S W Duffy

Summary

Affiliation: Imperial Cancer Research Fund
Country: UK

Publications

  1. pmc Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations
    S W Duffy
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Br J Cancer 86:218-21. 2002
  2. ncbi request reprint Breast density and breast cancer risk factors in a high-risk population
    J Warwick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK
    Breast 12:10-6. 2003
  3. ncbi request reprint Screening younger women with a family history of breast cancer--does early detection improve outcome?
    A Maurice
    Breast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK
    Eur J Cancer 42:1385-90. 2006
  4. ncbi request reprint Cross-issue synthesis: potential application to breast cancer, tamoxifen and genetic susceptibility
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    J Cancer Epidemiol Prev 7:205-12. 2002
  5. ncbi request reprint Audit of negative assessments in a breast-screening programme in women who later develop breast cancer-implications for survival
    P C Allgood
    QA Reference Centre for Cancer Screening for Eastern Region, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1 M 6BQ, UK
    Breast 15:503-9. 2006
  6. ncbi request reprint Development of a protocol for evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer
    J Mackay
    North East Thames Regional Genetics Service, Institute of Child Health, London, UK
    J Epidemiol Biostat 6:365-9; discussion 371-5. 2001
  7. ncbi request reprint Evaluation of service screening mammography in practice: the impact on breast cancer mortality
    R Gabe
    Wolfson Institute of Preventive Medicine, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, London, UK
    Ann Oncol 16:ii153-62. 2005
  8. pmc Lymph node status in screen-detected cancers
    S W Duffy
    Br J Cancer 92:3-4. 2005
  9. pmc What should the detection rates of cancers be in breast screening programmes?
    S W Duffy
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 92:597-600. 2005
  10. ncbi request reprint A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive
    A Pal
    Addenbrookes NHS Foundation Trust, Cambridge, UK
    Br J Surg 95:302-9. 2008

