P Elliott

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Adult cancers near high-voltage overhead power lines
    Paul Elliott
    Small Area Health Statistics Unit, MRC HPA Centre for Environment and Health, School of Public Health, Imperial College London, St Mary s Campus, London, United Kingdom
    Epidemiology 24:184-90. 2013
  2. pmc Current standards for the storage of human samples in biobanks
    Tim Peakman
    UK Biobank, Units 1 2 Spectrum Way, Adswood, Cheshire SK3 0SA, UK
    Genome Med 2:72. 2010
  3. pmc Design issues in small-area studies of environment and health
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, UK
    Environ Health Perspect 116:1098-104. 2008
  4. doi request reprint Geographic density of landfill sites and risk of congenital anomalies in England
    P Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Occup Environ Med 66:81-9. 2009
  5. pmc Spatial epidemiology: current approaches and future challenges
    Paul Elliott
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    Environ Health Perspect 112:998-1006. 2004
  6. pmc Mobile phone base stations and early childhood cancers: case-control study
    Paul Elliott
    Small Area Health Statistics Unit, MRC HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 340:c3077. 2010
  7. pmc Long-term associations of outdoor air pollution with mortality in Great Britain
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Thorax 62:1088-94. 2007
  8. doi request reprint The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 37:234-44. 2008
  9. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
  10. doi request reprint Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008

Detail Information

Publications113 found, 100 shown here

  1. doi request reprint Adult cancers near high-voltage overhead power lines
    Paul Elliott
    Small Area Health Statistics Unit, MRC HPA Centre for Environment and Health, School of Public Health, Imperial College London, St Mary s Campus, London, United Kingdom
    Epidemiology 24:184-90. 2013
    ..Extremely low-frequency magnetic fields are designated as possibly carcinogenic in humans, based on an epidemiologic association with childhood leukemia. Evidence for associations with adult cancers is weaker and inconsistent...
  2. pmc Current standards for the storage of human samples in biobanks
    Tim Peakman
    UK Biobank, Units 1 2 Spectrum Way, Adswood, Cheshire SK3 0SA, UK
    Genome Med 2:72. 2010
    ..This should enable the data derived from biobanks to contribute as part of wider collaborative efforts with other similar resources...
  3. pmc Design issues in small-area studies of environment and health
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, UK
    Environ Health Perspect 116:1098-104. 2008
    ..We focus on etiologic research, where the aim is to make inferences about spatially varying environmental factors influencing the risk of disease...
  4. doi request reprint Geographic density of landfill sites and risk of congenital anomalies in England
    P Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Occup Environ Med 66:81-9. 2009
    ..To investigate the risk of congenital anomalies in relation to an index of geographic density of landfill sites across 5x5 km grid squares in England...
  5. pmc Spatial epidemiology: current approaches and future challenges
    Paul Elliott
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    Environ Health Perspect 112:998-1006. 2004
    ....
  6. pmc Mobile phone base stations and early childhood cancers: case-control study
    Paul Elliott
    Small Area Health Statistics Unit, MRC HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 340:c3077. 2010
    ..To investigate the risk of early childhood cancers associated with the mother's exposure to radiofrequency from and proximity to macrocell mobile phone base stations (masts) during pregnancy...
  7. pmc Long-term associations of outdoor air pollution with mortality in Great Britain
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Thorax 62:1088-94. 2007
    ..Recent studies have indicated long-term effects on mortality of particulate and sulphur dioxide (SO(2)) pollution, but uncertainties remain over the size of any effects, potential latency and generalisability...
  8. doi request reprint The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 37:234-44. 2008
    ..The biological samples that are collected and how they are processed and stored will have a major impact on the future scientific usefulness of the UK Biobank resource...
  9. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
    ..Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
  10. doi request reprint Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008
    ..These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension...
  11. ncbi request reprint Change in salt intake affects blood pressure of chimpanzees: implications for human populations
    Paul Elliott
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Circulation 116:1563-8. 2007
    ..Effects of more modest alterations to sodium intakes in chimpanzees, akin to current efforts to lower sodium intakes in the human population, are unknown...
