M Feldmann

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
  2. pmc The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
    Niccolò Terrando
    Department of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Crit Care 14:R88. 2010
  3. pmc Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
    Pei Jin
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Arthritis Res Ther 10:R73. 2008
  4. pmc Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
  5. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
  6. pmc Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
    Fionula M Brennan
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 10:R36. 2008
  7. pmc Many cytokines are very useful therapeutic targets in disease
    Marc Feldmann
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK
    J Clin Invest 118:3533-6. 2008
  8. ncbi Design of effective immunotherapy for human autoimmunity
    Marc Feldmann
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Medicine, ARC Building, 1 Aspenlea Road, London W6 8LH, UK
    Nature 435:612-9. 2005
  9. doi Translating molecular insights in autoimmunity into effective therapy
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK
    Annu Rev Immunol 27:1-27. 2009
  10. doi What have we learnt from targeted anti-TNF therapy?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Road, London W6 8LH, UK
    Ann Rheum Dis 69:i97-99. 2010

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. pmc Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
    ..We assessed the anti-inflammatory effects of a novel PDE4 inhibitor, apremilast, in human synovial cells from rheumatoid arthritis (RA) patients, as well as two murine models of arthritis...
  2. pmc The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
    Niccolò Terrando
    Department of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Crit Care 14:R88. 2010
    ..Disabling the interleukin (IL)-1 signaling pathway is sufficient to reduce inflammation and ameliorate the disability...
  3. pmc Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
    Pei Jin
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Arthritis Res Ther 10:R73. 2008
    ..The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis...
  4. pmc Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
    ....
  5. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
    ..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts...
  6. pmc Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
    Fionula M Brennan
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 10:R36. 2008
    ....
  7. pmc Many cytokines are very useful therapeutic targets in disease
    Marc Feldmann
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK
    J Clin Invest 118:3533-6. 2008
    ..Their role as potential therapeutic targets is also highlighted...
  8. ncbi Design of effective immunotherapy for human autoimmunity
    Marc Feldmann
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Medicine, ARC Building, 1 Aspenlea Road, London W6 8LH, UK
    Nature 435:612-9. 2005
    ....
  9. doi Translating molecular insights in autoimmunity into effective therapy
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK
    Annu Rev Immunol 27:1-27. 2009
    ..My current scientific challenge is exploring the hypothesis of whether all major medical needs can be approached via cytokine blockade...
  10. doi What have we learnt from targeted anti-TNF therapy?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Road, London W6 8LH, UK
    Ann Rheum Dis 69:i97-99. 2010
    ..Focus will be on the TNF-dependent cytokine cascade and what it means, and potential new approaches to treatment. Finally, an entertaining challenge: might many or even all unmet clinical needs be dealt with through cytokine analysis?..
  11. doi Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
    Immunol Rev 223:7-19. 2008
    ..This success has encouraged a burgeoning industry of biologicals for chronic diseases...
  12. doi Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
    Marc Feldmann
    Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom
    J Immunol 185:791-4. 2010
    ..The work with TNF clearly demonstrated the importance of cytokines in medicine as well as the capacity of mAbs (or receptor fusion proteins) to be used long-term in large populations, thus changing the therapeutic landscape...
  13. ncbi The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Best Pract Res Clin Rheumatol 18:59-80. 2004
    ..The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made...
  14. ncbi Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, 1 Aspenlea Road, London W6 8LH, UK
    Nat Med 9:1245-50. 2003
  15. ncbi Anti-TNF therapy: where have we got to in 2005?
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, 1 Aspenlea Road, London W6 8LH, UK
    J Autoimmun 25:26-8. 2005
    ..There are still many limitations, but the prospects for the future are intriguing...
  16. pmc High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach
    B M Foxwell
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK
    Ann Rheum Dis 60:iii13-7. 2001
    ..Studying the intracellular signalling mechanism used by dendritic cells would provide an insight into the functioning of these cells and give clues to strategies for immunomodulation...
  17. ncbi Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy
    R O Williams
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, United Kingdom
    J Immunol 165:7240-5. 2000
    ..Combined anti-TNF-alpha/anti-CD4 treatment almost completely blocked the expression of IL-1beta, thereby confirming the ability of this form of combination therapy to prevent IL-1ss-mediated pathology...
