Adam E Frampton

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Expert Rev Mol Diagn 13:325-9. 2013
  2. ncbi request reprint Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Expert Rev Mol Diagn 13:425-30. 2013
  3. doi request reprint Towards a clinical use of miRNAs in pancreatic cancer biopsies
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 13:31-4. 2013
  4. ncbi request reprint Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways
    Adam E Frampton
    Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:1275-8. 2012
  5. doi request reprint Loss of miR-126 is crucial to pancreatic cancer progression
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:881-4. 2012
  6. ncbi request reprint Integrated analysis of miRNA and mRNA profiles enables target acquisition in human cancers
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:323-30. 2012
  7. ncbi request reprint MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, London, UK
    Gastroenterology 146:268-77.e18. 2014
  8. ncbi request reprint Tumor infiltration in the medial resection margin predicts survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
    Yaojun Zhang
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    J Gastrointest Surg 16:1875-82. 2012
  9. ncbi request reprint Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?
    Tamara M H Gall
    Deptartment of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 13:793-6. 2013
  10. ncbi request reprint The clinico-pathologic role of microRNAs miR-9 and miR-151-5p in breast cancer metastasis
    Jonathan Krell
    Division of Oncology, Department of Surgery and Cancer, Imperial College, London, UK
    Mol Diagn Ther 16:167-72. 2012

