K Fan Chung

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Defining phenotypes in asthma: a step towards personalized medicine
    Kian Fan Chung
    Experimental Studies, National Heart and Lung Institute, Imperial College London, Dovehouse St, London, SW3 6LY, UK
    Drugs 74:719-28. 2014
  2. pmc TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011
  3. pmc IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema
    Mariona Pinart
    Airways Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 8:e58452. 2013
  4. pmc Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model
    Feng Li
    Experimental Studies Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom Department of Respiratory Medicine, The Affiliated First People s Hospital of Shanghai Jiao Tong University, Shanghai, P R China
    PLoS ONE 8:e80782. 2013
  5. doi New treatments for severe treatment-resistant asthma: targeting the right patient
    Kian Fan Chung
    Experimental Studies, National Heart and Lung Institute, Imperial College London and Royal Brompton National Institute for Health Research Biomedical Research Unit, London, UK Electronic address
    Lancet Respir Med 1:639-52. 2013
  6. ncbi Chronic cough as a neuropathic disorder
    Kian Fan Chung
    Experimental Studies Unit, National Heart and Lung Institute, Imperial College London, London, UK Biomedical Research Unit, Royal Brompton Hospital, London, UK Electronic address
    Lancet Respir Med 1:414-22. 2013
  7. pmc John Widdicombe's contribution to respiratory physiology and cough: reminiscences
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, Dovehouse St, London, SW3 6LY, UK
    Cough 9:6. 2013
  8. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
  9. pmc Bacteria in sputum of stable severe asthma and increased airway wall thickness
    Qingling Zhang
    Airways Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 13:35. 2012
  10. pmc Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. ncbi Defining phenotypes in asthma: a step towards personalized medicine
    Kian Fan Chung
    Experimental Studies, National Heart and Lung Institute, Imperial College London, Dovehouse St, London, SW3 6LY, UK
    Drugs 74:719-28. 2014
    ..This will pave the way towards personalized medicine and healthcare for asthma. ..
  2. pmc TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    Charalambos Michaeloudes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 300:L295-304. 2011
    ..Knockdown of Nox4 using small interfering RNA partially prevented the inhibition of MnSOD but had no effect on catalase and IL-6 expression. These findings provide novel insights into redox regulation of ASM function by TGF-β...
  3. pmc IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema
    Mariona Pinart
    Airways Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 8:e58452. 2013
    ..The emphysema and lung inflammation induced by ozone is not dependent on IL-17...
  4. pmc Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model
    Feng Li
    Experimental Studies Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom Department of Respiratory Medicine, The Affiliated First People s Hospital of Shanghai Jiao Tong University, Shanghai, P R China
    PLoS ONE 8:e80782. 2013
    ..Chronic exposure to high levels of ozone induces emphysema and chronic inflammation in mice. We determined the recovery from ozone-induced injury and whether an antioxidant, N-acetylcysteine (NAC), could prevent or reverse the lung damage...
  5. doi New treatments for severe treatment-resistant asthma: targeting the right patient
    Kian Fan Chung
    Experimental Studies, National Heart and Lung Institute, Imperial College London and Royal Brompton National Institute for Health Research Biomedical Research Unit, London, UK Electronic address
    Lancet Respir Med 1:639-52. 2013
    ..Newer treatments for asthma will emerge from better endotyping, leading to personalised medicine in asthma. ..
  6. ncbi Chronic cough as a neuropathic disorder
    Kian Fan Chung
    Experimental Studies Unit, National Heart and Lung Institute, Imperial College London, London, UK Biomedical Research Unit, Royal Brompton Hospital, London, UK Electronic address
    Lancet Respir Med 1:414-22. 2013
    ..Regarding cough as a neuropathic disorder could lead to new, more effective antitussives. ..
  7. pmc John Widdicombe's contribution to respiratory physiology and cough: reminiscences
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, Dovehouse St, London, SW3 6LY, UK
    Cough 9:6. 2013
    ..John Widdicombe was interested in all aspects of cough from the definition to potential new antitussives. This article will focus on his contributions and on his generous personality through reminiscences from three friends...
  8. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
    ..abstract:..
  9. pmc Bacteria in sputum of stable severe asthma and increased airway wall thickness
    Qingling Zhang
    Airways Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 13:35. 2012
    ..Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness...