  18. ncbi NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts
    C Smith
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, Hammersmith, London, United Kingdom
    J Immunol 167:5895-903. 2001
    ..These data also highlight the potential problems in extrapolating the function of signaling pathways between primary and transfected cell lines...
  19. ncbi Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines
    S Yoshimura
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Int Immunol 13:675-83. 2001
    ....
  20. doi Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717
    P F Sumariwalla
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Rheumatology (Oxford) 48:32-8. 2009
    ..To evaluate the clinical efficacy of a novel synthetic peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, CLX-090717, in several in vitro cell culture systems and murine CIA, an experimental model of RA...
  21. ncbi Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression
    A D Foey
    Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Cytokine 12:1496-505. 2000
    ..These data indicate that CD40 ligation regulates cell contact mediated macrophage IL-10 and that the route of differentiation determines the cytokine profile...
  22. ncbi Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI
    S Yoshimura
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, GB
    Eur J Immunol 31:1883-93. 2001
    ....
  23. ncbi Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy
    Evangelos Andreakos
    Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
    Arthritis Rheum 48:1901-12. 2003
    ....
  24. ncbi Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies
    A M Malfait
    Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, UK
    Arthritis Rheum 44:1215-24. 2001
    ..CONCLUSION: Chronic relapsing homologous collagen-induced arthritis is a valuable model for identifying remission-inducing antiarthritic drugs and has predictive value with respect to their joint-protective potency...
  25. ncbi Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver
    E Quattrocchi
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, Hammersmith, London, United Kingdom
    J Immunol 166:5970-8. 2001
    ..These findings provide further insights into the diverse interplay of immune processes involved in autoimmune inflammation and the mechanism of cytokine immunotherapy...
  26. ncbi Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways
    M Conron
    Kennedy Institute of Rheumatology, London, United Kingdom
    Am J Respir Cell Mol Biol 25:141-9. 2001
    ..The results of this study have implications for the future investigation of molecular pathways in inflammatory lung disease...
  27. ncbi Cytokines and anti-cytokine biologicals in autoimmunity: present and future
    Evangelos T Andreakos
    Faculty of Medicine, Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cytokine Growth Factor Rev 13:299-313. 2002
    ..The future developments of anti-TNFalpha and anti-cytokine therapy in general will be interesting...
  28. ncbi Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo
    S Yoshimura
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Scand J Immunol 58:165-72. 2003
    ..This finding has potential implications for the development of therapeutic agents for use in various pathological conditions of the immune system, including allergy and autoimmunity, and also in transplantation...
  29. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    ..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
  30. ncbi Cytokine blockade in rheumatoid arthritis
    M Feldmann
    Kennedy Institute of Rheumatology, Hammersmith, London, UK
    Adv Exp Med Biol 490:119-27. 2001
    ..New approaches to studying TNF regulation in RA and of elucidating the controversial role of T cells in this complex disease will be described...
  31. pmc Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR
    S K Drexler
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, Hammersmith, London, UK
    Scand J Immunol 71:393-402. 2010
    ..This study describes MyD88lpr as a potential adjuvant for vaccinations, which would be able to target DC specifically...
  32. ncbi Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system
    J L Croxford
    Neuroinflammation Group, Department of Neurochemistry, Institutes of Neurology and Ophthalmology, UCL, University of London, London, United Kingdom
    J Immunol 166:4124-30. 2001
    ..Thus the action of IL-10 may differ depending on the local cytokine microenvironment produced by the gene-secreting cell types...
  33. pmc Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant
    E Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 103:14459-64. 2006
    ..These findings define NIK, and possibly other inducers of NF-kappaB activation, as a potent adjuvant strategy that offers great potential for genetic vaccine development...
  34. pmc Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production
    B M Foxwell
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, Hammersmith, London, UK
    Ann Rheum Dis 59:i54-9. 2000
    ....
  35. ncbi Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Novartis Found Symp 256:53-69; discussion 69-73, 106-11, 266-9. 2004
    ..The era of anti-cytokine therapeutics is just dawning...
  36. pmc Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies
    C Haworth
    Charing Cross Sunley Research Centre, London, UK
    Br J Cancer 67:1346-50. 1993
    ..These results show that FAA alone can induce cytokine release from primed target cells. This may be associated with the therapeutic effect and/or toxicity of the agent...
