K Fan Chung

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
  2. ncbi Bacteria in sputum of stable severe asthma and increased airway wall thickness
    Qingling Zhang
    Airways Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 13:35. 2012
  3. ncbi Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004
  4. ncbi Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells
    Razao Issa
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK
    Respir Res 9:30. 2008
  5. ncbi Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
  6. ncbi Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
    Ute Oltmanns
    Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
    Respir Res 6:74. 2005
  7. ncbi Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle
    Hanna M Larner-Svensson
    Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:68. 2010
  8. ncbi Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
  9. ncbi Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respir Res 6:42. 2005
  10. ncbi Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy
    Bhupinder S Mann
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, UK
    Respir Res 7:59. 2006

Research Grants

  1. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005

Detail Information

Publications125 found, 100 shown here

  1. ncbi STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
    ..abstract:..
  2. ncbi Bacteria in sputum of stable severe asthma and increased airway wall thickness
    Qingling Zhang
    Airways Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 13:35. 2012
    ..Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness...
  3. ncbi Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004
    ..Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations...
  4. ncbi Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells
    Razao Issa
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK
    Respir Res 9:30. 2008
    ..We hypothesize that bacteria and bacterial products could induce cytokine/chemokine release from ASMC...
  5. ncbi Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
    ..We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids...
  6. ncbi Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
    Ute Oltmanns
    Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
    Respir Res 6:74. 2005
    ..Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette smoke could directly induce the release of chemokines from HASMC...
  7. ncbi Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle
    Hanna M Larner-Svensson
    Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:68. 2010
    ..We have therefore examined the role of miR-146a during the interleukin (IL)-1beta-stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle (HASM) cells...
  8. ncbi Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
    ..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases...
  9. ncbi Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respir Res 6:42. 2005
    ..Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery...
  10. ncbi Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy
    Bhupinder S Mann
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, UK
    Respir Res 7:59. 2006
    ..Neutrophils are increased in the airways and in induced sputum of severe asthma patients. We determined the expression of activation markers from circulating neutrophils in severe asthma, and their supressibility by corticosteroids...
  11. ncbi Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough
    Shaoping Xie
    Airway Disease Section, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3 6LY, UK
    Respir Res 10:40. 2009
    ..TGFbeta in the airways may be important in the airway remodelling changes observed in chronic idiopathic cough patients, that could in turn lead to activation of the cough reflex...
  12. ncbi Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:33. 2010
    ..However, the impact of cigarette smoke exposure on the expression of mSin3a and Mi2alpha/beta and their role in glucocorticoid responsiveness is unknown...
  13. ncbi Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  14. ncbi Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3 6LY, UK
    Eur Respir J 27:230-2. 2006
    ..This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity...
  15. ncbi Phosphodiesterase inhibitors in airways disease
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3, UK
    Eur J Pharmacol 533:110-7. 2006
    ..A dual PDE3-PDE4 compound may provide more bronchodilator and bronchoprotective effect in addition to the beneficial PDE4 effects...
  16. ncbi Measurement of cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Respir Physiol Neurobiol 152:329-39. 2006
    ..How the information obtained between these different measurements interrelate needs to be determined...
  17. ncbi The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 2:347-54; discussion 371-2. 2005
    ..Specific therapies for airway wall remodeling may be necessary, together with noninvasive methods of imaging small airway wall remodeling to assess responses...
  18. ncbi Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Sci STKE 2005:pe47. 2005
    ..However, other PGE2 receptor subtypes may also have beneficial effects, and a greater understanding of the signaling pathways of these receptor subtypes will help to clarify the role of these receptors in asthma...
  19. ncbi Drugs to suppress cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, SW3, UK
    Expert Opin Investig Drugs 14:19-27. 2005
    ....
  20. ncbi Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma
    K Fan Chung
    Imperial College, National Heart and Lung Institute, London, UK
    Treat Respir Med 3:279-89. 2004
    ..Improvements in combination therapy include a once-daily preparation and possible combination of inhaled corticosteroids with newer drugs such as phosphodiesterase IV inhibitors...