  12. ncbi request reprint Association between protein intake and blood pressure: the INTERMAP Study
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, England
    Arch Intern Med 166:79-87. 2006
    ..Findings from epidemiological studies suggest an inverse relationship between individuals' protein intake and their blood pressure...
  13. pmc Risk of adverse birth outcomes in populations living near landfill sites
    P Elliott
    Small Area Health Statistics Unit SAHSU, Department of Epidemiology and Public Health, Imperial College, St Mary s Campus, London W2 1PG
    BMJ 323:363-8. 2001
    ..To investigate the risk of adverse birth outcomes associated with residence near landfill sites in Great Britain...
  14. pmc Proximity to coke works and hospital admissions for respiratory and cardiovascular disease in England and Wales
    P Aylin
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Thorax 56:228-33. 2001
    ..The incidence of hospital admissions for respiratory and cardiovascular diseases in areas close to operating coke works in England and Wales was investigated...
  15. doi request reprint Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
  16. ncbi request reprint Temperature, housing, deprivation and their relationship to excess winter mortality in Great Britain, 1986-1996
    P Aylin
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College School of Medicine, London W2 1PG, UK
    Int J Epidemiol 30:1100-8. 2001
    ..To examine the associations between temperature, housing, deprivation and excess winter mortality using census variables as proxies for housing conditions...
  17. ncbi request reprint A regression-based method for mapping traffic-related air pollution: application and testing in four contrasting urban environments
    D J Briggs
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, London, UK
    Sci Total Environ 253:151-67. 2000
    ..It is concluded that the model might thus be used as a means of mapping long-term air pollution concentrations either in support of local authority air-quality management strategies, or in epidemiological studies...
  18. doi request reprint Human metabolic phenotype diversity and its association with diet and blood pressure
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nature 453:396-400. 2008
    ..Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk...
  19. doi request reprint Enzyme replacement therapy with agalsidase alfa in patients with Fabry's disease: an analysis of registry data
    A Mehta
    University College London, London, UK
    Lancet 374:1986-96. 2009
    ..We analysed 5-year treatment with agalsidase alfa enzyme replacement therapy in patients with Fabry's disease who were enrolled in the Fabry Outcome Survey observational database (FOS)...
  20. pmc Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Norfolk Place, London, W2 1PG, UK
    Radiat Environ Biophys 49:139-53. 2010
    ..Although the predictions of the model are consistent with the epidemiological data, the experimental predictions made have yet to be tested. Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
  21. pmc Small-area study of the incidence of neoplasms of the brain and central nervous system among adults in the West Midlands region, 1974-86. Small Area Health Statistics Unit
    N Eaton
    Department of Epidemiology and Public Health, Imperial College School of Medicine at St Mary s, London, UK
    Br J Cancer 75:1080-3. 1997
    ..02) of cancer risk with deprivation (8% higher risk in affluent areas), but no significant association with urban-rural status. Results were not indicative of a strong geographically determined risk at small-area level...
  22. doi request reprint Uncovering selection bias in case-control studies using Bayesian post-stratification
    S Geneletti
    Department of Statistics, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK
    Stat Med 32:2555-70. 2013
    ..In both case-control studies, our method showed that the odds ratios were only moderately sensitive to selection bias...
  23. pmc Cancer incidence near municipal solid waste incinerators in Great Britain
    P Elliott
    Small Area Health Statistics Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, UK
    Br J Cancer 73:702-10. 1996
    ....
  24. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
    ..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
  25. pmc Cancer risks in populations living near landfill sites in Great Britain
    L Jarup
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Br J Cancer 86:1732-6. 2002
    ..Our results do not support suggestions of excess risks of cancer associated with landfill sites reported in other studies...
  26. ncbi request reprint Comparison of UK paediatric cardiac surgical performance by analysis of routinely collected data 1984-96: was Bristol an outlier?
    P Aylin
    Division of Primary Care and Population Health Sciences, Imperial College School of Medicine, London, UK
    Lancet 358:181-7. 2001
    ..A key question was whether or not the mortality statistics in Bristol were unusual compared with other specialist centres. To answer this question, we did a retrospective analysis of mortality in the UK using two datasets...