  10. pmc Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004
    ..Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations...
  11. pmc Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells
    Razao Issa
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK
    Respir Res 9:30. 2008
    ..We hypothesize that bacteria and bacterial products could induce cytokine/chemokine release from ASMC...
  12. pmc Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
    ..We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids...
  13. pmc Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
    Ute Oltmanns
    Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
    Respir Res 6:74. 2005
    ..Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette smoke could directly induce the release of chemokines from HASMC...
  14. pmc Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle
    Hanna M Larner-Svensson
    Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:68. 2010
    ..We have therefore examined the role of miR-146a during the interleukin (IL)-1beta-stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle (HASM) cells...
  15. pmc Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
    ..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases...
  16. pmc Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Respir Res 6:42. 2005
    ..Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery...
  17. pmc Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy
    Bhupinder S Mann
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, UK
    Respir Res 7:59. 2006
    ..Neutrophils are increased in the airways and in induced sputum of severe asthma patients. We determined the expression of activation markers from circulating neutrophils in severe asthma, and their supressibility by corticosteroids...
  18. pmc Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough
    Shaoping Xie
    Airway Disease Section, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3 6LY, UK
    Respir Res 10:40. 2009
    ..TGFbeta in the airways may be important in the airway remodelling changes observed in chronic idiopathic cough patients, that could in turn lead to activation of the cough reflex...
  19. pmc Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:33. 2010
    ..However, the impact of cigarette smoke exposure on the expression of mSin3a and Mi2alpha/beta and their role in glucocorticoid responsiveness is unknown...
  20. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  21. ncbi Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma
    K Fan Chung
    Imperial College, National Heart and Lung Institute, London, UK
    Treat Respir Med 3:279-89. 2004
    ..Improvements in combination therapy include a once-daily preparation and possible combination of inhaled corticosteroids with newer drugs such as phosphodiesterase IV inhibitors...
  22. ncbi Effective antitussives for the cough patient: an unmet need
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London SW3, UK
    Pulm Pharmacol Ther 20:438-45. 2007
    ..Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis...
  23. ncbi Should treatments for asthma be aimed at the airway smooth muscle?
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Rev Respir Med 1:209-17. 2007
    ..Targeting the ASM cell in asthma could be the focus of therapies for asthma. Specific delivery of active agents to ASM cells may also be part of this strategy...
  24. doi Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College, MRC Asthma UK Centre for Allergic Mechanisms in Asthma and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Ann N Y Acad Sci 1203:85-91. 2010
    ..Antioxidants may prove to be beneficial in inhibiting inflammatory responses and restoring corticosteroid function...
  25. ncbi Acute and chronic cough
    Kian Fan Chung
    Thoracic Medicine Department, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 17:471-3. 2004
  26. ncbi Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Sci STKE 2005:pe47. 2005
    ..However, other PGE2 receptor subtypes may also have beneficial effects, and a greater understanding of the signaling pathways of these receptor subtypes will help to clarify the role of these receptors in asthma...
  27. pmc The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 2:347-54; discussion 371-2. 2005
    ..Specific therapies for airway wall remodeling may be necessary, together with noninvasive methods of imaging small airway wall remodeling to assess responses...
  28. ncbi Chronic cough: future directions in chronic cough: mechanisms and antitussives
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK
    Chron Respir Dis 4:159-65. 2007
    ..Future directions in chronic cough include the pathophysiological mechanisms of the enhanced cough reflex, and the discovery of effective antitussives that can successfully alleviate chronic cough...
  29. pmc Salmeterol/fluticasone combination in the treatment of COPD
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Int J Chron Obstruct Pulmon Dis 1:235-42. 2006
    ..While long-acting beta2-agonists such as Sal can be recommended for treatment of moderate COPD, addition of inhaled steroid therapy such as FP should be considered in more severe disease...
  30. ncbi Cytokines as targets in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3, UK
    Curr Drug Targets 7:675-81. 2006
    ..Other treatments such as phosphodiesterase 4 inhibitors have anti-cytokine effects that may underlie their beneficial effects in COPD...
  31. doi Prevalence, pathogenesis, and causes of chronic cough
    Kian Fan Chung
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 371:1364-74. 2008
    ..Effective control of cough requires not only controlling the disease causing the cough but also desensitisation of cough pathways...