  21. ncbi Acute and chronic cough
    Kian Fan Chung
    Thoracic Medicine Department, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 17:471-3. 2004
  22. ncbi p38 mitogen-activated protein kinase pathways in asthma and COPD
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, and Biomedical Research Unit, Royal Brompton Hospital, London, England
    Chest 139:1470-9. 2011
    ..Side effects such as liver toxicity remain a possibility, and whether the beneficial effects of p38 inhibitors are clinically significant and sustained need to be determined...
  23. ncbi Cytokines as targets in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3, UK
    Curr Drug Targets 7:675-81. 2006
    ..Other treatments such as phosphodiesterase 4 inhibitors have anti-cytokine effects that may underlie their beneficial effects in COPD...
  24. ncbi Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
    ..This would focus the problem on the cough symptomatology and lead to greater focus on understanding the mechanisms of cough sensitisation, with the ultimate aim of obtaining more effective antitussives...
  25. ncbi Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College, MRC Asthma UK Centre for Allergic Mechanisms in Asthma and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Ann N Y Acad Sci 1203:85-91. 2010
    ..Antioxidants may prove to be beneficial in inhibiting inflammatory responses and restoring corticosteroid function...
  26. ncbi Should treatments for asthma be aimed at the airway smooth muscle?
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Rev Respir Med 1:209-17. 2007
    ..Targeting the ASM cell in asthma could be the focus of therapies for asthma. Specific delivery of active agents to ASM cells may also be part of this strategy...
  27. ncbi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  28. ncbi Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
    K F Chung
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
    Eur Respir J 31:1334-56. 2008
    ..Treatments may be targeted to patients with specific mechanisms...
  29. ncbi Prevalence, pathogenesis, and causes of chronic cough
    Kian Fan Chung
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 371:1364-74. 2008
    ..Effective control of cough requires not only controlling the disease causing the cough but also desensitisation of cough pathways...
  30. ncbi Salmeterol/fluticasone combination in the treatment of COPD
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Int J Chron Obstruct Pulmon Dis 1:235-42. 2006
    ..While long-acting beta2-agonists such as Sal can be recommended for treatment of moderate COPD, addition of inhaled steroid therapy such as FP should be considered in more severe disease...
  31. ncbi Outdoor air pollution and respiratory health in Asia
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, and NIHR Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Respirology 16:1023-6. 2011
    ....
  32. ncbi Chronic cough: future directions in chronic cough: mechanisms and antitussives
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK
    Chron Respir Dis 4:159-65. 2007
    ..Future directions in chronic cough include the pathophysiological mechanisms of the enhanced cough reflex, and the discovery of effective antitussives that can successfully alleviate chronic cough...
  33. ncbi Inflammatory mediators in chronic obstructive pulmonary disease
    Kian F Chung
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Curr Drug Targets Inflamm Allergy 4:619-25. 2005
    ..TGFbeta and EGF activate proliferation of fibroblasts, while activation of the EGF receptor leads to mucin gene expression...
  34. ncbi Effective antitussives for the cough patient: an unmet need
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London SW3, UK
    Pulm Pharmacol Ther 20:438-45. 2007
    ..Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis...
  35. ncbi Currently available cough suppressants for chronic cough
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield NHS Trust, London, UK
    Lung 186:S82-7. 2008
    ..Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis...
  36. ncbi Current and future prospects for drugs to suppress cough
    K Fan Chung
    National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    IDrugs 6:781-6. 2003
    ....
  37. ncbi Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma
    K Fan Chung
    National Heart and Lung Institute, Imperial College, London, UK
    Expert Opin Pharmacother 5:439-46. 2004
    ..Omalizumab is well-tolerated by asthma patients and represents a new approach to the treatment of the moderate-to-severe asthmatic patient. It is likely that it will first be used at the more severe end of the asthmatic diathesis...
  38. ncbi Individual cytokines contributing to asthma pathophysiology: valid targets for asthma therapy?
