Liliane Fossati-Jimack

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice
    Liliane Fossati-Jimack
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mol Immunol 45:787-95. 2008
  2. pmc Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice
    Liliane Fossati-Jimack
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London, UK
    Arthritis Rheum 58:2131-41. 2008
  3. ncbi request reprint C1q deficiency and autoimmunity: the effects of genetic background on disease expression
    Daniel A Mitchell
    Rheumatology Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK W12 0NN
    J Immunol 168:2538-43. 2002
  4. pmc Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice
    Marten Trendelenburg
    Rheumatology Section, Eric Bywaters Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Immunology 113:80-8. 2004
  5. pmc Identification and characterization of a lupus suppressor 129 locus on chromosome 3
    Francesco Carlucci
    Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 184:6256-65. 2010
  6. pmc C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens
    Lucie Baudino
    Department of Medicine, Division of Immunology and Inflammation, Centre for Complement and Inflammation Research and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 111:1503-8. 2014
  7. ncbi request reprint Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice
    Francesco Carlucci
    Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 178:2352-60. 2007
  8. ncbi request reprint Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis
    Peter J Norsworthy
    Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    J Immunol 172:3406-14. 2004
  9. pmc Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells
    Liliane Fossati-Jimack
    Centre for Complement and Inflammation Research, Division of Immunology and Inflammation, Department of Medicine, Imperial College, London, United Kingdom
    PLoS ONE 8:e57082. 2013
  10. ncbi request reprint The role of complement in cryoglobulin-induced immune complex glomerulonephritis
    Marten Trendelenburg
    Rheumatology Section, Imperial College, London, UK
    J Immunol 175:6909-14. 2005

