Research Topics
| Neil M FergusonSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Strategies for containing an emerging influenza pandemic in Southeast AsiaNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Nature 437:209-14. 2005..Policy effectiveness depends critically on how quickly clinical cases are diagnosed and the speed with which antiviral drugs can be distributed...
The foot-and-mouth epidemic in Great Britain: pattern of spread and impact of interventionsN M Ferguson
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Science 292:1155-60. 2001..Culling is predicted to be more effective than vaccination...
Ecological and immunological determinants of influenza evolutionNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Nature 422:428-33. 2003....
Poverty, death, and a future influenza pandemicNeil Ferguson
Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
Lancet 368:2187-8. 2006
Adherence to antiretroviral therapy and its impact on clinical outcome in HIV-infected patientsN M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
J R Soc Interface 2:349-63. 2005....
Estimating the human health risk from possible BSE infection of the British sheep flockN M Ferguson
Department of Infectious Disease Epidemiology, Imperial College of Science, Technology and Medicine, St Mary s Campus, London, UK
Nature 415:420-4. 2002....
Transmission intensity and impact of control policies on the foot and mouth epidemic in Great BritainN M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, London, UK
Nature 413:542-8. 2001....
Short-term projections for variant Creutzfeldt-Jakob disease onsetsAzra C Ghani
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Stat Methods Med Res 12:191-201. 2003..These results demonstrate the continued uncertainty in the future scale of this disease...
Within-farm transmission dynamics of foot and mouth disease as revealed by the 2001 epidemic in Great BritainIrina Chis Ster
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College, London, United Kingdom
Epidemics 4:158-69. 2012..We highlighted evidence which reinforces the role of within-farm dynamics in contributing to the long tail of the 2001 epidemic...
Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemicRoy M Anderson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Philos Trans R Soc Lond B Biol Sci 359:1091-105. 2004..These lessons learnt from the SARS experience are presented in an epidemiological and public health context...
Public health. Public health risk from the avian H5N1 influenza epidemicNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, UK
Science 304:968-9. 2004
Epidemiological and genetic analysis of severe acute respiratory syndromeChristl A Donnelly
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Lancet Infect Dis 4:672-83. 2004....
Strategies for mitigating an influenza pandemicNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Nature 442:448-52. 2006..Estimates of policy effectiveness will change if the characteristics of a future pandemic strain differ substantially from those seen in past pandemics...
Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong KongChristl A Donnelly
Department of Infectious Disease Epidemiology, Imperial College, London, UK
Lancet 361:1761-6. 2003..We assessed the epidemiology of SARS in Hong Kong...
Estimating the location and spatial extent of a covert anthrax releaseJudith Legrand
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Diseases Epidemiology, Imperial College London, London, United Kingdom
PLoS Comput Biol 5:e1000356. 2009..In addition, estimates of release features could be used to parameterize more detailed models allowing the simulation of control strategies and intervention logistics...
Factors determining the pattern of the variant Creutzfeldt-Jakob disease (vCJD) epidemic in the UKAzra C Ghani
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, Norfolk Place, London W2 1PG, UK
Proc Biol Sci 270:689-98. 2003....
Modelling the impact of antiretroviral use in resource-poor settingsRebecca F Baggaley
Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
PLoS Med 3:e124. 2006..Mathematical models can explore the potential impacts of various treatment strategies, including timing of treatment initiation and provision of laboratory monitoring facilities, to complement evidence from pilot programmes...
Implications of BSE infection screening data for the scale of the British BSE epidemic and current European infection levelsChristl A Donnelly
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Proc Biol Sci 269:2179-90. 2002..Infection incidence for cattle born after mid-1996 was highest in Greece, Italy and Belgium, with Spain and The Netherlands having intermediate levels, and estimates for Great Britain, Germany and France being comparably low...
A many-body field theory approach to stochastic models in population biologyPeter J Dodd
Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, United Kingdom
PLoS ONE 4:e6855. 2009..Here we argue that they make many calculations easier and are a possible starting point for new approximations...
Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventionsSteven Riley
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Science 300:1961-6. 2003..We estimate that most currently infected persons are now hospitalized, which highlights the importance of control of nosocomial transmission...
Updated projections of future vCJD deaths in the UKAzra C Ghani
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
BMC Infect Dis 3:4. 2003..However, recent vCJD case data have indicated a decrease in the annual incidence of deaths over the past two years...