  32. doi Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
    K F Chung
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
    Eur Respir J 31:1334-56. 2008
    ..Treatments may be targeted to patients with specific mechanisms...
  33. ncbi Measurement of cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Respir Physiol Neurobiol 152:329-39. 2006
    ..How the information obtained between these different measurements interrelate needs to be determined...
  34. ncbi Inflammatory mediators in chronic obstructive pulmonary disease
    Kian F Chung
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Curr Drug Targets Inflamm Allergy 4:619-25. 2005
    ..TGFbeta and EGF activate proliferation of fibroblasts, while activation of the EGF receptor leads to mucin gene expression...
  35. ncbi Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3 6LY, UK
    Eur Respir J 27:230-2. 2006
    ..This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity...
  36. ncbi Currently available cough suppressants for chronic cough
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield NHS Trust, London, UK
    Lung 186:S82-7. 2008
    ..Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis...
  37. doi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  38. ncbi Phosphodiesterase inhibitors in airways disease
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3, UK
    Eur J Pharmacol 533:110-7. 2006
    ..A dual PDE3-PDE4 compound may provide more bronchodilator and bronchoprotective effect in addition to the beneficial PDE4 effects...
  39. doi Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
    ..This would focus the problem on the cough symptomatology and lead to greater focus on understanding the mechanisms of cough sensitisation, with the ultimate aim of obtaining more effective antitussives...
  40. doi Outdoor air pollution and respiratory health in Asia
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, and NIHR Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Respirology 16:1023-6. 2011
    ....
  41. doi p38 mitogen-activated protein kinase pathways in asthma and COPD
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, and Biomedical Research Unit, Royal Brompton Hospital, London, England
    Chest 139:1470-9. 2011
    ..Side effects such as liver toxicity remain a possibility, and whether the beneficial effects of p38 inhibitors are clinically significant and sustained need to be determined...
  42. ncbi Current and future prospects for drugs to suppress cough
    K Fan Chung
    National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    IDrugs 6:781-6. 2003
    ....
  43. ncbi Drugs to suppress cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, SW3, UK
    Expert Opin Investig Drugs 14:19-27. 2005
    ....
  44. ncbi Individual cytokines contributing to asthma pathophysiology: valid targets for asthma therapy?
    Kian Fan Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK
    Curr Opin Investig Drugs 4:1320-6. 2003
    ..Blocking the effects of more than one cytokine may be more successful, and greater therapeutic effects may be observed in particular categories of asthma...
  45. ncbi Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma
    K Fan Chung
    National Heart and Lung Institute, Imperial College, London, UK
    Expert Opin Pharmacother 5:439-46. 2004
    ..Omalizumab is well-tolerated by asthma patients and represents a new approach to the treatment of the moderate-to-severe asthmatic patient. It is likely that it will first be used at the more severe end of the asthmatic diathesis...
  46. doi Inflammatory biomarkers in severe asthma
    Kian F Chung
    National Heart and Lung Institute, Imperial College and NIHR Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Curr Opin Pulm Med 18:35-41. 2012
    ..The development of biomarkers for phenotypic diagnosis and prognostic reasons is important...
  47. pmc Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease
    Paul A Kirkham
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY UK
    Am J Respir Crit Care Med 184:796-802. 2011
    ....
  48. ncbi Systematic assessment of difficult-to-treat asthma
    D S Robinson
    Dept of Allergy, Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Eur Respir J 22:478-83. 2003
    ..Systematic evaluation of difficult asthma is useful as it can identify alternative or additional diagnoses, psychiatric illness or nonconcordance with therapy in a substantial proportion of cases (32% in the present series)...
  49. doi Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  50. doi Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
    P Bhavsar
    Section of Airways Disease, National Heart and Lung Institute, Imperial College and Royal Brompton and Harefield NHS Trust Hospital, London, UK
    Eur Respir J 35:750-6. 2010
    ..Corticosteroid insensitivity in severe asthma patients may be improved by inhibitors of p38 MAPK...