Collaborators

Detail Information

Publications29

  1. pmc C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice
    Liliane Fossati-Jimack
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mol Immunol 45:787-95. 2008
    ..However, the lack of C1q led to an increased production of Tg IgM and IgG3 antibodies only in VH3H9R mice indicating that additional genetic susceptibility factors are required to break self-tolerance...
  2. pmc Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice
    Liliane Fossati-Jimack
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London, UK
    Arthritis Rheum 58:2131-41. 2008
    ..The aim of the present study was to elucidate the mechanisms by which this locus contributes to the loss of peripheral tolerance...
  3. ncbi request reprint C1q deficiency and autoimmunity: the effects of genetic background on disease expression
    Daniel A Mitchell
    Rheumatology Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK W12 0NN
    J Immunol 168:2538-43. 2002
    ..The work also highlights the potential value of the C1q-deficient MRL/Mp(+/+) strain as a tool with which to dissect further the underlying mechanisms of the autoimmune syndrome associated with C1q deficiency...
  4. pmc Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice
    Marten Trendelenburg
    Rheumatology Section, Eric Bywaters Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Immunology 113:80-8. 2004
    ..These data show that C1q deficiency causes splenic monocytosis together with accelerated T-cell activation in an autoimmune-prone mouse strain...
  5. pmc Identification and characterization of a lupus suppressor 129 locus on chromosome 3
    Francesco Carlucci
    Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 184:6256-65. 2010
    ..Further characterization of this locus will help to uncover the immune mechanism(s) conferring protection against lupus...
  6. pmc C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens
    Lucie Baudino
    Department of Medicine, Division of Immunology and Inflammation, Centre for Complement and Inflammation Research and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 111:1503-8. 2014
    ..These data indicate that activated C3 may act as a "chaperone" in the intracellular processing of an apoptotic cargo and, thus, may modulate the T-cell response to self-antigens displayed on dying cells. ..
  7. ncbi request reprint Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice
    Francesco Carlucci
    Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 178:2352-60. 2007
    ..These findings have important implication for the interpretation of the autoimmune phenotype associated with gene-targeted models...
  8. ncbi request reprint Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis
    Peter J Norsworthy
    Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    J Immunol 172:3406-14. 2004
    ..However, our results suggest that it may contribute to the in vivo clearance of dying cells...
  9. pmc Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells
    Liliane Fossati-Jimack
    Centre for Complement and Inflammation Research, Division of Immunology and Inflammation, Department of Medicine, Imperial College, London, United Kingdom
    PLoS ONE 8:e57082. 2013
    ..The association between 77H and susceptibility to systemic lupus erythematosus most likely relates to impaired waste disposal, a key component of lupus pathogenesis...
  10. ncbi request reprint The role of complement in cryoglobulin-induced immune complex glomerulonephritis
    Marten Trendelenburg
    Rheumatology Section, Imperial College, London, UK
    J Immunol 175:6909-14. 2005
    ..Thus, blocking C5 is a potential therapeutic strategy for preventing renal injury in cryoglobulinemia...
  11. ncbi request reprint Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice
    Josefina Cortes-Hernandez
    Rheumatology Section, Eric Bywaters Centre, Faculty of Medicine, Imperial College, London, UK
    Eur J Immunol 34:3713-22. 2004
    ..These results provide supporting evidence that BMT may be a therapeutic option in the treatment of autoimmunity associated with human C1q deficiency...
  12. pmc Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages
    Guang Sheng Ling
    Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nat Commun 5:3039. 2014
    ..Thus, by modulating the trafficking and signalling functions of TLR4 in a cell-type-specific manner CD11b fine tunes the balance between adaptive and innate immune responses initiated by LPS...
  13. pmc Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia
    Myles J Lewis
    Imperial College London, London, UK
    Arthritis Rheum 64:2707-18. 2012
    ..The aim of this study was to explore the hypothesis that lupus autoimmunity modulates the effect of hypercholesterolemia in driving arterial pathologic development...
  14. doi request reprint Mice with defective Fas ligand are protected from crescentic glomerulonephritis
    Ruth M Tarzi
    Renal Section, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK
    Kidney Int 81:170-8. 2012
    ..Thus, Fas ligand-defective mice are protected from nephrotoxic nephritis, a disease in which both circulating and intrinsic renal cells appear to have a role...
  15. pmc IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut
    Susanne Sattler
    Department of Medicine, Division of Immunology and Inflammation, Imperial College, London, UK
    J Autoimmun 50:107-22. 2014
    ..Our findings indicate an essential protective role, hence therapeutic potential, of Breg(IL-33) against mucosal inflammatory disorders in the gut. ..
  16. ncbi request reprint Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease
    Michelle E K Haywood
    Rheumatology Section, Eric Bywaters Centre, Faculty of Medicine, Imperial College, London, UK
    J Immunol 173:4277-85. 2004
    ..Yaa.BXSB-Bxs1/4. Disease in the Bxs3 mice was delayed in comparison to the BXSB parental strain, emphasizing the necessity for multiple interactions in the production of the full BXSB phenotype...
  17. ncbi request reprint Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus
    Hirofumi Amano
    University of Geneva, Geneva, Switzerland
    Arthritis Rheum 52:2790-8. 2005
    ..The present study was designed to define the cellular mechanism responsible for the development of monocytosis and to characterize the effect of the Yaa mutation on the development of monocyte subsets...
  18. pmc Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody
    Samareh Azeredo da Silveira
    Department of Pathology, University of Geneva, 1211 Geneva 4, Switzerland
    J Exp Med 195:665-72. 2002
    ....
  19. ncbi request reprint Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor
    Aki Kuroki
    Department of Pathology, Faculty of Medicine, University of Geneva, Switzerland
    Blood 99:2922-8. 2002
    ....
  20. ncbi request reprint A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia
    Shuichi Kikuchi
    Department of Pathology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    J Immunol 169:4644-50. 2002
    ....
  21. ncbi request reprint Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus
    Frédéric Lajaunias
    Department of Pathology, University of Geneva, Geneva, Switzerland
    Arthritis Rheum 48:1612-21. 2003
    ..In this study, we investigated how the expression of CD22 ligand (CD22L) is modulated following lymphocyte activation or during the course of systemic lupus erythematosus (SLE)...
  22. ncbi request reprint Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production
    Aki Kuroki
    Department of Pathology, CMU, Geneva, Switzerland
    Eur J Immunol 34:1077-84. 2004
    ....
  23. ncbi request reprint IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
    Lucie Baudino
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Blood 109:5355-62. 2007
    ..Our data demonstrate a remarkably high pathogenic potential of polymeric forms of IgM and IgA anti-RBC autoantibodies due to their ability to induce hemagglutination but completely independent of complement activation...
  24. ncbi request reprint Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis
    Shuichi Kikuchi
    Department of Pathology and Immunology, Centre Medical Universitaire, Geneva, Switzerland
    J Immunol 174:1111-7. 2005
    ..This locus had no apparent individual effect, but most likely modulated disease severity through interaction with NZB-derived susceptibility loci...
  25. ncbi request reprint Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus
    Shuichi Kikuchi
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Immunol 176:3240-7. 2006
    ....
  26. pmc Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis
    Lucie Baudino
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 181:2846-54. 2008
    ..Our data indicate that the genetic origin of serum gp70 is more heterogeneous than previously thought, and that distinct retroviral gp70s are differentially regulated in physiological vs inflammatory conditions...
  27. ncbi request reprint Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells
    Ruth M Tarzi
    Division of Medicine and Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Kidney Int 62:2087-96. 2002
    ..FcRgamma-/- mice were protected from renal inflammation following the induction of accelerated nephrotoxic nephritis using sheep anti-mouse glomerular basement membrane anti-serum in mice sensitized to sheep IgG...
  28. ncbi request reprint Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses
    Liliane Fossati-Jimack
    Department of Pathology, University of Geneva, Switzerland
    J Autoimmun 18:17-25. 2002
    ....
  29. pmc Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice
    Shuichi Kikuchi
    Department of Pathology and Immunology, C M U, 1211 Geneva 4, Switzerland
    Blood 106:1323-9. 2005
    ..Finally, our analysis of BC mice also demonstrated the presence of a B6-derived H2-linked locus on chromosome 17 that apparently regulated the production of Coombs antibodies as a result of its overall autoimmune promoting effect...