  27. pmc Spatial variation and temporal trends of testicular cancer in Great Britain
    M B Toledano
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College School of Medicine, Norfolk Place, London, W2 1PG, UK
    Br J Cancer 84:1482-7. 2001
    ..The absence of any marked geographical variability at small area scale argues against a geographically varying environmental factor operating strongly in the aetiology of testicular cancer...
  28. pmc Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
    ..Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years...
  29. ncbi request reprint Standardised coding of diet records: experiences from INTERMAP UK
    Rana Conway
    Department of Nutrition and Dieics, Kings College London, London, UK
    Br J Nutr 91:765-71. 2004
    ..While the methods used in INTERMAP to reduce coding errors were time consuming, the experiences suggest that such errors are important and that they can be reduced...
  30. ncbi request reprint Uptake of chlorination disinfection by-products; a review and a discussion of its implications for exposure assessment in epidemiological studies
    M J Nieuwenhuijsen
    The TH Huxley School of Environmental, Earth Sciences and Engineering, Imperial College School of Science, Technology and Medicine, London, UK
    J Expo Anal Environ Epidemiol 10:586-99. 2000
    ..Recommendations are made for further areas of study...
  31. ncbi request reprint No excess risk of adverse birth outcomes in populations living near special waste landfill sites in Scotland
    S E Morris
    Small Area Health Statistics Unit SAHSU, Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK
    Scott Med J 48:105-7. 2003
    ..There was no excess risk of stillbirth. In conclusion, we found no statistically significant excess risks of congenital anomalies or low birth weight in populations living near special waste landfill sites in Scotland...
  32. pmc Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions in England
    Mireille B Toledano
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
    Environ Health Perspect 113:225-32. 2005
    ..Further work is needed looking at cause-specific stillbirths and effects of other disinfection by-products and to help differentiate between alternative (noncausal) explanations and those that may derive from the water supply...
  33. ncbi request reprint Modelling exposure to disinfection by-products in drinking water for an epidemiological study of adverse birth outcomes
    Heather Whitaker
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, UK
    J Expo Anal Environ Epidemiol 15:138-46. 2005
    ..We conclude that our modelling approach enabled us to provide robust quarterly estimates of ecological exposure to THMs in a situation where the raw data were too sparse to base exposure assessment on empirical summaries alone...
  34. doi request reprint Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, W2 1PG, London, UK
    Eur Heart J 29:1049-56. 2008
    ..Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years...
  35. ncbi request reprint Trends in acoustic neuroma and cellular phones: is there a link?
    P D Nelson
    Department of Epidemiology and Public Health, Imperial College London, UK
    Neurology 66:284-5. 2006
  36. doi request reprint Heritability and genetic correlations of insulin resistance and component phenotypes in Asian Indian families using a multivariate analysis
    D Zabaneh
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Diabetologia 52:2585-9. 2009
    ..Little is known about the heritability of insulin resistance traits in Asian Indians. Our objective was to estimate heritabilities and genetic correlations in Asian Indian families...
  37. pmc Excess risk of kidney disease in a population living near industrial plants
    S Hodgson
    Small Area Health Statistics Unit SAHSU, Imperial College London, UK
    Occup Environ Med 61:717-9. 2004
    ..The excess risk of kidney disease in the Runcorn area requires further investigation...
  38. ncbi request reprint Outdoor sulphur dioxide and respiratory symptoms in Czech and Polish school children: a small-area study (SAVIAH). Small-Area Variation in Air Pollution and Health
    H Pikhart
    Department of Epidemiology and Public Health, University College London, UK
    Int Arch Occup Environ Health 74:574-8. 2001
    ..We used a novel technique to estimate the outdoor concentrations of sulphur dioxide (SO2) at small-area level to study the long-term effects on respiratory symptoms and disease in children...
  39. doi request reprint Rationale and design of a prospective trial to assess the sensitivity and positive predictive value of implantable intrathoracic impedance monitoring in the prediction of heart failure hospitalizations: the SENSE-HF study
    Martin R Cowie
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    J Card Fail 15:394-400. 2009
    ..Intrathoracic impedance monitoring is a new diagnostic tool for patients with heart failure that may aid early identification of decompensation and pulmonary congestion...