  37. ncbi Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis
    S Ballara
    Imperial College School of Medicine, London, UK
    Arthritis Rheum 44:2055-64. 2001
    ....
  38. doi TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes
    C Brenner
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK
    Scand J Immunol 76:359-70. 2012
    ..These data suggest that Pam3CSK4 and LPS signal via the expected routes in human adipocytes, whereas poly(I:C)/TLR3 signalling may act via a TRIF-independent, MyD88-dependent route...
  39. pmc Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein
    P W Gray
    Charing Cross Sunley Research Centre, Hammersmith, London, England
    Proc Natl Acad Sci U S A 87:7380-4. 1990
    ..Mammalian cells transfected with the entire TNF receptor cDNA bind radiolabeled TNF alpha with an affinity of 2.5 x 10(-9) M. This binding can be competitively inhibited with unlabeled TNF alpha or lymphotoxin (TNF beta)...
  40. pmc Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents
    B Foxwell
    The Kennedy Institute of Rheumatology Division, Imperial College London, The Charing Cross Campus, ARC Building, 1 Aspenlea Road, London W6 8LH, UK
    Ann Rheum Dis 62:ii90-3. 2003
  41. ncbi Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group
    R Maini
    The Kennedy Institute of Rheumatology and The Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Lancet 354:1932-9. 1999
    ..We therefore investigated whether infliximab, a chimeric human-mouse anti-TNFalpha monoclonal antibody would provide additional clinical benefit to patients who had active rheumatoid arthritis despite receiving methotrexate...
  42. ncbi The importance of T cell interactions with macrophages in rheumatoid cytokine production
    F M Brennan
    Imperial College of Science, Technology and Medicine, Kennedy Institute of Rheumatology Division, Faculty of Medicine, London, UK
    Curr Top Microbiol Immunol 305:177-94. 2006
    ....
  43. ncbi Autocrine and paracrine regulation of human T cell IL-10 production
    S B Cohen
    Kennedy Institute of Rheumatology and The Anthony Nolan Bone Marrow Trust and the Department of Hematology, The Royal Free Hospital, London, United Kingdom
    J Immunol 158:5596-602. 1997
    ....
  44. ncbi The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis
    J J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Rheumatology (Oxford) 46:1428-32. 2007
    ....
  45. ncbi Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
    Blood 103:2229-37. 2004
    ....
  46. ncbi Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination
    J Wales
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, U K
    Biochem Soc Trans 35:1501-3. 2007
    ..The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules...
  47. ncbi Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis
    A O Afuwape
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Gene Ther 10:1950-60. 2003
    ..The actions of AdvsFlt-1 are likely to be mediated by reduced synovial neovascularization, and these results support the concept that VEGF blockade may be an effective therapeutic adjunct for the treatment of RA...
  48. ncbi Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB
    V L Calder
    Institute of Ophthalmology, UCL, London, UK
    Scand J Immunol 57:261-70. 2003
    ..The effective downregulation of antigen-specific T-cell responses following blockade of NF-kappaB in DCs could be a useful approach for immunomodulating inflammatory T-cell responses...
  49. ncbi Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Immunol Rev 202:250-65. 2004
    ..Whether targeting TLRs and their downstream signaling pathway will prove to be a successful approach for the treatment of these devastating diseases remains to be determined...
  50. ncbi Development of anti-TNF therapy for rheumatoid arthritis
    Marc Feldmann
    Kennedy Institute, Rheumatology Division, Faculty of Medicine, Imperial College School of Medicine, London, UK
    Nat Rev Immunol 2:364-71. 2002
    ..This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases...
  51. ncbi Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis
    Fionula M Brennan
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Arthritis Rheum 46:31-41. 2002
    ..To investigate the mechanism that leads to the spontaneous production of tumor necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA) synovial tissue...
  52. ncbi VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
    Serafim Kiriakidis
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, UK
    J Cell Sci 116:665-74. 2003
    ..NF-kappaB regulates many of the genes involved in immune and inflammatory responses, and our study adds the angiogenic cytokine VEGF to the list of NF-kappaB-dependent cytokines...
