Sarah Fidler

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters
    Astrid Gall
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Retrovirology 10:8. 2013
  2. ncbi request reprint Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort
    Sarah Fidler
    Imperial College, St Mary s Hospital, London, UK
    AIDS 21:1283-91. 2007
  3. ncbi request reprint Comparative potency of three antiretroviral therapy regimes in primary HIV infection
    Sarah Fidler
    Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
    AIDS 20:247-52. 2006
  4. doi request reprint Primary HIV infection: to treat or not to treat?
    Sarah Fidler
    Department of GUM and HIV, Division of Medicine, Imperial College, UK
    Curr Opin Infect Dis 21:4-10. 2008
  5. doi request reprint Sexual and reproductive health in a UK cohort of young adults perinatally infected with HIV
    Adam P Croucher
    Jefferiss Wing, St Mary s Hospital, Imperial College Healthcare NHS Trust, London, UK
    Sex Transm Infect 89:392-4. 2013
  6. doi request reprint Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection
    Elizabeth Hamlyn
    Imperial College, London, UK
    AIDS 26:887-90. 2012
  7. pmc Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infection
    J Fox
    Department of Genitourinary Medicine and Infectious Disease, Division of Medicine, Wright Fleming Institute, Imperial College London, London, UK
    Clin Exp Immunol 152:532-7. 2008
  8. ncbi request reprint Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection
    Sarah Fidler
    Wright Fleming Institute, Department of GUM and Communicable Diseases, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    AIDS 16:2049-54. 2002
  9. ncbi request reprint HIV-1-specific CD4+ responses in primary HIV-1 infection predict disease progression
    John Frater
    aNuffield Department of Clinical Medicine, John Radcliffe Hospital bPeter Medawar Building for Pathogen Research cInstitute for Emerging Infections, The Oxford Martin School dOxford National Institute of Health Research Biomedical Research Centre, Oxford eMedical Research Council Clinical Trials Unit fMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK gMwanza Intervention Trials Unit, Mwanza, Tanzania hDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK Fiona Ewings and Jacob Hurst contributed equally to the writing of this article
    AIDS 28:699-708. 2014
  10. ncbi request reprint Survival following HIV infection of a cohort followed up from seroconversion in the UK
    Fiona M Ewings
    MRC Clinical Trials Unit, London, UK
    AIDS 22:89-95. 2008

Detail Information

Publications28

  1. pmc Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters
    Astrid Gall
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Retrovirology 10:8. 2013
    ....
  2. ncbi request reprint Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort
    Sarah Fidler
    Imperial College, St Mary s Hospital, London, UK
    AIDS 21:1283-91. 2007
    ..To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change...
  3. ncbi request reprint Comparative potency of three antiretroviral therapy regimes in primary HIV infection
    Sarah Fidler
    Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
    AIDS 20:247-52. 2006
    ..To best achieve the most rapid reduction in primary viraemia we compared three different ART regimens in PHI...
  4. doi request reprint Primary HIV infection: to treat or not to treat?
    Sarah Fidler
    Department of GUM and HIV, Division of Medicine, Imperial College, UK
    Curr Opin Infect Dis 21:4-10. 2008
    ..The aim of this article is to review new data on the use of antiretroviral therapy in primary HIV infection...
  5. doi request reprint Sexual and reproductive health in a UK cohort of young adults perinatally infected with HIV
    Adam P Croucher
    Jefferiss Wing, St Mary s Hospital, Imperial College Healthcare NHS Trust, London, UK
    Sex Transm Infect 89:392-4. 2013
    ..To assess sexual health and behaviour outcomes of young adults with perinatally acquired HIV-1 (PaHIV), and audit sexual health interventions against published standards of care...
  6. doi request reprint Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection
    Elizabeth Hamlyn
    Imperial College, London, UK
    AIDS 26:887-90. 2012
    ..Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus...