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK
    Curr Opin Investig Drugs 4:1320-6. 2003
    ..Blocking the effects of more than one cytokine may be more successful, and greater therapeutic effects may be observed in particular categories of asthma...
  39. ncbi Inflammatory biomarkers in severe asthma
    Kian F Chung
    National Heart and Lung Institute, Imperial College and NIHR Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Curr Opin Pulm Med 18:35-41. 2012
    ..The development of biomarkers for phenotypic diagnosis and prognostic reasons is important...
  40. ncbi Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease
    Paul A Kirkham
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY UK
    Am J Respir Crit Care Med 184:796-802. 2011
    ....
  41. ncbi Systematic assessment of difficult-to-treat asthma
    D S Robinson
    Dept of Allergy, Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Eur Respir J 22:478-83. 2003
    ..Systematic evaluation of difficult asthma is useful as it can identify alternative or additional diagnoses, psychiatric illness or nonconcordance with therapy in a substantial proportion of cases (32% in the present series)...
  42. ncbi Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  43. ncbi Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    N Lazzeri
    Thoracic Medicine and Cardiothoracic Surgery, National Heart and Lung Institute, London; Pharmacology Department, Dagenham Research Centre, Dagenham, Essex; and Unit of Critical Care Medicine, Royal Brompton Hospital, IC School of Medicine, London, UK
    Am J Respir Cell Mol Biol 24:44-48. 2001
    ..Thus, when HASM cells are activated with cytokines they release PGE2, which acts as a "braking mechanism" to limit the coproduction of GM-CSF. Moreover, agents that elevate cAMP also reduce GM-CSF formation by these cells...
  44. ncbi Pathophysiology and therapy of chronic cough
    K F Chung
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, London, UK
    Minerva Med 96:29-40. 2005
    ..Currently-available antitussives such as dextromethorphan or codeine are modestly successful in controlling cough. New antitussives may be developed that act on the sensory receptors or prevent their sensitisation...
  45. ncbi Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
    P Bhavsar
    Section of Airways Disease, National Heart and Lung Institute, Imperial College and Royal Brompton and Harefield NHS Trust Hospital, London, UK
    Eur Respir J 35:750-6. 2010
    ..Corticosteroid insensitivity in severe asthma patients may be improved by inhibitors of p38 MAPK...
  46. ncbi EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD
    Stephane Jouneau
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London Royal Brompton Hospital, London, UK
    Respirology 16:705-12. 2011
    ..We determined its cellular origin and role in MMP-9 production in COPD...
  47. ncbi Cough: potential pharmacological developments
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Investig Drugs 11:955-63. 2002
    ..Large scale trials of these novel compounds have not been carried out in cough in man but there is a serious need for more effective antitussives devoid of side effects...
  48. ncbi Cytokines in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur Respir J Suppl 34:50s-59s. 2001
    ..The role of these cytokines needs to be defined and there is a potential for anticytokine therapy in chronic obstructive pulmonary disease...
  49. ncbi Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough
    A Niimi
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Thorax 59:608-12. 2004
    ..pH and chloride levels did not change after capsaicin challenge. CONCLUSIONS: The epithelial lining fluid of patients with chronic cough has a reduced pH and reduced chloride levels which could contribute to the enhanced cough reflex...
  50. ncbi Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Mol Biotechnol 18:213-32. 2001
    ..The important outcome of this is that new preventive and curative treatments may ensue...
  51. ncbi Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma
    P Macedo
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 39:1668-76. 2009
    ..About 5-10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy...
  52. ncbi Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects
    K F Chung
    Dept of Medicine, Charing Cross and Westminster Medical School, London, UK
    Eur Respir J 1:890-5. 1988
    ..The distribution of inhaled aerosol, but not the dose, is largely dependent on airway calibre. The differences in PI between normal and asthmatic subjects may at best be explained by the differences in central airway calibre...
  53. ncbi Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages
    L Atzori
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:530-5. 2004
    ..We concluded that HO-2 expression is reduced in alveolar macrophages of smokers, possibly due to the oxidative stress of cigarette smoke. This may in turn lead to reduced protection against further oxidative insults...