Collaborators

Detail Information

Publications35

  1. pmc Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations
    S W Duffy
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Br J Cancer 86:218-21. 2002
    ..The benefit of prophylactic use of tamoxifen in BRCA1 mutation carriers is likely to be modest, and the effect in BRCA2 mutation carriers somewhat greater...
  2. ncbi request reprint Breast density and breast cancer risk factors in a high-risk population
    J Warwick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK
    Breast 12:10-6. 2003
    ....
  3. ncbi request reprint Screening younger women with a family history of breast cancer--does early detection improve outcome?
    A Maurice
    Breast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK
    Eur J Cancer 42:1385-90. 2006
    ..These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies...
  4. ncbi request reprint Cross-issue synthesis: potential application to breast cancer, tamoxifen and genetic susceptibility
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    J Cancer Epidemiol Prev 7:205-12. 2002
    ..Here we describe a procedure for combining information from studies addressing different but clinically related questions, referred to, for brevity, as cross-issue synthesis...
  5. ncbi request reprint Audit of negative assessments in a breast-screening programme in women who later develop breast cancer-implications for survival
    P C Allgood
    QA Reference Centre for Cancer Screening for Eastern Region, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1 M 6BQ, UK
    Breast 15:503-9. 2006
    ..Increased use of percutaneous biopsy in recent years should address the problem...
  6. ncbi request reprint Development of a protocol for evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer
    J Mackay
    North East Thames Regional Genetics Service, Institute of Child Health, London, UK
    J Epidemiol Biostat 6:365-9; discussion 371-5. 2001
    ..Incremental cost-effectiveness ratios of implementing the standardised mammography strategy compared with no screening will be presented in terms of the additional cost per cancer detected, per life saved and per life-year saved...
  7. ncbi request reprint Evaluation of service screening mammography in practice: the impact on breast cancer mortality
    R Gabe
    Wolfson Institute of Preventive Medicine, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, London, UK
    Ann Oncol 16:ii153-62. 2005
  8. pmc Lymph node status in screen-detected cancers
    S W Duffy
    Br J Cancer 92:3-4. 2005
  9. pmc What should the detection rates of cancers be in breast screening programmes?
    S W Duffy
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 92:597-600. 2005
    ..1 and 4.3 at prevalence screen and incidence screens, respectively; expected rates should be 6.9 and 4.8 and maximum rates of 9.6 and 5.5. These are consistent with observed detection rates in the UK programme...
  10. ncbi request reprint A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive
    A Pal
    Addenbrookes NHS Foundation Trust, Cambridge, UK
    Br J Surg 95:302-9. 2008
    ..The Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram to estimate the risk of non-SLN disease. This study critically appraised the nomogram and refined the model to improve predictive accuracy...
  11. pmc A case-control study of the impact of the East Anglian breast screening programme on breast cancer mortality
    P C Allgood
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 98:206-9. 2008
    ....
  12. ncbi request reprint Exposure to traffic emissions throughout life and risk of breast cancer
    N M Perry
    Cancer Causes Control 19:435. 2008
  13. ncbi request reprint A case-control study to estimate the impact of the Icelandic population-based mammography screening program on breast cancer death
    R Gabe
    Cancer Research UK, Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK and Icelandic Cancer Society Krabbameinsfélag Islands, Reykjavik, Iceland
    Acta Radiol 48:948-55. 2007
    ..The Icelandic breast cancer screening program, initiated November 1987 in Reykjavik and covering the whole country from December 1989, comprises biennial invitation to mammography for women aged 40-69 years old...
  14. pmc The LLP risk model: an individual risk prediction model for lung cancer
    A Cassidy
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK
    Br J Cancer 98:270-6. 2008
    ..70, indicating good discrimination.If independent validation studies confirm these results, the LLP risk models' application as the first stage in an early detection strategy is a logical evolution in patient care...
  15. pmc Early onset of breast cancer in a group of British black women
    R L Bowen
    Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 98:277-81. 2008
    ..There were no disparities in socioeconomic status or treatment received. Our findings could have major implications for the biology of breast cancer and the detection and treatment of the disease in black women...
  16. pmc Screen-detected vs symptomatic breast cancer: is improved survival due to stage migration alone?
    G C Wishart
    Cambridge Breast Unit, Box 97, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Br J Cancer 98:1741-4. 2008
    ..Current prognostication tools may, therefore, overestimate the benefit of systemic treatments in screen-detected cancers and lead to overtreatment of these patients...
  17. pmc Second breast cancers in a Tuscan case series: characteristics, prognosis, and predictors of survival
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Istituto scientifico della Regione Toscana, Florence, Italy
    Br J Cancer 99:539-44. 2008
    ..Prognosis following a second breast cancer in this cohort was generally good. However, large or node-positive second tumours, and shorter intervals between diagnoses were indicators of poorer survival...
  18. pmc Complexities in the estimation of overdiagnosis in breast cancer screening
    S W Duffy
    Cancer Research UK Centre for Epidemiology Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1 M 6BQ, UK
    Br J Cancer 99:1176-8. 2008
    ..We illustrate this using an example of analysis of breast cancer incidence data from Sweden...
  19. ncbi request reprint A case-control study to estimate the impact on breast cancer death of the breast screening programme in Wales
    H M Fielder
    Breast Test Wales, Cardiff, UK
    J Med Screen 11:194-8. 2004
    ..Furthermore, we wished to ascertain whether a reduction in breast cancer mortality consistent with that observed in the randomised screening trials was being achieved...
  20. ncbi request reprint Number needed to screen: lives saved over 20 years of follow-up in mammographic screening
    L Tabar
    Mammography Department, Central Hospital, Falun, Sweden
    J Med Screen 11:126-9. 2004
    ..To estimate the number needed to screen with mammography to save one life, based on a stated amount of screening activity and long-term follow-up for breast cancer death...
  21. pmc Quantification of the effect of mammographic screening on fatal breast cancers: The Florence Programme 1990-96
    E Paci
    Unit of Epidemiology, CSPO, Florence, Italy
    Br J Cancer 87:65-9. 2002
    ..58, 95% CI : 0.45-0.74). This study confirmed that new treatments and the first rounds of the screening programme contributed to reducing mortality from breast cancer...
  22. pmc Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease
    N Hamajima
    Cancer Research UK Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Cancer 87:1234-45. 2002
    ....
  23. ncbi request reprint Deterministic models for breast cancer progression: application to the association between mammographic parenchymal pattern and histologic grade of breast cancers
    D A Harrison
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    J Clin Epidemiol 55:1113-8. 2002
    ..It is concluded that the majority of the enhanced risk of grade 3 tumors is due to enhanced innate predisposition to grade 3 tumors in dense breasts...
  24. ncbi request reprint All-cause mortality among breast cancer patients in a screening trial: support for breast cancer mortality as an end point
    L Tabar
    Department of Mammography, Falun Central Hospital, Sweden
    J Med Screen 9:159-62. 2002
    ....
  25. ncbi request reprint Radiology review of the UKCCCR Breast Screening Frequency Trial: potential improvements in sensitivity and lead time of radiological signs
    R M L Warren
    Department of Radiology, St Margaret s Hospital, Epping, UK
    Clin Radiol 58:128-32. 2003
    ....
  26. ncbi request reprint The Swedish Two-County Trial of mammographic screening: cluster randomisation and end point evaluation
    S W Duffy
    Queen Mary University of London, London, UK
    Ann Oncol 14:1196-8. 2003
    ..The Swedish Two-County Trial has been criticised on the grounds of the cluster randomisation and alleged bias in classification of cause of death...
  27. ncbi request reprint Quantifying the potential problem of overdiagnosis of ductal carcinoma in situ in breast cancer screening
    M F Yen
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Eur J Cancer 39:1746-54. 2003
    ..There is an element of overdiagnosis of DCIS in breast cancer screening, but the phenomenon is small in both relative and absolute terms...
  28. ncbi request reprint The relative contributions of screen-detected in situ and invasive breast carcinomas in reducing mortality from the disease
    S W Duffy
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Eur J Cancer 39:1755-60. 2003
    ..Treatment decisions in DCIS, as in invasive carcinoma, should take full account of histopathological, clinical and radiological attributes of the tumour...
  29. ncbi request reprint Assessing progression and efficacy of treatment for diabetic retinopathy following the proliferative pathway to blindness: implication for diabetic retinopathy screening in Taiwan
    W J Liu
    Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Diabet Med 20:727-33. 2003
    ..Therefore, the natural history of DR and rates of transition after treatment (including metabolic control and laser photocoagulation) from no diabetic retinopathy (NDR) to blindness were quantified...
  30. ncbi request reprint A potentially useful distribution model for dietary intake data
    J P Myles
    Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, EC1M 6BQ, UK
    Public Health Nutr 6:513-9. 2003
    ..Conventional mixed models for the analysis of diet diary data have introduced several simplifying assumptions, such as that of a single standard deviation for within-person day-to-day variation which is common to all individuals...
  31. pmc Socioeconomic effects on breast cancer survival: proportion attributable to stage and morphology
    F Kaffashian
    Cancer Intelligence Unit, Strangeways Research Laboratory, Cambridge, UK
    Br J Cancer 89:1693-6. 2003
    ..Thus, stage at presentation explains some but not all of the socioeconomic differences in breast cancer survival. Future research on histological grade and socioeconomic status is indicated...
  32. ncbi request reprint Mammographic casting-type calcification associated with small screen-detected invasive breast cancers: is this a reliable prognostic indicator?
    C Peacock
    The South West London Breast Screening Service, The Duchess of Kent Unit, London, UK
    Clin Radiol 59:165-70; discussion 163-4. 2004
    ..The aim of the present study was to establish whether mammographic casting-type calcification associated with small screen-detected invasive breast cancers is a reliable prognostic indicator...
  33. ncbi request reprint Overdiagnosis in screening: is the increase in breast cancer incidence rates a cause for concern?
    E Paci
    Clinical and Descriptive Epidemiology Unit, Center for Study and Prevention of Cancer CSPO, Scientific Institute, Tuscany Region, Florence, Italy
    J Med Screen 11:23-7. 2004
    ..To estimate the degree of overdiagnosis of breast cancer in a mammographic screening programme...
  34. pmc Interaction of dense breast patterns with other breast cancer risk factors in a case-control study
    S W Duffy
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 91:233-6. 2004
    ..The results are consistent with dense breast patterns as a marker for hormonal modification of breast cancer risk...
  35. doi request reprint Single reading with computer-aided detection for screening mammography
    Fiona J Gilbert
    Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    N Engl J Med 359:1675-84. 2008
    ..We conducted a trial to determine whether the performance of a single reader using a computer-aided detection system would match the performance achieved by two readers...