  40. ncbi request reprint Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study
    Marc Emmanuel Dumas
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London UK
    Anal Chem 78:2199-208. 2006
    ..These cross-population differences in urinary metabolites could be related to genetic, dietary, and gut microbial factors...
  41. ncbi request reprint Kidney disease mortality and environmental exposure to mercury
    Susan Hodgson
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    Am J Epidemiol 165:72-7. 2007
    ....
  42. pmc Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966
    Ulla Sovio
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 5:e1000409. 2009
    ....
  43. ncbi request reprint Tracing ingestion of 'novel' foods in UK diets for possible health surveillance--a feasibility study
    Claire Robertson
    Department of Epidemiology and Public Health, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Public Health Nutr 7:345-52. 2004
    ..To investigate the feasibility of using commercially available data on household food consumption to carry out food and nutritional surveillance...
  44. doi request reprint Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study
    Ioanna Tzoulaki
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, W2 1PG London, United Kingdom
    Am J Epidemiol 171:989-98. 2010
    ..These results showed that growth during the immediate postnatal period is associated with adulthood obesity and BP. Lifestyle changes from early life might be important in reducing adulthood obesity and high-BP risk...
  45. ncbi request reprint Prevalence of hypospadias in the same geographic region as ascertained by three different registries
    Paul Nelson
    Department of Epidemiology and Public Health, Imperial College School of Clinical Medicine, Norfolk Place, London W2 1PG
    Birth Defects Res A Clin Mol Teratol 79:685-7. 2007
    ..NCAR's utility could be improved if it returned to including "minor" hypospadias. Meanwhile routine data such as HES are potentially suitable for surveillance of this condition...
  46. ncbi request reprint Down syndrome in births near landfill sites
    Lars Jarup
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Prenat Diagn 27:1191-6. 2007
    ..The aim of the study was to examine the risk of giving birth to a child with Down syndrome associated with residence near landfill sites in England and Wales...
  47. doi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  48. pmc Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure
    Ian J Brown
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
    Hypertension 57:695-701. 2011
    ..These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced...
  49. pmc Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 337:a258. 2008
    ..To investigate associations of dietary iron (total, haem, and non-haem), supplemental iron, and red meat with blood pressure...
  50. pmc Paediatric cardiac surgical mortality in England after Bristol: descriptive analysis of hospital episode statistics 1991-2002
    Paul Aylin
    Dr Foster Unit at Imperial College London, Department of Epidemiology and Public Health, Imperial College School of Medicine, London W2 1PG
    BMJ 329:825. 2004
    ..To describe trends in mortality of open cardiac surgery in children in Bristol and England since 1991...
  51. ncbi request reprint Geographical epidemiology of prostate cancer in Great Britain
    Lars Jarup
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College School of Medicine, London, United Kingdom
    Int J Cancer 97:695-9. 2002
    ..The absence of any marked geographical variability at a small-area scale argues against a geographically varying environmental factor operating strongly in the aetiology of prostate cancer...
  52. ncbi request reprint Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
    Liisa Lauren
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 32:862-76. 2003
    ....
  53. ncbi request reprint Protein intake and blood pressure in cardiovascular disease
    Paul Elliott
    Department of Epidemiology and Public Health, Imperial College, London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Proc Nutr Soc 62:495-504. 2003
    ..Recent controlled clinical trials of soyabean supplementation have also suggested a BP-lowering effect of protein intake. Results of further large-scale epidemiological studies of protein and BP are awaited...
  54. ncbi request reprint Hemoglobin concentration in pregnancy and perinatal mortality: a London-based cohort study
    Mark P Little
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, St Mary s Campus, Norfolk Place, United Kingdom
    Am J Obstet Gynecol 193:220-6. 2005
    ..The objective of the study was to determine the association between maternal hemoglobin concentration during pregnancy and perinatal mortality...