Space and contact networks: capturing the locality of disease transmissionPaul E Parham
Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Praed Street, London W2 1PG, UK
J R Soc Interface 3:483-93. 2006....
Household transmission of 2009 pandemic influenza A (H1N1) virus in the United StatesSimon Cauchemez
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London
N Engl J Med 361:2619-27. 2009..Risk factors for transmission remain largely uncharacterized. We characterize the risk factors and describe the transmission of the virus within households...
Epidemiological inference for partially observed epidemics: the example of the 2001 foot and mouth epidemic in Great BritainIrina Chis Ster
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, UK
Epidemics 1:21-34. 2009..However, for the parameter estimated obtained, preliminary simulation results indicate that had contiguous culling not been applied in 2001, the epidemic might have been substantially larger...
Pandemic potential of a strain of influenza A (H1N1): early findingsChristophe Fraser
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
Science 324:1557-61. 2009..Transmissibility is therefore substantially higher than that of seasonal flu, and comparable with lower estimates of R0 obtained from previous influenza pandemics...
Epidemic growth rate and household reproduction number in communities of households, schools and workplacesLorenzo Pellis
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, Norfolk Place, London, W2 1PG, UK
J Math Biol 63:691-734. 2011..g. reproduction numbers, critical vaccination coverage, epidemic final size) to new results on the epidemic dynamics...
Transmission characteristics of the 2009 H1N1 influenza pandemic: comparison of 8 Southern hemisphere countriesLulla Opatowski
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
PLoS Pathog 7:e1002225. 2011..Our analysis indicates that between-country-differences in transmission were at least partly due to differences in population demography...
Antigen-driven T-cell turnoverChristophe Fraser
Department of Infectious Disease Epidemiology, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, Paddington, London W21PG, UK
J Theor Biol 219:177-92. 2002..We show that our model can resolve the paradox of high levels of viral replication occurring while only a small fraction of cells are infected...
Assessment of the risk posed by bovine spongiform encephalopathy in cattle in Great Britain and the impact of potential changes to current control measuresNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Proc Biol Sci 270:1579-84. 2003..04 additional vCJD deaths over the next 60 years. However, there is substantial (more than 40-fold) uncertainty surrounding this estimate, the sources of which are discussed...
Methods to infer transmission risk factors in complex outbreak dataSimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK
J R Soc Interface 9:456-69. 2012..We also discuss approaches to integrate parametric model fitting and tree reconstruction methods in coherent statistical analyses. The methods are tested on both real and simulated datasets of large outbreaks in structured populations...
Transmission parameters of the 2001 foot and mouth epidemic in Great BritainIrina Chis Ster
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
PLoS ONE 2:e502. 2007..Predictive risk maps of the transmission potential in different geographic areas of GB are presented for the fitted models...
Robust parameter estimation techniques for stochastic within-host macroparasite modelsSteven Riley
Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Norfolk Place, W2 1PG London, UK
J Theor Biol 225:419-30. 2003..This indicates that the observed aggregation of parasite load may be dynamically generated by random variation in the development of an effective immune response against parasite larvae...
Factors that make an infectious disease outbreak controllableChristophe Fraser
Department of Infectious Disease Epidemiology, Imperial College, St Mary s, London W2 1PG, United Kingdom
Proc Natl Acad Sci U S A 101:6146-51. 2004..Direct estimation of the proportion of asymptomatic and presymptomatic infections is achievable by contact tracing and should be a priority during an outbreak of a novel infectious agent...
Antigenic diversity, transmission mechanisms, and the evolution of pathogensAlexander Lange
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS Comput Biol 5:e1000536. 2009....
Likelihood-based estimation of continuous-time epidemic models from time-series data: application to measles transmission in LondonSimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
J R Soc Interface 5:885-97. 2008..This indicates that simple models assuming homogenous mixing (even with age structure) of the type which are standard in mathematical epidemiology miss key features of epidemics in large populations...
Frequent travelers and rate of spread of epidemicsT Deirdre Hollingsworth
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease and Epidemiology, Imperial College London, London, United Kingdom
Emerg Infect Dis 13:1288-94. 2007....
Estimating the impact of school closure on influenza transmission from Sentinel dataSimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Diseases Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
Nature 452:750-4. 2008..The impact of school closure would be reduced if it proved difficult to maintain low contact rates among children for a prolonged period...