Collaborators

Detail Information

Publications36

  1. doi request reprint Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Expert Rev Mol Diagn 13:325-9. 2013
    ..Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. Here, the authors evaluate the published miRNA profiles of premalignant pancreatic lesions in order to consolidate these data...
  2. ncbi request reprint Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Expert Rev Mol Diagn 13:425-30. 2013
    ..In this article, we have examined the evidence for using circulating miRNAs to diagnose/prognose PDAC...
  3. doi request reprint Towards a clinical use of miRNAs in pancreatic cancer biopsies
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 13:31-4. 2013
    ..The paper under evaluation provides further evidence for the use of miRNAs as diagnostic biomarkers for PDAC. We have reviewed the use of miRNAs as diagnostic analytes for detecting PDAC in biopsies...
  4. ncbi request reprint Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways
    Adam E Frampton
    Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:1275-8. 2012
    ..Several genes involved in the PI3K/AKT and SRC signaling pathways were identified and further investigated...
  5. doi request reprint Loss of miR-126 is crucial to pancreatic cancer progression
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:881-4. 2012
    ..miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK. Replacing miR-126 in PDAC patients may be a novel strategy for preventing progression and metastasis...
  6. ncbi request reprint Integrated analysis of miRNA and mRNA profiles enables target acquisition in human cancers
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 12:323-30. 2012
    ..Many studies have now investigated the integrated analysis of miRNA:mRNA profiles in human malignancies, the goal as always being to identify novel biomarkers and therapeutic targets for each tumor...
  7. ncbi request reprint MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, London, UK
    Gastroenterology 146:268-77.e18. 2014
    ..There has not been a broad analysis of the combined effects of altered activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it is unclear how these might affect tumor progression or patient outcomes...
  8. ncbi request reprint Tumor infiltration in the medial resection margin predicts survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
    Yaojun Zhang
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    J Gastrointest Surg 16:1875-82. 2012
    ..Microscopic tumor involvement (R1) in different surgical resection margins after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) has been debated...
  9. ncbi request reprint Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?
    Tamara M H Gall
    Deptartment of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 13:793-6. 2013
    ..Therefore, this expensive assay needs further investigation before being used a prognostic marker in patients with LAPC. ..
  10. ncbi request reprint The clinico-pathologic role of microRNAs miR-9 and miR-151-5p in breast cancer metastasis
    Jonathan Krell
    Division of Oncology, Department of Surgery and Cancer, Imperial College, London, UK
    Mol Diagn Ther 16:167-72. 2012
    ..We aimed to further establish the potential roles of miR-9 and miR-151-5p in tumor invasion and metastasis and investigate their use as biomarkers...
  11. ncbi request reprint Cell-free DNA for the detection of pancreatic, liver and upper gastrointestinal cancers: has progress been made?
    Tamara M H Gall
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Future Oncol 9:1861-9. 2013
    ..However, few well-designed trials have been carried out to translate these findings effectively. In this review, we have assessed the clinical utility of cfDNA in pancreatic, liver and upper gastrointestinal malignancies...
  12. ncbi request reprint Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation
    Filipa G Pinho
    Authors Affiliations Division of Oncology, Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine ICTEM Department of Medicine and HPB Surgical Unit, Department of Surgery and Cancer, Imperial College Department of Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London and School of Medicine, University of East Anglia, Norwich, United Kingdom
    Cancer Res 73:5936-48. 2013
    ..Overall, we identify a new link between ERα, miR-515-5p, proliferation, and apoptosis in breast cancer tumorigenesis...
  13. pmc Growth Arrest-Specific Transcript 5 Associated snoRNA Levels Are Related to p53 Expression and DNA Damage in Colorectal Cancer
    Jonathan Krell
    Division of Cancer, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 9:e98561. 2014
    ..Here, we investigate the relationship between DNA damage, p53, and the GAS5 snoRNAs to gain further insight into the potential role of this locus in cell survival and oncogenesis both in vivo and in vitro...
  14. doi request reprint A microRNA meta-signature for pancreatic ductal adenocarcinoma
    Adam E Frampton
    Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 14:267-71. 2014
    ..Furthermore, they validated high miR-21, high miR-31 and low miR-375 tumoural expression as independently prognostic for poor overall-survival (OS; n = 70)...
  15. ncbi request reprint The p53 miRNA interactome and its potential role in the cancer clinic
    Jonathan Krell
    Division of Oncology, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London, W12 0NN, UK
    Epigenomics 5:417-28. 2013
    ..Improving our knowledge of the role of miRNAs in such p53 signaling networks may be crucial to achieving this. ..
  16. pmc miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts
    Loredana Pellegrino
    Division of Oncology, Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 41:5400-12. 2013
    ..In aggregate, miR-23b expression invokes a sophisticated interaction network that co-ordinates a wide range of cellular responses required to alter the cytoskeleton during cancer cell motility...
  17. pmc MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors
    Long R Jiao
    Hepato Pancreato Biliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, London, UK
    PLoS ONE 7:e32068. 2012
    ..The mechanistic consequences of miRNA dysregulation were further evaluated...
  18. doi request reprint Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer
    Tamara M H Gall
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Mol Diagn 13:141-5. 2013
    ..Plasma miR-21 was able to correctly identify CRC with 90% specificity and sensitivity. In this article, we have considered the use of miRNAs as blood-based biomarkers for CRC...
  19. doi request reprint Reactive lymphoid hyperplasia of the pancreas: a clinical conundrum
    Thalis Christophides
