Alastair Forbes

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Differential immunohistochemical expression of syndecan-1 and tumor necrosis factor alpha in colonic mucosa of patients with Crohn's disease
    Mariabeatrice Principi
    Gastroenterology Unit, Ospedali Riuniti, Foggia, Italy
    Immunopharmacol Immunotoxicol 28:185-95. 2006
  2. ncbi request reprint Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial
    Alastair Forbes
    St Mark s Hospital, Watford Road, Harrow HA1 3UJ, United Kingdom
    World J Gastroenterol 11:4040-4. 2005
  3. ncbi request reprint Investigation of diarrhoea in adults
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Imperial College of Science, Technology and Medicine, Harrow, Middlesex
    Clin Med 2:410-4. 2002
  4. ncbi request reprint Crohn's disease: the cold chain hypothesis
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Watford Road, Harrow, HA1 3UJ, UK
    Int J Colorectal Dis 21:399-401. 2006
  5. ncbi request reprint Achieving and maintaining venous access for home parenteral nutrition
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Harrow, UK
    Curr Opin Clin Nutr Metab Care 8:285-9. 2005
  6. ncbi request reprint Parenteral nutrition
    Alastair Forbes
    St Mark s Hospital, Harrow, UK
    Curr Opin Gastroenterol 21:192-6. 2005
  7. ncbi request reprint Regulation of epithelial syndecan-1 expression by inflammatory cytokines
    Richard M Day
    IBD Research Group, St Mark s Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Cytokine 21:224-33. 2003
  8. ncbi request reprint Alternative immunomodulators
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Harrow, UK
    Eur J Gastroenterol Hepatol 15:245-8. 2003
  9. ncbi request reprint Microscopic colitis: the tip of the iceberg?
    Paul A Kitchen
    Northwick Park and St Mark s Hospitals, Harrow, UK
    Eur J Gastroenterol Hepatol 14:1199-204. 2002
  10. ncbi request reprint Safe and efficacious prolonged use of an olive oil-based lipid emulsion (ClinOleic) in chronic intestinal failure
    Siwan Thomas-Gibson
    St Mark s Hospital, Watford Road, Harrow HA1 3UJ, UK
    Clin Nutr 23:697-703. 2004

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Differential immunohistochemical expression of syndecan-1 and tumor necrosis factor alpha in colonic mucosa of patients with Crohn's disease
    Mariabeatrice Principi
    Gastroenterology Unit, Ospedali Riuniti, Foggia, Italy
    Immunopharmacol Immunotoxicol 28:185-95. 2006
    ..However, the expression of the two molecules is inversely related when a single field is considered, these data supporting the possibility of a downregulation exerted by TNFalpha...
  2. ncbi request reprint Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial
    Alastair Forbes
    St Mark s Hospital, Watford Road, Harrow HA1 3UJ, United Kingdom
    World J Gastroenterol 11:4040-4. 2005
    ..Irritable bowel syndrome (IBS) is a common disorder and many patients fail to find adequate relief from conventional therapies for their symptoms. This study tests the claim that acupuncture is effective for a majority of these patients...
  3. ncbi request reprint Investigation of diarrhoea in adults
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Imperial College of Science, Technology and Medicine, Harrow, Middlesex
    Clin Med 2:410-4. 2002
  4. ncbi request reprint Crohn's disease: the cold chain hypothesis
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Watford Road, Harrow, HA1 3UJ, UK
    Int J Colorectal Dis 21:399-401. 2006
    ..3, 10.9 and 15.0 years for Crohn's disease, UC and controls, respectively). This support for the hypothesis reached statistical significance for those with Crohn's disease compared to the controls (p=0.045)...
  5. ncbi request reprint Achieving and maintaining venous access for home parenteral nutrition
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Harrow, UK
    Curr Opin Clin Nutr Metab Care 8:285-9. 2005
    ..Means to preserve venous access are therefore crucial...
  6. ncbi request reprint Parenteral nutrition
    Alastair Forbes
    St Mark s Hospital, Harrow, UK
    Curr Opin Gastroenterol 21:192-6. 2005
    ....
  7. ncbi request reprint Regulation of epithelial syndecan-1 expression by inflammatory cytokines
    Richard M Day
    IBD Research Group, St Mark s Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Cytokine 21:224-33. 2003
    ..TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression and may account in part for the reduced expression of syndecan-1 seen in IBD...
  8. ncbi request reprint Alternative immunomodulators
    Alastair Forbes
    St Mark s Hospital and Academic Institute, Harrow, UK
    Eur J Gastroenterol Hepatol 15:245-8. 2003
    ..The biological agents, however, bring a more novel and potentially powerful approach. Natalizumab, and targeted mucosal delivery of interleukin-10 already show considerable promise...
  9. ncbi request reprint Microscopic colitis: the tip of the iceberg?
    Paul A Kitchen
    Northwick Park and St Mark s Hospitals, Harrow, UK
    Eur J Gastroenterol Hepatol 14:1199-204. 2002
    ..The aims were to determine whether a wide variation exists between hospitals in the diagnosis of microscopic colitis and to assimilate clinical data...
  10. ncbi request reprint Safe and efficacious prolonged use of an olive oil-based lipid emulsion (ClinOleic) in chronic intestinal failure
    Siwan Thomas-Gibson
    St Mark s Hospital, Watford Road, Harrow HA1 3UJ, UK
    Clin Nutr 23:697-703. 2004
    ..This study evaluated the efficacy and safety of ClinOleic in adults already receiving parenteral nutrition, comparing it to their usual lipid (soybean-oil-based)...
  11. ncbi request reprint Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
    Lancet 365:1794-6. 2005
    ....
  12. ncbi request reprint Association of DLG5 R30Q variant with inflammatory bowel disease
    Mark J Daly
    The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
    Eur J Hum Genet 13:835-9. 2005
    ..This study provides support for the hypothesis that DLG5 constitutes a true IBD risk factor of modest effect...
  13. ncbi request reprint Parenteral nutrition
    Alastair Forbes
    Department of Gastroenterology and Clinical Nutrition, University College Hospital, London, UK
    Curr Opin Gastroenterol 23:183-6. 2007
    ..The past 12 months have seen advances in the safe use of intravenous nutrition and its place in the therapeutic armamentarium...
  14. pmc IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
    Mark Tremelling
    IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    Gastroenterology 132:1657-64. 2007
    ..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
  15. ncbi request reprint Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease
    David A van Heel
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Inflamm Bowel Dis 12:598-605. 2006
    ..Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and developed a rapid diagnostic assay...
  16. ncbi request reprint Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population
    Alexandra V Pearce
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Int J Colorectal Dis 22:419-24. 2007
    ....
  17. ncbi request reprint Genetic variation in myosin IXB is associated with ulcerative colitis
    Adriaan A van Bodegraven
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Gastroenterology 131:1768-74. 2006
    ..These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease...
  18. ncbi request reprint Plasma citrulline concentration: a reliable marker of small bowel absorptive capacity independent of intestinal inflammation
    Cinzia Papadia
    Department of Gastroenterology, University College Hospital, London, United Kingdom
    Am J Gastroenterol 102:1474-82. 2007
    ..The aim of this study was to address the potentially confounding impact of intestinal inflammation...
  19. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  20. ncbi request reprint Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease
    Clive M Onnie
    Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Eur J Gastroenterol Hepatol 20:37-45. 2008
    ..We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD...
  21. doi request reprint Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up
    Loris Pironi
    Department of Clinical Medicine, University of Bologna, Italy
    Gastroenterology 135:61-71. 2008
    ..The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated the appropriateness of these indications...
  22. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  23. ncbi request reprint A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Gastroenterology 132:1665-71. 2007
    ..We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis...
  24. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  25. ncbi request reprint Combined evidence from three large British Association studies rejects TUCAN/CARD8 as an IBD susceptibility gene
    Sheila A Fisher
    Gastroenterology 132:2078-80. 2007
  26. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  27. doi request reprint Idiopathic sclerosing peritonitis
    Yashwant Koak
    Department of General Surgery, Basildon Hospital, Nethermayes, Basildon, London, UK
    Eur J Gastroenterol Hepatol 20:148-50. 2008
    ..The patient continues to have chronic intestinal failure, managed conservatively by long-term parenteral nutrition and steroids for more than 12 years...
  28. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  29. ncbi request reprint Recruiting first-degree relatives for prevention research: a comparison of clinician and proband-led methods of contact in Crohn's disease
    Erin P Reid
    Department of Psychology, Health Psychology Section, Institute of Psychiatry, King s College London, London, UK
    Eur J Hum Genet 14:1263-8. 2006
    ..High levels of interest in research across the two recruitment methods suggest that although proband-led methods may maximise privacy, they may deny relatives the opportunity to take part in research that would be of interest...
  30. ncbi request reprint Candidates for intestinal transplantation: a multicenter survey in Europe
    Loris Pironi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Am J Gastroenterol 101:1633-43; quiz 1679. 2006
    ..Patient candidacy and physician attitudes toward ITx were investigated among centers that participated in previous European surveys on home parenteral nutrition (HPN)...
  31. ncbi request reprint Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6
    Sheila A Fisher
    Division of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, UK
    Eur J Hum Genet 10:259-65. 2002
    ..The existence of sex-specific linkage is further evidence of the complex mechanisms involved in IBD and will facilitate future studies to identify susceptibility genes...
  32. ncbi request reprint Pharmacogenomics of response to anti-tumor necrosis factor therapy in patients with Crohn's disease
    Ajeya Shetty
    St Mark s Hospital and Academic Institute, Harrow, England
    Am J Pharmacogenomics 2:215-21. 2002
    ..This is a rapidly changing field, and more information of greater direct clinical benefit can be expected soon...
  33. ncbi request reprint Review article: Immunosuppressants in distal ulcerative colitis
    G Falasco
    Department of Gastroenterology, St Mark s Hospital, Watford Road, Harrow, HA1 3UJ, UK
    Aliment Pharmacol Ther 16:181-7. 2002
    ..Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease...
  34. ncbi request reprint Potential therapeutic role for cytokine or adhesion molecule manipulation in Crohn's disease: in the shadow of infliximab?
    Alan Shand
    St Mark s Hospital, Watford Road, Harrow, HA1 3UJ, UK
    Int J Colorectal Dis 18:1-11. 2003
    ..These agents have considerable potential which, in combination with new delivery systems (perhaps taking into account some form of genetic engineering), hold great promise...
  35. pmc Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    Muddassar M Mirza
    Division of Medical and Molecular Genetics, Guy s, King s, and Thomas s School of Medicine, King s College London, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 72:1018-22. 2003
    ..0019). These findings suggest that genetic variants at the 5q31 (IBD5) locus may hasten the onset of Crohn disease and cooperate with CARD15 in disease causation...
  36. ncbi request reprint Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis
    Matthew Rutter
    Department of Gastroenterology, University Hospital of North Tees, Stockton on Tees, Teesside, England
    Gastroenterology 126:451-9. 2004
    ..Patients with ulcerative colitis are at increased risk of colorectal cancer. It is widely believed that this is secondary to colonic inflammation. However, the severity of colonic inflammation has never been shown to be a risk factor...
  37. ncbi request reprint Use of fecal lactoferrin to diagnose irritable pouch syndrome: a word of caution
    Matthew Warren Johnson
    Gastroenterology 127:1647-8; author reply 1648. 2004
  38. ncbi request reprint Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor
    Paul A Kitchen
    St Mark s Hospital, Imperial College London, Harrow, United Kingdom
    JPEN J Parenter Enteral Nutr 29:248-54. 2005
    ..We report studies aimed to determine whether there may be synergistic effects of these 2 peptides...
  39. ncbi request reprint Infliximab use in Crohn's disease: impact on health care resources in the UK
    Derek P Jewell
    Gastroenterology Unit, University of Oxford, Sheffield, UK
    Eur J Gastroenterol Hepatol 17:1047-52. 2005
    ..To quantify the impact of infliximab therapy on health care resource utilization in the UK...
  40. ncbi request reprint Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15
    Kathy King
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Hum Mutat 27:44-54. 2006
    ..The strategy developed here may have general application to the assessment of mutation pathogenicity and genetic models in other complex disorders...
  41. ncbi request reprint Parenteral nutrition
    Alastair Forbes
    Department of Gastroenterology and Clinical Nutrition, University College Hospital, London, UK
    Curr Opin Gastroenterol 22:160-4. 2006
    ..During the past 12 months there have been clinically important advances in intravenous nutrition and adjunctive therapies...
  42. ncbi request reprint Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study
    Clive M Onnie
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, UK
    Inflamm Bowel Dis 12:263-71. 2006
    ....
  43. ncbi request reprint Intangible costs and benefits of ulcerative colitis surveillance: a patient survey
    Matthew D Rutter
    University Hospital of North Tees, Stockton on Tees, Cleveland, United Kingdom
    Dis Colon Rectum 49:1177-83. 2006
    ..Colonoscopic surveillance in ulcerative colitis has costs and benefits beyond cancer prevention, which might influence program efficacy. This study assesses the more intangible aspects of surveillance...
  44. ncbi request reprint Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?
    Dimitrios Polymeros
    University College London, London, United Kindgom
    Gastroenterology 131:85-96. 2006
    ..Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD...
  45. ncbi request reprint Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    Hum Mutat 27:778-85. 2006
    ....
  46. ncbi request reprint The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    Andrew P Cuthbert
    Division of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, England, United Kingdom
    Gastroenterology 122:867-74. 2002
    ....