  55. pmc Maternal blood pressure in pregnancy, birth weight, and perinatal mortality in first births: prospective study
    Philip J Steer
    Academic Department of Obstetrics and Gynaecology, Imperial College London, Faculty of Medicine, Chelsea and Westminster Hospital, London SW10 9NH
    BMJ 329:1312. 2004
    ..To investigate the relation of diastolic blood pressure in pregnancy with birth weight and perinatal mortality...
  56. ncbi request reprint Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort
    Marjo Riitta Jarvelin
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Hypertension 44:838-46. 2004
    ..7, -1.1) mm Hg lower systolic blood pressure. Our results support the concept that birth weight, other birth measures, and infant growth are important determinants of blood pressure and hence cardiovascular disease risk in later life...
  57. ncbi request reprint Attainment of precision in implementation of 24 h dietary recalls: INTERMAP UK
    Claire Robertson
    Department of Nutrition and Dietetics, King s College London, 150 Stamford Street, London SE1 8WA, UK
    Br J Nutr 94:588-94. 2005
    ..1 % were below. Experiences from the INTERMAP Belfast centre indicate that difficulties in collection of dietary information can be anticipated and contained by the systematic use of methods to prevent, detect and correct errors...
  58. pmc Interpreting posterior relative risk estimates in disease-mapping studies
    Sylvia Richardson
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
    Environ Health Perspect 112:1016-25. 2004
    ..5- to 2-fold). Larger (3-fold) excess risks are detected almost certainly using this rule, even when based on small expected counts, although the mean of the posterior distribution is typically smoothed to about half the true value...
  59. pmc Cancer incidence near municipal solid waste incinerators in Great Britain. Part 2: histopathological and case-note review of primary liver cancer cases
    P Elliott
    Small Area Health Statistics Unit, Imperial College School of Medicine, St Mary s Campus, London, UK
    Br J Cancer 82:1103-6. 2000
    ..The proportions of true primaries ranging between 55% and 82% (i.e. excluding secondary cancers) give revised estimates of between 0.53 and 0.78 excess cases per 10(5) per year within 1 km...
  60. pmc Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998
    S D Taylor-Robinson
    Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Campus, South Wharf Street, London W2 1PG, UK
    Gut 48:816-20. 2001
    ..We further analysed the mortality statistics to determine which anatomical subcategories were involved...
  61. doi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  62. doi request reprint Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology
    Magda Bictash
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    J Clin Epidemiol 63:970-9. 2010
    ....
  63. doi request reprint Salt intakes around the world: implications for public health
    Ian J Brown
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, UK
    Int J Epidemiol 38:791-813. 2009
    ..Comprehensive, contemporaneous sodium intake data from around the world are needed to inform national/international public health initiatives to reduce sodium consumption...
  64. pmc Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure
    Ian J Brown
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London, UK
    J Hypertens 27:231-6. 2009
    ..Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary starch intake to blood pressure in men and women from four countries...
  65. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...
  66. doi request reprint UK Biobank Pilot Study: stability of haematological and clinical chemistry analytes
    Chris Jackson
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 37:i16-22. 2008
    ..Analytes in blood and urine may vary over time according to conditions of transport and storage...
  67. ncbi request reprint Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples
    Leon M Smith
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Anal Chem 79:5682-9. 2007
    ..Both methods either alone or in combination have the potential for general applications to any complex mixture analysis where the sample contains compounds with a range of diffusion coefficients...
  68. pmc Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption
    Silke S Heinzmann
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    Am J Clin Nutr 92:436-43. 2010
    ..New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns...
  69. ncbi request reprint Assessment of uncertainty in a probabilistic model of consumer exposure to pesticide residues in food
    Helen Ferrier
    Department of Environmental Science and Technology, Imperial College London, SW7 2BP, London, UK
    Food Addit Contam 23:601-15. 2006
    ..The findings have important implications for how probabilistic modelling should be conducted, communicated and used by policy and decision makers as part of consumer risk assessment of pesticides...
  70. pmc Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion
    Stephen Newhouse
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    PLoS ONE 4:e5003. 2009
    ....
  71. doi request reprint High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study
    Richard H Barton
    Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Int J Epidemiol 37:i31-40. 2008
    ....
