Research Topics
Genomes and Genes
| A J EdgarSummaryAffiliation: Imperial College Country: UK Publications
| Collaborators
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Detail Information
Publications
Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenasesAlasdair J Edgar
Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
BMC Biochem 3:19. 2002..The L-threonine 3-dehydrogenase enzyme has been purified and characterised, but the L-threonine 3-dehydrogenase gene has not previously been identified in mammals...- The human L-threonine 3-dehydrogenase gene is an expressed pseudogeneAlasdair J Edgar
Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
BMC Genet 3:18. 2002..The murine and porcine L-threonine dehydrogenase genes (TDH) have been identified previously, but the human gene has not been identified... 
Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAsA J Edgar
Department of Histochemistry, Division of Investigative Science, Imperial College School of Medicine, London, UK
Eur J Biochem 267:1805-12. 2000....- Human homologues of yeast vacuolar protein sorting 29 and 35A J Edgar
Department of Histochemistry and Tissue Engineering Centre, Imperial College School of Medicine, London, United Kingdom
Biochem Biophys Res Commun 277:622-30. 2000..6 kb, 17 exon, VPS35 gene is on chromosome 16. In humans, Vps29p, Vps35p, and Hbeta58, the homologue of Vps26p, may form an inner shell of the retromer coat similar to that found in yeast... - Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signalsA J Edgar
Department of Histochemistry, Division of Investigative Science, Commonwealth Building, Hammersmith Campus, Imperial College School of Medicine, Du Cane Road, London W12 0NN, UK
Int J Biochem Cell Biol 33:53-64. 2001..The long central alpha-helical domain may form a coiled-coil. We have isolated and characterised a cDNA encoding the human flotillin-1 gene, which may play an important role in raft formation... - Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysemaA J Edgar
Department of Histochemistry, Division of Investigative Sciences, Imperial College School of Medicine, 3rd Floor Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Am J Respir Cell Mol Biol 25:119-24. 2001..The human mRNA has a single 1.3-kb transcript. We suggest that the increased expression of DEXI in emphysema may either be relevant to disease progression or be indicative of glucocorticoid responsiveness in treated patients... - Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAsAlasdair J Edgar
Tissue Engineering Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
Biochem Biophys Res Commun 292:617-25. 2002..mRNA expression levels of LABH1 and 3 were highest in liver and LABH2 highest in testis. These findings suggest that the LABH proteins consist of a novel family of membrane bound enzymes whose function has yet to be determined... - Loss of cell surface microvilli on rat basophilic leukaemia cells precedes secretion and can be mimicked using the calmodulin antagonist trifluoperazineA J Edgar
Department of Anatomy and Cell Biology, Imperial College School of Medicine at St Mary s, Imperial College of Science, Technology and Medicine, London, UK
Inflamm Res 46:354-60. 1997..We studied changes in cell surface morphology following treatment with secretagogue or trifluoperazine in a mast cell model... - Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolutionI D Xynos
Department of Histochemistry, Hammersmith Campus, Imperial College School of Science, Technology and Medicine, London, United Kingdom
J Biomed Mater Res 55:151-7. 2001..The identification of differentially expressed genes by cDNA microarray analysis has offered new insights into the mode of action of bioactive glasses and has proven to be an effective tool in evaluating their osteoproductive properties... - Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin VaA J Edgar
Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
J Anat 195:173-84. 1999..We conclude that in addition to its involvement in melanosome transport, myosin Va has a role in the extension of new dendrites by melanocytes but not in maintenance of pre-existing dendrites... - Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptorsAlasdair J Edgar
Department of Craniofacial Development, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London, UK
DNA Seq 18:235-41. 2007..LUSTR proteins are also found in Drosophila, Saccharomyces and Arabidopsis, but are absent from bacteria, archaea and viruses. This suggests that GPCRs are present in higher plants... - Upregulated genes in sporadic, idiopathic pulmonary arterial hypertensionAlasdair J Edgar
Department of Craniofacial Development, King s College, London, SE1 9RT, UK
Respir Res 7:1. 2006.... - Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogeneAlasdair J Edgar
Department of Craniofacial Development, King s College, London, UK
BMC Genomics 6:32. 2005..Low levels of TA enzymatic activity have been found in vertebrates. It has been suggested that any detectable activity is due to serine hydroxymethyltransferase and that mammals lack a genuine threonine aldolase... - Genomic structure and cloning of two transcript isoforms of human Sp8Maria athina Milona
Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
BMC Genomics 5:86. 2004..They also have malformed brains with defective closure of the anterior and posterior neuropore during brain development... - Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450Alasdair J Edgar
Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London SE1 9RT, United Kingdom
J Cell Biochem 94:202-15. 2005..However, ZNF450 mRNA was found also in a wide range of adult tissues. The consistent induction of ZNF450 by BMP-2 after 4 h in three murine pluripotent cell lines suggests that ZNF450 may play a role in the BMP-2 signalling pathway... - Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cellsMaria athina Milona
Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center, Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
BMC Genomics 4:43. 2003..Regulation of its expression may prove useful for mediating skeletal repair... - The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12Alasdair J Edgar
Department of Clinical and Diagnostic Oral Science, Clinical Research Centre, Queen Mary, University of London, 2 Newark Street, London, E1 2AD, UK
BMC Genomics 4:18. 2003..Overlapping polyadenylation signal sequences have not been described previously... - Cyclin L is an RS domain protein involved in pre-mRNA splicingLiliane A Dickinson
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 277:25465-73. 2002..Significantly, the IC(50) for splicing inhibition by p21 is similar to the IC(50) for inhibition of the cyclin L-associated kinase activity. Cyclin L and its associated kinase are thus new members of the pre-mRNA processing machinery...