Nicholas P Franks

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Seeing the light: protein theories of general anesthesia. 1984
    Nicholas P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College, London, United Kingdom
    Anesthesiology 101:235-7. 2004
  2. pmc Structural basis for the inhibition of firefly luciferase by a general anesthetic
    N P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London, England
    Biophys J 75:2205-11. 1998
  3. ncbi request reprint Which molecular targets are most relevant to general anaesthesia?
    N P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London, UK
    Toxicol Lett 100:1-8. 1998
  4. doi request reprint Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia
    Paul Banks
    Biophysics Section, Blackett Laboratory, Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London SW7 2AZ, United Kingdom
    Anesthesiology 112:614-22. 2010
  5. pmc GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness
    Anna Y Zecharia
    Biophysics Section, Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    J Neurosci 32:13062-75. 2012
  6. doi request reprint Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site
    Katie Harris
    Ph D Student, Masters student, Professor of Biophysics and Anaesthetics, Lecturer in Anaesthetics, Anaesthetics, Pain Medicine, and Intensive Care Section, Department of Surgery and Cancer, Biophysics Section, Imperial College London, London, United Kingdom
    Anesthesiology 119:1137-48. 2013
  7. ncbi request reprint Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 106:746-53. 2007
  8. doi request reprint Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding
    Scott P Armstrong
    Biophysics Section, Imperial College London, London, United Kingdom
    Anesthesiology 117:38-47. 2012
  9. doi request reprint The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse
    Anna Y Zecharia
    Biophysics Section, Blackett Laboratory, Imperial College, London SW7 2AZ, United Kingdom
    J Neurosci 29:2177-87. 2009
  10. pmc An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action
    Daniel S J Pang
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 106:17546-51. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Seeing the light: protein theories of general anesthesia. 1984
    Nicholas P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College, London, United Kingdom
    Anesthesiology 101:235-7. 2004
    ..The obvious mechanism suggested by our results is that general anaesthetics, despite their chemical and structural diversity, act by competing with endogenous ligands for binding to specific receptors...
  2. pmc Structural basis for the inhibition of firefly luciferase by a general anesthetic
    N P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London, England
    Biophys J 75:2205-11. 1998
    ..2-A resolution. These results provide a structural basis for understanding the anesthetic inhibition of the enzyme, as well as an explanation for the ATP modulation of its anesthetic sensitivity...
  3. ncbi request reprint Which molecular targets are most relevant to general anaesthesia?
    N P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London, UK
    Toxicol Lett 100:1-8. 1998
    ..3. The targets which currently emerge as most important belong to an anaesthetic-sensitive superfamily of genetically related fast neurotransmitter-gated receptor channels present at central synapses...
  4. doi request reprint Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia
    Paul Banks
    Biophysics Section, Blackett Laboratory, Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London SW7 2AZ, United Kingdom
    Anesthesiology 112:614-22. 2010
    ..Xenon inhibits NMDA receptors by competing with glycine at the glycine-binding site. We test the hypothesis that inhibition of the NMDA receptor at the glycine site underlies xenon neuroprotection against hypoxia-ischemia...
  5. pmc GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness
    Anna Y Zecharia
    Biophysics Section, Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    J Neurosci 32:13062-75. 2012
    ..GABA(B) receptors on histaminergic neurons were dispensable for all behaviors examined. Synaptic inhibition of histaminergic cells by GABA(A) receptors, however, was essential for habituation to a novel environment...
  6. doi request reprint Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site
    Katie Harris
    Ph D Student, Masters student, Professor of Biophysics and Anaesthetics, Lecturer in Anaesthetics, Anaesthetics, Pain Medicine, and Intensive Care Section, Department of Surgery and Cancer, Biophysics Section, Imperial College London, London, United Kingdom
    Anesthesiology 119:1137-48. 2013
    ..The authors investigate the neuroprotective mechanisms of the inert gases such as xenon, argon, krypton, neon, and helium in an in vitro model of traumatic brain injury...
  7. ncbi request reprint Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain
    Daqing Ma
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 106:746-53. 2007
    ..Therefore, the current study sought to investigate xenon's putative protective properties against anesthetic-induced neuronal apoptosis...
  8. doi request reprint Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding
    Scott P Armstrong
    Biophysics Section, Imperial College London, London, United Kingdom
    Anesthesiology 117:38-47. 2012
    ..Here we identify specific amino acids important for xenon binding to the NMDA receptor, with the aim of finding silent mutations that eliminate xenon binding but leave normal receptor function intact...