The relationship between real-time and discrete-generation models of epidemic spreadLorenzo Pellis
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
Math Biosci 216:63-70. 2008..In this paper, we reanalyse Ludwig's result, highlighting some of the conditions under which it does not hold and providing a general framework to examine the differences between the continuous-time and the discrete-generation process...
Viral replication under combination antiretroviral therapy: a comparison of four different regimensAzra C Ghani
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
J Acquir Immune Defic Syndr 30:167-76. 2002..04; 95% CI, 1.0-1.07). Measurement of viral load after approximately 7 days provided the most accurate measure of the degree of viral suppression induced by a given drug regimen...
Closure of schools during an influenza pandemicSimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, London, UK
Lancet Infect Dis 9:473-81. 2009..Implications for the mitigation of the swine-origin influenza A H1N1 pandemic are also discussed...
Control of a highly pathogenic H5N1 avian influenza outbreak in the GB poultry flockJames Truscott
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, St Mary s Campus, London W2 1PG, UK
Proc Biol Sci 274:2287-95. 2007..The most effective of these contingent interventions are large radius (10 km) localized culling and national vaccination. However, the modest impact of these approaches must be balanced against their substantial inconvenience and cost...
The transmission dynamics of BSE and vCJDAzra C Ghani
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine St Mary s, Norfolk Place, London W2 1PG, UK
C R Biol 325:37-47. 2002..We also consider the epidemiological determinants of the future course of the vCJD epidemic, including the age and genetic characteristics of the confirmed cases, and present predictions of future case numbers...
Scale-free networks and sexually transmitted diseases: a description of observed patterns of sexual contacts in Britain and ZimbabweAnne Schneeberger
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Sex Transm Dis 31:380-7. 2004..CONCLUSIONS: A scale-free network approach provides a reasonable description of distributions of reported numbers of sexual partners...
Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendationsChristl A Donnelly
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
Clin Infect Dis 52:S123-30. 2011..Only 5% of transmission events were estimated to take place >3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI...
Role of social networks in shaping disease transmission during a community outbreak of 2009 H1N1 pandemic influenzaSimon Cauchemez
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
Proc Natl Acad Sci U S A 108:2825-30. 2011....
Influenza transmission in households during the 1918 pandemicChristophe Fraser
Medical Research Council Centre for Outbreak Modelling and Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, St Mary s Campus, London W2 1PG, United Kingdom
Am J Epidemiol 174:505-14. 2011..Together, these analyses demonstrate that the 1918 influenza virus, though highly virulent, was only moderately transmissible and thus in a modern context would be considered controllable...
Using routine surveillance data to estimate the epidemic potential of emerging zoonoses: application to the emergence of US swine origin influenza A H3N2v virusSimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS Med 10:e1001399. 2013..Additionally, existing methods do not correct for important selection and under-ascertainment biases. Here, we present simple estimation methods that overcome many of these limitations...
Inferring pandemic growth rates from sequence dataEric de Silva
Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London W2 1PG, UK
J R Soc Interface 9:1797-808. 2012..We illustrate this with an application to the 2009 H1N1 pandemic...
Comment on "Seroevidence for H5N1 influenza infections in humans: meta-analysis"Maria D Van Kerkhove
Medical Research Council Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
Science 336:1506; author reply 1506. 2012..Although the true risk of death from H5N1 infection will likely be lower than the 60% of reported laboratory-confirmed cases, there is little evidence of millions of missed infections...
Planning for smallpox outbreaksNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Nature 425:681-5. 2003..We review the use of models in smallpox planning within the broader epidemiological context set by recent outbreaks of both novel and re-emerging pathogens...
The impact of cross-immunity, mutation and stochastic extinction on pathogen diversityLaith J Abu-Raddad
Department of Infectious Disease Epidemiology, Imperial College London, St Marys Campus, Norfolk Place, London W2 1PG, UK
Proc Biol Sci 271:2431-8. 2004..While the model framework developed is simplified, we show that it can capture essential aspects of the complex evolutionary dynamics of pathogens such as influenza...
Estimating air temperature and its influence on malaria transmission across AfricaTini Garske
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS ONE 8:e56487. 2013..We present high resolution maps of the malaria transmission parameters driven by air temperature and their seasonal variation. The fitted air temperature datasets are made publicly available alongside this publication...
