Research Topics
Genomes and GenesSpecies | Russell G FosterSummaryAffiliation: Imperial College Country: UK Publications
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Publications
In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolutionJames Bellingham
Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, UK
BMC Genomics 4:3. 2003..Exceptions to this are RGR-opsin and melanopsin, whose genes have very different intron insertion positions. The gene structure of another opsin, peropsin (retinal pigment epithelium-derived rhodopsin homologue, RRH) is unknown...
The rhythm of rest and excessRussell G Foster
Department of Visual Neuroscience, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Nat Rev Neurosci 6:407-14. 2005..Our occupation of the night is having unanticipated costs for both our physical and mental health, which, if continued, might condemn whole sectors of our society to a dismal future...- Teleost multiple tissue (tmt) opsin: a candidate photopigment regulating the peripheral clocks of zebrafish?Paraskevi Moutsaki
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
Brain Res Mol Brain Res 112:135-45. 2003..Collectively the data suggest that tmt-opsin is a strong candidate for the photic regulation of zebrafish peripheral clocks... - Zebrafish melanopsin: isolation, tissue localisation and phylogenetic positionJames Bellingham
Department of Integrative and Molecular Neuroscience, Imperial College Faculty of Medicine, Charing Cross Hospital, London, UK
Brain Res Mol Brain Res 107:128-36. 2002..They might represent a separate branch of photopigment evolution in the vertebrates or they may have a non-direct photosensory function, perhaps as a photoisomerase, in non-rod, non-cone light detection... - Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunitAlun R Barnard
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, London, UK
Vis Neurosci 21:675-83. 2004..Thus, it seems that non-rod non-cone photoreceptors can drive many, but not all, non-image-forming light responses... - Neuropsin (Opn5): a novel opsin identified in mammalian neural tissueEmma E Tarttelin
Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
FEBS Lett 554:410-6. 2003..Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord... - Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?James Bellingham
Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, United Kingdom
J Exp Zool B Mol Dev Evol 297:1-10. 2003.... - Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epitheliumStuart N Peirson
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Brain Res Mol Brain Res 123:132-5. 2004..Our results raise questions about the presumed function of melanopsin, and highlight the need for biochemical studies on this protein... - Melanopsin: another way of signaling lightStuart Peirson
Division of Neuroscience and Mental Health, Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom
Neuron 49:331-9. 2006..This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead... - Expression of opsin genes early in ocular development of humans and miceEmma E Tarttelin
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
Exp Eye Res 76:393-6. 2003..Human non-rod, non-cone opsins are also all expressed early, by 8.6 weeks post-conception. The implications of these observations are discussed with regard to the possible functions of these opsins at early stages of ocular development... - Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) miceMa ayan Semo
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Eur J Neurosci 17:1793-801. 2003..These findings, together with recent studies on melanopsin knockout mice, are consistent with the hypothesis that melanopsin-expressing ganglion cells are photosensitive and mediate a range of irradiance-detection tasks... - Opsins and mammalian photoentrainmentJames Bellingham
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK
Cell Tissue Res 309:57-71. 2002.... - Light-evoked FOS induction within the suprachiasmatic nuclei (SCN) of melanopsin knockout (Opn4-/-) mice: a developmental studyDaniela Lupi
Department of Visual Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, UK
Chronobiol Int 23:167-79. 2006..These results are related to the broader context of recent findings and the potential role(s) of a neonatal photoreceptor... - Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retinaFarhan H Zaidi
Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
Curr Biol 17:2122-8. 2007.... - The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: a case reportKatharina Wulff
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
Chronobiol Int 23:485-95. 2006..These circadian abnormalities may reinforce the altered sleep patterns and the problems of cognitive function and social engagement associated with schizophrenic... - Melanopsin (Opn4) positive cells in the cat retina are randomly distributed across the ganglion cell layerMa ayan Semo
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
Vis Neurosci 22:111-6. 2005..Melanopsin containing cells showed no clear center-to-periphery gradient in their distribution and were comprised of a relatively uniform cellular population... - Long-term constant light induces constitutive elevated expression of mPER2 protein in the murine SCN: a molecular basis for Aschoff's rule?Marta Muñoz
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College, Charing Cross Hospital, London, UK
J Biol Rhythms 20:3-14. 2005.... - Seeing the light...in a new wayRussell G Foster
Department of Visual Neuroscience, Imperial College Faculty of Medicine, London, UK
J Neuroendocrinol 16:179-80. 2004..These receptors may even help modulate our mood and sense of well-being... - Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) miceMa ayan Semo
Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Eur J Neurosci 18:3007-17. 2003..Collectively, our data suggest that melanopsin RGCs form a heterogeneous population of neurons, and that most of the light-induced c-fos expression within these cells is associated with the endogenous photosensitivity of these neurons... - Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neuronsSumathi Sekaran
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital, London, United Kingdom
Curr Biol 13:1290-8. 2003..CONCLUSIONS: Collectively, our data reveal a heterogeneous syncytium of intrinsically photosensitive neurons in the GCL coupled to a secondary population of light-driven cells, in the absence of rod and cone inputs... - Keeping an eye on the time: the Cogan LectureRussell G Foster
Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imperial College of Science, Engineering, and Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom
Invest Ophthalmol Vis Sci 43:1286-98. 2002 - Non-rod, non-cone photoreception in the vertebratesRussell G Foster
Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
Prog Retin Eye Res 21:507-27. 2002..We also hope to convince the more casual reader that there is much more to vertebrate photoreceptors than the study of retinal rods and cones... - Non-rod, non-cone photoreception in rodents and teleost fishRussell G Foster
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Novartis Found Symp 253:3-23; discussion 23-30, 52-5, 102-9. 2003..We compare non-rod, non-cone ocular photoreceptors in mammals and fish, and examine the criteria used to place candidate photopigment molecules into a functional context... - Inner retinal photoreceptors (IRPs) in mammals and teleost fishRussell G Foster
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, Charing Cross Hospital, Fulham Palace Road, London, UK W6 8RF
Photochem Photobiol Sci 3:617-27. 2004..The discovery of IRPs in the vertebrates tells us that despite 150 years of research, we still have much to learn about how the eye processes light... 
Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by lightStewart Thompson
Howard Hughes Medical Institute, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242, USA
Eur J Neurosci 27:1973-9. 2008..Together the evidence demonstrates a pronounced and sustained classical photoreceptor input to irradiance detection for negative masking, and suggests one role of classical photoreceptor input is to constrain dynamic range...- Microarray analysis and functional genomics identify novel components of melanopsin signalingStuart N Peirson
Circadian and Visual Neuroscience Group, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Curr Biol 17:1363-72. 2007..Here, we use a microarray-based approach, which we term transcriptional recalibration, coupled with functional genomics to identify downstream targets of melanopsin signaling... - Isolation and characterization of melanopsin (Opn4) from the Australian marsupial Sminthopsis crassicaudata (fat-tailed dunnart)Susana S Pires
Circadian and Visual Neuroscience, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Proc Biol Sci 274:2791-9. 2007..This approach reveals that the two marsupials show a higher sequence identity than that seen between rodents and primates, despite separating at approximately the same point in time, some 65-85 Myr ago... - Melanopsin: an exciting photopigmentMark W Hankins
Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Trends Neurosci 31:27-36. 2008..Here we outline the discovery of this remarkable new photoreceptor system, review the structure of melanopsin and conclude with a working model of melanopsin phototransduction... - Neurobiology: bright blue timesRussell G Foster
Imperial Coll, London, UK
Nature 433:698-9. 2005 - Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cellsSimon N Archer
School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
Eur J Neurosci 19:2923-30. 2004..We hypothesize that the unique metabolic needs of photoreceptors justify this trade-off... - The effects of rod and cone loss on the photic regulation of locomotor activity and heart rateStewart Thompson
Nuffield Laboratory of Ophthalmology, The John Radcliffe Hospital, Headley Way, University of Oxford, Roosevelt Drive, Oxford OX3 9DU, UK
Eur J Neurosci 28:724-9. 2008..Surprisingly, this irradiance detection response is dependent upon rod and cone photoreceptors, with no apparent contribution from melanopsin pRGCs... - Placing ocular mutants into a functional context: a chronobiological approachUrs Albrecht
Division of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musee 5, Switzerland
Methods 28:465-77. 2002..Such measurements have, and continue to provide, a remarkably powerful assay of how light is detected and transduced to regulate circadian rhythms. The methods used for such measurements in mice are described in the following article... - VA opsin, melanopsin, and an inherent light response within retinal interneuronsAaron Jenkins
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom
Curr Biol 13:1269-78. 2003..Our data suggest that this light information is, at least in part, derived from a population of intrinsically photosensitive VA opsin and/or melanopsin horizontal cells... - A green cone-like pigment in the 'blind' mole-rat Spalax ehrenbergi: functional expression and photochemical characterizationJannie W H Janssen
Department of Biochemistry UMC-160, Nijmegen Center for Molecular Lift, Sciences, University of Nijmegen Medical School, PO Box 9101, Nijmegen, The Netherlands
Photochem Photobiol Sci 2:1287-91. 2003..Finally, the slow part of the photocascade deviates in some aspects from that of sighted mammals. The possible relevance of these findings for the evolutionary adaptation of Spalax to a subterranean ecotope is discussed... - Circadian visionRussell G Foster
Department of Ophthalmology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Curr Biol 17:R746-51. 2007 - 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivoSumathi Sekaran
Circadian and Visual Neuroscience Group, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
J Neurosci 27:3981-6. 2007..Collectively, our data further elucidate the phototransduction pathway in the photosensitive RGCs and demonstrate that 2-APB can be used to silence activity in these cells both in vitro and in vivo... - Light, photoreceptors, and circadian clocksRussell G Foster
Division of Circadian and Visual Neuroscience, University of Oxford, UK
Methods Mol Biol 362:3-28. 2007..The aims of this chapter are to provide an accessible introduction to photobiological methods and explain why these approaches need to be applied to the study of circadian systems... - Visual pigments and oil droplets in diurnal lizards: a comparative study of Caribbean anolesEllis R Loew
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
J Exp Biol 205:927-38. 2002..These findings suggest that anoline visual pigments, as far as they determine visual system spectral sensitivity, are not necessarily adapted to the photic environment or to the color of significant visual targets (e.g. dewlaps)...