Paul T Elkington

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Matrix metalloproteinases in destructive pulmonary pathology
    P T G Elkington
    Department of Infectious Diseases, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 61:259-66. 2006
  2. doi Matrix metalloproteinases in tuberculosis
    P T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Eur Respir J 38:456-64. 2011
  3. pmc MMP-1 drives immunopathology in human tuberculosis and transgenic mice
    Paul Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, London, UK
    J Clin Invest 121:1827-33. 2011
  4. pmc Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
    Paul T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, London W6 0DT, UK
    Sci Transl Med 3:71ps6. 2011
  5. pmc In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway
    Justin A Green
    Section of Infectious Diseases and Immunity and the Imperial College Wellcome Trust Centre for Clinical Tropical Medicine, Hammersmith Campus, Imperial College London, London W12 0NN, UK
    J Neuroinflammation 10:107. 2013
  6. doi Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks
    Justin A Green
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    J Immunol 184:6492-503. 2010
  7. pmc STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 43:465-74. 2010
  8. pmc Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways
    Justin A Green
    Section of Infectious Diseases and Immunity and the Imperial College Wellcome Trust Centre for Clinical Tropical Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN, UK
    J Neuroinflammation 8:46. 2011
  9. doi Monocyte-dependent oncostatin M and TNF-alpha synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Imperial College London, London, UK
    Eur J Immunol 38:1321-30. 2008
  10. ncbi Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis
    Paul T Elkington
    Department of Infectious Diseases, Imperial College, Hammersmith Hospital, London, UK
    Am J Respir Cell Mol Biol 37:431-7. 2007

Collaborators

Detail Information

Publications18

  1. pmc Matrix metalloproteinases in destructive pulmonary pathology
    P T G Elkington
    Department of Infectious Diseases, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 61:259-66. 2006
    ....
  2. doi Matrix metalloproteinases in tuberculosis
    P T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Eur Respir J 38:456-64. 2011
    ....
  3. pmc MMP-1 drives immunopathology in human tuberculosis and transgenic mice
    Paul Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, London, UK
    J Clin Invest 121:1827-33. 2011
    ..In summary, MMP-1 may drive tissue destruction in TB and represents a therapeutic target to limit immunopathology...
  4. pmc Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
    Paul T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, London W6 0DT, UK
    Sci Transl Med 3:71ps6. 2011
    ....
  5. pmc In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway
    Justin A Green
    Section of Infectious Diseases and Immunity and the Imperial College Wellcome Trust Centre for Clinical Tropical Medicine, Hammersmith Campus, Imperial College London, London W12 0NN, UK
    J Neuroinflammation 10:107. 2013
    ..However, relatively little is known about the regulation of these MMPs in the CNS...
  6. doi Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks
    Justin A Green
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    J Immunol 184:6492-503. 2010
    ..Dexamethasone suppression of MMP-1/-3 gene expression provides a novel mechanism explaining the benefit of steroid therapy in these patients...
  7. pmc STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 43:465-74. 2010
    ....
  8. pmc Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways
    Justin A Green
    Section of Infectious Diseases and Immunity and the Imperial College Wellcome Trust Centre for Clinical Tropical Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN, UK
    J Neuroinflammation 8:46. 2011
    ..In summary, suppression of microglial MMP-2 secretion by M.tb-infected monocyte-dependent networks paradoxically involves the pro-inflammatory mediators TNF-α, p38 MAP kinase and NFκB in addition to a novel caspase 8-dependent pathway...
  9. doi Monocyte-dependent oncostatin M and TNF-alpha synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Imperial College London, London, UK
    Eur J Immunol 38:1321-30. 2008
    ..In summary, Mtb infection of monocytes results in PG-dependent OSM secretion, which synergizes with TNF-alpha to drive functionally unopposed fibroblast MMP-1/-3 secretion, demonstrating a previously unrecognized role for OSM in TB...
  10. ncbi Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis
    Paul T Elkington
    Department of Infectious Diseases, Imperial College, Hammersmith Hospital, London, UK
    Am J Respir Cell Mol Biol 37:431-7. 2007
    ..01 compared with either stimulus alone). Together, these data reveal a new mechanism by which host- and pathogen-derived factors act together in MTb infection to drive MAPK-dependent MMP-9 secretion from respiratory epithelial cells...
  11. pmc Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases
    Naomi F Walker
    Infectious Diseases and Immunity, Imperial College London, London, UK
    Am J Respir Crit Care Med 185:989-97. 2012
    ..In advanced HIV infection, tissue destruction is reduced, but underlying mechanisms are poorly defined and no current antituberculous therapy reduces host tissue damage...
  12. ncbi Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo
    James E Harris
    Department of Infectious Diseases and Immunity, Imperial College, Du Cane Road, London, United Kingdom
    J Immunol 178:1199-207. 2007
    ..Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality...
  13. ncbi Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages
    Joseph J Boyle
    Department of Infectious Diseases Immunity, Imperial College, Hammersmith Campus, Du Cane Road, London, UK
    J Immunol 178:3767-76. 2007
    ..These data show that fibroblasts have a previously unrecognized role in modulating inflammation in TB by their CXCL8-dependent contribution to cell recruitment and mycobacterial killing within the granuloma...
  14. doi Analysis of matrix metalloproteinase secretion by macrophages
    Paul T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus, London, UK
    Methods Mol Biol 531:253-65. 2009
    ..The ability to analyze and quantify MMP secretion by macrophages offers an additional window through which to understand the contributions of macrophages to a wide variety of infectious, inflammatory, and immunologic disorders...
  15. pmc Optimisation of bioluminescent reporters for use with mycobacteria
    Nuria Andreu
    Department of Medicine, Imperial College London, London, UK
    PLoS ONE 5:e10777. 2010
    ..Despite the extensive use of luminescent reporters in mycobacteria, the resultant luminescent strains have not been fully applied to BLI...
  16. ncbi Monocytes infected with Mycobacterium tuberculosis regulate MAP kinase-dependent astrocyte MMP-9 secretion
    James E Harris
    Department of Infectious Diseases and Immunity, Imperial College, Hammersmith Campus, London, UK
    J Leukoc Biol 81:548-56. 2007
    ..In summary, the data suggest that monocyte-dependent cytokine networks may play a key role in the development of a matrix-degrading environment during CNS-TB...
  17. ncbi Filter sterilization of highly infectious samples to prevent false negative analysis of matrix metalloproteinase activity
    P T G Elkington
    Department of Infectious Diseases, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol Methods 309:115-9. 2006
    ..This study demonstrates the importance of selecting the appropriate filter in MMP analysis to avoid incorrectly excluding MMP involvement in infection-related immunopathology...
  18. pmc The paradox of matrix metalloproteinases in infectious disease
    P T G Elkington
    Department of Infectious Diseases, Hammersmith Campus, Imperial College, London, UK
    Clin Exp Immunol 142:12-20. 2005
    ..Tissue destruction may be exacerbated further by bacterial-derived enzymes which activate the host pro-MMPs. Finally, the potential for therapeutic targeting of excess MMP activity in infection is considered...