  51. ncbi Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    N Lazzeri
    Thoracic Medicine and Cardiothoracic Surgery, National Heart and Lung Institute, London; Pharmacology Department, Dagenham Research Centre, Dagenham, Essex; and Unit of Critical Care Medicine, Royal Brompton Hospital, IC School of Medicine, London, UK
    Am J Respir Cell Mol Biol 24:44-48. 2001
    ..Thus, when HASM cells are activated with cytokines they release PGE2, which acts as a "braking mechanism" to limit the coproduction of GM-CSF. Moreover, agents that elevate cAMP also reduce GM-CSF formation by these cells...
  52. ncbi Pathophysiology and therapy of chronic cough
    K F Chung
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, London, UK
    Minerva Med 96:29-40. 2005
    ..Currently-available antitussives such as dextromethorphan or codeine are modestly successful in controlling cough. New antitussives may be developed that act on the sensory receptors or prevent their sensitisation...
  53. doi EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD
    Stephane Jouneau
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London Royal Brompton Hospital, London, UK
    Respirology 16:705-12. 2011
    ..We determined its cellular origin and role in MMP-9 production in COPD...
  54. ncbi Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects
    K F Chung
    Dept of Medicine, Charing Cross and Westminster Medical School, London, UK
    Eur Respir J 1:890-5. 1988
    ..The distribution of inhaled aerosol, but not the dose, is largely dependent on airway calibre. The differences in PI between normal and asthmatic subjects may at best be explained by the differences in central airway calibre...
  55. ncbi Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Mol Biotechnol 18:213-32. 2001
    ..The important outcome of this is that new preventive and curative treatments may ensue...
  56. ncbi Cough: potential pharmacological developments
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Investig Drugs 11:955-63. 2002
    ..Large scale trials of these novel compounds have not been carried out in cough in man but there is a serious need for more effective antitussives devoid of side effects...
  57. doi Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma
    P Macedo
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 39:1668-76. 2009
    ..About 5-10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy...
  58. ncbi Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages
    L Atzori
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:530-5. 2004
    ..We concluded that HO-2 expression is reduced in alveolar macrophages of smokers, possibly due to the oxidative stress of cigarette smoke. This may in turn lead to reduced protection against further oxidative insults...
  59. ncbi Cytokines in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur Respir J Suppl 34:50s-59s. 2001
    ..The role of these cytokines needs to be defined and there is a potential for anticytokine therapy in chronic obstructive pulmonary disease...
  60. pmc Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough
    A Niimi
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Thorax 59:608-12. 2004
    ..Increased hydrogen and reduced chloride ionic environments of the airways are conducive to the stimulation of cough. However, the constituents of the local milieu of the airways of patients with chronic cough are unknown...
  61. doi A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children
    Aristea Binia
    Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Hum Mutat 34:1131-9. 2013
    ..Our association between a variant MYB binding site in PDCD4 and the severest form of childhood asthma therefore suggests that PDCD4 is a novel molecule of importance to asthmatic inflammatory responses. ..
  62. doi Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD
    Christopher K M Hui
    Airway Disease and Experimental Studies Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UK
    Expert Rev Respir Med 5:9-16. 2011
    ..It is likely that indacaterol could be used in conjunction with other agents such as inhaled corticosteroids and anticholinergics for the treatment of COPD as a single once-daily combination treatment...
  63. ncbi Therapy for cough: active agents
    K F Chung
    Royal Brompton Hospital, National Heart and Lung Institute, London, England
    Pulm Pharmacol Ther 15:335-8. 2002
    ..Large scale trials of these novel compounds have not been tried in cough in man, but there is a serious need for more effective antitussives devoid of side-effects...
  64. pmc Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:1009-14. 1989
    ..Most of the bronchoconstriction is not inhibited by antimuscarinic agents; the underlying mechanisms require further investigation...
  65. ncbi Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system
    J W Lammers
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, United Kingdom
    J Appl Physiol 67:856-61. 1989
    ..This reflex could not be distinguished from that caused by coughing or by deep inhalation. A defect in nonadrenergic mechanisms, at least in mild asthma, seems unlikely...
  66. pmc Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction
    A Nix
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Br J Clin Pharmacol 29:321-4. 1990
    ..2- and 2.9-fold at 2 and 5 h respectively). 4. Thus, formoterol has a protective effect against methacholine-induced bronchoconstriction which lasts for at least 5 h...