  72. ncbi request reprint Current knowledge and recent developments in consumer exposure assessment of pesticides: a UK perspective
    H Ferrier
    Department of Environmental Science and Technology EMMA, Imperial College of Science, Technology and Medicine, Royal School of Mines, Prince Consort Road, London, SW7 2BP, UK
    Food Addit Contam 19:837-52. 2002
    ..Communicating results to both risk managers and consumers will be a considerable challenge...
  73. pmc Electrocardiographic changes in 1000 highly trained junior elite athletes
    S Sharma
    St George s Hospital Medical School, London, United Kingdom
    Br J Sports Med 33:319-24. 1999
    ..To evaluate the spectrum of electrocardiographic (ECG) changes in 1000 junior (18 or under) elite athletes...
  74. ncbi request reprint A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom
    Radiat Res 169:99-109. 2008
    ..Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
  75. pmc Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation
    Leon M Smith
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Anal Chem 81:4847-56. 2009
    ....
  76. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
    ..13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance...
  77. ncbi request reprint Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin
    Matthew Hickman
    Centre for Research on Drugs and Health Behaviour, Social Science and Medicine, Imperial College, London, UK
    Addiction 98:419-25. 2003
    ..To test the hypothesis that methadone is responsible for a greater increase in overdose deaths than heroin, and causes proportionally more overdose deaths than heroin at weekends...
  78. ncbi request reprint Evidence on salt and blood pressure is consistent and persuasive
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Int J Epidemiol 31:316-9; discussion 331-2. 2002
  79. doi request reprint Prevention of hypertrophic cardiomyopathy-related deaths: theory and practice
    P Elliott
    The Heart Hospital, London, UK
    Heart 94:1269-75. 2008
    ..In this paper, we review the underlying mechanisms of death and discuss the strengths and weaknesses of current international guidelines for the identification and treatment of high-risk patients...
  80. doi request reprint Natural course of Fabry disease: changing pattern of causes of death in FOS - Fabry Outcome Survey
    A Mehta
    University College London, London, UK
    J Med Genet 46:548-52. 2009
    ..This paper provides an update on the first analysis of FOS data...
  81. pmc A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    R G Walters
    Section of Genomic Medicine, Imperial College London, London W12 0NN, UK
    Nature 463:671-5. 2010
    ..3). The most productive approach may therefore be to combine the 'power of the extreme' in small, well-phenotyped cohorts, with targeted follow-up in case-control and population cohorts...
  82. pmc Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  83. ncbi request reprint Changing international trends in mortality rates for liver, biliary and pancreatic tumours
    Shahid A Khan
    Liver Unit, Department of Medicine A, Faculty of Medicine, 10th Floor, QEQM Wing, Imperial College School of Medicine, St Mary s Hospital, South Wharf Street, London W2 1PG, UK
    J Hepatol 37:806-13. 2002
    ..Trends in cholangiocarcinoma in most other industrialized countries are unknown. To further study trends in hepatobiliary and pancreatic tumours, we analysed mortality data from the United States, Japan, Australia and Europe...
  84. ncbi request reprint Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 79:2629-40. 2007
    ..This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies...
  85. ncbi request reprint Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans
    Claire Teague
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Analyst 129:259-64. 2004
    ..The potential problems associated with using this glucoside metabolite as a marker of ethanol consumption are considered...
  86. pmc Temporal trends in orchidopexy, Great Britain, 1992-1998
    Mireille B Toledano
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College, London, United Kingdom
    Environ Health Perspect 111:129-32. 2003
    ..Either way, our findings do not support the postulate of a recent worsening of male reproductive health of the scale suggested by some recent commentators on the endocrine disruptor hypothesis...
  87. pmc Chlorination disinfection by-products and risk of congenital anomalies in England and Wales
    Mark J Nieuwenhuijsen
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, London, United Kingdom
    Environ Health Perspect 116:216-22. 2008
    ..Increased risk of various congenital anomalies has been reported to be associated with trihalomethane (THM) exposure in the water supply...
