A V Emmanuel

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with a positive response
    A V Emmanuel
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 19:687-94. 2004
  2. ncbi Anorexia nervosa in gastrointestinal practice
    Anton V Emmanuel
    St Mark s Hospital, Northwick Park, Harrow, UK, and Eating Disorder Unit, Maudsley Hospital, London, UK
    Eur J Gastroenterol Hepatol 16:1135-42. 2004
  3. ncbi Pharmacological modulation of gut mucosal and large vessel blood flow
    M A Kamm
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 25:693-702. 2007
  4. doi Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome
    N M Thoua
    GI Physiology Unit, University College Hospital, London, UK
    Aliment Pharmacol Ther 29:552-60. 2009
  5. pmc Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder
    A V Emmanuel
    St Mark's Hospital, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 49:209-13. 2001
  6. pmc Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow
    M E D Jarrett
    Physiology Unit, St Mark s Hospital, Harrow, UK
    Gut 53:368-70. 2004
  7. pmc Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study
    A V Emmanuel
    University College, London, UK
    Aliment Pharmacol Ther 35:48-55. 2012
  8. pmc Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation
    A V Emmanuel
    St Mark's Hospital, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 49:214-9. 2001
  9. doi Relationship between gut-specific autonomic testing and bowel dysfunction in spinal cord injury patients
    A V Emmanuel
    University College Hospital, London, UK
    Spinal Cord 47:623-7. 2009
  10. ncbi Azathioprine dose escalation in inflammatory bowel disease
    C K Rayner
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 20:65-71. 2004