  7. pmc Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infection
    J Fox
    Department of Genitourinary Medicine and Infectious Disease, Division of Medicine, Wright Fleming Institute, Imperial College London, London, UK
    Clin Exp Immunol 152:532-7. 2008
    ..Long-term (>3 years) preservation of virus-specific CD4+ cells occurred in 45% of patients receiving SCART in PHI. There was no correlation between either the presence or magnitude of these responses and clinical outcome...
  8. ncbi request reprint Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection
    Sarah Fidler
    Wright Fleming Institute, Department of GUM and Communicable Diseases, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    AIDS 16:2049-54. 2002
    ..We sought to investigate whether a short course of antiretroviral therapy (SCART) at PHI was sufficient to preserve HIV-specific cellular immunity...
  9. ncbi request reprint HIV-1-specific CD4+ responses in primary HIV-1 infection predict disease progression
    John Frater
    aNuffield Department of Clinical Medicine, John Radcliffe Hospital bPeter Medawar Building for Pathogen Research cInstitute for Emerging Infections, The Oxford Martin School dOxford National Institute of Health Research Biomedical Research Centre, Oxford eMedical Research Council Clinical Trials Unit fMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK gMwanza Intervention Trials Unit, Mwanza, Tanzania hDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK Fiona Ewings and Jacob Hurst contributed equally to the writing of this article
    AIDS 28:699-708. 2014
    ..The SPARTAC trial randomized 366 participants in primary HIV infection (PHI) to different short-course therapies. The aim of this study was to investigate how early immune responses in PHI impacted clinical progression in SPARTAC...
  10. ncbi request reprint Survival following HIV infection of a cohort followed up from seroconversion in the UK
    Fiona M Ewings
    MRC Clinical Trials Unit, London, UK
    AIDS 22:89-95. 2008
    ..To estimate changes over calendar time in survival following HIV seroconversion in the era of HAART and to provide updated survival estimates...
  11. doi request reprint Postexposure prophylaxis, preexposure prophylaxis or universal test and treat: the strategic use of antiretroviral drugs to prevent HIV acquisition and transmission
    Jonathan Weber
    Faculty of Medicine, Imperial College London, St Mary s Hospital, London, UK
    AIDS 24:S27-39. 2010
    ..Specifically, we consider the evidences for and against targeting HIV-uninfected individuals compared with enhanced HIV testing and treatment of HIV-infected individuals in terms of impact on viral transmission...
  12. doi request reprint Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK
    Julie Fox
    Department of HIV, Guys and St Thomas NHS Trust Kings College London, St Thomas Hospital, London, UK
    AIDS 24:2397-401. 2010
    ..To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK...
  13. ncbi request reprint Antiretroviral treatment of primary HIV infection to reduce onward transmission
    Elizabeth Hamlyn
    GUM HIV, HIV Clinical Trials Unit, Imperial College London, London, UK
    Curr Opin HIV AIDS 5:283-90. 2010
    ..This review will discuss the role of antiretroviral therapy to treat primary HIV infection (PHI) as a strategy to prevent onward viral transmission...
  14. ncbi request reprint Risk of HIV transmission in discordant partners
    Julie Fox
    Imperial College London, UK
    J HIV Ther 12:48-53. 2007
  15. doi request reprint Reductions in HIV transmission risk behaviour following diagnosis of primary HIV infection: a cohort of high-risk men who have sex with men
    Julie Fox
    Department of Genitourinary Medicine and Infectious Disease, Clinical Trials Centre, Winston ChurchillBuilding, Imperial College London, St Mary s Hospital Campus, London W2 1PG, UK
    HIV Med 10:432-8. 2009
    ..We explored the potential impact on HIV transmission-risk behaviour of PHI diagnosis in men who have sex with men (MSM)...
  16. doi request reprint Sexual transmission of HIV-1
    Julie Fox
    Department of HIV, Faculty of Medicine, Harrison Unit, Lambeth Wing, Guys and St Thomas NHS Trust Kings College London, Westminster Bridge Road, London, UK
    Antiviral Res 85:276-85. 2010
    ..This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010...
