J Domin

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
    J Domin
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    J Biol Chem 275:11943-50. 2000
  2. pmc Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    A Arcaro
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    Mol Cell Biol 20:3817-30. 2000
  3. ncbi request reprint Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo
    J Domin
    Ludwig Institute for Cancer Research, London, W1P 8BT, United Kingdom
    J Biol Chem 271:21614-21. 1996
  4. pmc A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
    S Volinia
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 14:3339-48. 1995
  5. ncbi request reprint The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
    I Gaidarov
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 7:443-9. 2001
  6. pmc Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation
    P E Row
    Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 353:655-61. 2001
  7. ncbi request reprint Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
    R A Brown
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 274:14529-32. 1999
  8. pmc Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
    J Domin
    Ludwig Institute for Cancer Research, London, U K
    Biochem J 326:139-47. 1997
  9. pmc Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase
    C Linassier
    Ludwig Institute for Cancer Research, University College London, U K
    Biochem J 321:849-56. 1997
  10. ncbi request reprint Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
    C Panaretou
    Ludwig Institute of Cancer Research, University College London, Riding House Street, London W1P 8BT, UK
    J Biol Chem 272:2477-85. 1997

Collaborators

  • A Arcaro
  • C Wallasch
  • M D Waterfield
  • I Gaidarov
  • L K MacDougall
  • M Wheeler
  • P E Row
  • C Panaretou
  • R A Brown
  • C Linassier
  • M E Smith
  • J P Luzio
  • H W Davidson
  • B J Reaves
  • J H Keen
  • S Volinia
  • P R Shepherd
  • S Cockcroft
  • R Stein
  • R Dhand
  • M J Zvelebil
  • B Vanhaesebroeck

Detail Information

Publications12

  1. ncbi request reprint The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
    J Domin
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    J Biol Chem 275:11943-50. 2000
    ....
  2. pmc Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    A Arcaro
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    Mol Cell Biol 20:3817-30. 2000
    ..We conclude that class II PI3K enzymes may contribute to the generation of 3' phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity...
  3. ncbi request reprint Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo
    J Domin
    Ludwig Institute for Cancer Research, London, W1P 8BT, United Kingdom
    J Biol Chem 271:21614-21. 1996
    ....
  4. pmc A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
    S Volinia
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 14:3339-48. 1995
    ..These results suggest that the major components of the yeast Vps intracellular trafficking complex are conserved in humans...
  5. ncbi request reprint The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
    I Gaidarov
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 7:443-9. 2001
    ....
  6. pmc Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation
    P E Row
    Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 353:655-61. 2001
    ....
  7. ncbi request reprint Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
    R A Brown
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 274:14529-32. 1999
    ..The finding that insulin activates PI3K-C2alpha in cell types known to possess a wide range of responses to insulin suggests that PI3K-C2alpha is a novel component of insulin-stimulated signaling cascades...
  8. pmc Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
    J Domin
    Ludwig Institute for Cancer Research, London, U K
    Biochem J 326:139-47. 1997
    ..The comparative insensitivity of PI3-K-C2 alpha to these inhibitors suggests that their use should be reevaluated in the study of PI3-Ks...
  9. pmc Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase
    C Linassier
    Ludwig Institute for Cancer Research, University College London, U K
    Biochem J 321:849-56. 1997
    ..This activity is sensitive to inhibition both by non-ionic detergent (Nonidet P40) and by wortmannin (IC50 10 nM). PI3K_59F, therefore, conserves both the structural and biochemical properties of the Vps34 class of enzymes...
  10. ncbi request reprint Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
    C Panaretou
    Ludwig Institute of Cancer Research, University College London, Riding House Street, London W1P 8BT, UK
    J Biol Chem 272:2477-85. 1997
    ..These results suggest that the Vps15p.Vps34p complex has been conserved from yeast to man and in both species is involved in protein trafficking...
  11. ncbi request reprint A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
    L K MacDougall
    Ludwig Institute for Cancer Research, University College Branch, London, UK
    Curr Biol 5:1404-15. 1995
    ..Additionally, a PI 3-kinase activity which generates phosphatidylinositol 3-phosphate has been shown to be required for protein trafficking in yeast...
  12. pmc Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2
    M Wheeler
    Division of Medicine, Imperial College School of Medicine, London W12 0NN, United Kingdom
    Mol Cell Biol 21:6660-7. 2001
    ..We conclude that proline-rich motifs within the N terminus of PI3K-C2beta mediate the association of this enzyme with activated EGF receptor and that this interaction involves the Grb2 adaptor...