  53. ncbi Interleukin-10 inhibition of the progression of established collagen-induced arthritis
    M Walmsley
    Kennedy Institute of Rheumatology, London, England
    Arthritis Rheum 39:495-503. 1996
    ..The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA...
  54. doi Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis
    A K Andersson
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, London, UK
    Scand J Immunol 68:103-11. 2008
    ..The data confirm that IL-15 plays a role in RA and suggests that IL-21 is also involved in driving the pro-inflammatory cytokine response in RA...
  55. pmc Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Ann Rheum Dis 66:iii81-6. 2007
    ....
  56. pmc The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology, Imperial College London, and the Department of Orthopedics, Royal United Hospital, Bath, UK
    Am J Pathol 170:518-25. 2007
    ..Thus, TLRs not only protect against infection but may also promote the inflammatory and destructive process in RA...
  57. ncbi A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis
    Jamie Campbell
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine Hammersmith, London, United Kingdom
    J Immunol 173:6928-37. 2004
    ..These results indicate despite disappointing results with p38 MAPK inhibitors in the clinic, this kinase is a valid target in rheumatoid disease...
  58. pmc Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis
    Claudia Monaco
    Kennedy Institute of Rheumatology, Imperial College, Charing Cross Campus, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 101:5634-9. 2004
    ....
  59. ncbi Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer
    A M Waterston
    Department of Cancer Medicine, Faculty of Medicine, Imperial College School of Medicine, London, W12 0HS, UK
    Cancer Immunol Immunother 54:848-57. 2005
    ..However, since the antibodies were only able to cross-react with partly denatured TNFalpha, evaluation of safety and tumour responses to the TNFalpha vaccine was compromised...
  60. pmc P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor
    P F Sumariwalla
    Kennedy Institute of Rheumatology, Imperial College London, UK
    Clin Exp Immunol 136:67-75. 2004
    ..The mechanism of action involves reduced cellularity of synovium as anticipated, along with a reduction in TNF production from inflammatory cells in the synovium. The latter mechanism needs further mechanistic analysis...
  61. pmc TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model
    A M Waterston
    Department of Cancer Medicine, Faculty of Medicine, Chelsea and Westminster Hospital, 369 Fulham Rd, Imperial College School of Medicine, London SW10 9NH, UK
    Br J Cancer 90:1279-84. 2004
    ..This study suggests that TNF autovaccination is a cheaper and highly efficient alternative that can block TNF and reduce metastasis in vivo and trials with TNF autovaccination are already underway in patients with metastatic cancer...
  62. doi Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis
    Percy F Sumariwalla
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
    Arthritis Rheum 58:3071-80. 2008
    ..To evaluate the therapeutic potential of the human epidermal growth factor receptor (HER) family inhibitor, herstatin, in an animal model of arthritis...
  63. doi Rac mediates TNF-induced cytokine production via modulation of NF-kappaB
    Lynn M Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, United Kingdom
    Mol Immunol 45:2446-54. 2008
    ..This would suggest that TNF-induced activation of Rac, lies upstream of NF-kappaB activation, and that the inhibition of this pathway results in inhibition of cytokine production...
  64. doi CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis
    Egle Simelyte
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:1038-43. 2008
    ....
  65. ncbi Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood
    Theresa H Page
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 185:3694-701. 2010
    ..Thus, by reducing the level of PGE(2), NSAIDs can increase TNF production and may exacerbate the proinflammatory environment both within the rheumatoid arthritis joint and the systemic environment...
  66. ncbi Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases
    Richard O Williams
    The Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Curr Opin Pharmacol 7:412-7. 2007
    ..Cytokines driving angiogenesis are also important in disease chronicity and thus might be valid therapeutic targets...
  67. doi Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 149:386-92. 2010
    ..They also suggest that, unlike post-operative pain, induction of pain in OA may not necessarily be driven by classical inflammatory processes...
  68. ncbi Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
    Michael J Elliot
    Clinical Immunology Division, Kennedy Institute of Rheumatology, London W6 7DW, United Kingdom
    Arthritis Rheum 58:S92-S101. 2008
    ..To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor necrosis factor alpha (TNF alpha) in the treatment of patients with rheumatoid arthritis (RA)...
  69. ncbi Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 56:4015-23. 2007
    ..We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA...