  17. ncbi request reprint Prevalence of primary genotypic resistance in a UK centre: Comparison of primary HIV-1 and newly diagnosed treatment-naive individuals
    Julie Fox
    St Mary s Hospital, London, UK
    AIDS 21:237-9. 2007
    ..Variations in the prevalence of TrDR-HIV-1 may reflect the heterogeneity of methodologies and definitions used for resistance...
  18. doi request reprint Intimate relationships in young adults with perinatally acquired HIV: partner considerations
    Clare Greenhalgh
    Department of Clinical Psychology, Royal Holloway, University of London, London, UK
    AIDS Care 25:447-50. 2013
    ..These findings have important implications for supporting young people in disclosing their HIV status to intimate partners in appropriate ways. Suggestions for future research are offered...
  19. doi request reprint Optimizing antiretroviral therapy in adolescents with perinatally acquired HIV-1 infection
    Caroline Foster
    The 900 Clinic, Jefferies Wing, Imperial College Healthcare NHS Trust, London, W2 1NY, UK
    Expert Rev Anti Infect Ther 8:1403-16. 2010
    ..Careful follow-up of this early perinatal cohort as they enter adulthood will inform the future management of the growing numbers of adolescents surviving worldwide as access to therapy increases...
  20. doi request reprint Crossing the divide: transition care services for young people with HIV-their views
    Hannah Bundock
    Department of Cardiology, St Mary s Hospital, London, UK
    AIDS Patient Care STDS 25:465-73. 2011
    ..This service evaluation illustrates that careful transition can be a positive event for young people with PaHIV, comparable to that of a well-established diabetes services...
  21. pmc Low levels of HIV test coverage in clinical settings in the U.K.: a systematic review of adherence to 2008 guidelines
    Rahma Elmahdi
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Sex Transm Infect 90:119-24. 2014
    ..To quantify the extent to which guideline recommendations for routine testing for HIV are adhered to outside of genitourinary medicine (GUM), sexual health (SH) and antenatal clinics...
  22. pmc Laboratory adverse events and discontinuation of therapy according to CD4+ cell count at the start of antiretroviral therapy
    Sophie Jose
    aResearch Department of Infection and Population Health, UCL bImperial College London Department of Medicine, London cThe Lothian University Hospitals NHS Trust, Edinburgh dSt George s Healthcare NHS Trust, London eBrighton and Sussex University Hospitals NHS Trust, Brighton fKings College Hospital NHS Foundation Trust and King s College London gChelsea and Westminster NHS Foundation Trust, London hNorth Bristol NHS Trust, Bristol iRoyal Free Hampstead NHS Trust, London jSouth Tees Hospital NHS Foundation Trust, Middlesbrough kMortimer Market Centre, University College Medical School, London, UK
    AIDS 28:1333-9. 2014
    ..We compared rates of laboratory-defined adverse events (LDAEs) according to CD4 cell count at ART initiation...
  23. pmc Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis
    Kalpana Sabapathy
    London School of Hygiene and Tropical Medicine, London, UK
    PLoS Med 9:e1001351. 2012
    ..Improving access to HIV testing is a key priority in scaling up HIV treatment and prevention services. Home-based voluntary counselling and testing (HBT) as an approach to delivering wide-scale HIV testing is explored here...
  24. ncbi request reprint Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART
    Rebecca Sutherland
    MRC Human Immunology Unit, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
    AIDS 20:821-9. 2006
    ..To determine whether long-term HAART in chronic HIV-1 infection restores fully functional Mycobacterium tuberculosis (MTB)-specific CD4 T-cell responses...
  25. pmc HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound
    Thomas J Scriba
    Peter Medawar Building for Pathogen Research and Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    J Clin Invest 115:443-50. 2005
    ..The turnover of these virus-specific cells increased and they adopted an effector phenotype when viremia returned...
  26. doi request reprint Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom
    Julie Fox
    AIDS 22:666-8. 2008
  27. ncbi request reprint Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining
    Thomas J Scriba
    The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    J Immunol 175:6334-43. 2005
    ..These cells would not be detectable with normal flow-cytometric techniques...
  28. pmc Resistance to HIV drugs in UK may be lower in some areas
    Julie M Fox
    BMJ 332:179-80. 2006