Affiliation: Imperial College
- Mullineaux Sanders C, Collins J, Ruano Gallego D, Levy M, Pevsner Fischer M, Glegola Madejska I, et al. Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa. Cell Rep. 2017;21:3381-3389 pubmed publisher..These results show that expression of virulence genes is not sufficient for colonization of the colonic mucosa and that commensals are essential for a physiological infection course. ..
- Witcomb L, Czupryna J, Francis K, Frankel G, Taylor P. Non-invasive three-dimensional imaging of Escherichia coli K1 infection using diffuse light imaging tomography combined with micro-computed tomography. Methods. 2017;127:62-68 pubmed publisher..We highlight technical issues associated with imaging of infections in new born rat pups and show that the whole-body and organ bioburden correlates with disease severity. ..
- Berger C, Crepin V, Roumeliotis T, Wright J, Carson D, Pevsner Fischer M, et al. Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo. Cell Metab. 2017;26:738-752.e6 pubmed publisher..These results suggest that C. rodentium manipulates host metabolism to evade innate immune responses and establish a favorable gut ecosystem. ..
- Johnson R, Ravenhall M, Pickard D, Dougan G, Byrne A, Frankel G. Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile. Infect Immun. 2018;86: pubmed publisher..Overall, we found that S Typhi exhibits a specific response to bile, especially with regard to virulence gene expression, which could impact pathogenesis and transmission. ..