  70. doi Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
    ..However, up to 40% of individuals with radiologic damage are asymptomatic. The purpose of this study was to assess the role of the endogenous opioid system in delaying the onset of pain in a murine model of osteoarthritis (OA)...
  71. doi Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis
    Claudia Monaco
    Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Rd, London W6 8LH, UK
    Circulation 120:2462-9. 2009
    ..We explored the effects of blocking TLR-2, TLR-4, and myeloid differentiation primary response gene 88 (MyD88), a signaling adaptor shared by most TLRs and interleukin-1 receptor (IL-1R), in an in vitro model of human atherosclerosis...
  72. doi Targeting intracellular signaling: a novel approach to vaccination
    Jeremy Wales
    Imperial College London, Kennedy Institute of Rheumatology, The Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK
    Expert Rev Vaccines 6:971-80. 2007
    ..Targeting intracellular signaling pathways may allow for greater specificity of the adjuvant, as well as reducing systemic toxicity. Studies targeting these pathways are discussed, as well as their potential applications in the future...
  73. ncbi Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W68LH, UK
    Curr Opin Biotechnol 15:557-63. 2004
    ..Better understanding of these pathogenic pathways will inform the development of new therapeutic approaches leading to more complete and sustained disease remissions...
  74. ncbi A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    Percy F Sumariwalla
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 50:985-98. 2004
    ....
  75. ncbi T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases
    Claudia Monaco
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
    Curr Drug Targets Inflamm Allergy 3:35-42. 2004
    ..This cascade of events is discussed in the context of disease initiation/progression, with particular reference to atherosclerosis and rheumatoid arthritis, and to potential novel therapeutic targets for their treatment...
  76. ncbi Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
    Joint Bone Spine 69:12-8. 2002
    ..There is now extensive clinical use of anti-TNFalpha biologicals for severe rheumatoid arthritis in the US and Europe...
  77. doi Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Nat Rev Rheumatol 5:578-82. 2009
    ..Furthermore, new approaches to blockade of signaling mediated by bioactive TNF might have the potential to generate higher-magnitude clinical responses than are currently elicited...
  78. ncbi Emerging approaches for the therapy of autoimmune and chronic inflammatory disease
    Andrew P Cope
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Curr Opin Immunol 16:780-6. 2004
    ..It is our belief that the future of immunotherapy in the clinic will depend to some extent upon the availability of biomarkers for defining biological signatures of immune function in vivo...
  79. ncbi Monoclonal antibodies in immune and inflammatory diseases
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, W6 8LH, London, UK
    Curr Opin Biotechnol 13:615-20. 2002
    ..In the clinic, monoclonal antibodies are proving to be safe and effective for the treatment of a wide range of diseases including rheumatoid arthritis, Crohn's disease, spondyloarthropathies, psoriasis and allograft rejection...
  80. ncbi The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Front Biosci 10:2478-88. 2005
    ....
  81. pmc Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis
    Andrew D Foey
    Kennedy Institute of Rheumatology Division, Charing Cross Hospital Campus, Imperial College School of Medicine, London, UK
    Arthritis Res Ther 5:R317-28. 2003
    ..In conclusion, VIP may represent an efficaceous anti-arthritic treatment modulating macrophage and T-cell cytokine profiles when used alongside a phosphodiesterase inhibitor...
  82. ncbi Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB
    Jennifer Grosjean
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK
    Biochem Biophys Res Commun 340:984-94. 2006
    ..This study highlights that different molecular mechanisms of NFkappaB activation may be involved downstream of stimuli which activate the endothelial lining of blood vessels...
  83. ncbi Molecular therapeutic targets in rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Expert Rev Mol Med 7:1-20. 2005
    ..This review describes therapies that are approved, in clinical trials or under pre-clinical investigation at the laboratory level, particularly focusing on cytokines, although other therapeutic targets of interest are mentioned...
  84. ncbi Cytokines in autoimmunity
    F M Brennan
    Kennedy Institute of Rheumatology, Hammersmith, London, UK
    Curr Opin Immunol 8:872-7. 1996
    ..Recent contributions to this field, derived from in vivo studies in animal models of autoimmunity, and increasingly from clinical trials, have greatly enhanced our understanding of this field...