  54. ncbi Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD
    Christopher K M Hui
    Airway Disease and Experimental Studies Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UK
    Expert Rev Respir Med 5:9-16. 2011
    ..It is likely that indacaterol could be used in conjunction with other agents such as inhaled corticosteroids and anticholinergics for the treatment of COPD as a single once-daily combination treatment...
  55. ncbi Regulation of human lung epithelial cell numbers by diesel exhaust particles
    H Bayram
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 27:705-13. 2006
    ..Therefore, low-dose diesel exhaust particle exposure may lead to lung epithelial cell hyperplasia...
  56. ncbi Therapy for cough: active agents
    K F Chung
    Royal Brompton Hospital, National Heart and Lung Institute, London, England
    Pulm Pharmacol Ther 15:335-8. 2002
    ..Large scale trials of these novel compounds have not been tried in cough in man, but there is a serious need for more effective antitussives devoid of side-effects...
  57. ncbi Expression of respiratory mucins in fatal status asthmaticus and mild asthma
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Histopathology 40:367-73. 2002
    ..CONCLUSIONS: The expression of MUC5AC and MUC5B shares a similar distribution to normal airways in different states of asthma. The distribution is not affected by topical corticosteroid therapy...
  58. ncbi Capsaicin cough sensitivity in bronchiectasis
    A Torrego
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 61:706-9. 2006
    ..CONCLUSIONS: : Patients with bronchiectasis have a sensitive cough reflex which reflects the severity of cough symptoms. A measure of cough severity could be part of health assessment for patients with bronchiectasis...
  59. ncbi RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol
    N Lazzeri
    Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 433:231-5. 2001
    ..These data suggest that, in settings where cyclo-oxygenase activity is low, both drugs may relieve the symptoms of airway diseases by reducing RANTES production...
  60. ncbi Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma
    S Lim
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 164:273-6. 2001
    ..Low-dose theophylline induced antiinflammatory effects in asthma, reflected by a fall in airway eosinophils with no change in exhaled NO or changes in lung function...
  61. ncbi Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system
    J W Lammers
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, United Kingdom
    J Appl Physiol 67:856-61. 1989
    ..This reflex could not be distinguished from that caused by coughing or by deep inhalation. A defect in nonadrenergic mechanisms, at least in mild asthma, seems unlikely...
  62. ncbi Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:1009-14. 1989
    ..Most of the bronchoconstriction is not inhibited by antimuscarinic agents; the underlying mechanisms require further investigation...
  63. ncbi Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone
    E B Haddad
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Mol Pharmacol 57:1123-31. 2000
    ..Nuclear run-on experiments demonstrate that the induction of B1 and the up-regulation of B2 receptors as well as the inhibitory effect of dexamethasone are entirely mediated through post-transcriptional mechanisms...
  64. ncbi Role for platelet-activating factor in asthma
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Lipids 26:1277-9. 1991
    ..The interaction between PAF and eosinophils may be crucial in the pathogenesis of bronchial hyperresponsiveness in asthma. A role for PAF in asthma can now be studied using the recently developed antagonists of the PAF receptor...
  65. ncbi Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages
    S Lim
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, UK
    Allergy 59:505-14. 2004
    ..CONCLUSION: Our study suggests that the bronchial epithelium is not a source of IL-10 and cannot respond to exogenous IL-10 because of a lack of IL-10R expression...
  66. ncbi Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction
    A Nix
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Br J Clin Pharmacol 29:321-4. 1990
    ..2- and 2.9-fold at 2 and 5 h respectively). 4. Thus, formoterol has a protective effect against methacholine-induced bronchoconstriction which lasts for at least 5 h...
  67. ncbi TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011
    ..Knockdown of Nox4 using small interfering RNA partially prevented the inhibition of MnSOD but had no effect on catalase and IL-6 expression. These findings provide novel insights into redox regulation of ASM function by TGF-β...