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, Hammersmith Hospital Campus, London, United Kingdom
    JOP 14:207-11. 2013
    ..Localized reactive lymphoid hyperplasia is a rare condition characterized by the presence of lymphoid follicles...
  20. ncbi request reprint Determination of cut-offs for circulating tumor cell measurement in metastatic cancer
    Jimmy Jacob
    Dept of Oncology, Dept of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Expert Rev Anticancer Ther 11:1345-50. 2011
    ..It also provides proof that CTCs should be investigated in ongoing interventional trials to see if better patient outcomes can be attained by altering treatment based on CTC levels...
  21. doi request reprint Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers
    Loredana Pellegrino
    Division of Oncology, Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    Expert Rev Anticancer Ther 13:21-7. 2013
    ..Reduced Dicer expression in malignant melanoma is an independent predictor of poor survival. In this review, we assess the prognostic significance of Dicer expression in different tumor types...
  22. ncbi request reprint miRNAs in breast cancer: ready for real time?
    Jonathan Krell
    Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK
    Pharmacogenomics 13:709-19. 2012
    ..This review focuses on the currently accepted roles of miRNAs in breast cancer pathogenesis, and highlights the clinical challenges and breakthroughs in this field to date...
  23. ncbi request reprint microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK
    Expert Rev Anticancer Ther 11:1837-42. 2011
    ..In addition, miR-10b may be able to guide neoadjuvant gemcitabine-based chemoradiotherapy and predict metastatic-free survival and overall survival...
  24. ncbi request reprint MicroRNAs in the cancer clinic
    Jonathan Krell
    Department of Surgery and Cancer, MRC Cyclotron Building, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 ONN, UK
    Front Biosci (Elite Ed) 5:204-13. 2013
    ..This review focuses on currently accepted roles of miRNAs in cancer pathogenesis, and highlights the challenges and breakthroughs in this field to date with relevance to the cancer clinic...
  25. doi request reprint 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors
    Yaojun Zhang
    Department of Surgery and Cancer, HPB Surgical Unit, Hammersmith Hospital Campus, Imperial College, Du Cane Road, W12 0HS London, UK
    Nucl Med Biol 39:982-5. 2012
    ..To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors...
  26. doi request reprint Loco-recurrence after resection for ductal adenocarcinoma of the pancreas: predictors and implications for adjuvant chemoradiotherapy
    Yaojun Zhang
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    J Cancer Res Clin Oncol 138:1063-71. 2012
    ..We aimed to assess predictors of loco-recurrence in order to tailor the indications for adjuvant chemoradiotherapy...
  27. doi request reprint Two-stage resection for bilobar colorectal liver metastases: R0 resection is the key
    Nicole Tsim
    Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK
    Ann Surg Oncol 18:1939-46. 2011
    ..The long-term outcomes after 2-SLR for multiple bilobar colorectal liver metastases (CLM) was examined...
  28. doi request reprint Is there a 'margin' for error in pancreatic cancer surgery?
    Adam E Frampton
    HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Future Oncol 9:31-4. 2013
    ..Similar results have been reported in other studies and this study illustrates that standardized pathological reporting of PDAC specimens may allow further investigation of factors affecting R1 patients...
  29. ncbi request reprint Retinoblastoma protein determines aggressiveness in triple-negative breast cancer
    Jimmy Jacob
    Division of Cancer, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK
    Expert Rev Anticancer Ther 12:581-4. 2012
    ..Furthermore, exploring links between RB inactivation and EMT might reveal new therapeutic targets for triple-negative breast cancer...
  30. doi request reprint Surgical techniques for improving outcomes in pancreatic ductal adenocarcinoma
    Tamara Mh Gall
    Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK
    Expert Rev Gastroenterol Hepatol 8:241-6. 2014
    ..With the increased use of these techniques we hope to see better quality of life and survival for these patients. ..
  31. doi request reprint Preoperative superselective mesenteric angiography and methylene blue injection for localization of obscure gastrointestinal bleeding
    Madhava Pai
    Hepatopancreaticobiliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Healthcare NHS Trust, Hammersmith Hospital, London, England
    JAMA Surg 148:665-8. 2013
    ....
  32. ncbi request reprint Lymph node ratio can further stratify prognosis in subpopulations of breast cancer patients with axillary nodal metastases
    Anneliese M Lawn
    Department of Breast Surgery, St Georges Hospital NHS Trust, Blackshaw Road, Tooting, London, SW17 0QT, UK
    Future Oncol 9:1425-31. 2013
    ..It was, however, able to discriminate subpopulations within pathological nodal categories. In this article we examine the use of LNR in BC...
  33. ncbi request reprint En bloc resection of the pancreatic head and second part of duodenum for a duodenal gastrointestinal stromal tumor: a multi-media report
    Adam E Frampton
    Hepato Pancreato Biliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    JOP 11:396-400. 2010
    ..In our case, a conservative surgical approach was utilised therefore avoiding a formal pancreaticoduodenectomy...
  34. pmc The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?
    Jonathan Krell
    Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    BMC Cancer 12:135. 2012
    ..The importance of TILs appears to be subtype-specific and varies depending on the histologic characteristics of the tumor. As our understanding of tumorigenesis is increasing the relevance of immunobiology will become apparent...
  35. doi request reprint An alternative pancreatic anastomosis following pancreaticoduodenectomy
    Georgia Bitsakou
    HPB Surgical Unit, Department of Surgery and Cancer, Hammersmith Hospital, Imperial College, London, England
    Arch Surg 146:752-4. 2011
    ..This longitudinal ventral pancreatic anastomosis is quick, easy to perform, and a safe alternative method for pancreatic reconstruction after pancreaticoduodenectomy...
  36. pmc Surgical treatment for liver cancer
    Nicole C Tsim
    Department of Hepatopancreatobiliary Surgery, Division of Surgery, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 0HS, UK
    World J Gastroenterol 16:927-33. 2010
    ..Survival data after resection is also reviewed, as well as indications for curative resection...