  67. ncbi Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone
    E B Haddad
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Mol Pharmacol 57:1123-31. 2000
    ..Nuclear run-on experiments demonstrate that the induction of B1 and the up-regulation of B2 receptors as well as the inhibitory effect of dexamethasone are entirely mediated through post-transcriptional mechanisms...
  68. ncbi Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages
    S Lim
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, UK
    Allergy 59:505-14. 2004
    ..Reduced IL-10 may result in exaggerated and more prolonged inflammatory responses in asthmatic airways. IL-10 acting through the IL-10 receptor (IL-10R) stimulates the transcription factors STAT1 and STAT3...
  69. ncbi Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma
    S Lim
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 164:273-6. 2001
    ..Low-dose theophylline induced antiinflammatory effects in asthma, reflected by a fall in airway eosinophils with no change in exhaled NO or changes in lung function...
  70. pmc Capsaicin cough sensitivity in bronchiectasis
    A Torrego
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 61:706-9. 2006
    ..A study was undertaken to determine whether cough sensitivity is increased in bronchiectatic patients...
  71. ncbi Regulation of human lung epithelial cell numbers by diesel exhaust particles
    H Bayram
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 27:705-13. 2006
    ..Therefore, low-dose diesel exhaust particle exposure may lead to lung epithelial cell hyperplasia...
  72. ncbi RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol
    N Lazzeri
    Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 433:231-5. 2001
    ..These data suggest that, in settings where cyclo-oxygenase activity is low, both drugs may relieve the symptoms of airway diseases by reducing RANTES production...
  73. ncbi Expression of respiratory mucins in fatal status asthmaticus and mild asthma
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Histopathology 40:367-73. 2002
    ..The effect of inhaled corticosteroids on the expression of these mucins was also investigated...
  74. ncbi Role for platelet-activating factor in asthma
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Lipids 26:1277-9. 1991
    ..The interaction between PAF and eosinophils may be crucial in the pathogenesis of bronchial hyperresponsiveness in asthma. A role for PAF in asthma can now be studied using the recently developed antagonists of the PAF receptor...
  75. pmc Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells
    Mark M Perry
    Experimental Studies, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 45:746-52. 2011
    ..Therefore, regulation of H(2)S may represent a novel approach to controlling ASM proliferation and cytokine release that is found in patients with asthma...
  76. pmc A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice
    Kostas Triantaphyllopoulos
    Experimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Am J Physiol Lung Cell Mol Physiol 300:L691-700. 2011
    ..Exposure of mice to ozone for 6 wk induced a chronic inflammatory process, with alveolar enlargement and damage linked to epithelial apoptosis and increased protease expression...
  77. ncbi Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Rev Respir Dis 142:576-80. 1990
    ..Nasal PD was measured before and after placebo or furosemide, and again after MBS inhalation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  78. pmc Failure of sputum eosinophilia after eotaxin inhalation in asthma
    D Bumbacea
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Thorax 59:372-5. 2004
    ..The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined...
  79. ncbi Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema
    J O Lotvall
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    J Appl Physiol (1985) 69:1473-8. 1990
    ..We conclude that the inability of hyperinflation to fully reverse changes in RL after SP may be due to the formation of both airway and pulmonary edema, which may also contribute to the deterioration in RL...
  80. ncbi Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferation after repeated allergen exposures
    S Y Leung
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 34:213-20. 2004
    ..Chronic inflammation in asthmatic airways can lead to characteristic airway smooth muscle (ASM) thickening and pathological changes within the airway wall...
  81. ncbi Assessment and measurement of cough: the value of new tools
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:267-72. 2002
    ..We need a greater assessment and evaluation of all these tools...
  82. ncbi Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Respir Med 96:81-6. 2002
    ..MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia...
  83. pmc Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma
    E L van Rensen
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Thorax 56:935-40. 2001
    ..CONCLUSION: The effects of IL-5 appear to be mainly in the circulation, inducing peripheral mobilisation of eosinophils to the circulation without any effect on eosinophil mobilisation in the lungs or on bronchial responsiveness...
  84. ncbi Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma
    R G Stirling
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:1403-9. 2001
    ..Further, IL-5 causes terminal maturation of the eosinophil by increasing CCR3 expression, potentially affecting CCR3-dependent chemotaxis by eosinophils and lymphocytes...