Collaborators

Detail Information

Publications23

  1. ncbi Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with a positive response
    A V Emmanuel
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 19:687-94. 2004
    ..Chronic intestinal pseudo-obstruction, due to intestinal myopathy or neuropathy, is characterized by the signs and symptoms of intestinal obstruction in the absence of true obstruction. Episodes are resistant to medical therapy...
  2. ncbi Anorexia nervosa in gastrointestinal practice
    Anton V Emmanuel
    St Mark s Hospital, Northwick Park, Harrow, UK, and Eating Disorder Unit, Maudsley Hospital, London, UK
    Eur J Gastroenterol Hepatol 16:1135-42. 2004
    ..To characterize the demographic, psychosocial and prognostic features of patients with anorexia nervosa (AN) presenting to a gastroenterology service, and to compare them with patients presenting to an eating disorders unit...
  3. ncbi Pharmacological modulation of gut mucosal and large vessel blood flow
    M A Kamm
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 25:693-702. 2007
    ..Constipation, diminished gut blood flow, ischaemic colitis and drug therapy may be associated...
  4. doi Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome
    N M Thoua
    GI Physiology Unit, University College Hospital, London, UK
    Aliment Pharmacol Ther 29:552-60. 2009
    ..Acute physical stress causes alteration in gut autonomic function and visceral hypersensitivity in patients with irritable bowel syndrome (IBS). We have developed a model to measure this stress response...
  5. pmc Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder
    A V Emmanuel
    St Mark's Hospital, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 49:209-13. 2001
    ..These findings suggest that psychological factors are likely to influence gut function via autonomic efferent neural pathways...
  6. pmc Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow
    M E D Jarrett
    Physiology Unit, St Mark s Hospital, Harrow, UK
    Gut 53:368-70. 2004
    ..Rectal mucosal blood flow was used as a validated measure of extrinsic autonomic nerve function...
  7. pmc Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study
    A V Emmanuel
    University College, London, UK
    Aliment Pharmacol Ther 35:48-55. 2012
    ..Chronic intestinal pseudo-obstruction is a disabling condition for which there are no established drug therapies. The condition is caused by a diverse range of intestinal myopathies and neuropathies...
  8. pmc Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation
    A V Emmanuel
    St Mark's Hospital, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 49:214-9. 2001
    ..Successful outcome after biofeedback treatment is associated with improved activity of the direct cerebral innervation to the gut and improved gut transit. This effect is gut specific; cardiovascular autonomic reflexes were not altered...
  9. doi Relationship between gut-specific autonomic testing and bowel dysfunction in spinal cord injury patients
    A V Emmanuel
    University College Hospital, London, UK
    Spinal Cord 47:623-7. 2009
    ..Investigation of bowel function in 55 patients and 26 healthy volunteers using radiological, anorectal physiological and laser Doppler blood flow monitoring...
  10. ncbi Azathioprine dose escalation in inflammatory bowel disease
    C K Rayner
    St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 20:65-71. 2004
    ..Forty per cent of patients with inflammatory bowel disease fail to respond to standard dose azathioprine (2 mg/kg/day)...
  11. ncbi Ghrelin augments afferent response to distension in rat isolated jejunum
    C D R Murray
    St Mark s Hospital, Harrow, UK
    Neurogastroenterol Motil 18:1112-20. 2006
    ..Ghrelin augments the mechanosensation of jejunal vagal afferents and hence may lead to increased perception of hunger contractions...
  12. ncbi Gut mucosal response to food antigens in Crohn's disease
    J Van Den Bogaerde
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1903-15. 2002
    ..Food antigens may contribute to gut inflammation in Crohn's disease...
  13. pmc Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study
    C D R Murray
    Physiology Unit, St Mark s Hospital, Harrow HA1 3UJ, UK
    Gut 54:1693-8. 2005
    ..In animals, ghrelin increases gastric emptying and reverses postoperative ileus. We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis...
  14. ncbi Vector volume manometry--methods and normal values
    A M P Schizas
    Department of Colorectal Surgery, Guy s and St Thomas Hospitals NHS Foundation Trust, London, UK
    Neurogastroenterol Motil 23:886-e393. 2011
    ..Currently no standard technique or equipment exists to assess anal canal VVM. This study aimed to assess the different techniques to produce repeatable results, and generate normal values for the vector volume profile...
  15. ncbi Consensus review of best practice of transanal irrigation in adults
    A V Emmanuel
    Department of GI Physiology, University College London, London, UK
    Spinal Cord 51:732-8. 2013
    ..Review article...
  16. ncbi Normal ranges for anorectal manometry and sensation in women of reproductive age
    C Chaliha
    University College Hospital, London, UK
    Colorectal Dis 9:839-44. 2007
    ..To derive a range of normal values for anal sphincter resting and squeeze pressure, and anorectal sensation in healthy women without anorectal disease before and after their first childbirth...
  17. ncbi Acid-related oesophageal sensitivity, not dysmotility, differentiates subgroups of patients with non-erosive reflux disease
    N M Thoua
    Physiology Unit, University College Hospital, London, UK
    Aliment Pharmacol Ther 27:396-403. 2008
    ..Patients with non-erosive reflux disease can experience reflux symptoms with similar frequency and severity as those with erosive reflux disease. Oesophageal motility and acid sensitivity are thought to influence symptom occurrence...
  18. ncbi Pharmacological management of constipation
    A V Emmanuel
    Physiology Unit, University College Hospital, London, UK
    Neurogastroenterol Motil 21:41-54. 2009
    ..The approach of this review is to give a pragmatic approach to using laxatives, based on a combination of what is known about mechanism of action and the available literature on evidence...
  19. ncbi Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis
    C K Rayner
    Department of Medicine, St Mark s Hospital, London, UK
    Aliment Pharmacol Ther 18:303-8. 2003
    ..This is associated with considerable morbidity. We have been using a low-dose regimen, most commonly without concurrent steroids, for seven years, and present the outcome...
  20. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
    ..Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis...
  21. ncbi Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury
    Eric A L Chung
    St Mark s Hospital, Northwick Park, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
    Prog Brain Res 152:317-33. 2006
    ..Together with a following summary of current bowel management regimens and techniques, this chapter aims to provide an overall view of the effect that autonomic dysfunction due to spinal cord injury has on gastrointestinal function...
  22. ncbi Patterns of constipation in urogynecology: clinical importance and pathophysiologic insights
    Marco Soligo
    Department of Gynecological Surgery, University of Milan Bicocca Bassini Hospital, Cinisello Balsamo Milano, Italy
    Am J Obstet Gynecol 195:50-5. 2006
    ..We have analyzed the prevalence and patterns of constipation in women with urinary symptoms and/or genital prolapse...
  23. ncbi Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome
    Charles D R Murray
    St Mark s Hospital, Harrow, Middlesex HA1 3UJ, England
    Gastroenterology 127:1695-703. 2004
    ..We studied the effect of acute physical and psychological stress on autonomic innervation and visceral sensitivity in healthy volunteers and patients with IBS...