWA School of Women s and Infants Health, King Edward Memorial Hospital, University of Western Australia, 375 Bagot Road, WA 6008 Subiaco, Perth, Australia
    Best Pract Res Clin Obstet Gynaecol 18:671-83. 2004
    ..This revised definition provides an international framework for the clinical assessment of PCOS and for future research and collaboration...
  45. ncbi request reprint Environment, lifestyle and infertility--an inter-generational issue
    Richard M Sharpe
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Old Dalkieth Road, Edinburgh, EH16 4SB, UK
    Nat Cell Biol 4:s33-40. 2002
    ..This review summarizes the effects of season, modern lifestyles and environmental chemicals on human fertility, and discusses the implications of these effects for future generations...
  46. ncbi request reprint Metabolic syndrome in polycystic ovary syndrome
    Thomas M Barber
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University, Oxford, UK
    Endokrynol Pol 58:34-41. 2007
    ..We also review the literature on the prevalence of MS in women with PCOS and consider the impact that the particular criteria used to diagnose both MS and PCOS may have had on these estimates of prevalence...
  47. ncbi request reprint Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome
    Thomas M Barber
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 93:999-1004. 2008
    ..Obesity-related predisposition to polycystic ovary syndrome (PCOS) could reflect overall adiposity and/or regional accumulation of abdominal visceral fat...