  85. ncbi CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways
    A D Foey
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK
    Cytokine 16:131-42. 2001
    ..These observations suggest that CD40 ligation induces macrophage IL-10 and TNF-alpha production, the mechanism of which is p70S6K-dependent yet bifurcates at the level of PI3K and p42/44 MAPK...
  86. pmc Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes
    J J O Turner
    Kennedy Institute of Rheumatology, Charing Cross Hospital, London, UK
    Clin Exp Immunol 162:487-93. 2010
    ....
  87. pmc The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis
    Percy F Sumariwalla
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Arthritis Res Ther 5:R32-9. 2003
    ..These data suggest that antiangiogenic therapies, which block formation of new blood vessels and hence reduce synovial expansion, might be effective in treating rheumatoid arthritis...
  88. ncbi Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 181:8002-9. 2008
    ..Together, these data suggest that TLR8 may play a role in driving TNF production in RA. Because this receptor can be inhibited by small m.w. molecules, it may prove to be an important therapeutic target...
  89. ncbi Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages
    Magdalena Pertyńska-Marczewska
    Kennedy Institute of Rheumatology, Arthritis Research Campaign Building, Faculty of Medicine, Imperial College, 1, Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cytokine 28:35-47. 2004
    ....
  90. pmc Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis
    Philippa Hillyer
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Rheumatology (Oxford) 48:1581-9. 2009
    ..IL-23 is a pro-inflammatory cytokine proposed to be central to the development of autoimmune disease. We investigated whether IL-23, together with the downstream mediator IL-17A, was present and functional in RA in humans...
  91. ncbi TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion
    Cathleen J Ciesielski
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, London, GB
    Eur J Immunol 32:2037-45. 2002
    ....
  92. ncbi Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Blood 101:983-91. 2003
    ..In addition, our results support IKK2 as a potential therapeutic target for the down-regulation of unwanted immune responses that may occur during transplantation or autoimmunity...
  93. pmc Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis
    Andrew Foey
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, Hammersmith, London, W6 8LH, UK
    Arthritis Res 4:64-70. 2002
    ..IL-10 production in RA-SMCs and M-CSF-primed macrophages, activated by interaction with Tck, is PI3K- and p70S6K-dependent...
  94. pmc How does infliximab work in rheumatoid arthritis?
    Ravinder N Maini
    The Kennedy Institute of Rheumatology Division, Imperial College of Science Technology and Medicine, London, UK
    Arthritis Res 4:S22-8. 2002
    ....
  95. ncbi Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 178:2148-54. 2007
    ..We conclude that TRAM is an adaptor protein for both TLR4 and TLR2/6 signaling in SFs, HUVECs, and murine embryonic fibroblasts, but cannot demonstrate a role in human macrophages...
  96. ncbi T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor
    Claudia Monaco
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Leukoc Biol 71:659-68. 2002
    ....
  97. ncbi Role of interleukin-1beta in postoperative cognitive dysfunction
    Mario Cibelli
    Department of Anesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Ann Neurol 68:360-8. 2010
    ..We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery...
  98. doi RelB/p50 regulates CCL19 production, but fails to promote human DC maturation
    Chiara Gasparini
    Kennedy Institute of Rheumatology Division, School of Medicine, Imperial College London, London, UK
    Eur J Immunol 39:2215-23. 2009
    ..In conclusion, we demonstrated that RelB/p50 was active only in DC expressing both RelB and p50, and induced CCL19 production, but not DC maturation...
  99. doi SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis
    Stefan K Drexler
    Imperial College London, London, UK
    Arthritis Rheum 62:2249-61. 2010
    ..Therefore, the purpose of this study was to investigate the involvement of SIGIRR in regulating inflammation in disease-relevant models...
  100. ncbi Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems
    Anna M Lundberg
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, 1 Aspenlea Road, Hammersmith, London, United Kingdom
    Blood 110:3245-52. 2007
    ..This is the first report of such cell type- and species-specific response for any TLR stimulation and helps to explain important difficulties in correlating murine models of inflammatory diseases and human inflammation...
  101. ncbi The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity
    Ling Weng
    Kennedy Institute of Rheumatology, Imperial College, London, UK
    Ann Rheum Dis 69:1519-26. 2010
    ..In the present work it is demonstrated that partial myeloablation induces a relative expansion of T(regs) that is sufficient to mediate immunological tolerance...