  68. ncbi Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells
    Mark M Perry
    Experimental Studies, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 45:746-52. 2011
    ..Therefore, regulation of H(2)S may represent a novel approach to controlling ASM proliferation and cytokine release that is found in patients with asthma...
  69. ncbi A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice
    Kostas Triantaphyllopoulos
    Experimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Am J Physiol Lung Cell Mol Physiol 300:L691-700. 2011
    ..Exposure of mice to ozone for 6 wk induced a chronic inflammatory process, with alveolar enlargement and damage linked to epithelial apoptosis and increased protease expression...
  70. ncbi Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma
    R G Stirling
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:1403-9. 2001
    ..Further, IL-5 causes terminal maturation of the eosinophil by increasing CCR3 expression, potentially affecting CCR3-dependent chemotaxis by eosinophils and lymphocytes...
  71. ncbi Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma
    E L van Rensen
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Thorax 56:935-40. 2001
    ..CONCLUSION: The effects of IL-5 appear to be mainly in the circulation, inducing peripheral mobilisation of eosinophils to the circulation without any effect on eosinophil mobilisation in the lungs or on bronchial responsiveness...
  72. ncbi Non-invasive biomarkers of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Pediatr Pulmonol Suppl 18:41-4. 1999
    ....
  73. ncbi Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma
    S Lim
    National Heart and Lung Institute, Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Allergy 55:489-95. 2000
    ..We determined the effect of late-phase responses to allergen challenge of mildly allergic asthmatic patients on the expression and release of the cytokines IL-10 and MIP-1alpha from peripheral blood monocytes...
  74. ncbi Failure of sputum eosinophilia after eotaxin inhalation in asthma
    D Bumbacea
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Thorax 59:372-5. 2004
    ..05). CONCLUSIONS: Inhaled eotaxin up to 40 microg induced no changes in sputum eosinophil count but at 40 microg it increased the sputum neutrophil count. The significance of this finding is unknown...
  75. ncbi Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids
    K F Chung
    Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 127:1145-50. 1999
    ..Thus, human airway smooth muscle cells can release eotaxin and could be an important source of chemokine production during airway inflammatory events...
  76. ncbi Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, England
    Allergy Proc 10:333-7. 1989
    ..These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis...
  77. ncbi Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Rev Respir Dis 142:576-80. 1990
    ..Nasal PD was measured before and after placebo or furosemide, and again after MBS inhalation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  78. ncbi Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferation after repeated allergen exposures
    S-Y Leung
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 34:213-20. 2004
    ..CONCLUSION: Repeated OVA-challenge results in persistent ASM cell proliferation in the absence of bronchial inflammation and BHR, which lasts for at least 1 week following cessation of exposure...
  79. ncbi Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema
    J O Lotvall
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    J Appl Physiol 69:1473-8. 1990
    ..We conclude that the inability of hyperinflation to fully reverse changes in RL after SP may be due to the formation of both airway and pulmonary edema, which may also contribute to the deterioration in RL...
  80. ncbi Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:102-7. 1989
    ..Thus a therapeutic dose of salbutamol caused partial inhibition of platelet activating factor induced bronchoconstriction and had a minimal effect on the increased bronchial responsiveness following platelet activating factor...
  81. ncbi Assessment and measurement of cough: the value of new tools
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:267-72. 2002
    ..We need a greater assessment and evaluation of all these tools...
  82. ncbi Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:108-15. 1989
    ....
  83. ncbi Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Respir Med 96:81-6. 2002
    ..MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia...
  84. ncbi Effect of theophylline on airway responses to inhaled platelet-activating factor in man
    K F Chung
    Dept of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, UK
    Eur Respir J 2:763-8. 1989
    ..Our results suggest that theophylline has negligible influence on the airway effects of PAF...
  85. ncbi Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma
    E Bucchioni
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:651-5. 2004
    ..The detection of LTs and histamine in exhaled breath condensate may be useful in monitoring asthma...