  85. pmc Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids
    K F Chung
    Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 127:1145-50. 1999
    ..Thus, human airway smooth muscle cells can release eotaxin and could be an important source of chemokine production during airway inflammatory events...
  86. ncbi Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma
    S Lim
    National Heart and Lung Institute, Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Allergy 55:489-95. 2000
    ..We determined the effect of late-phase responses to allergen challenge of mildly allergic asthmatic patients on the expression and release of the cytokines IL-10 and MIP-1alpha from peripheral blood monocytes...
  87. ncbi Non-invasive biomarkers of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Pediatr Pulmonol Suppl 18:41-4. 1999
    ....
  88. pmc Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:102-7. 1989
    ..Thus a therapeutic dose of salbutamol caused partial inhibition of platelet activating factor induced bronchoconstriction and had a minimal effect on the increased bronchial responsiveness following platelet activating factor...
  89. ncbi Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, England
    Allergy Proc 10:333-7. 1989
    ..These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis...
  90. pmc Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:108-15. 1989
    ....
  91. ncbi Effect of theophylline on airway responses to inhaled platelet-activating factor in man
    K F Chung
    Dept of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, UK
    Eur Respir J 2:763-8. 1989
    ..Our results suggest that theophylline has negligible influence on the airway effects of PAF...
  92. ncbi Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma
    E Bucchioni
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:651-5. 2004
    ..The detection of LTs and histamine in exhaled breath condensate may be useful in monitoring asthma...
  93. ncbi Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease
    Fabio L M Ricciardolo
    Unit of Respiratory Disease, Istituto di Ricovero e Cura a Carattere Scientifico Gaslini Institute, Genoa, Italy
    J Allergy Clin Immunol 116:1028-35. 2005
    ..Reactive nitrogen species formation and nitrosative stress are potentially involved in chronic obstructive pulmonary disease (COPD) pathogenesis...
  94. ncbi Nature of airway inflammation and remodeling in chronic cough
    Akio Niimi
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    J Allergy Clin Immunol 116:565-70. 2005
    ..Chronic cough may be a result of asthma and non-asthma causes, but it is unclear whether there are specific inflammatory or remodeling changes...
  95. ncbi Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma
    Lan Tien Nguyen
    Department of Thoracic Medicine, Imperial College and Royal Brompton Hospital, National Heart and Lung Institute, London SW36LY, UK
    Respir Med 99:200-7. 2005
    ..We determined whether inhaled or oral corticosteroid therapy can induce airway neutrophilia...
  96. ncbi Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays
    Gabor Jarai
    Novartis Horsham Research Centre, Horsham, West Sussex, UK
    Eur J Pharmacol 497:255-65. 2004
    ..The rich profile of mediators, growth factors and signalling molecules released from airway smooth muscle depends on the inflammatory milieu...
  97. ncbi Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids
    Maria B Sukkar
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, Dovehouse St, SW3 6LY, London, UK
    Am J Physiol Lung Cell Mol Physiol 287:L1230-40. 2004
    ..In summary, FKN production by human ASMC in vitro is regulated by inflammatory and anti-inflammatory factors...
  98. ncbi Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features
    Sum Yee Leung
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    J Allergy Clin Immunol 115:989-96. 2005
    ..Several topical corticosteroids are available as anti-inflammatory treatment for asthma. Their comparative effects on allergic inflammation and airway remodeling are unclear...
  99. pmc Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma
    Chun Hua Wang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Br J Pharmacol 138:1147-55. 2003
    ..The anti-inflammatory properties of theophylline include an inhibition of circulating progenitor cells...
  100. doi Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A
    Manminder Kaur
    Dept of Cell Biology and Anatomy, Faculty of Medicine, Univ of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    Am J Physiol Lung Cell Mol Physiol 295:L505-14. 2008
    ..Collectively, these results indicate that repression of IL-1beta-induced ICAM-1 expression and GM-CSF release by cAMP-elevating agents, including beta(2)-adrenoceptor agonists, may not occur through a generic effect on NF-kappaB...

Research Grants5

  1. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2001
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  2. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2002
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  3. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2003
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  4. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2004
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  5. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..