Paul Facer

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri
    Berith K Tingaker
    Karolinska Institutet, Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 6:8. 2008
  2. ncbi Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    Paul Facer
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 7:11. 2007
  3. ncbi Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    BMC Neurol 6:1. 2006
  4. ncbi COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 6:12. 2006
  5. ncbi Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, And Nav1.9 in rhinitis
    Siew M Keh
    Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Laryngoscope 118:573-9. 2008
  6. ncbi Expression of the sodium channel beta3 subunit in injured human sensory neurons
    Maria A Casula
    Peripheral Neuropathy Unit, Imperial College London, Area A, Ground Floor, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Neuroreport 15:1629-32. 2004
  7. ncbi Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain)
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Neurosci Lett 427:77-82. 2007
  8. ncbi Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 9:15-25. 2004
  9. ncbi Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
    Duncan D Atherton
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    BMC Neurol 7:21. 2007
  10. ncbi Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
    Uma Anand
    Peripheral Neuropathy Unit, Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W120NN, UK
    Pain 138:667-80. 2008

Collaborators

Detail Information

Publications14

  1. ncbi Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri
    Berith K Tingaker
    Karolinska Institutet, Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 6:8. 2008
    ..Therefore, the aim of this study was to investigate human corpus and cervix uteri during pregnancy and labor and non-pregnant controls for the presence of TRPV1...
  2. ncbi Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    Paul Facer
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 7:11. 2007
    ..However, the role of TRPs in common clinical sensory neuropathies needs to be established...
  3. ncbi Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    BMC Neurol 6:1. 2006
    ..We have now investigated the time course of EP1 and Cox-2 changes in injured human nerves and dorsal root ganglia (DRG), and the chronic constriction nerve injury (CCI) model in the rat...
  4. ncbi COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 6:12. 2006
    ..Therefore, three key molecules known to be expressed in activated microglial cells/macrophages, COX-2, CB2 and P2X7, which plays a role in inflammatory cascades, were studied in MS and ALS post-mortem human spinal cord...
  5. ncbi Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, And Nav1.9 in rhinitis
    Siew M Keh
    Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Laryngoscope 118:573-9. 2008
    ..Voltage-gated sodium channels Nav1.7, Nav1.8, and Nav1.9 are involved in nerve action potentials and have been proposed to underlie neuronal hypersensitivity. We have therefore studied their levels in allergic and nonallergic rhinitis...
  6. ncbi Expression of the sodium channel beta3 subunit in injured human sensory neurons
    Maria A Casula
    Peripheral Neuropathy Unit, Imperial College London, Area A, Ground Floor, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Neuroreport 15:1629-32. 2004
    ..beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8. Targeting beta3 interactions with key alpha-subunits, particularly Nav1.3 and Nav1.8, may provide novel selective analgesics...
  7. ncbi Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain)
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Neurosci Lett 427:77-82. 2007
    ..7 immunoreactivity or expression. Drugs that target Na(v)1.7-expressing nerve terminals may be useful for treating rectal hypersensitivity, and combining these with TRPV1 antagonists may enhance efficacy...
  8. ncbi Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 9:15-25. 2004
    ..Selection of patients 4-6 weeks after nerve injury would be more likely to show any efficacy of Cox-2 inhibitors...
  9. ncbi Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
    Duncan D Atherton
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    BMC Neurol 7:21. 2007
    ..e. the histamine-induced skin flare response and intra-epidermal fibres (IEF), and also quantitative sensory testing (QST), a subjective measure...
  10. ncbi Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
    Uma Anand
    Peripheral Neuropathy Unit, Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W120NN, UK
    Pain 138:667-80. 2008
    ..We conclude that CB2 agonists deserve imminent clinical trials for nociceptive, inflammatory and neuropathic chronic pain, in which capsaicin or heat-activated responses via TRPV1 may provide a clinical marker...
  11. ncbi Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart
    Paul Facer
    Department of Clinical Neuroscience, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Int Heart J 52:146-52. 2011
    ..We conclude that sodium channel Na(v)1.8 is present in sensory nerves and cardiomyocytes of human heart. Na(v)1.8 and other pain channels provide new targets for the understanding and treatment of cardiac pain and dysrhythmia...
  12. ncbi Neuronal markers in allergic rhinitis: expression and correlation with sensory testing
    Paul Facer
    Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Laryngoscope 117:1519-27. 2007
    ..5 (PGP 9.5), sensory and autonomic neuropeptides, the capsaicin/heat receptor TRPV1, and nerve growth factor (NGF) in patients with allergic rhinitis and controls and their correlation with nasal sensitivity...
  13. ncbi Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel
    Steven J Arnold
    Imperial College of Sciences, Technology and Medicine, Hammersmith Hospital, London, UK
    Neuroreport 14:191-5. 2003
    ..Our findings may explain the diarrhoea and colicky abdominal pain produced by inflammatory bowel disease, and by IK1-blocking pyridine drugs prescribed for neuromuscular disorders...
  14. ncbi Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skin
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 7:190-7. 2002
    ..The different molecular forms derived from prepro-NGF are likely to be of importance in sensory mechanisms, and deserve further investigation...