  86. ncbi Management of chronic cough
    Ian D Pavord
    Institute for Lung Health, Department of Respiratory Medicine, Allergy and Thoracic Surgery, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK
    Lancet 371:1375-84. 2008
    ..We call for more research into the basic mechanisms and pharmacological control of an abnormally heightened cough reflex, and recommend ways to assess the effects of potentially antitussive treatments...
  87. ncbi Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB
    Pankaj K Bhavsar
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, UK
    FASEB J 22:1807-16. 2008
    ..This study also provides support for the action of glucocorticoids mediating their suppressive effects on expression by interfering with the binding of transcriptional activators at native gene promoters...
  88. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  89. ncbi Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A
    Manminder Kaur
    Dept of Cell Biology and Anatomy, Faculty of Medicine, Univ of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    Am J Physiol Lung Cell Mol Physiol 295:L505-14. 2008
    ..Collectively, these results indicate that repression of IL-1beta-induced ICAM-1 expression and GM-CSF release by cAMP-elevating agents, including beta(2)-adrenoceptor agonists, may not occur through a generic effect on NF-kappaB...
  90. ncbi Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
    Sarah J Ballantyne
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Allergy Clin Immunol 120:1324-31. 2007
    ..Its roles in antigen-driven airway inflammation and airway hyperresponsiveness (AHR) remain to be fully established...
  91. ncbi Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease
    Fabio L M Ricciardolo
    Unit of Respiratory Disease, Istituto di Ricovero e Cura a Carattere Scientifico Gaslini Institute, Genoa, Italy
    J Allergy Clin Immunol 116:1028-35. 2005
    ..CONCLUSION: These data suggest that nitrosative stress, mainly mediated by MPO and neutrophilic inflammation, may contribute to the pathogenesis of severe COPD...
  92. ncbi Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma
    Lan Tien Nguyen
    Department of Thoracic Medicine, Imperial College and Royal Brompton Hospital, National Heart and Lung Institute, London SW36LY, UK
    Respir Med 99:200-7. 2005
    ..This could explain the increase in airway neutrophils observed in severe asthmatics treated with oral corticosteroids...
  93. ncbi Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features
    Sum Yee Leung
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    J Allergy Clin Immunol 115:989-96. 2005
    ..Fluticasone prevented airway inflammation but not BHR, but both fluticasone and ciclesonide are effective at reversal of BHR, inflammation, and remodeling features...
  94. ncbi Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
    Sum Yee Leung
    National Heart and Lung Institute, Dovehouse St, London SW3 6LY, UK
    J Pharmacol Exp Ther 319:586-94. 2006
    ..Inhibition of TGF-betaRI kinase activities by SD-208 may be a useful approach to the reversal of BHR and to the prevention and reversal of inflammatory and remodeling features of chronic asthma...
  95. ncbi Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta
    Shaoping Xie
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 293:L245-53. 2007
    ..NF-kappaB is also involved in the TGF-beta1 mitogenic signaling, but Smad pathway does not appear important...
  96. ncbi Nature of airway inflammation and remodeling in chronic cough
    Akio Niimi
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    J Allergy Clin Immunol 116:565-70. 2005
    ..These are linked to chronic cough rather than to asthma. Mast cell hyperplasia rather than eosinophilia is distinctive for non-asthmatic cough...
  97. ncbi Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
    Mark Hew
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 174:134-41. 2006
    ....
  98. ncbi American College of Chest Physicians' cough guidelines
    Kian Fan Chung
    Lancet 367:981-2. 2006
  99. ncbi Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma
    Chun-Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Br J Pharmacol 138:1147-55. 2003
    ..The anti-inflammatory properties of theophylline include an inhibition of circulating progenitor cells...
  100. ncbi Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids
    Maria B Sukkar
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, Dovehouse St, SW3 6LY, London, UK
    Am J Physiol Lung Cell Mol Physiol 287:L1230-40. 2004
    ..In summary, FKN production by human ASMC in vitro is regulated by inflammatory and anti-inflammatory factors...
  101. ncbi Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle
    Ute Oltmanns
    Experimental Studies, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 21:292-7. 2008
    ....

Research Grants5

  1. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..