  88. doi request reprint Water consumption and use, trihalomethane exposure, and the risk of hypospadias
    Nina Iszatt
    Department of Epidemiology and Biostatistics and MRC HPA Centre for Environment and Health, Imperial College London, London, United Kingdom
    Pediatrics 127:e389-97. 2011
    ..Ingestion of drinking-water-disinfection byproducts such as trihalomethanes (THMs) has been associated with hypospadias in a small sample. We examined risk of hypospadias and exposure to THMs through water consumption and use...
  89. pmc SLC2A9 is a high-capacity urate transporter in humans
    Mark J Caulfield
    Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    PLoS Med 5:e197. 2008
    ..We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man...
  90. ncbi request reprint Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues
    Jane Key
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Cancer Causes Control 17:759-70. 2006
    ..To give an up-to-date assessment of the association of alcohol with female breast cancer, addressing methodological issues and shortfalls in previous overviews...
  91. ncbi request reprint Evaluating evidence on environmental health risks
    Lesley Rushton
    MRC Institute for Environment and Health, Leicester, UK
    Br Med Bull 68:113-28. 2003
    ....
  92. pmc Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  93. ncbi request reprint Estimating laboratory precision of urinary albumin excretion and other urinary measures in the International Study on Macronutrients and Blood Pressure
    Alan R Dyer
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 4402, USA
    Am J Epidemiol 160:287-94. 2004
    ..4%, 11.4%, and 6.4%, respectively. Results indicate that mean and median CV are not equivalent to %TE and that values below the detection limit can markedly affect estimates and should be excluded...
  94. ncbi request reprint Variation at the insulin gene VNTR (variable number tandem repeat) polymorphism and early growth: studies in a large Finnish birth cohort
    Amanda J Bennett
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, UK
    Diabetes 53:2126-31. 2004
    ..09). Studies of this large population-based cohort have failed to generate convincing evidence that INS-VNTR variation influences early growth...
  95. ncbi request reprint Detailed analysis of variation at and around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years
    Sreena Das
    Women s Centre Level 3, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 92:3219-23. 2007
    ..In small studies, variation within the OriB origin of replication (at mt16189 in particular) has been associated with both early growth and adult metabolic phenotypes and may contribute to life-course relationships between the two...
  96. ncbi request reprint Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study
    Hirotsugu Ueshima
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho Seta, Otsu, Shiga 520 2192, Japan
    Hypertension 50:313-9. 2007
    ..In summary, food omega-3 PFA intake related inversely to blood pressure, including in nonhypertensive persons, with small estimated effect size. Food omega-3 PFA may contribute to prevention and control of adverse blood pressure levels...
  97. ncbi request reprint Relation of nutrient intake to microalbuminuria in nondiabetic middle-aged men and women: International Population Study on Macronutrients and Blood Pressure (INTERMAP)
    Martha L Daviglus
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Kidney Dis 45:256-66. 2005
    ..Microalbuminuria (MA) is a risk factor for cardiovascular and renal disease. However, little is known about the relation of nutritional factors to MA, especially in individuals without diabetes...
  98. ncbi request reprint A combination of serum low albumin and above-average cholesterol level was associated with excess mortality
    Tomonori Okamura
    Department of Health Science, Shiga University of Medical Science, Seta tsukinowa cho, Otsu City, Shiga, 520 2192, Japan
    J Clin Epidemiol 57:1188-95. 2004
    ..There is no population-based prospective study concerning the relation between serum albumin and mortality in a non-Western population, and few previous studies included the subgroup analysis stratified by serum cholesterol level...
  99. doi request reprint The UK Biobank sample handling and storage validation studies
    Tim C Peakman
    UK Biobank, Spectrum Way, Adswood, Stockport, Cheshire SK3 0SA, UK
    Int J Epidemiol 37:i2-6. 2008
    ..A series of validation studies was recommended to test the robustness of the draft sample handling and storage protocol...
  100. ncbi request reprint Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population
    Tomonori Okamura
    Department of Health Science, Shiga University of Medical Science, Otsu City, Shiga, Japan
    Am Heart J 147:1024-32. 2004
    ..However, there have been few prospective data from non-Western populations...
  101. ncbi request reprint Study of genes and environmental factors in complex diseases
    Paul Burton
    Lancet 359:1155-6; author reply 1157. 2002