Modelling the impact of vector control interventions on Anopheles gambiae population dynamicsMichael T White
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK
Parasit Vectors 4:153. 2011....
A population-dynamic model for evaluating the potential spread of drug-resistant influenza virus infections during community-based use of antiviralsNeil M Ferguson
Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
J Antimicrob Chemother 51:977-90. 2003..It is also shown that until high levels of therapy are attained, early treatment of symptomatic cases is more efficient (per unit of drug) at preventing infections than prophylactic therapy...
Influenza infection rates, measurement errors and the interpretation of paired serologySimon Cauchemez
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS Pathog 8:e1003061. 2012..Determining which biological phenomenon contributes most to 2-fold rises in antibody titers is essential to assess bias with the traditional case definition and offer improved estimates of influenza ARs...
Evaluating the adequacy of gravity models as a description of human mobility for epidemic modellingJames Truscott
MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
PLoS Comput Biol 8:e1002699. 2012..An assortative model based on node population size captures this heterogeneity, considerably improving the epidemiological match between synthetic and data networks...
Spatial dynamics of the 1918 influenza pandemic in England, Wales and the United StatesRosalind M Eggo
MRC Centre for Outbreak Analysis and Modelling, Imperial College London, Department of Infectious Disease Epidemiology, St Mary s Campus, London W2 1PG, UK
J R Soc Interface 8:233-43. 2011..We find that parameters estimated from the England and Wales dataset can be applied to the US data with no likelihood penalty...
Improving the realism of deterministic multi-strain models: implications for modelling influenza APavlo Minayev
Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College Faculty of Medicine, Norfolk Place, London W2 1PG, UK
J R Soc Interface 6:509-18. 2009....
Smallpox transmission and control: spatial dynamics in Great BritainSteven Riley
Department of Community Medicine and School of Public Health, University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, People s Republic of China
Proc Natl Acad Sci U S A 103:12637-42. 2006....
Real-time estimates in early detection of SARSSimon Cauchemez
Institut National de la Sante et de la Recherche Medicale, Paris, France
Emerg Infect Dis 12:110-3. 2006..Using simulation studies of SARS-like outbreaks, we have shown that the method may be used for early monitoring of the effect of control measures...
Modeling targeted layered containment of an influenza pandemic in the United StatesM Elizabeth Halloran
Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
Proc Natl Acad Sci U S A 105:4639-44. 2008....
Time lines of infection and disease in human influenza: a review of volunteer challenge studiesFabrice Carrat
Universite Pierre et Marie Curie PARIS6, UMR S 707, Paris, France
Am J Epidemiol 167:775-85. 2008....
The effect of public health measures on the 1918 influenza pandemic in U.S. citiesMartin C J Bootsma
Mathematical Institute, Faculty of Sciences, Utrecht University, Budapestlaan 6, 3508 TA Utrecht, The Netherlands
Proc Natl Acad Sci U S A 104:7588-93. 2007..Our analysis also suggests that individuals reactively reduced their contact rates in response to high levels of mortality during the pandemic...
Will travel restrictions control the international spread of pandemic influenza?T Deirdre Hollingsworth
Nat Med 12:497-9. 2006
Unveiling the burden of pertussisMichiel van Boven
Animal Sciences Group, Wageningen University and Research Centre, P.O. Box 65, 8200 AB Lelystad, The Netherlands
Trends Microbiol 12:116-9. 2004
SARS-CoV antibody prevalence in all Hong Kong patient contactsGabriel M Leung
University of Hong Kong, Hong Kong Special Administrative Region, China
Emerg Infect Dis 10:1653-6. 2004..19%) were positive for SARS coronavirus immunoglobulin G antibody. SARS rarely manifests as a subclinical infection, and at present, wild animal species are the only important natural reservoirs of the virus...
The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patientsGabriel M Leung
University of Hong Kong, Government of the Hong Kong Special Administrative Region, and Hong Kong Hospital Authority, Hong Kong, China
Ann Intern Med 141:662-73. 2004..CONCLUSIONS: This analysis of the complete data on the 2003 SARS epidemic in Hong Kong has revealed key epidemiologic features of the epidemic as it evolved...
Predicting evolutionary change in the influenza A virusNeil M Ferguson
Nat Med 8:562-3. 2002