  9. doi request reprint The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse
    Anna Y Zecharia
    Biophysics Section, Blackett Laboratory, Imperial College, London SW7 2AZ, United Kingdom
    J Neurosci 29:2177-87. 2009
    ..Overall, our results support the idea that GABAergic anesthetics such as propofol exert their effects, at least in part, by modulating hypothalamic sleep pathways...
  10. pmc An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action
    Daniel S J Pang
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 106:17546-51. 2009
    ..These results imply a previously unexpected role for TASK-3 channels in the cellular mechanisms underlying these behaviors and suggest that endogenous modulators of these channels may regulate theta oscillations...
  11. pmc Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection
    Robert Dickinson
    Biophysics Section, Blackett Laboratory, Imperial College London, South Kensington, London SW7 2AZ, UK
    Crit Care 14:229. 2010
    ..We summarize recent in vitro and in vivo studies on the actions of helium and the other inert gases, and discuss their potential to be used as neuroprotective agents...
  12. doi request reprint A propofol binding site on mammalian GABAA receptors identified by photolabeling
    Grace M S Yip
    1 Department of Life Sciences, Imperial College, London, UK 2
    Nat Chem Biol 9:715-20. 2013
    ..The binding site is located within the β subunit at the interface between the transmembrane domains and the extracellular domain and lies close to known determinants of anesthetic sensitivity in the transmembrane segments TM1 and TM2. ..
  13. ncbi request reprint Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis
    Isabelle Andres-Enguix
    Biophysics Section, Blackett Laboratory, and Division of Biology, Imperial College, South Kensington, London SW7 2AZ
    J Biol Chem 282:20977-90. 2007
    ..The L159A mutation in LyTASK disrupts the stereoselective response to isoflurane while having no effect on the pH sensitivity of the channel, suggesting this critical amino acid may form part of an anesthetic binding site...
  14. doi request reprint The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury
    Mark Coburn
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Crit Care Med 36:588-95. 2008
    ..The "inert" gas xenon has been shown to be an effective neuroprotectant in a variety of in vitro and in vivo models of neuronal injury. We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  15. ncbi request reprint Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel
    Damian P Bright
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 282:12038-47. 2007
    ..The acyl azide etomidate may prove to be a useful new photolabel to identify anesthetic binding sites on the GABA(A) receptor or other putative targets...
  16. doi request reprint Sleep and general anesthesia
    Nicholas P Franks
    Biophysics Section, Blackett Laboratory, Division of Cell and Molecular Biology, Imperial College, South Kensington, London, SW7 2AZ, UK
    Can J Anaesth 58:139-48. 2011
    ..In this review, we examine the evidence that anesthetic-induced loss of consciousness may be caused by actions on the neuronal pathways that produce natural sleep...
  17. pmc Molecular targets underlying general anaesthesia
    Nicholas P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College London, London SW7 2AZ
    Br J Pharmacol 147:S72-81. 2006
    ....
  18. ncbi request reprint Expansion of gas bubbles by nitrous oxide and xenon
    Rodrigo Benavides
    Biophysics Section, The Blackett Laboratory, Imperial College London, London SW7 2AZ, UK
    Anesthesiology 104:299-302. 2006
    ....
  19. doi request reprint Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?
    Catriona M Houston
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    J Neurosci 32:3887-97. 2012
    ..These issues will be important when considering drug strategies designed to target extrasynaptic GABA(A) receptors in the treatment of sleep disorders and other neurological conditions...
  20. ncbi request reprint Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study
    Geoffrey G Lockwood
    Hammersmith Hospitals Trust, London, UK
    Anesthesiology 104:458-65. 2006
    ....
  21. ncbi request reprint The TREK K2P channels and their role in general anaesthesia and neuroprotection
    Nicholas P Franks
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Trends Pharmacol Sci 25:601-8. 2004
    ....
  22. doi request reprint General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
    Nicholas P Franks
    Blackett Laboratory Biophysics Section, Imperial College, South Kensington, London, SW7 2AZ, UK
    Nat Rev Neurosci 9:370-86. 2008
    ..Recent work suggests that the thalamus and the neuronal networks that regulate its activity are the key to understanding how anaesthetics cause loss of consciousness...
  23. ncbi request reprint Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
    Ann Neurol 58:182-93. 2005
    ..If applied to humans, these data suggest that low (subanesthetic) concentrations of xenon in combination with mild hypothermia may provide a safe and effective therapy for perinatal asphyxia...
  24. ncbi request reprint The common chemical motifs within anesthetic binding sites
    Edward J Bertaccini
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 104:318-24. 2007
    ..These structures show anesthetic-protein interactions at the atomic level...
  25. ncbi request reprint Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology
    Robert Dickinson
    Blackett Laboratory, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Anesthesiology 107:756-67. 2007
    ..However, the site of action of these agents on the NMDA receptor is unknown. The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit...