Research Topics
| N M FiskSummaryAffiliation: Imperial College Country: UK Publications
| Collaborators
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Detail Information
Publications
Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needlingN M Fisk
Department of Maternal and Fetal Medicine, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
Anesthesiology 95:828-35. 2001....- Fetal hypothalamic-pituitary-adrenal stress responses to invasive procedures are independent of maternal responsesR Gitau
Department of Maternal Medicine, Division of Paediatrics, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, Hammersmith Campus, London W12 0NN, United Kingdom
J Clin Endocrinol Metab 86:104-9. 2001..4 + 5.08x, r = 0.51; n = 16; P = 0.04; CI for slope, 0.16-10.0), consistent with the maturation of the fetal pituitary before the fetal adrenal... 
Transfusional fetal complications after single intrauterine death in monochorionic multiple pregnancy are reduced but not prevented by vascular occlusionK O'Donoghue
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, London, UK
BJOG 116:804-12. 2009..To document co-twin death/pregnancy loss and brain injury after single intrauterine death (sIUD) in monochorionic pregnancies...- Doppler detection of arterio-arterial anastomoses in monochorionic twins: feasibility and clinical applicationM J Taylor
Centre for Fetal Care, Department of Materno Fetal Medicine, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK
Hum Reprod 15:1632-6. 2000..6). We conclude that AAA can be detected in vivo with high sensitivity and specificity without undue prolongation of scanning times and have a role in risk stratification in the antenatal assessment of MC twins... - Umbilical cortisol levels as an indicator of the fetal stress response to assisted vaginal deliveryR Gitau
Department of Maternal and Fetal Medicine, Fetal and Neonatal Stress Research Centre, Imperial College School of Medicine, London, UK
Eur J Obstet Gynecol Reprod Biol 98:14-7. 2001..While it is well established that delivery by elective caesarean section is less stressful for the fetus than normal vaginal delivery, little attention has been paid to the effect on the baby of an assisted delivery... - Pain and stress in the human fetusR P Smith
Department of Maternal and Fetal Medicine, Centre for Fetal Care, Institute of Obstetrics and Gynaecology, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, Goldhawk Rd, W6 0XG, London, UK
Eur J Obstet Gynecol Reprod Biol 92:161-5. 2000..During open fetal surgery, maternal general anaesthesia provides fetal anaesthesia. However, in closed procedures, fetal analgesia presents difficulties. The optimal drug, dose, and route of administration remain to be determined... 
Effect of antenatal administration of thyrotrophin releasing hormone on fetal flow velocity waveformsR Bajoria
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Queen Charlotte s and Chelsea Hospital, London
Arch Dis Child Fetal Neonatal Ed 77:F127-30. 1997....- Transfer and metabolism of thyrotropin releasing hormone across the perfused human term placentaR Bajoria
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
J Clin Endocrinol Metab 81:3476-82. 1996..These results suggest that human placenta acts as an enzymatic barrier to the free passage of TRH... - Freehand three-dimensional Doppler demonstration of monochorionic vascular anastomoses in vivo: a preliminary reportA W Welsh
Department of Maternal and Fetal Medicine, Queen Charlotte s and Chelsea Hospital, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London UK
Ultrasound Obstet Gynecol 18:317-24. 2001..To demonstrate the three-dimensional vascular anatomy of monochorionic placental anastomoses in vivo, both arterioarterial and arteriovenous... - Development of three-dimensional power Doppler ultrasound imaging of fetoplacental vasculatureA W Welsh
Department of Maternal and Fetal Medicine, Queen Charlotte s and Chelsea Hospital, Institute of Reproductive and Developmental Biology, London, UK
Ultrasound Med Biol 27:1161-70. 2001..Fully freehand 3-D US does have a role in off-line reconstruction of vascular anatomy, although variability in the z plane precludes its use for volumetric measurement. (E-mail: a.welsh@ic.ac.uk).. - Quantitative digital analysis of regional placental perfusion using power Doppler in placental abruptionA W Welsh
Centre for Fetal Care, Institute of Osbtetrics and Gynecology, Department of Maternal and Fetal Medicine, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, London, UK a
Ultrasound Obstet Gynecol 17:203-8. 2001..To apply digital imaging techniques to the quantification of placental vascularity using power Doppler... - Liposomal thyroxine: a noninvasive model for transplacental fetal therapyR Bajoria
Academic Department of Obstetrics and Gynecology, Charring Cross and Westminster Medical School, London, United Kingdom
J Clin Endocrinol Metab 82:3271-7. 1997..7 +/- 0.8%; P < 0.001). Our data suggest that anionic liposomes increase transplacental transfer of T4. If confirmed in vivo, liposomes may provide an alternative noninvasive method of drug delivery to the fetus... - Intrauterine rescue transfusion in monochorionic multiple pregnancies with recent single intrauterine deathS Tanawattanacharoen
Centre for Fetal Care, Department of Maternal and Fetal Medicine, Imperial College School of Medicine, Queen Charlotte's and Chelsea Hospital, Du Cane Road, Hammersmith Hospital, London W12 0NN, UK
Prenat Diagn 21:274-8. 2001..Until its role becomes clearer, we recommend that its use be restricted to situations in which the parents and the local jurisdiction allow late termination as an option if brain injury subsequently manifests on ultrasound... - In utero therapy for lower urinary tract obstructionS K Agarwal
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, London, UK
Prenat Diagn 21:970-6. 2001..It also discusses the limited data against which the efficacy of the various options can be assessed. The current state of fetal intervention is detailed in the present review... - Transport and metabolism of thyrotrophin-releasing hormone across the fetal membraneR Bajoria
Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
J Clin Endocrinol Metab 82:3399-407. 1997..26 +/- 1.50%; P < 0.05). These results suggest that the human fetal membrane acts as an enzymatic barrier to the bidirectional transfer of TRH from 24 weeks gestation... - Caesarean section: every woman's right to choose?S Paterson-Brown
Institute of Obstetrics and Gynaecology, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, London, UK
Curr Opin Obstet Gynecol 9:351-5. 1997.... - Interstitial laser: a new surgical technique for twin reversed arterial perfusion sequence in early pregnancyM Jolly
Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, UK
BJOG 108:1098-102. 2001..Both pregnancies continued uneventfully and each resulted in the birth of a healthy baby at term... - Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrowC Campagnoli
Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, United Kingdom
Blood 98:2396-402. 2001..MSCs similar to those derived from adult bone marrow, fetal liver, and fetal bone marrow circulate in first-trimester human blood and may provide novel targets for in utero cellular and gene therapy... - Effects of fetal intravenous glucose challenge in normal and growth retarded fetusesU Nicolini
Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London, United Kingdom
Horm Metab Res 22:426-30. 1990..79) (P less than 0.02). These results support the concept of a low energy state in IUGR. Fetal glucose supplementation in IUGR is unlikely to be of benefit and may even exacerbate underlying acidosis... - Fetal telemedicine: interactive transfer of realtime ultrasound and video via ISDN for remote consultationN M Fisk
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, London, UK
J Telemed Telecare 1:38-44. 1995..If confirmed, the success of this technology has implications for future referral practice in fetal medicine... - Re: Intra-amniotic Doppler measurement of blood flow in placental vascular anastomoses in twin-twin transfusion syndromeM J O Taylor
Ultrasound Obstet Gynecol 24:479; author reply 479-81. 2004 - Pseudo-arterio-arterial anastomoses in twin-twin transfusion syndromeM J O Taylor
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital and Institute of Reproductive and Developmental Biology, Imperial College, London, UK
Placenta 25:742-7; discussion 748-52. 2004..We applied a computer model of chorionic vessels to determine a configuration that reproduced this phenomenon... - Characterisation of deep arterio-venous anastomoses within monochorionic placentae by vascular castingL Y Wee
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, United Kingdom
Placenta 26:19-24. 2005.... - Increased latency of absent end-diastolic flow in the umbilical artery of monochorionic twin fetusesT M Vanderheyden
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, and Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
Ultrasound Obstet Gynecol 26:44-9. 2005..To determine if absent end-diastolic flow (AEDF) in the umbilical artery (UA) has a longer latency in monochorionic (MC) twin fetuses compared to singleton or dichorionic twin (DC) fetuses... - High perinatal survival in monoamniotic twins managed by prophylactic sulindac, intensive ultrasound surveillance, and Cesarean delivery at 32 weeks' gestationL Pasquini
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, London, UK
Ultrasound Obstet Gynecol 28:681-7. 2006.... - Longitudinal blood flow in shared (arteriovenous anastomoses) and non-shared cotyledons in monochorionic placentaeL Y Wee
Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
Placenta 28:516-22. 2007..In this study we aimed to quantitate monochorionic twin placental blood flow in vivo through arterio-venous anastomoses (AVA) and corresponding vessels within normal cotyledons... - Stage I twin-twin transfusion syndrome: rates of progression and regression in relation to outcomeK O'Donoghue
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, London, UK
Ultrasound Obstet Gynecol 30:958-64. 2007..We investigated rates of progression and regression in Stage I TTTS and determined factors influencing the course of the disease... - The placenta contributes to activation of the renin angiotensin system in twin-twin transfusion syndromeP Galea
Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
Placenta 29:734-42. 2008..Given the markedly different phenotypes in the genetically identical fetuses with TTTS, we suggest that the source of RAS components may influence their clinical manifestations... - Management of other complications specific to monochorionic twin pregnanciesL Pasquini
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital, Du Cane Road, Hammaersmith, W12 0HS London, UK
Best Pract Res Clin Obstet Gynaecol 18:577-99. 2004..Recent strategies to reduce the high perinatal mortality due to cord entanglement in antenatally diagnosed monoamniotic twins including medical amnioreduction and elective caesarean delivery at 32 weeks, are also discussed... - Derivation of rate of arterio-arterial anastomotic transfusion between monochorionic twin fetuses by Doppler waveform analysisM L Denbow
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
Placenta 25:664-70. 2004..Although AA net flows are modest, chronic unbalanced counterflow of this magnitude in the absence of compensatory superficial anastomoses could lead to significant haemodynamic compromise... - Occlusion of arterio-arterial anastomosis manifesting as acute twin-twin transfusion syndromeT Y T Tan
Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, UK
Placenta 25:238-42. 2004..This case report shows that the unmasking of unbalanced AVA configurations by occlusion of a protective AAA can manifest as TTTS... - Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnanciesA A Karatza
Department of Maternal-Fetal Medicine, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK
Heart 88:271-7. 2002..The high prevalence of congenital heart disease in monochorionic diamniotic twins merits detailed fetal echocardiography... - Test amnioinfusion to determine suitability for serial therapeutic amnioinfusion in midtrimester premature rupture of membranesL-K Tan
Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, and Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
Fetal Diagn Ther 18:183-9. 2003..However, even successful serial amnioinfusion remains associated with procedure-related complications (i.e. chorioamnionitis, placental abruption) which themselves may predispose to preterm delivery... - Reducing the incidence of twins and tripletsR C Wimalasundera
Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Du Cane Road, Hammersmith, London W12 0HS, UK
Best Pract Res Clin Obstet Gynaecol 17:309-29. 2003..New developments in blastocyst culture, single embryo transfer, embryo cryopreservation and pre-implantation aneuploidy exclusion, should allow improvements in pregnancy rates without increasing multiple pregnancies... - Ultrasound-guided umbilical cord occlusion using bipolar diathermy for Stage III/IV twin-twin transfusion syndromeM J O Taylor
Centre for Fetal Care, Department of Maternal and Fetal Medicine, Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, Du Cane Road, London W12 0HS, UK
Prenat Diagn 22:70-6. 2002..To evaluate bipolar diathermy as a technique for selective fetocide in the treatment of advanced (Stage III/IV) twin-twin transfusion syndrome (TTTS)... - Transmitted arterio-arterial anastomosis waveforms causing cyclically intermittent absent/reversed end-diastolic umbilical artery flow in monochorionic twinsL Y Wee
Centre for Fetal Care, Queen Charlotte s and Chelsea Hospital and Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK
Placenta 24:772-8. 2003.... - Twin-to-twin transfusion syndrome results from dynamic asymmetrical reduction in placental anastomoses: a hypothesisN J Sebire
Centre for Fetal Care, Department of Maternal-Fetal Medicine, Imperial College School of Medicine at Queen Charlotte's, Hammersmith Hospital Site, Du Cane Road, London, UK
Placenta 22:383-91. 2001.... - Validation of the Quintero staging system for twin-twin transfusion syndromeM J O Taylor
Centre for Fetal Care, Department of Maternal and Fetal Medicine, Imperial College of Science, Technology and Medicine, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
Obstet Gynecol 100:1257-65. 2002..To validate an established staging system for twin-twin transfusion syndrome... - Amniotic fluid testosterone: relationship with cortisol and gestational ageP Sarkar
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
Clin Endocrinol (Oxf) 67:743-7. 2007..Although best investigated in foetal plasma, this is now difficult because of the decline in frequency of foetal blood sampling; in this study, we used amniotic fluid as a biomarker to investigate foetal exposure... - FastFISH: technique for ultrarapid fluorescence in situ hybridization on uncultured amniocytes yielding results within 2 h of amniocentesisM Choolani
Diagnostic Biomarker Discovery Laboratory, Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore
Mol Hum Reprod 13:355-9. 2007..FastFISH allows results to be released on the same day as amniocentesis. It represents the necessary development for a 1-day prenatal diagnosis service... - Maternal anxiety at amniocentesis and plasma cortisolP Sarkar
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, UK
Prenat Diagn 26:505-9. 2006..To assess whether anticipation of amniocentesis is linked with maternal anxiety, and whether this anxiety is associated with increased maternal plasma cortisol... - Histomorphometric characterisation of shared and non-shared cotyledonary villus territories of monochorionic placentae in relation to pregnancy complicationsL Y Wee
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
Placenta 27:475-82. 2006.... - Fetal plasma testosterone correlates positively with cortisolR Gitau
Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK
Arch Dis Child Fetal Neonatal Ed 90:F166-9. 2005..CONCLUSION: Unlike the norm in the adult, where testosterone production is often inhibited by cortisol, in the fetus there is a positive link between the two... - Variable umbilical artery end-diastolic frequency is associated with arterio-arterial anastomosisL Y Wee
Ultrasound Obstet Gynecol 21:626. 2003 - Human fetal and maternal corticotrophin releasing hormone responses to acute stressR Gitau
Fetal and Neonatal Stress Research Group, Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London W12 0NN, UK
Arch Dis Child Fetal Neonatal Ed 89:F29-32. 2004..However, it did not result in measurable CRH release into fetal plasma. This suggests that fetal plasma CRH is not derived from the hypophyseal-portal circulation, but from another source, presumably the placenta... - Standardization of power Doppler quantification of blood flow in the human fetus using the aorta and inferior vena cavaA W Welsh
Department of Obstetrics, Royal Prince Alfred Hospital, Camperdown, Australia
Ultrasound Obstet Gynecol 26:33-43. 2005..This study aimed to test the applicability to the fetus of mathematical techniques developed to standardize power Doppler indices of adult regional perfusion...